IndraLab

Statements


OTUD5 affects TRAF3
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OTUD5 deubiquitinates TRAF3. 10 / 14
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"For example, the deubiquitinase DUBA reverses TRAF3 ubiquitination, disconnecting TRAF3 from its substrates TBK1 and IKKɛ [38]."

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"Two close relatives of DUBA, OTUB1 and OTUB2, were shown to reduce TRAF3 ubiquitination coupled with decreased anti-viral signaling responses in Sendai virus infected HEK 293T cells."

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"DUBA deubiquitinates TRAF3 to downregulate its interaction with TBK1 and consequent activation of IRF-3 (Kayagaki et al., 2007)."

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"Cellular protein DUBA specifically deubiquitinates TRAF3 that is critical for activation of IRF3, resulting in inhibiting phosphorylation of IRF3."

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"DUBA interacts with and de-ubiquitinates TRAF3, thereby attenuating TLR dependent and TLR independent antiviral responses XREF_BIBR."

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"Cellular protein DUBA specifically deubiquitinates TRAF3 that is critical for activation of IRF3, resulting in inhibiting phosphorylation of IRF3 (Kayagaki et al., 2007; Wang et al., 2011)."

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"For example, the deubiquitinase DUBA reverses TRAF3 ubiquitination, disconnecting TRAF3 from its substrates TBK1 and IKKe [38] ."

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"DUBA deubiquitinates TRAF3 to down-regulate its interaction with TBK1 and consequent activation of IRF-3."

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"For example, the deubiquitinase DUBA reverses TRAF3 ubiquitination, disconnecting TRAF3 from its substrates TBK1 and IKKepsilon XREF_BIBR."

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"TRIAD3A dependent TRAF3 proteasomal destruction, like TRAF3 de-ubiquitination by DUBA, halts the activation of TBK1 and IKKepsilon and subsequent IFN production."
OTUD5 deubiquitinates TRAF3 on lysine. 1 / 1
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No evidence text available
OTUD5 affects TP53
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OTUD5 deubiquitinates TP53. 8 / 8
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"In this study, we provide new evidences that OTUD5 can also function to deubiquitinate and stabilize p53."

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"We show that (1) OTUD5 is a novel p53 interacting protein; (2) OTUD5 deubiquitinates p53, leading to the stabilization of p53; (3) OTUD5 can help in the stabilization and activation of p53 in response to DNA damage; (4) OTUD5 is required for p53 induced apoptosis in response to DNA damage."

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"To verify that the deubiquitination of p53 by OTUD5 is specific, MDM2 was also tested in the in vitro deubiquitination assay."

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"To verify that the deubiquitination of p53 by OTUD5 is specific, MDM2 was also tested in the in vitro deubiquitination assay and found thatMDM2 can not be deubiquitinated by OTUD5 (XREF_FIG)."

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"OTUD1, OTUD5 and USP11 directly deubiquitinating p53 and functional proteins were required for p53 stabilization [XREF_BIBR - XREF_BIBR]."

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"Overall, OTUD5 deubiquitinates p53, leading to the stabilization of p53."

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"Another DUB, OTUD5, interacts and deubiquitylates p53 in response to DNA damage stress."
OTUD5 affects PDCD5
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OTUD5 deubiquitinates PDCD5. 1 / 1
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"Conversely, PDCD5 knockdown greatly attenuated the effect of OTUD5 on p53 activation."
OTUD5 deubiquitinates PDCD5 on K97. 1 / 1
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"OTUD5 thus deubiquitinates PDCD5 at Lys97 and Lys98 subsequently regulating p53 levels."
OTUD5 deubiquitinates PDCD5 on K98. 1 / 1
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"OTUD5 thus deubiquitinates PDCD5 at Lys97 and Lys98 subsequently regulating p53 levels."
OTUD5 affects UBR5
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OTUD5 deubiquitinates UBR5. 2 / 2
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"When DUBA deubiquitylates UBR5 and rescues it from degradation, UBR5 is free to polyubiquitylate RORgammaT, driving its degradation and consequently limiting Th17 differentiation."

"DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells. DUBA accumulated in activated T cells and stabilized UBR5, which then ubiquitylated ROR纬t in response to TGF-尾 signalling.?"
OTUD5 affects TRAF6
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OTUD5 deubiquitinates TRAF6. 1 / 1
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"Given that TRAF3 may be dispensable for RIG-I signalling?92, it cannot be excluded, however, that DUBA also targets other E3 ligases like TRAF2, 5 and 6."
OTUD5 affects TRAF5
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OTUD5 deubiquitinates TRAF5. 1 / 1
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"Given that TRAF3 may be dispensable for RIG-I signalling?92, it cannot be excluded, however, that DUBA also targets other E3 ligases like TRAF2, 5 and 6."
OTUD5 affects TRAF2
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OTUD5 deubiquitinates TRAF2. 1 / 1
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"Given that TRAF3 may be dispensable for RIG-I signalling?92, it cannot be excluded, however, that DUBA also targets other E3 ligases like TRAF2, 5 and 6."
OTUD5 affects MDM2
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OTUD5 deubiquitinates MDM2. 1 / 1
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"As shown in XREF_FIG, MDM2 can not be deubiquitinated by OTUD5."
OTUD5 affects Interferon
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OTUD5 deubiquitinates Interferon. 1 / 1
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"TRIAD3A dependent TRAF3 proteasomal destruction, like TRAF3 de-ubiquitination by DUBA, halts the activation of TBK1 and IKKepsilon and subsequent IFN production."
OTUD5 affects IKBKE
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OTUD5 deubiquitinates IKBKE. 1 / 1
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"TRIAD3A dependent TRAF3 proteasomal destruction, like TRAF3 de-ubiquitination by DUBA, halts the activation of TBK1 and IKKepsilon and subsequent IFN production."
OTUD5 affects DDX58
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OTUD5 leads to the deubiquitination of DDX58. 1 / 1
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"Other DUBs that target the RIG-I and MDA5 pathway include CYLD and DUBA which target RIG-I and TRAF3 ubiquitination respectively (XREF_FIG)."