IndraLab

Statements

MINDY1 affects ESR

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MINDY1 increases the amount of ESR.

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MINDY1 increases the amount of ESR. 5 / 5

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"We found that the decreased ERα expression induced by MINDY1 depletion could be largely recovered by addition of MG132, suggesting MINDY1 regulates ERα degradation through ubiquitin-proteasome system (UPS)."

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"Besides, MINDY1 depletion decreased ERα protein level in both estrogen and vehicle conditions (Fig. S1C)."

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"It was found that depletion of MINDY1 by siRNAs significantly decreased ERα protein level."

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"MINDY1 depletion significantly reduced the expression of endogenous ERα target genes such as PS2, GREB1, and PDZK1 in the presence or absence of estrogen (Fig. 1C, D)."

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"It is found that ERα protein level and ERα signaling activity were significantly inhibited by MINDY1 depletion."

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MINDY1 activates ESR.

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MINDY1 activates ESR. 5 / 5

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"To further identify MINDY1 promoted ERα-positive breast cancer cell proliferation and migration by increasing ERα stabilization, we ectopic expressed ERα in MINDY1 knockdown MCF-7 cells."

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"Importantly, the catalytically inactive mutant of MINDY1 (C137A) lost the ability in modulating ERα, indicating that MINDY1 promoted ERα stability through its enzymatically active site."

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"Consistently, Overexpression of MINDY1 significantly enhanced ERα transcriptional activity (Fig. S1D)."

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"We observed that MINDY1 depletion significantly decreased ERα (Fig. S1A)."

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"It was observed that MINDY1 depletion inhibited the activity of ERα-luciferase reporter gene both in the presence or absence of estrogen (Fig. 1E, F)."

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MINDY1 deubiquitinates ESR.

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MINDY1 leads to the deubiquitination of ESR. 3 / 3

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"As show in Fig. 6A, MINDY1 depletion significantly increased ERα ubiquitylation in MCF-7 cells."

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"We observed that MINDY1 reduced ERα ubiquitylation in MCF-7 cells in a dose-dependent manner (Fig. 6C)."

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"Furthermore, MINDY1 reduced the ubiquitylation of ERα induced by the E3 ligase TRIM8 (Fig. 6D) [26]."

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MINDY1 binds ESR.

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ESR binds MINDY1. 3 / 3

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"Endogenous MINDY1 and ERα from lysates of MCF-7 cells were co-immunoprecipitated, suggesting the interaction of MINDY1 and ERα in the physiological condition (Fig. 4B)."

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"The Co-IP experiment demonstrated that endogenous MINDY1 and ERα from lysates of MCF-7 cells were co-immunoprecipitated, indicating the interaction of MINDY1 and ERα in the physiological condition."

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"GST-pull-down assay confirmed the direct interaction between MINDY1 and ERα."

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MINDY1 affects cell population proliferation

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MINDY1 activates cell population proliferation.

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MINDY1 activates cell population proliferation. 10 / 14

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"These results indicated that MINDY1 promoted bladder cancer cell proliferation, at least partially, via the regulation of YAP."

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"In addition, MINDY1 could promote the proliferation and migration of breast cancer cells by stabilizing ERα."

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"Our data further demonstrated that MINDY1 depletion dramatically decreased the proliferation bladder cancer cells."

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"We also found that MINDY1 promoted cell proliferation through YAP ."

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"MINDY1 depletion significantly decreased bladder cancer cell proliferation."

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"MINDY1 promotes breast cancer cell proliferation by stabilizing estrogen receptor α."

34645792

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"These results demonstrated that MINDY1 promoted bladder cancer proliferation through increasing YAP stability."

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"Further investigations revealed that MINDY1 promoted the proliferation and migration of breast cancer cells through ERα."

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"Correction to: MINDY1 promotes breast cancer cell proliferation by stabilizing estrogen receptor α."

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"Our results demonstrated that depletion of MINDY1 significantly decreased cell proliferation and increased the population in G1 phases , indicating that MINDY1 may regulate G1 to S transition in bladder cancer cells ( Fig. 5A , B ) ."

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MINDY1 inhibits cell population proliferation.

