IndraLab

Statements

USP54 deubiquitinates PLK4. 4 / 4
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"In this study, we demonstrated that CEP120 promotes centrosome amplification and GC progression by promoting USP54 expression and centrosome aggregation to inhibit PLK4 ubiquitination and degradation."
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"Subsequently, we explored the effects of these three DUBs on PLK4 ubiquitination, and the results showed that only USP54 significantly reduced PLK4 ubiquitination (Figure 5B)."
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"USP54 promotes gastric cancer progression by deubiquitinating PLK4 [23]."
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"Conversely, USP54 knockdown significantly increased PLK4 ubiquitination (Figure 5H)."
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