IndraLab

Statements

USP33 affects ROBO1
1 1 | 7
USP33 deubiquitinates ROBO1. 7 / 7
1 | 6
reach
"USP33 mediates Slit2 signaling by deubiquitinating and stabilizing Robo1."
25242263
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"USP33 deubiquitinates ROBO1 in lung cancer cells to maintain its stability, thereby regulating SLIT2 activity and inhibiting cancer cell metastasis [XREF_BIBR]."
29743814
reach
"Cell based assays support a model in which USP33 reverses Robo1 ubiquitination : knockdown of USP33 increases levels of ubiquitinated Robo1, while USP33 overexpression reduces ubiquitinated Robo1 levels [XREF_BIBR]."
21704388
reach
"These results show that USP33 mediates Slit-Robo signaling by deubiquitinating and stabilizing Robo1 in CRC cells (XREF_SUPPLEMENTARY)."
25242263
ubibrowser
"Robo-interacting ubiquitin-specific protease 33 (USP33) is required for the inhibitory function of Slit2 on CRC cell migration by deubiquitinating and stabilizing Robo1."
25242263
reach
"USP33 deubiquitinates and stabilizes Robo1."
25242263
reach
"Though direct deubiquitination of Robo1 by USP33 has not been reported, it is reasonable to speculate that USP33 deubiquitinates and thus rescues Robo1 from degradation during the Slit response."
21704388
Modified USP33 leads to the deubiquitination of ROBO1. 1 / 1
| 1
reach
"Overexpression of wild-type USP33, but not catalytically inactive C163A mutant of USP33, decreased the ubiquitination of Robo1."
24981056
USP33 deubiquitinates ROBO1 on lysine. 1 / 1
1 |
biopax:reactome
No evidence text available
USP33 affects ARRB2
1 | 6
USP33 deubiquitinates ARRB2. 7 / 7
1 | 6
reach
"Subsequent deubiquitination of beta-arrestin 2 by the deubiquitinase USP33 dissociates the receptor, beta, and arrestin complex."
19853559
reach
"USP33 leads to de-ubiquitination of beta-arrestin2 with non degradative effects."
27835898
reach
"Further results verified that USP33 can deubiquitinate beta-arrestin2, subsequently block the internalization of SDF-1-stimulated CXCR4, and disrupt beta-arrestin-dependent ERK activation."
27835898
ubibrowser
No evidence text available
reach
"Beta-arrestin-2 can be ubiquitinated by Mdm2 (see above) and deubiquitinated by the DUB enzyme USP33."
20854416
reach
"Importantly, a knockdown of USP20 and USP33 enhances beta-arrestin2 ubiquitination and increases beta 2 AR degradation [XREF_BIBR, XREF_BIBR]."
24680432
reach
"Given that the enzymatic activity of USP33 is important in regulating CXCR4 internalization, we were interested in whether USP33 can deubiquitinate beta-arrestin2 and subsequently regulate CXCR4 endocytosis."
27835898
USP33 affects CCP110
1 | 4
USP33 deubiquitinates CCP110. 4 / 4
1 | 3
reach
"For example, USP33 deubiquitylates the centrosomal protein CP110, regulating centrosome biogenesis [76] and USP33 depletion has a co-operative effect with CDK2 on the CP110-dependent clustering function mentioned earlier [77]."
31506331
reach
"USP33 potently and specifically deubiquitinates CP110, but not other cyclin-F substrates."
23486064
ubibrowser
"USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110"
23486064
reach
"Thus, USP33 specifically de-ubiquitylates CP110 in vitro and in vivo, explaining how USP33 stabilizes CP110."
23486064
Modified USP33 leads to the deubiquitination of CCP110. 1 / 1
| 1
reach
"Remarkably, USP33 over-expression diminished CP110 ubiquitylation provoked by ectopic production of cyclin F in cells (XREF_FIG)."
23486064
USP33 affects PRKN
| 4
USP33 deubiquitinates PRKN. 2 / 2
| 2
reach
"USP33 deubiquitinates PRKN and parkin and antagonizes its role in mitophagy."
