IndraLab

Statements


USP54 affects PLK4
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USP54 binds PLK4.
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"USP54 reportedly interacts with PLK4 to remove ubiquitin, thereby increasing PLK4 protein levels."

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"Coimmunoprecipitation (CoIP) experiments confirmed the interaction between USP54 and PLK4 ( xref E)."

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"Coimmunoprecipitation (CoIP) experiments confirmed the interaction between USP54 and PLK4 (Figure 5E)."

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"The immunoprecipitation (IP) results showed that PLK4 bound with USP54 via BD1 (Figure 5F)."
USP54 deubiquitinates PLK4.
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USP54 deubiquitinates PLK4. 4 / 4
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"In this study, we demonstrated that CEP120 promotes centrosome amplification and GC progression by promoting USP54 expression and centrosome aggregation to inhibit PLK4 ubiquitination and degradation."

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"Subsequently, we explored the effects of these three DUBs on PLK4 ubiquitination, and the results showed that only USP54 significantly reduced PLK4 ubiquitination (Figure 5B)."

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"USP54 promotes gastric cancer progression by deubiquitinating PLK4 [23]."

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"Conversely, USP54 knockdown significantly increased PLK4 ubiquitination (Figure 5H)."
USP54 decreases the amount of PLK4.
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USP54 decreases the amount of PLK4. 4 / 4
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"As shown in Figure 5D, USP54 overexpression significantly increased PLK4 protein level, whereas USP54 knockdown significantly decreased PLK4 protein level."

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"We found that knockdown of USP54 could reverse the increased PLK4 protein level by CEP120 overexpression, while overexpression of USP54 could rescue the reduced PLK4 protein level by CEP120 knockdown (Figure 5I)."

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"Overexpression of USP54 could rescue the reduced PLK4 protein level and GC progression, which were triggered by CEP120 knockdown."

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"The results above suggested that CEP120 promotes USP54 expression and centrosome aggregation, which inhibits the ubiquitination degradation of PLK4 and increases PLK4 protein level, thus promoting centrosome amplification and GC progression (Figure 7D)."
USP54 increases the amount of PLK4.
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USP54 increases the amount of PLK4. 2 / 2
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"As shown in Figure 5D, USP54 overexpression significantly increased PLK4 protein level, whereas USP54 knockdown significantly decreased PLK4 protein level."

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"We found that knockdown of USP54 could reverse the increased PLK4 protein level by CEP120 overexpression, while overexpression of USP54 could rescue the reduced PLK4 protein level by CEP120 knockdown (Figure 5I)."
USP54 ubiquitinates PLK4.
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USP54 leads to the ubiquitination of PLK4. 1 / 1
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"CEP120 was reported to promote the expansion of the centrosome and the progress of gastric cancer through the ubiquitination of PLK4 mediated by USP54 ."
USP54 activates PLK4.
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USP54 activates PLK4. 1 / 1
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"These results suggested that USP54 plays a key role in the CEP120-mediated stabilization of PLK4 and is expected to become a novel target for the treatment of GC.In conclusion, we revealed the key role of the CEP120-USP54-PLK4 axis in centrosome amplification and GC progression."
Rep affects USP54
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"Silencing of USP54 in colorectal cancer cells decreases their proliferation, invasiveness, and colony-forming capacity, as well as their tumorigenicity, when injected into immunodeficient mice [72] ."

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"USP54 gene disruption significantly inhibited CRPC cell proliferation, both in vitro and in vivo."

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"Thus, the loss of USP54 significantly reduced CRPC cell proliferation in vivo."

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"USP54 silencing suppressed the proliferation of PCa cell lines, both in vitro and in vivo."

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"USP54 depletion suppressed CRPC cell proliferation both in vitro and in vivo."

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"These findings demonstrate that USP54 deficiency restores gefitinib sensitivity in resistant PC9/GR spheroids, reducing their viability and proliferation to levels observed in nonresistant spheroids."

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"Collectively, the data suggested that USP54 targeting inhibited CRPC cell proliferation in vitro."

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"The results of functional experiments revealed that up-regulation of USP54 suppressed LUAD cell proliferation in vivo and in vitro."

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"Therefore, understanding the biological function of USP54 in androgen-dependent prostate cancer cells requires further exploration.In conclusion, our results reveal the pivotal role of USP54 during HSPC transformation into CRPC, and they indicate that USP54 targeting could significantly inhibit PCa proliferation in vivo."
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Benzo[a]pyrene increases the amount of USP54.
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Benzo[a]pyrene increases the amount of USP54. 2 / 2
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Benzo[a]pyrene decreases the amount of USP54.
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Benzo[a]pyrene decreases the amount of USP54. 2 / 2
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Benzo[a]pyrene methylates USP54.
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Benzo[a]pyrene demethylates USP54.
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USP54 affects EGFR
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USP54 ubiquitinates EGFR.
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USP54 leads to the ubiquitination of EGFR. 2 / 2
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"Ubiquitin-specific peptidase 54 (USP54), an active deubiquitinase (DUB), modulates the ubiquitination of the epidermal growth factor receptor (EGFR)."

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"These results reveal a compensatory role for USP54 in modulating EGFR ubiquitination and cell cycle regulation, highlighting its contribution to gefitinib resistance in NSCLC cells.USP54 was silenced using siRNA in gefitinib-resistant PC9/GR and HCC827/GR cell lines to evaluate its role in EGFR regulation and drug sensitivity."
USP54 deubiquitinates EGFR.
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USP54 deubiquitinates EGFR. 2 / 2
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"To evaluate its role, we assessed the effects of USP54 deletion on gefitinib-induced EGFR ubiquitination and cell cycle arrest in the gefitinib-resistant NSCLC cell lines PC9/GR and HCC827/GR."

