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USP54 leads to the ubiquitination of EGFR. 2 / 2

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"Ubiquitin-specific peptidase 54 (USP54), an active deubiquitinase (DUB), modulates the ubiquitination of the epidermal growth factor receptor (EGFR)."

40168312

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"These results reveal a compensatory role for USP54 in modulating EGFR ubiquitination and cell cycle regulation, highlighting its contribution to gefitinib resistance in NSCLC cells.USP54 was silenced using siRNA in gefitinib-resistant PC9/GR and HCC827/GR cell lines to evaluate its role in EGFR regulation and drug sensitivity."

40168312

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IndraLab

Statements

USP54 leads to the ubiquitination of EGFR. 2 / 2

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