IndraLab

Statements

USP19 deubiquitinates HDAC1/2. 3 / 3
| 3
reach
"Based on this observation, and considering that USP19 interacts with and deubiquitinates HDAC1/2 in order to regulate DNA damage repair and chromosomal stability (Wu et al., 2017) and that both ccRCC and HGSC are characterized by high genomic instability, it is plausible that USP19-mediated deubiquitination of key regulators associated with DSB repair or genome instability might be responsible for the worse prognosis observed in ccRCC and HGSC patients with low USP19 levels (Kang et al., 2021)."
35646888
reach
"USP19 physically interacts with and deubiquitinates HDAC1/2 in order to regulate DNA damage repair, chromosomal stability, and tumorigenesis, and USP19 expression is low or depleted in several types of tumors [32]."
| PMC
reach
"USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability."
27517492