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"Deubiquitination of epidermal growth factor receptor by ubiquitin-specific peptidase 54 enhances drug sensitivity to gefitinib in gefitinib-resistant non-small cell lung cancer cells."
USP54 increases the amount of EGFR.
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USP54 increases the amount of EGFR. 1 / 1
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"Silencing USP54 with siRNA in PC9/GR and HCC827/GR cells significantly reduced EGFR levels and enhanced PARP cleavage following gefitinib treatment (Fig 3A and 3B)."
USP54 activates EGFR.
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USP54 activates EGFR. 1 / 1
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"(A, B) Effects of USP54 knockdown on gefitinib-induced EGFR degradation and PARP cleavage in PC9/GR (A) and HCC827/GR (B) cells."
AR affects USP54
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AR decreases the amount of USP54.
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AR decreases the amount of USP54. 4 / 4
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AR binds USP54.
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"Investigating whether USP54 directly interacts with AR, potentially inhibiting its ubiquitination and degradation, is crucial."
USP54 affects CRPC
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USP54 activates CRPC.
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USP54 activates CRPC. 4 / 4
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"USP54 gene disruption significantly inhibited CRPC cell proliferation, both in vitro and in vivo."

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"Thus, the loss of USP54 significantly reduced CRPC cell proliferation in vivo."

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"USP54 depletion suppressed CRPC cell proliferation both in vitro and in vivo."

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"USP54 knockdown substantially reduced CRPC cell growth, as revealed by the CCK-8 assay (Figs."
USP54 inhibits CRPC.
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USP54 inhibits CRPC. 1 / 1
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"Collectively, the data suggested that USP54 targeting inhibited CRPC cell proliferation in vitro."
PLK4 affects USP54
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"USP54 reportedly interacts with PLK4 to remove ubiquitin, thereby increasing PLK4 protein levels."

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"Coimmunoprecipitation (CoIP) experiments confirmed the interaction between USP54 and PLK4 ( xref E)."

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"Coimmunoprecipitation (CoIP) experiments confirmed the interaction between USP54 and PLK4 (Figure 5E)."

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"The immunoprecipitation (IP) results showed that PLK4 bound with USP54 via BD1 (Figure 5F)."
Bisphenol A affects USP54
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Bisphenol A increases the amount of USP54.
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Bisphenol A increases the amount of USP54. 2 / 2
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Bisphenol A methylates USP54.
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Bisphenol A decreases the amount of USP54.
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Bisphenol A decreases the amount of USP54. 1 / 1
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USP54 affects cell growth
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"Thus, USP54 targeting might inhibit AR signaling and reduce CRPC cell growth."

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"To investigate mechanisms by which USP54 inhibition could reduce CRPC cell growth, we subjected the TCGA and SU2C 2019 datasets to GSEA (Fig. 5A and B)."

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"USP54 knockdown decreases CRPC cell growth in vitro."

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"USP54 knockdown substantially reduced CRPC cell growth, as revealed by the CCK-8 assay (Figs."
USP54 affects RNA-directed RNA polymerase nsp12
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"The nsp12/USP54 interaction is detected only by the High confidence scoring method since the nsp12 protein is not included in the MIST, Saint, and K dataset."

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USP54 affects ATXN1
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USP54 affects AR
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USP54 binds AR.
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"Investigating whether USP54 directly interacts with AR, potentially inhibiting its ubiquitination and degradation, is crucial."
USP54 inhibits AR.
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USP54 inhibits AR. 1 / 1
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"Thus, USP54 targeting might inhibit AR signaling and reduce CRPC cell growth."
USP54 activates AR.
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USP54 activates AR. 1 / 1
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"USP54 expression was positively correlated with the androgen receptor (AR) signaling level in PCa samples, and USP54 knockdown inhibited AR signaling in PCa cells."
RNA-directed RNA polymerase nsp12 affects USP54
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"The nsp12/USP54 interaction is detected only by the High confidence scoring method since the nsp12 protein is not included in the MIST, Saint, and K dataset."

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ATXN1 affects USP54
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YWHAH affects USP54
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YWHAG affects USP54
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YWHAB affects USP54
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USP54 affects gefitinib
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USP54 activates gefitinib.
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"USP54 upregulation in gefitinib-treated cells was associated with reduced EGFR ubiquitination, stabilizing EGFR and promoting cell survival."

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"Suppressing USP54 in gefitinib-resistant cells reversed gefitinib insensitivity, restoring EGFR ubiquitination and reducing resistance (Figs 3 and 4)."
USP54 inhibits gefitinib.
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"In contrast, silencing USP54, which is upregulated during the acquisition of gefitinib resistance, significantly enhances gefitinib efficacy in both 2D cell culture and 3D spheroid models."
USP54 affects YWHAH
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USP54 affects YWHAG
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USP54 affects YWHAB
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USP54 affects TP53
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USP54 ubiquitinates TP53.
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USP54 ubiquitinates TP53. 1 / 1
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"Chen et al. found that USP54 can ubiquitinate and degrade p53 expression, thereby affecting GLUT1-mediated aerobic glycolysis in lung adenocarcinoma [28]."
USP54 deubiquitinates TP53.
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USP54 deubiquitinates TP53. 1 / 1
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"USP54 directly interacted with p53 protein and the levels of ubiquitinated p53 were inversely related to USP54 levels, consistent with a role of USP54 in deubiquitinating p53 in p53-WT LUAD cells."
USP54 binds TP53.
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"USP54 directly interacted with p53 protein and the levels of ubiquitinated p53 were inversely related to USP54 levels, consistent with a role of USP54 in deubiquitinating p53 in p53-WT LUAD cells."
USP54 affects SKAP1
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"Silencing of USP54 in colorectal cancer cells decreases their proliferation, invasiveness, and colony-forming capacity, as well as their tumorigenicity, when injected into immunodeficient mice [72] ."

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"USP54 promotes cancer invasion in chemically induced colorectal carcinomas."

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"Similarly, USP54 downregulation decreased the invasiveness of HCT116 cells."
USP54 affects CLEC11A
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USP54 affects ATXN1L
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SKAP1 affects USP54
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NR3C1 affects USP54
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NR3C1 decreases the amount of USP54. 3 / 3
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CLEC11A affects USP54
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ATXN1L affects USP54
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Valproic acid increases the amount of USP54.
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Valproic acid increases the amount of USP54. 1 / 1
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Valproic acid demethylates USP54.
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Deltamethrin increases the amount of USP54. 2 / 2
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Aflatoxin B1 methylates USP54.
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Aflatoxin B1 increases the amount of USP54.
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Aflatoxin B1 increases the amount of USP54. 1 / 1
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ZEB1 affects USP54
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YWHAZ affects USP54
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YWHAE affects USP54
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VPS39 affects USP54
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"Importantly, we confirmed that USP54 inhibited aerobic glycolysis and the growth of tumor cells by a p53-mediated decrease in glucose transporter 1 (GLUT1) expression in p53-WT LUAD cells."