31432739
reach
"Cellular and in vitro assays illustrated that USP33 deubiquitinates PRKN in a DUB activity dependent manner."
31432739
USP33 deubiquitinates PRKN on K435. 2 / 2
| 2
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"Different from USP30 which regulates substrates of Parkin, USP33 can directly and selectively deubiquitinate Parkin at Lys435 and preferentially remove K6, K11, K48, and K63-linked ubiquitin conjugates from Parkin."
34804365
reach
"USP33 prefers to remove K6, K11, K48 and K63 linked ubiquitin conjugates from PRKN, and deubiquitinates PRKN mainly at Lys435."
31432739
USP33 affects RALB
1 | 2
USP33 deubiquitinates RALB. 3 / 3
1 | 2
reach
"Starvation induced deubiquitination of RALB by USP33 (XREF_FIG c) prevents the association with SEC5 and triggers the interaction to another exocyst subunit, EXO84 [XREF_BIBR]."
26445063
ubibrowser
"Review"
26445063
reach
"Another example in the context of early signaling events is the deubiquitination of RALB by USP33, which enables the interaction of non modified RALB with Beclin 1 complexes in order to induce autophagy."
26445063
USP33 affects GCGR
| 3
USP33 deubiquitinates GCGR. 3 / 3
| 3
reach
"Our data suggest that USP33 constitutively deubiquitinates the GCGR, whereas both STAMBP and USP33 deubiquitinate agonist-activated GCGRs at early endosomes."
32967969
reach
"USP33 knockdown drastically increases GCGR ubiquitination in quiescent cells; one possibility is that USP33 deubiquitinates and protects newly synthesized receptors from 26S proteasomal degradation."
32967969
reach
"Our data suggest that USP33 constitutively deubiquitinates the GCGR, whereas both STAMBP and USP33 deubiquitinate agonist activated GCGRs at early endosomes."
33453899
USP33 affects beta-arrestins
| 2
USP33 leads to the deubiquitination of beta-arrestins. 2 / 2
| 2
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"We now report the discovery that the deubiquitinating enzyme ubiquitin specific protease 33 (USP33) binds beta-arrestin2 and leads to the deubiquitination of beta-arrestins."
19363159
reach
"Deubiquitination of beta-arrestins is also regulated by agonist activation of the beta2AR and other GPCRs and is mediated by USP20 and USP33 and is important for beta, arrestin, and beta2AR complex disassembly, lysosomal sorting and signaling [XREF_BIBR, XREF_BIBR] (XREF_FIG)."
30353650
USP33 affects MYC
| 2
USP33 deubiquitinates MYC. 2 / 2
| 2
reach
"USP33, as a deubiquitinating enzyme, could deubiquitinate c-Myc, an important proliferation regulator."
33718387
reach
"IP experiments showed that USP33 interacted with c-Myc (XREF_FIG), and USP33 knockdown profoundly enhanced c-Myc ubiquitination (XREF_FIG)."
33718387
USP33 affects AR
| 2
USP33 leads to the deubiquitination of AR. 2 / 2
| 2
reach
"104 Two DUBs USP20 and USP33 have been shown to mediate deubiquitination of beta 2 AR."
26055058
reach
"Ubiquitination of the beta 2 AR is reversed by the deubiquitinases USP20 and USP33, which tonically associate with the beta 2 AR."
23166351
USP33 affects pVHL-E3 ligase
| 1
USP33 deubiquitinates pVHL-E3 ligase. 1 / 1
| 1
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"Can VDU1 and VDU2 deubiquitinate the ubiquitinated downstream targets of pVHL-E3 ligase, such as HIF-1alpha, therefore, counteract or modify the ubiquitinating function of VCB-E3 ligase?"
12056827
USP33 affects VHL
| 1
USP33 deubiquitinates ubiquitinated VHL. 1 / 1
| 1
reach
"Can VDU1 or VDU2 deubiquitinate the ubiquitinated pVHL to salvage it from degradation on certain conditions?"
