IndraLab

Statements

USP19 affects SYVN1
1 | 3
USP19 deubiquitinates SYVN1. 4 / 4
1 | 3
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"We demonstrate that USP19 rescues HRD1 from proteasomal degradation by deubiquitination of K48-linked ubiquitin chains."
27827840
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"USP19 negatively regulates the ubiquitination of HRD1 and prevents it from undergoing proteasomal degradation."
27827840
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"These results suggest that USP19 deubiquitinates HRD1."
27827840
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"USP19 Deubiquitinates HRD1."
27827840
USP19 affects MARCHF6
1 | 3
USP19 deubiquitinates MARCHF6. 2 / 2
1 | 1
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"In this study, we show that USP19 deubiquitinates and stabilizes MARCH6."
25088257
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"USP19 was found to protect MARCH6 by deubiquitination from the p97-dependent proteasomal degradation."
25088257
Modified USP19 leads to the deubiquitination of MARCHF6. 2 / 2
| 2
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"We also show that USP19 overexpression reduced ubiquitination of MARCH6, while its knockdown had the opposite effect."
25088257
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"USP19 overexpression reduces the K48 linked ubiquitination of MARCH6."
25088257
USP19 affects RNF123
1 | 2
USP19 deubiquitinates RNF123. 3 / 3
1 | 2
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"USP19 deubiquitinates and stabilizes KPC1, an E3 ligase for p27."
34660907
ubibrowser
"USP19 deubiquitinates Kip1 ubiquitination-promoting complex protein 1 (KPC1) regulating p27Kip1"
25121098
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"USP19 deubiquitinates and stabilizes KPC1, an E3 ligase for p27."
25605410
USP19 affects HDAC1/2
| 3
USP19 deubiquitinates HDAC1/2. 2 / 2
| 2
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"USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability."
27517492
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"USP19 physically interacts with and deubiquitinates HDAC1/2 in order to regulate DNA damage repair, chromosomal stability, and tumorigenesis, and USP19 expression is low or depleted in several types of tumors [32]."
| PMC
USP19 deubiquitinates HDAC1/2 on K63. 1 / 1
| 1
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"USP19 specifically deubiquitinates HDAC1/2 for their K63 linked ubiquitination."
27517492
USP19 affects BECN1
1 | 2
USP19 deubiquitinates BECN1. 3 / 3
1 | 2
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"Conversely, reversal of Beclin1 ubiquitylation by the DUB protein USP19 stabilized the protein under starvation conditions and promoted autophagy."
30333975
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"USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1"
26988033
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"USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1."
26988033
USP19 affects ROR
| 2
USP19 deubiquitinates ROR. 2 / 2
| 2
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"USP19 decreases the ubiquitination level on RORγt-K313, but not that on RORγt-K69 or K446 (Fig. 5C)."
34135062
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"Therefore, lysine residue 313 could be the major acting site of USP19 to prevent RORγt ubiquitination."
34135062
USP19 affects PAH
| 2
USP19 deubiquitinates PAH. 2 / 2
| 2
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"Our study indicates that USP19 interacts with PAH and prevents polyubiquitination of PAH subsequently extending the half-life of PAH protein."
35449354
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"USP19 deubiquitinates and stabilizes PAH further protecting it from rapid degradation."
35449354
USP19 affects LRP6
1 | 1
USP19 deubiquitinates LRP6. 2 / 2
1 | 1
ubibrowser
"We show that folding of the Wnt signaling coreceptor LRP6 is promoted by ubiquitination of a specific lysine, retaining it in the ER while avoiding degradation. Subsequent ER exit requires removal of ubiquitin from this lysine by the deubiquitinating enzyme USP19."
27751231
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"Upon release from this putative ubiquitin binding chaperone, LRP6 is deubiquitinated by USP19."
27751231
USP19 affects CORO2A
1 | 1
USP19 deubiquitinates CORO2A. 2 / 2
1 | 1
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"And USP19 deubiquitinated CORO2A, suggesting that USP19 might have function to stabilize NCoR co and repressor complex in cells."
27129179
ubibrowser
"Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A"
27129179
USP19 deubiquitinates endoplasmic reticulum. 1 / 1
| 1
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"In contrast, our studies have clearly demonstrated that USP19 catalytic activity is essential for its effects on differentiation and argue that USP19 is deubiquitinating an ER localized protein that represses the ER stress response."