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"Moreover, up-regulation of the USP54 expression inhibited aerobic glycolysis in LUAD cells."
USP54 affects ZEB1
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USP54 affects YWHAZ
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USP54 affects YWHAE
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USP54 affects VPS39
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USP54 affects THSD4
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USP54 affects SIRT6
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USP54 affects PIGT
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USP54 affects OLFM2
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USP54 affects NINL
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USP54 affects LGALS3BP
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USP54 affects IQCN
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USP54 affects HCC827/GR
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USP54 deubiquitinates HCC827/GR.
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USP54 leads to the deubiquitination of HCC827/GR. 1 / 1
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"To evaluate its role, we assessed the effects of USP54 deletion on gefitinib-induced EGFR ubiquitination and cell cycle arrest in the gefitinib-resistant NSCLC cell lines PC9/GR and HCC827/GR."
USP54 activates HCC827/GR.
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USP54 activates HCC827/GR. 1 / 1
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"(A, B) Effects of USP54 knockdown on gefitinib-induced EGFR degradation and PARP cleavage in PC9/GR (A) and HCC827/GR (B) cells."
USP54 affects GATD1
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USP54 affects FLVCR1
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USP54 inhibits FLVCR1.
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USP54 inhibits FLVCR1. 1 / 1
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"Therefore, understanding the biological function of USP54 in androgen-dependent prostate cancer cells requires further exploration.In conclusion, our results reveal the pivotal role of USP54 during HSPC transformation into CRPC, and they indicate that USP54 targeting could significantly inhibit PCa proliferation in vivo."
USP54 activates FLVCR1.
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USP54 activates FLVCR1. 1 / 1
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"USP54 silencing suppressed the proliferation of PCa cell lines, both in vitro and in vivo."
USP54 affects FBXW11
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USP54 affects DYRK1A
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USP54 affects CEP135
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USP54 affects CELA1
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USP54 affects CDC16
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USP54 affects CARD8
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USP54 affects BBS7
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USP54 affects ATN1
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USP54 affects ASB3
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THSD4 affects USP54
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TCF3 affects USP54
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TCF3 decreases the amount of USP54. 2 / 2
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SIRT6 affects USP54
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PIGT affects USP54
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PGR affects USP54
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PGR decreases the amount of USP54. 2 / 2
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OLFM2 affects USP54
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USP54 is modified
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USP54 is phosphorylated on S481. 1 / 1
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USP54 is phosphorylated on S671. 1 / 1
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NINL affects USP54
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MYOD1 affects USP54
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MYOD1 decreases the amount of USP54. 2 / 2
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LGALS3BP affects USP54
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IQCN affects USP54
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GATD1 affects USP54
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FBXW11 affects USP54
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DYRK1A affects USP54
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CEP135 affects USP54
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CEP120 affects USP54
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CEP120 increases the amount of USP54.
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CEP120 increases the amount of USP54. 1 / 1
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"Similarly, overexpression of CEP120 increased USP54 protein level, whereas knockdown of CEP120 decreased USP54 protein level (Figure 6C)."
CEP120 activates USP54.
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CEP120 activates USP54. 1 / 1
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"Overexpression of CEP120 promoted the relative fluorescence intensity of USP54 in centrosomes, whereas knockdown of CEP120 weakened it (Figure 6D)."
CELA1 affects USP54
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CDC16 affects USP54
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CARD8 affects USP54
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BBS7 affects USP54
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ATN1 affects USP54
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ASB3 affects USP54
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6-propyl-2-thiouracil decreases the amount of USP54. 2 / 2
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2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP54.
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2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP54.
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Triphenyl phosphate increases the amount of USP54. 1 / 1
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Tetrachloromethane increases the amount of USP54. 1 / 1
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Sulfadimethoxine decreases the amount of USP54. 1 / 1
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Sodium arsenite decreases the amount of USP54. 1 / 1
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Paracetamol affects USP54
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Paracetamol decreases the amount of USP54. 1 / 1
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Nickel atom affects USP54
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Nickel atom decreases the amount of USP54. 1 / 1
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Monosodium L-glutamate decreases the amount of USP54. 1 / 1
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Methyl methanesulfonate increases the amount of USP54. 1 / 1
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Methimazole affects USP54
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Methimazole decreases the amount of USP54. 1 / 1
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Methamphetamine increases the amount of USP54. 1 / 1
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Isoflurane affects USP54
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Inulin affects USP54
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Inulin increases the amount of USP54. 1 / 1
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Hsa-miR-215-5p decreases the amount of USP54. 1 / 1
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Hsa-miR-192-5p decreases the amount of USP54. 1 / 1
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Hsa-let-7b-5p decreases the amount of USP54. 1 / 1
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Gefitinib affects USP54
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"These results demonstrate that extended gefitinib exposure induces sustained UCHL3 downregulation and USP54 upregulation in gefitinib-resistant sublines, suggesting a potential interplay between these genes in NSCLC cells under prolonged drug exposure.Total RNA was extracted from PC9 cells treated with 1 μM gefitinib for 1, 6, and 24 h and analyzed by QuantSeq 3’ mRNA sequencing."
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Fluoranthene increases the amount of USP54. 1 / 1
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Ethanol affects USP54
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Ethanol increases the amount of USP54. 1 / 1
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Doxorubicin affects USP54
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Doxorubicin decreases the amount of USP54. 1 / 1
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Dicrotophos affects USP54
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Dicrotophos increases the amount of USP54. 1 / 1
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Dexamethasone increases the amount of USP54. 1 / 1
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Deoxynivalenol decreases the amount of USP54. 1 / 1
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Coumestrol affects USP54
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Coumestrol decreases the amount of USP54. 1 / 1
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Clobetasol affects USP54
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Clobetasol increases the amount of USP54. 1 / 1
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Cadmium dichloride decreases the amount of USP54. 1 / 1
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Antirheumatic drug increases the amount of USP54. 1 / 1
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Amitrole affects USP54
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Amitrole decreases the amount of USP54. 1 / 1
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All-trans-retinoic acid decreases the amount of USP54. 1 / 1
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Abrine affects USP54
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Abrine increases the amount of USP54. 1 / 1
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ZNF76 affects USP54
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ZNF148 affects USP54
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ZFP36 affects USP54
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ZCCHC14 affects USP54
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ZBTB49 affects USP54
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YWHAQ affects USP54
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WDTC1 affects USP54
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VRK3 affects USP54
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VIRMA affects USP54
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VENTX affects USP54
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USP54 affects triubiquitin
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USP54 inhibits triubiquitin. 1 / 1
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"This substitution led to a decrease in cleavage of triubiquitin and tetraubiquitin chains by USP54 (Fig. 6d), visualized through quantitative gel-based cleavage assays."
USP54 affects tetraubiquitin chains
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USP54 inhibits tetraubiquitin chains. 1 / 1
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"This substitution led to a decrease in cleavage of triubiquitin and tetraubiquitin chains by USP54 (Fig. 6d), visualized through quantitative gel-based cleavage assays."
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"Promising therapeutic targets include USP8, the USP8-Trichoplein-AurA pathway, and USP54, which may enhance ciliogenesis and inhibit tumor progression, particularly in colorectal cancer [165,167]."
USP54 affects ZNF76
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USP54 affects ZNF148
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USP54 affects ZFP36
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USP54 affects ZCCHC14
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USP54 affects ZBTB49
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USP54 affects YWHAQ
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USP54 affects WDTC1
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USP54 affects WDR37
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USP54 inhibits WDR37. 1 / 1
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"PIF Increased the expression of : (USP54, BRD2, ARRB2) and decreased the expression of (WDR37, CUL1, SIAHA, HIC2."
USP54 affects VRK3
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USP54 affects VIRMA
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USP54 affects VENTX
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USP54 affects USP53
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sparser
"Also like Echinus, the USP53 and USP54 long forms are inactive in a deubiquitination assay using a model ubiquitin-β-gal fusion protein substrate [ xref ]."
USP54 affects USP2
1 |
1 |

