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USP19 deubiquitinates FUNDC1. 6 / 7
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"In addition, in the initial phase of hypoxia, membrane associated ring–CH–type finger 5 (MARCH5) ubiquitinates FUNDC1 at Lys119, leading to its degradation [ 44 ], while USP19 deubiquitinates and stab[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38097131
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"USP19 deubiquitinates FUNDC1."
37808166
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"To understand the deubiquitination of FUNDC1 by USP19, shUSP19 and/or Flag-FUNDC1 expression plasmids were co-transfected with His-Ub expression plasmids into BEAS-2B cells."
37808166
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"Under hypoxic conditions, USP19, an ER-resident, deubiquitinating enzyme, accumulates at the MERCs, binds to and deubiquitinates FUNDC1, which facilitates DRP1 oligomerization, GTP-binding, and GTP hydrolysis, to enhance mitochondrial division (Chai et al., 2021)."
37530713
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"In response to hypoxia, USP19 binds to and deubiquitinates FUNDC1 at ER-mitochondria contact sites, which facilitates Drp1 oligomerization and Drp1 GTP binding and hydrolysis activities, thereby promoting mitochondrial division."
33978709
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"In PINK1-Parkin-independent mitophagy: Upon conditions like hypoxia or loss of mitochondrial membrane potential, USP19 promotes the de-ubiquitination of FUNDC1, which promotes mitochondrial fission, leading to mitophagy 36."
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