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USP19 deubiquitinates BECN1. 8 / 9
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"Ultimately, we identified that SIAH1-mediated degradation of USP19 reversed USP19-mediated deubiquitination of MAVS, Beclin1, TRAF3, and TRIF, resulting in the activation of antiviral immune responses."
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"Deubiquitinase ubiquitin-specific protein 19 (USP19) is known to be involved in deubiquitinating Beclin1, TRAF3, and TRIF for downregulation of the type I IFN signaling."
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"USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1."
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"USP19 can also deubiquitinate and stabilize Beclin 1 (BECN1), thereby promoting autophagy [65] ."
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"USP19, which catalyzes the hydrolysis of ubiquitin from its ubiquitin-conjugated protein substrates, is widely expressed in a variety of tissues, including liver, small intestine, and colon ( Combaret[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1."
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"Conversely, reversal of Beclin1 ubiquitylation by the DUB protein USP19 stabilized the protein under starvation conditions and promoted autophagy."
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"However, the substrate(s) that mediate these effects of USP19 remain unknown.A recent report has shown that USP19 can deubiquitinate Beclin-1 and protect it from degradation in cultured non-muscle cel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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