No evidence text available
USP54 affects UBC
1 |
1 |

No evidence text available
USP54 affects TTC19
1 |
1 |

No evidence text available
USP54 affects TSSK3
1 |
1 |

No evidence text available
USP54 affects TSEN15
1 |
1 |

No evidence text available
USP54 affects TRIM66
1 |
1 |

No evidence text available
USP54 affects TRIM52
1 |
1 |

No evidence text available
USP54 affects TRIM25
1 |
1 |

No evidence text available
USP54 affects TRAF2
1 |
1 |

No evidence text available
USP54 affects TOLLIP
1 |
1 |

No evidence text available
USP54 affects TNS2
1 |
1 |

No evidence text available
USP54 affects TNRC6C
1 |
1 |

No evidence text available
USP54 affects TNRC6B
1 |
1 |

No evidence text available
USP54 affects TNRC6A
1 |
1 |

No evidence text available
USP54 affects TNIP2
1 |
1 |

No evidence text available
USP54 affects TLE5
1 |
1 |

No evidence text available
USP54 affects TLE2
1 |
1 |

No evidence text available
USP54 affects TJP2
1 |
1 |

No evidence text available
USP54 affects TFAP2D
1 |
1 |

No evidence text available
USP54 affects TENT5B
1 |
1 |

No evidence text available
USP54 affects TEKT5
1 |
1 |

No evidence text available
USP54 affects TCEA2
1 |
1 |

No evidence text available
USP54 affects TBX6
1 |
1 |

No evidence text available
USP54 affects TAGLN
1 |
1 |

No evidence text available
| 1

reach
"The results above suggested that CEP120 promotes USP54 expression and centrosome aggregation, which inhibits the ubiquitination degradation of PLK4 and increases PLK4 protein level, thus promoting centrosome amplification and GC progression (Figure 7D)."
USP54 affects SYNE3
1 |
1 |

No evidence text available
USP54 affects STK16
1 |
1 |

No evidence text available
USP54 affects STIL
1 |
1 |

No evidence text available
USP54 affects SS18L1
1 |
1 |

No evidence text available
USP54 affects SQSTM1
1 |
1 |

No evidence text available
USP54 affects SNRPB
1 |
1 |

No evidence text available
USP54 affects SNRNP200
1 |

No evidence text available
USP54 affects SNIP1
1 |
1 |

No evidence text available
USP54 affects SMYD1
1 |
1 |

No evidence text available
USP54 affects SMARCD1
1 |
1 |

No evidence text available
USP54 affects SHC3
1 |
1 |

No evidence text available
USP54 affects SHARPIN
1 |
1 |

No evidence text available
USP54 affects SFN
1 |
1 |

No evidence text available
USP54 affects SEC24A
1 |
1 |

No evidence text available
USP54 affects S100A2
1 |
1 |

No evidence text available
USP54 affects RP9
1 |
1 |

No evidence text available
USP54 affects RNF43
1 |
1 |

No evidence text available
USP54 affects RNF208
1 |
1 |

No evidence text available
USP54 affects RNF113A
1 |
1 |

No evidence text available
USP54 affects RHOBTB3
1 |
1 |

No evidence text available
USP54 affects RELA
1 |
1 |

No evidence text available
USP54 affects RC3H1
1 |
1 |

No evidence text available
USP54 affects RBPMS2
1 |
1 |

No evidence text available
USP54 affects RBMXL1
1 |
1 |

No evidence text available
USP54 affects RAMAC
1 |
1 |

No evidence text available
USP54 affects RAF1
1 |
1 |

No evidence text available
USP54 affects RACK1
1 |
1 |

No evidence text available
USP54 affects R3HDM2
1 |
1 |

No evidence text available
USP54 affects QRICH1
1 |
1 |

No evidence text available
USP54 affects PRSS50
1 |
1 |

No evidence text available
USP54 affects PRRC2A
1 |
1 |

No evidence text available
USP54 affects PRR35
1 |
1 |

No evidence text available
USP54 affects PRPH
1 |
1 |

No evidence text available
USP54 affects PRPF38A
1 |
1 |

No evidence text available
USP54 affects PRKAB2
1 |
1 |

No evidence text available
USP54 affects PRDM6
1 |
1 |

No evidence text available
USP54 affects PPP4R1L
1 |
1 |

No evidence text available
USP54 affects POLR1C
1 |
1 |

No evidence text available
USP54 affects PNMA2
1 |
1 |

No evidence text available
USP54 affects PLEKHN1
1 |
1 |

No evidence text available
USP54 affects PLEKHA4
1 |
1 |

No evidence text available
USP54 affects PLAC8
1 |
1 |

No evidence text available
USP54 affects PLA2G6
1 |
1 |

No evidence text available
USP54 affects PHF1
1 |
1 |

No evidence text available
USP54 affects PDCL3
1 |
1 |

No evidence text available
USP54 affects PCSK5
1 |
1 |

No evidence text available
USP54 affects PC9/GR (A)
| 1
USP54 activates PC9/GR (A). 1 / 1
| 1