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MINDY1 inhibits cell population proliferation. 1 / 1

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"MINDY1 depletion significantly decreased bladder cancer cell proliferation."

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MINDY1 affects YAP1

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MINDY1 activates YAP1.

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MINDY1 activates YAP1. 4 / 4

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"It was found that depletion of MINDY1 decreased the YAP/TEAD-luciferase reporter gene activity (Fig. 1G, H)."

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"MINDY1 promotes bladder cancer progression by stabilizing YAP."

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"MINDY1 increases the stability of YAP."

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"Four nonoverlapping siRNA mixtures specific for each of the DUBs belonging to MINDY were transfected into T24 cells, it was found that silencing MINDY1 markedly decreased YAP (Fig. 1A)."

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MINDY1 increases the amount of YAP1.

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MINDY1 increases the amount of YAP1. 3 / 3

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"Depletion of MINDY1 decreased the YAP protein level and the expression of YAP/TEAD target genes in bladder cancer, including CTGF, ANKRD1 and CYR61."

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"We then tested whether ubiquitin–proteasome system (UPS) was required to YAP degradation induced by MINDY1 depletion, and found that MG132 largely recovered the decreased YAP expression induced by MINDY1 silence."

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"Depletion of MINDY1 significantly decreased the YAP protein level and inhibited the Hippo signaling activity."

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MINDY1 deubiquitinates YAP1.

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MINDY1 deubiquitinates YAP1. 3 / 3

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"Then, we examined MINDY1 deubiquitination activity on YAP in two common ubiquitination manners (K48-linked ubiquitination and K63-linked ubiquitination)."

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"MINDY1 deubiquitylates YAP."

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"Conversely, ectopic expression of MINDY1-WT, but not MINDY1 , markedly decreased YAP ubiquitylation in cells (Fig. 4B)."

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MINDY1 inhibits YAP1.

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MINDY1 inhibits YAP1. 2 / 2

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"The present study also demonstrated that MINDY1 removed the K48-linked ubiquitin chain from YAP, thus inhibiting proteasome-mediated YAP degradation."

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"Therefore, targeting MINDY1 may also provide a new means to inhibit tumor‐specific YAP activity."

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MINDY1 binds YAP1.

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YAP1 binds MINDY1. 2 / 2

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"We then made these deletion constructs in order to delineate the interaction between YAP and MINDY1."

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"The interaction between MINDY1 and YAP suggested that YAP might be a substrate of MINDY1, and therefore we evaluated the possibility of YAP deubiquitylation by MINDY1."

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MINDY1 decreases the amount of YAP1.

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MINDY1 decreases the amount of YAP1. 1 / 1

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"It was found that MINDY1 deletion dramatically decreased YAP protein level, and this effect could be reversed by addition of the proteasome inhibitor MG132 or overexpression of MINDY1-WT, but not its catalytically inactive mutant MINDY1 (Fig. 3A, B)."

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MINDY1 affects ESR1

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MINDY1 binds ESR1.

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ESR1 binds MINDY1. 4 / 4

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"GST-pull-down assay confirmed the direct interaction between MINDY1 and ERα."

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"MINDY1 interacted with ERα and increased its stabilization through removing the K48-linked ubiquitin from ERα."

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"MINDY1 interacted with ERα protein and enhanced its stability via removing the K48-linked ubiquitin chain from ERα."

34645792

MINDY1 deubiquitinates ESR1.

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MINDY1 deubiquitinates ESR1. 3 / 3

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"Specifically, MINDY1 associated with the N-terminal of ERalpha via its catalytic domain, thus inhibiting K48-specific poly-ubiquitination process on ERalpha protein."

34645792

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"MINDY1 deubiquitylates ERalpha."

34645792

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"MINDY1 interacted with ERalpha, thereby mediating the deubiquitination of ERalpha and increased its stability in a deubiquitylation activity-dependent manner."

34645792

MINDY1 increases the amount of ESR1.

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MINDY1 increases the amount of ESR1. 1 / 1

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"MINDY1 depletion significantly decreased the ERalpha protein level and ERalpha signaling activity in breast cancer cells."

