IndraLab

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USP19 deubiquitinates SYVN1. 5 / 5
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"USP19 Deubiquitinates HRD1."
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"We demonstrate that <span class="match term0">USP19</span> rescues <span class="match term1">HRD1</span> from proteasomal degradation by deubiquitination of K48-linked ubiquitin chains"
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"These results suggest that USP19 deubiquitinates HRD1."
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"USP19 negatively regulates the ubiquitination of HRD1 and prevents it from undergoing proteasomal degradation."
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"USP19 deubiquitinates HRD1, rescuing it from UPS-mediated degradation [153], while USP13 works in concert with the ERAD E3 ligase GP78 to maintain precise ubiquitination of the cytosolic ERAD component UBL4A [154]."
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