reach
"(A, B) Effects of USP54 knockdown on gefitinib-induced EGFR degradation and PARP cleavage in PC9/GR (A) and HCC827/GR (B) cells."
USP54 affects PATL1
1 |
1 |

No evidence text available
USP54 affects PARP1
| 1
USP54 inhibits PARP1. 1 / 1
| 1

reach
"(A, B) Effects of USP54 knockdown on gefitinib-induced EGFR degradation and PARP cleavage in PC9/GR (A) and HCC827/GR (B) cells."
USP54 affects PARD3
1 |
1 |

No evidence text available
USP54 affects P4HA2
1 |
1 |

No evidence text available
USP54 affects OTX1
1 |
1 |

No evidence text available
USP54 affects OLFM4
1 |
1 |

No evidence text available
USP54 affects OIP5
1 |
1 |

No evidence text available
USP54 affects OCLN
1 |
1 |

No evidence text available
USP54 affects Neoplasms
| 1
| 1

reach
"Promising therapeutic targets include USP8, the USP8-Trichoplein-AurA pathway, and USP54, which may enhance ciliogenesis and inhibit tumor progression, particularly in colorectal cancer [165,167]."
USP54 affects NXT2
1 |
1 |

No evidence text available
USP54 affects NUDT22
1 |
1 |

No evidence text available
USP54 affects NUDCD2
1 |
1 |

No evidence text available
USP54 affects NIN
1 |
1 |

No evidence text available
USP54 affects NCKIPSD
1 |
1 |

No evidence text available
USP54 affects MUSK
1 |
1 |

No evidence text available
USP54 affects MLST8
1 |
1 |

No evidence text available
USP54 affects MID2
1 |
1 |

No evidence text available
USP54 affects MEX3B
1 |
1 |

No evidence text available
USP54 affects MED25
1 |
1 |

No evidence text available
USP54 affects LZTS2
1 |
1 |

No evidence text available
USP54 affects LNX1
1 |
1 |

No evidence text available
USP54 affects LMO3
1 |
1 |

No evidence text available
USP54 affects LGR4
1 |
1 |

No evidence text available
USP54 affects LCK
1 |
1 |

No evidence text available
USP54 affects LATS2
1 |
1 |

No evidence text available
USP54 affects LATS1
1 |
1 |

No evidence text available
USP54 affects KRT2
1 |
1 |

No evidence text available
USP54 affects KRT19
1 |
1 |

No evidence text available
USP54 affects KIF20A
1 |
1 |

No evidence text available
USP54 affects KCTD9
1 |
1 |

No evidence text available
USP54 affects INSC
1 |
1 |

No evidence text available
USP54 affects IL17RA
1 |
1 |

No evidence text available
USP54 affects IKBKG
1 |
1 |

No evidence text available
USP54 affects IGFN1
1 |
1 |

No evidence text available
USP54 affects HSD17B7P2
1 |

No evidence text available
USP54 affects HOXC8
1 |
1 |

No evidence text available
USP54 affects HOOK1
1 |
1 |

No evidence text available
USP54 affects HNRNPF
1 |
1 |

No evidence text available
USP54 affects HNF1B
1 |
1 |

No evidence text available
USP54 affects HGS
1 |
1 |

No evidence text available
USP54 affects HABP4
1 |
1 |

No evidence text available
USP54 affects GNB2
1 |
1 |

No evidence text available
USP54 affects GCM2
1 |
1 |

No evidence text available
USP54 affects GARRE1
1 |
1 |

No evidence text available
USP54 affects FUBP3
1 |
1 |

No evidence text available
USP54 affects FOXI1
1 |
1 |

No evidence text available
USP54 affects FNDC3B
1 |
1 |

No evidence text available
USP54 affects FLOT1
1 |
1 |

No evidence text available
USP54 affects FLII
1 |
1 |

No evidence text available
USP54 affects FBXO17
1 |
1 |

No evidence text available
USP54 affects FAM124B
1 |
1 |

No evidence text available
USP54 affects FAM120C
1 |
1 |

No evidence text available
USP54 affects EXOC8
1 |
1 |

No evidence text available
USP54 affects EPM2AIP1
1 |

No evidence text available
USP54 affects EPHA2
1 |
1 |

No evidence text available
USP54 affects EIF4E2
1 |
1 |

No evidence text available
USP54 affects EGLN3
1 |
1 |

No evidence text available
| 1

reach
"USP54 was the most strongly upregulated DUB in LNCaP-AI cells compared with LNCaP cells."
USP54 affects DTX2
1 |
1 |

No evidence text available
USP54 affects DOK6
1 |
1 |

No evidence text available
USP54 affects DMRT3
1 |
1 |

No evidence text available
USP54 affects DISC1
1 |
1 |

No evidence text available
USP54 affects DET1
1 |
1 |

No evidence text available
USP54 affects DCAF4
1 |
1 |

No evidence text available
USP54 affects DCAF15
1 |
1 |

No evidence text available
| 1

reach
"USP54 is overexpressed in intestinal stem cells; USP54 downregulation in colorectal carcinoma cells impedes tumorigenesis [21]."
USP54 affects CYSRT1
1 |
1 |

No evidence text available
USP54 affects CXADR
1 |
1 |

No evidence text available
USP54 affects CUL1
| 1
USP54 inhibits CUL1. 1 / 1
| 1

reach
"PIF Increased the expression of : (USP54, BRD2, ARRB2) and decreased the expression of (WDR37, CUL1, SIAHA, HIC2."
USP54 affects CTNNB1
1 |
1 |

