IndraLab

Statements

USP19 deubiquitinates LRP6. 5 / 6
1 | 5
reach
"Co-receptor LRP6 is deubiquitinated by USP19 to regulate its protein maturation and expression on the cell surface, whereas its ubiquitin ligases remained unidentified (Perrody et al. 2016)."
38383910
reach
"Upon release from this putative ubiquitin binding chaperone, LRP6 is deubiquitinated by USP19."
27751231
reach
"USP8 and USP6 constitutively deubiquitylate Fz, 65 , 66 , 67 , 68 whereas USP19 deubiquitylates LRP6 in the endoplasmic reticulum, facilitating its transport."
39520379
reach
"After the deubiquitylation of LRP6 by USP19, Wnt signaling was increased, which induced cell migration and invasion [51]."
36646950
reach
"Before ER exit, LRP6 is deubiquitinated by USP19 and palmitoylated, then transported through the Golgi to the plasma membrane where it acts as a Wnt signaling coreceptor [66,67] ."
34802913