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MINDY1 activates ESR1.

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MINDY1 activates ESR1. 1 / 1

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"MINDY1 depletion inhibits ERalpha signaling pathway activity."

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ESR1 affects MINDY1

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ESR1 binds MINDY1.

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ESR1 binds MINDY1. 4 / 4

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"GST-pull-down assay confirmed the direct interaction between MINDY1 and ERα."

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"MINDY1 interacted with ERα and increased its stabilization through removing the K48-linked ubiquitin from ERα."

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"MINDY1 interacted with ERα protein and enhanced its stability via removing the K48-linked ubiquitin chain from ERα."

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ESR1 inhibits MINDY1.

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ESR1 inhibits MINDY1. 1 / 1

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"Finally, overexpression of ERalpha could rescue the MINDY1 depletion-induced growth inhibition both in vitro and in vivo, suggesting that MINDY1 promotes breast carcinogenesis through increasing ERalpha stability."

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ESR1 decreases the amount of MINDY1.

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ESR1 decreases the amount of MINDY1. 1 / 1

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biopax:msigdb

No evidence text available

Pirinixic acid affects MINDY1

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Pirinixic acid increases the amount of MINDY1.

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Pirinixic acid increases the amount of MINDY1. 2 / 2

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ctd

No evidence text available

19710929

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ctd

No evidence text available

23811191

Pirinixic acid decreases the amount of MINDY1.

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Pirinixic acid decreases the amount of MINDY1. 1 / 1

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ctd

No evidence text available

19710929

Pirinixic acid activates MINDY1.

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Pirinixic acid activates MINDY1. 1 / 1

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ctd

No evidence text available

19710929

MYB affects MINDY1

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MYB decreases the amount of MINDY1. 4 / 4

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

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biopax:msigdb

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biopax:msigdb

No evidence text available

MINDY1 affects YAP protein

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MINDY1 activates YAP protein. 4 / 4

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"Depletion of MINDY1 decreased the YAP protein level and the expression of YAP / TEAD target genes in bladder cancer , including CTGF , ANKRD1 and CYR61 ."

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"We then depleted MINDY1 with two non-overlapping siRNAs separately in T24 and UMUC3 cells to further validate the function of MINDY1 in regulating YAP , as shown in Fig. 1B , C , MINDY1 depletion significantly decreased the YAP protein levels without influence on the expression of YAP mRNA ."

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"Depletion of MINDY1 significantly decreased the YAP protein level and inhibited the Hippo signaling activity ."

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"A In the presence of the proteasome inhibitor MG132 , depletion of MINDY1 did not further decrease the YAP protein level ."

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MINDY1 affects Urinary Bladder Neoplasms

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MINDY1 activates Urinary Bladder Neoplasms. 4 / 4

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"These results demonstrated that MINDY1 promoted bladder cancer proliferation through increasing YAP stability ."

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"MINDY1 promotes bladder cancer progression by stabilizing YAP Background Bladder cancer is one of the most commonly diagnosed urological malignant tumor ."

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"50 In BE and 10.13039 / 100005820EAC , MINDY1 was identified in a set of 90 genes significantly predicting disease progression by distinguishing 10.13039 / 100005820EAC progressors from patients with non-dysplastic BE.51 Moreover , MINDY-1 was found to promote bladder cancer progression by stabilizing YAP ,52 a key tumorigenesis pathway member that can also be induced by conjugated bile acids in 10.13039 / 100005820EAC ."

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"Our data suggest that MINDY1 may drive bladder cancer progression via YAP expression ."

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YAP1 affects MINDY1

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YAP1 binds MINDY1.

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YAP1 binds MINDY1. 2 / 2

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"We then made these deletion constructs in order to delineate the interaction between YAP and MINDY1."

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"The interaction between MINDY1 and YAP suggested that YAP might be a substrate of MINDY1, and therefore we evaluated the possibility of YAP deubiquitylation by MINDY1."

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YAP1 inhibits MINDY1.

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YAP1 inhibits MINDY1. 1 / 1

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"Increased YAP expression reverses the effect of MINDY1 depletion ."

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MINDY1 affects cell cycle arrest

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MINDY1 activates cell cycle arrest.

