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USP54 activates gefitinib. 2 / 2

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"USP54 upregulation in gefitinib-treated cells was associated with reduced EGFR ubiquitination, stabilizing EGFR and promoting cell survival."

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"Suppressing USP54 in gefitinib-resistant cells reversed gefitinib insensitivity, restoring EGFR ubiquitination and reducing resistance (Figs 3 and 4)."

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USP54 activates gefitinib. 2 / 2

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