No evidence text available
USP54 affects CSTF2
1 |
1 |

No evidence text available
USP54 affects CSNK2A1
1 |
1 |

No evidence text available
USP54 affects CRYL1
1 |
1 |

No evidence text available
USP54 affects CRC
| 1
USP54 activates CRC. 1 / 1
| 1

reach
"Accordingly, silencing of USP54 in colorectal cancer (CRC) cells led to a significant decrease in cell proliferation, colony formation capacity, invasiveness, and tumorigenicity in an in vivo xenograft model, indicating that USP54 could promote CRC, potentially by controlling stem cell properties in intestinal cells."
USP54 affects CPEB4
1 |
1 |

No evidence text available
USP54 affects CPEB1
1 |
1 |

No evidence text available
USP54 affects CLEC16A
1 |
1 |

No evidence text available
USP54 affects CHMP4C
1 |
1 |

No evidence text available
USP54 affects CHMP2B
1 |
1 |

No evidence text available
USP54 affects CHMP2A
1 |
1 |

No evidence text available
USP54 affects CHMP1B
1 |
1 |

No evidence text available
USP54 affects CHERP
1 |
1 |

No evidence text available
USP54 affects CHCHD2
1 |
1 |

No evidence text available
USP54 affects CFAP184
1 |
1 |

No evidence text available
USP54 affects CEP128
1 |
1 |

No evidence text available
USP54 affects CEP120
| 1
USP54 activates CEP120. 1 / 1
| 1

reach
"The results showed that silence of USP54 significantly reversed the enhanced proliferative, migratory, and invasive abilities of CEP120-overexpressed cells, whereas USP54 overexpression restored the reduced proliferative, migratory, and invasive abilities of CEP120-knocked-down cells (Figures 6E–6G)."
USP54 affects CDIN1
1 |
1 |

No evidence text available
USP54 affects CDH1
1 |
CDH1 binds USP54. 1 / 1
1 |

No evidence text available
USP54 affects CDC23
1 |
1 |

No evidence text available
USP54 affects CCT2
1 |
1 |

No evidence text available
USP54 affects CCNK
1 |
1 |

No evidence text available
USP54 affects CCNJL
1 |
1 |

No evidence text available
USP54 affects CCDC24
1 |
1 |

No evidence text available
USP54 affects CCDC13
1 |
1 |

No evidence text available
USP54 affects CARD10
1 |
1 |

No evidence text available
USP54 affects CAPN2
1 |
1 |

No evidence text available
USP54 affects CALR
1 |
1 |

No evidence text available
USP54 affects BUD13
1 |
1 |

No evidence text available
USP54 affects BTRC
1 |
1 |

No evidence text available
USP54 affects BICD2
1 |
1 |

No evidence text available
USP54 affects BICD1
1 |
1 |

No evidence text available
USP54 affects BHLHE40
1 |
1 |

No evidence text available
USP54 affects BFSP2
1 |
1 |

No evidence text available
USP54 affects BCAR1
1 |
1 |

No evidence text available
USP54 affects ATXN7L2
1 |
1 |

No evidence text available
USP54 affects ATG16L1
1 |
1 |

No evidence text available
USP54 affects ARMC7
1 |
1 |

No evidence text available
USP54 affects ANKS1A
1 |
1 |

No evidence text available
USP54 affects ANKRD11
1 |
1 |

No evidence text available
USP54 affects ANAPC2
1 |
1 |

No evidence text available
USP54 affects AFDN
1 |
1 |

No evidence text available
USP54 affects ABTB2
1 |
1 |

No evidence text available
USP53 affects USP54
| 1
| 1

sparser
"Also like Echinus, the USP53 and USP54 long forms are inactive in a deubiquitination assay using a model ubiquitin-β-gal fusion protein substrate [ xref ]."
USP2 affects USP54
1 |
1 |

No evidence text available
UBP1 affects USP54
1 |
UBP1 decreases the amount of USP54. 1 / 1
1 |

No evidence text available
UBC affects USP54
1 |
1 |

No evidence text available
1 |
Trans Fatty Acids decreases the amount of USP54. 1 / 1
1 |

No evidence text available
TTC19 affects USP54
1 |
1 |

No evidence text available
TSSK3 affects USP54
1 |
1 |

No evidence text available
TSEN15 affects USP54
1 |
1 |

No evidence text available
TRIM66 affects USP54
1 |
1 |

No evidence text available
TRIM52 affects USP54
1 |
1 |

No evidence text available
TRIM25 affects USP54
1 |
1 |

No evidence text available
TRAF2 affects USP54
1 |
1 |

No evidence text available
TP53 affects USP54
| 1
| 1

sparser
"USP54 directly interacted with p53 protein and the levels of ubiquitinated p53 were inversely related to USP54 levels, consistent with a role of USP54 in deubiquitinating p53 in p53-WT LUAD cells."
TOLLIP affects USP54
1 |
1 |

No evidence text available
TNS2 affects USP54
1 |
1 |

No evidence text available
TNRC6C affects USP54
1 |
1 |

No evidence text available
TNRC6B affects USP54
1 |
1 |

No evidence text available
TNRC6A affects USP54
1 |
1 |

No evidence text available
TNIP2 affects USP54
1 |
1 |

No evidence text available
TNF affects USP54
| 1
TNF activates USP54. 1 / 1
| 1

reach
"Nonetheless, a minimum of two siRNA molecules led to increased levels of nuclear NF-kappaB in A549 cells depleted of A20, USP7, USP49, USP54, or FBXO36 and treated with TNF for 120min."
TLE5 affects USP54
1 |
1 |

No evidence text available
TLE2 affects USP54
1 |
1 |

No evidence text available
TJP2 affects USP54
1 |
1 |

No evidence text available
TFAP4 affects USP54
1 |
TFAP4 decreases the amount of USP54. 1 / 1
1 |

