IndraLab

Statements

USP54 decreases the amount of PLK4. 4 / 4
| 4
reach
"The results above suggested that CEP120 promotes USP54 expression and centrosome aggregation, which inhibits the ubiquitination degradation of PLK4 and increases PLK4 protein level, thus promoting centrosome amplification and GC progression (Figure 7D)."
36590171
reach
"As shown in Figure 5D, USP54 overexpression significantly increased PLK4 protein level, whereas USP54 knockdown significantly decreased PLK4 protein level."
36590171
reach
"We found that knockdown of USP54 could reverse the increased PLK4 protein level by CEP120 overexpression, while overexpression of USP54 could rescue the reduced PLK4 protein level by CEP120 knockdown (Figure 5I)."
36590171
reach
"Overexpression of USP54 could rescue the reduced PLK4 protein level and GC progression, which were triggered by CEP120 knockdown."
36590171