25568336
USP19 affects cIAP proteins
| 1
USP19 deubiquitinates cIAP proteins. 1 / 1
| 1
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"Previous studies in HEK293 cells have shown that USP19 can deubiquitinate and stabilize cIAP proteins (Mei et al., 2011)."
23680672
USP19 affects c-IAP1/2
| 1
USP19 leads to the deubiquitination of c-IAP1/2. 1 / 1
| 1
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"USP19 is shown to prevent ubiquitination of c-IAP1/2 and stabilizes them."
29479529
USP19 affects TRIM69
| 1
USP19 leads to the deubiquitination of TRIM69. 1 / 1
| 1
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"In this study, we have identified the first deubiquitinating enzyme, USP19, which mediates deubiquitination of TRIF and regulates TRIF-mediated innate immune responses.Several lines of evidence support a key role of USP19 in TRIF-mediated signaling."
31511519
USP19 affects TRAF3
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USP19 deubiquitinates TRAF3. 1 / 1
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ubibrowser
"USP19 suppresses cellular type I interferon signaling by targeting TRAF3 for deubiquitination"
28391724
USP19 affects SOAT1
| 1
USP19 deubiquitinates SOAT1. 1 / 1
| 1
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"USP19 enhances cholesterol esterification and contributes to hepatocarcinogenesis by deubiquitinating and stabilizing SOAT1."
35398929
USP19 affects PFKFB3
| 1
USP19 leads to the deubiquitination of PFKFB3. 1 / 1
| 1
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"By interacting with GPER, 17β-estradiol (E2) and the GPER agonist G1 enhance endothelial stability of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and capillary tube formation by increasing ubiquitin specific peptidase 19 (USP19) levels, thereby reducing PFKFB3 ubiquitination and proteasomal degradation."
37391222
USP19 affects NR3C1
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USP19 deubiquitinates NR3C1. 1 / 1
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"Thus, USP19 modulates GR levels and in so doing may modulate both insulin and glucocorticoid signaling, two critical pathways that control protein turnover in muscle and overall glucose homeostasis."
29901692
USP19 affects MAP3K7
| 1
USP19 deubiquitinates MAP3K7. 1 / 1
| 1
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"These observations suggest that USP18 and USP19 deubiquitinate TAK1 in a cell type specific dependent manner."
33469458
USP19 affects Htt-N552 fragment
| 1
USP19 deubiquitinates Htt-N552 fragment. 1 / 1
| 1
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"Our previous study has demonstrated that cytoplasmic USP19 deubiquitinates the Htt-N552 fragment and consequently increases the protein level and aggregation, and this effect is dependent on the interaction of USP19 with HSP90 31."
29093475
USP19 affects HDAC2
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USP19 deubiquitinates HDAC2. 1 / 1
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ubibrowser
"USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability"
27517492
USP19 affects HDAC1
1 |
USP19 deubiquitinates HDAC1. 1 / 1
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ubibrowser
"USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability"
27517492
USP19 affects FUNDC1
| 1
USP19 deubiquitinates FUNDC1. 1 / 1
| 1
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"In response to hypoxia, USP19 binds to and deubiquitinates FUNDC1 at ER-mitochondria contact sites, which facilitates Drp1 oligomerization and Drp1 GTP binding and hydrolysis activities, thereby promoting mitochondrial division."
33978709
USP19 affects EWS-FLI1
| 1
USP19 deubiquitinates EWS-FLI1. 1 / 1
| 1
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"USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth."
30700749
USP19 affects E3_Ub_ligase
| 1
USP19 deubiquitinates E3_Ub_ligase. 1 / 1
| 1
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"USP19 deubiquitinates and stabilizes KPC1, an E3 ligase for p27."
34660907
USP19 affects CDKN1B
| 1
USP19 deubiquitinates CDKN1B. 1 / 1
| 1
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"USP19 deubiquitinates and stabilizes KPC1, an E3 ligase for p27."
34660907
USP19 affects BIRC5
| 1
USP19 deubiquitinates BIRC5. 1 / 1
| 1
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"USP19 deubiquitinates survivin protein and extends its half-life."
35918893
USP19 affects BIRC3
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USP19 deubiquitinates BIRC3. 1 / 1
1 |
ubibrowser
No evidence text available
USP19 affects BIRC2
1 |
USP19 deubiquitinates BIRC2. 1 / 1
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ubibrowser
No evidence text available