No evidence text available
TFAP2D affects USP54
1 |
1 |

No evidence text available
TENT5B affects USP54
1 |
1 |

No evidence text available
TEKT5 affects USP54
1 |
1 |

No evidence text available
TCEA2 affects USP54
1 |
1 |

No evidence text available
TBX6 affects USP54
1 |
1 |

No evidence text available
TAGLN affects USP54
1 |
1 |

No evidence text available
| 1
Stomach Neoplasms increases the amount of USP54. 1 / 1
| 1

reach
"In this study, we demonstrated that CEP120 promotes centrosome amplification and GC progression by promoting USP54 expression and centrosome aggregation to inhibit PLK4 ubiquitination and degradation."
Soot affects USP54
1 |
Soot increases the amount of USP54. 1 / 1
1 |

No evidence text available
SYNE3 affects USP54
1 |
1 |

No evidence text available
STK16 affects USP54
1 |
1 |

No evidence text available
STIL affects USP54
1 |
1 |

No evidence text available
SS18L1 affects USP54
1 |
1 |

No evidence text available
SQSTM1 affects USP54
1 |
1 |

No evidence text available
SNRPB affects USP54
1 |
1 |

No evidence text available
SNRNP200 affects USP54
1 |

No evidence text available
SNIP1 affects USP54
1 |
1 |

No evidence text available
SMYD1 affects USP54
1 |
1 |

No evidence text available
SMARCD1 affects USP54
1 |
1 |

No evidence text available
SHC3 affects USP54
1 |
1 |

No evidence text available
SHARPIN affects USP54
1 |
1 |

No evidence text available
SFN affects USP54
1 |
1 |

No evidence text available
SEC24A affects USP54
1 |
1 |

No evidence text available
S100A2 affects USP54
1 |
1 |

No evidence text available
RP9 affects USP54
1 |
1 |

No evidence text available
RNF43 affects USP54
1 |
1 |

No evidence text available
RNF208 affects USP54
1 |
1 |

No evidence text available
RNF113A affects USP54
1 |
1 |

No evidence text available
RHOBTB3 affects USP54
1 |
1 |

No evidence text available
REPIN1 affects USP54
1 |
REPIN1 decreases the amount of USP54. 1 / 1
1 |

No evidence text available
RELA affects USP54
1 |
1 |

No evidence text available
RC3H1 affects USP54
1 |
1 |

No evidence text available
RBPMS2 affects USP54
1 |
1 |

No evidence text available
RBMXL1 affects USP54
1 |
1 |

No evidence text available
RAMAC affects USP54
1 |
1 |

No evidence text available
RAF1 affects USP54
1 |
1 |

No evidence text available
RACK1 affects USP54
1 |
1 |

No evidence text available
R3HDM2 affects USP54
1 |
1 |

No evidence text available
QRICH1 affects USP54
1 |
1 |

No evidence text available
PRSS50 affects USP54
1 |
1 |

No evidence text available
PRRC2A affects USP54
1 |
1 |

No evidence text available
PRR35 affects USP54
1 |
1 |

No evidence text available
PRPH affects USP54
1 |
1 |

No evidence text available
PRPF38A affects USP54
1 |
1 |

No evidence text available
PRKAB2 affects USP54
1 |
1 |

No evidence text available
PRDM6 affects USP54
1 |
1 |

No evidence text available
PPP4R1L affects USP54
1 |
1 |

No evidence text available
POLR1C affects USP54
1 |
1 |

No evidence text available
PNMA2 affects USP54
1 |
1 |

No evidence text available
PLEKHN1 affects USP54
1 |
1 |

No evidence text available
PLEKHA4 affects USP54
1 |
1 |

No evidence text available
PLAC8 affects USP54
1 |
1 |

No evidence text available
PLA2G6 affects USP54
1 |
1 |

No evidence text available
PITX2 affects USP54
1 |
PITX2 decreases the amount of USP54. 1 / 1
1 |

No evidence text available
PHF1 affects USP54
1 |
1 |

No evidence text available
PDCL3 affects USP54
1 |
1 |

No evidence text available
PCSK5 affects USP54
1 |
1 |

No evidence text available
PATL1 affects USP54
1 |
1 |

No evidence text available
PARD3 affects USP54
1 |
1 |

No evidence text available
P4HA2 affects USP54
1 |
1 |

No evidence text available
OTX1 affects USP54
1 |
1 |

No evidence text available
OLFM4 affects USP54
1 |
1 |

No evidence text available
OIP5 affects USP54
1 |
1 |

No evidence text available
OCLN affects USP54
1 |
1 |

No evidence text available
NXT2 affects USP54
1 |
1 |

No evidence text available
NUDT22 affects USP54
1 |
1 |

No evidence text available
NUDCD2 affects USP54
1 |
1 |

No evidence text available
NIN affects USP54
1 |
1 |

No evidence text available
NCKIPSD affects USP54
1 |
1 |

No evidence text available
MUSK affects USP54
1 |
1 |

No evidence text available
MLST8 affects USP54
1 |
1 |

No evidence text available
MIR1303 affects USP54
1 |
MIR1303 decreases the amount of USP54. 1 / 1
1 |

No evidence text available
MID2 affects USP54
1 |
1 |

No evidence text available
MEX3B affects USP54
1 |
1 |

No evidence text available
MED25 affects USP54
1 |
1 |

No evidence text available
MAZ affects USP54
1 |
MAZ decreases the amount of USP54. 1 / 1
1 |

No evidence text available
LZTS2 affects USP54
1 |
1 |

No evidence text available
LNX1 affects USP54
1 |
1 |

No evidence text available
LMO3 affects USP54
1 |
1 |

No evidence text available
LGR4 affects USP54
1 |
1 |

No evidence text available
LEF1 affects USP54
1 |
LEF1 decreases the amount of USP54. 1 / 1
1 |

No evidence text available
LCK affects USP54
1 |
1 |

No evidence text available
LATS2 affects USP54
1 |
1 |

No evidence text available
LATS1 affects USP54
1 |
1 |

No evidence text available
KRT2 affects USP54
1 |
1 |

No evidence text available
KRT19 affects USP54
1 |
1 |

No evidence text available
KIF20A affects USP54
1 |
1 |

No evidence text available
KCTD9 affects USP54
1 |
1 |

No evidence text available
INSC affects USP54
1 |
1 |

No evidence text available
IL17RA affects USP54
1 |
1 |

No evidence text available
IKBKG affects USP54
1 |
1 |

No evidence text available
IGFN1 affects USP54
1 |
1 |

No evidence text available
HSD17B7P2 affects USP54
1 |

No evidence text available
HOXC8 affects USP54
1 |
1 |

No evidence text available
HOOK1 affects USP54
1 |
1 |

No evidence text available
HNRNPF affects USP54
1 |
1 |

No evidence text available
HNF1B affects USP54
1 |
1 |

No evidence text available
HGS affects USP54
1 |
1 |

No evidence text available
HABP4 affects USP54
1 |
1 |

No evidence text available
Glyphosate affects USP54
1 |
Glyphosate increases the amount of USP54. 1 / 1
1 |

