IndraLab

Statements

USP19 deubiquitinates TRIM69. 5 / 5
| 5
reach
"In this study, we have identified the first deubiquitinating enzyme, USP19, which mediates deubiquitination of TRIF and regulates TRIF-mediated innate immune responses.Several lines of evidence support a key role of USP19 in TRIF-mediated signaling."
31511519
reach
"USP19, which catalyzes the hydrolysis of ubiquitin from its ubiquitin-conjugated protein substrates, is widely expressed in a variety of tissues, including liver, small intestine, and colon ( Combaret[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34965422
reach
"Additionally, USP19 is implicated in the deubiquitination of TRIF, thus inhibiting TLR3/4 signaling [15]."
37672892
reach
"Deubiquitinase ubiquitin-specific protein 19 (USP19) is known to be involved in deubiquitinating Beclin1, TRAF3, and TRIF for downregulation of the type I IFN signaling."
38483060
reach
"Ultimately, we identified that SIAH1-mediated degradation of USP19 reversed USP19-mediated deubiquitination of MAVS, Beclin1, TRAF3, and TRIF, resulting in the activation of antiviral immune responses."
38483060