12056827
USP33 affects TRAF6
| 1
USP33 deubiquitinates TRAF6. 1 / 1
| 1
reach
"We report that two ubiquitin specific peptidases, USP20 and USP33, deubiquitinate TRAF6 and suppress IL-1beta-induced NF-kappaB activation."
| PMC
USP33 affects TGFBR2
| 1
USP33 leads to the deubiquitination of TGFBR2. 1 / 1
| 1
reach
"Mechanistically, USP33 triggered the deubiquitination of TGFBR2 and prevented its degradation by lysosome, therefore promoted TGFBR2 accumulation in cell membrane and eventually contributed to the sustained activation of TGF-β signaling."
37322017
USP33 affects SP1
| 1
USP33 deubiquitinates SP1. 1 / 1
| 1
trips
"USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma."
32835698
USP33 affects RAB40AL
| 1
USP33 deubiquitinates RAB40AL. 1 / 1
| 1
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"It has also been demonstrated that USP33 deubiquitinates RAS like GTPase RALB and therefore promoting autophagosome formation [18]."
28506875
USP33 affects Phosphatase
| 1
USP33 deubiquitinates Phosphatase. 1 / 1
| 1
reach
"USP33 could deubiquitinate PPM1A (protein phosphatase, Mg2 +/Mn2 + dependent 1A), a phosphatase for Smad2/3."
30308513
USP33 affects PPM1A
| 1
USP33 deubiquitinates PPM1A. 1 / 1
| 1
reach
"USP33 could deubiquitinate PPM1A (protein phosphatase, Mg2 +/Mn2 + dependent 1A), a phosphatase for Smad2/3."
30308513
USP33 affects ID2
| 1
USP33 deubiquitinates ID2. 1 / 1
| 1
reach
"Therefore, we posit that overexpressed USP1 interferes with mesenchymal stem cell differentiation and thereby fosters the development of malignant mesenchymal cell populations.Our screen for DUBs capa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21925315
USP33 affects HIF1A
| 1
USP33 deubiquitinates HIF1A. 1 / 1
| 1
reach
"In addition, VDU2, but not VDU1, is able to interact with and deubiquitinate HIF1alpha, and rescue it from proteasome mediated degradation."
25605410
USP33 affects EPAS1
| 1
USP33 deubiquitinates EPAS1. 1 / 1
| 1
reach
"USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells."
35191554
USP33 affects DUSP1
| 1
USP33 leads to the deubiquitination of DUSP1. 1 / 1
| 1
reach
"Mechanistically, we found that USP33 could inhibit the Lys48 (K48)-linked polyubiquitination of DUSP1."
31857702
USP33 affects DIO2
1 |
USP33 deubiquitinates DIO2. 1 / 1
1 |
ubibrowser
"Ubiquitinated D2 can be either targeted to proteasomal degradation or reactivated by deubiquitination, a process that is mediated by the deubiquitinases USP20/33 and is important in adaptive thermogenesis."
22967761
USP33 affects CTNNB1
| 1
USP33 deubiquitinates CTNNB1. 1 / 1
| 1
reach
"USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells."
37076992
USP33 affects CNTLN
| 1
USP33 deubiquitinates CNTLN. 1 / 1
| 1
reach
"For example, USP33 deubiquitylates the centrosomal protein CP110, regulating centrosome biogenesis [76] and USP33 depletion has a co-operative effect with CDK2 on the CP110-dependent clustering function mentioned earlier [77]."
31506331
USP33 affects ARRB1
1 |
USP33 deubiquitinates ARRB1. 1 / 1
1 |
ubibrowser
"We now report the discovery that the deubiquitinating enzyme ubiquitin-specific protease 33 (USP33) binds beta-arrestin2 and leads to the deubiquitination of beta-arrestins."
19363159
USP33 affects ADRB2
1 |
USP33 deubiquitinates ADRB2. 1 / 1
1 |