No evidence text available
Gentamicins affects USP54
1 |
Gentamicins increases the amount of USP54. 1 / 1
1 |

No evidence text available
GSK-J4 affects USP54
1 |
GSK-J4 decreases the amount of USP54. 1 / 1
1 |

No evidence text available
GNB2 affects USP54
1 |
1 |

No evidence text available
GCM2 affects USP54
1 |
1 |

No evidence text available
GARRE1 affects USP54
1 |
1 |

No evidence text available
FUBP3 affects USP54
1 |
1 |

No evidence text available
FOXO4 affects USP54
1 |
FOXO4 decreases the amount of USP54. 1 / 1
1 |

No evidence text available
FOXI1 affects USP54
1 |
1 |

No evidence text available
FNDC3B affects USP54
1 |
1 |

No evidence text available
FLOT1 affects USP54
1 |
1 |

No evidence text available
FLII affects USP54
1 |
1 |

No evidence text available
FBXO17 affects USP54
1 |
1 |

No evidence text available
FAM124B affects USP54
1 |
1 |

No evidence text available
FAM120C affects USP54
1 |
1 |

No evidence text available
EXOC8 affects USP54
1 |
1 |

No evidence text available
EPM2AIP1 affects USP54
1 |

No evidence text available
EPHA2 affects USP54
1 |
1 |

No evidence text available
EIF4E2 affects USP54
1 |
1 |

No evidence text available
EGLN3 affects USP54
1 |
1 |

No evidence text available
1 |
Dietary Fats increases the amount of USP54. 1 / 1
1 |

No evidence text available
DTX2 affects USP54
1 |
1 |

No evidence text available
DOK6 affects USP54
1 |
1 |

No evidence text available
DMRT3 affects USP54
1 |
1 |

No evidence text available
DISC1 affects USP54
1 |
1 |

No evidence text available
DET1 affects USP54
1 |
1 |

No evidence text available
DCAF4 affects USP54
1 |
1 |

No evidence text available
DCAF15 affects USP54
1 |
1 |

No evidence text available
CYSRT1 affects USP54
1 |
1 |

No evidence text available
CXADR affects USP54
1 |
1 |

No evidence text available
CTNNB1 affects USP54
1 |
1 |

No evidence text available
CSTF2 affects USP54
1 |
1 |

No evidence text available
CSNK2A1 affects USP54
1 |
1 |

No evidence text available
CRYL1 affects USP54
1 |
1 |

No evidence text available
CPEB4 affects USP54
1 |
1 |

No evidence text available
CPEB1 affects USP54
1 |
1 |

No evidence text available
CLEC16A affects USP54
1 |
1 |

No evidence text available
CHMP4C affects USP54
1 |
1 |

No evidence text available
CHMP2B affects USP54
1 |
1 |

No evidence text available
CHMP2A affects USP54
1 |
1 |

No evidence text available
CHMP1B affects USP54
1 |
1 |

No evidence text available
CHERP affects USP54
1 |
1 |

No evidence text available
CHCHD2 affects USP54
1 |
1 |

No evidence text available
CFAP184 affects USP54
1 |
1 |

No evidence text available
CEP128 affects USP54
1 |
1 |

No evidence text available
CDIN1 affects USP54
1 |
1 |

No evidence text available
CDH1 affects USP54
1 |
CDH1 binds USP54. 1 / 1
1 |

No evidence text available
CDC23 affects USP54
1 |
1 |

No evidence text available
CCT2 affects USP54
1 |
1 |

No evidence text available
CCNK affects USP54
1 |
1 |

No evidence text available
CCNJL affects USP54
1 |
1 |

No evidence text available
CCDC24 affects USP54
1 |
1 |

No evidence text available
CCDC13 affects USP54
1 |
1 |

No evidence text available
CARD10 affects USP54
1 |
1 |

No evidence text available
CAPN2 affects USP54
1 |
1 |

No evidence text available
CALR affects USP54
1 |
1 |

No evidence text available
Bufotalin affects USP54
1 |
Bufotalin increases the amount of USP54. 1 / 1
1 |

No evidence text available
BUD13 affects USP54
1 |
1 |

No evidence text available
BTRC affects USP54
1 |
1 |

No evidence text available
BICD2 affects USP54
1 |
1 |

No evidence text available
BICD1 affects USP54
1 |
1 |

No evidence text available
BHLHE40 affects USP54
1 |
1 |

No evidence text available
BFSP2 affects USP54
1 |
1 |

No evidence text available
BCAR1 affects USP54
1 |
1 |

No evidence text available
Acrylamide affects USP54
1 |
Acrylamide decreases the amount of USP54. 1 / 1
1 |

No evidence text available
ATXN7L2 affects USP54
1 |
1 |

No evidence text available
ATG16L1 affects USP54
1 |
1 |

No evidence text available
ARMC7 affects USP54
1 |
1 |

No evidence text available
ANKS1A affects USP54
1 |
1 |

No evidence text available
ANKRD11 affects USP54
1 |
1 |

No evidence text available
ANAPC2 affects USP54
1 |
1 |

No evidence text available
AFDN affects USP54
1 |
1 |

No evidence text available
ABTB2 affects USP54
1 |
1 |

No evidence text available
17alpha-ethynylestradiol increases the amount of USP54. 1 / 1
1 |

No evidence text available
1-methylanthracene increases the amount of USP54. 1 / 1
1 |

No evidence text available
1,3-dinitrobenzene increases the amount of USP54. 1 / 1
1 |

No evidence text available
1,2-dimethylhydrazine decreases the amount of USP54. 1 / 1
1 |

No evidence text available

No evidence text available
4,4'-diaminodiphenylmethane increases the amount of USP54. 1 / 1
1 |

No evidence text available
1 |

No evidence text available