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MINDY1 activates cell cycle arrest. 2 / 2

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"In addition, MINDY1 depletion led to growth inhibition and cell cycle arrest of ERalpha-positive breast cancer cells."

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"In addition, MINDY1 depletion led to growth inhibition and cell cycle arrest of ERα-positive breast cancer cells."

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MINDY1 inhibits cell cycle arrest.

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MINDY1 inhibits cell cycle arrest. 1 / 1

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"Depletion of MINDY1 induced G1 phases cell cycle arrest, indicating that MINDY1 was involved in the G1 to S transition of ERα-positive breast cancer cells (Fig. 7B)."

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MINDY1 affects bladder cancer cell

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MINDY1 activates bladder cancer cell. 3 / 3

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"These results indicated that MINDY1 promoted bladder cancer cell proliferation , at least partially , via the regulation of YAP ."

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"MINDY1 depletion significantly decreased bladder cancer cell proliferation ."

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"MINDY1 depletion inhibits bladder cancer cell proliferation ."

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MINDY1 affects Neoplasms

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MINDY1 activates Neoplasms.

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MINDY1 activates Neoplasms. 2 / 2

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"Knockdown of MINDY1 significantly inhibited tumor growth in vivo, while the restoration of YAP expression abolished the inhibition induced by MINDY1 depletion (Fig. 6E)."

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"Then, we used xenograft mice models to further investigated if MINDY1 promoted tumor growth in vivo."

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MINDY1 inhibits Neoplasms.

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MINDY1 inhibits Neoplasms. 1 / 1

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"Therefore, targeting MINDY1 may also provide a new means to inhibit tumor‐specific YAP activity."

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ESR affects MINDY1

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ESR binds MINDY1. 3 / 3

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"Endogenous MINDY1 and ERα from lysates of MCF-7 cells were co-immunoprecipitated, suggesting the interaction of MINDY1 and ERα in the physiological condition (Fig. 4B)."

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"GST-pull-down assay confirmed the direct interaction between MINDY1 and ERα."

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Bisphenol A affects MINDY1

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Bisphenol A increases the amount of MINDY1.

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Bisphenol A increases the amount of MINDY1. 1 / 1

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ctd

No evidence text available

25047013

Bisphenol A decreases the amount of MINDY1.

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Bisphenol A decreases the amount of MINDY1. 1 / 1

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ctd

No evidence text available

30816183

RNF126 affects MINDY1

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RNF126 binds MINDY1. 2 / 2

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biogrid

No evidence text available

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biogrid

No evidence text available

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MINDY1 affects hippo signaling

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MINDY1 activates hippo signaling. 2 / 2

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"MINDY1 depletion inhibits Hippo signaling pathway activity."

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"Depletion of MINDY1 significantly decreased the YAP protein level and inhibited the Hippo signaling activity ."

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MINDY1 affects endoplasmic reticulum

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MINDY1 increases the amount of endoplasmic reticulum.

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MINDY1 increases the amount of endoplasmic reticulum. 1 / 1

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"MINDY1 depletion significantly decreased the ERα protein level and ERα signaling activity in breast cancer cells."

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MINDY1 deubiquitinates endoplasmic reticulum.

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MINDY1 leads to the deubiquitination of endoplasmic reticulum. 1 / 1

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"Specifically, MINDY1 associated with the N-terminal of ERα via its catalytic domain, thus inhibiting K48-specific poly-ubiquitination process on ERα protein."

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MINDY1 affects bladder cancer cells

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MINDY1 activates bladder cancer cells. 2 / 2

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"Our study demonstrated that MINDY1 could promote bladder cancer cells proliferation in vitro and in vivo ."

34315490

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"Our data further demonstrated that MINDY1 depletion dramatically decreased the proliferation bladder cancer cells ."

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MINDY1 affects TEAD

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MINDY1 increases the amount of TEAD.

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MINDY1 increases the amount of TEAD. 1 / 1

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"Depletion of MINDY1 decreased the YAP protein level and the expression of YAP/TEAD target genes in bladder cancer, including CTGF, ANKRD1 and CYR61."

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MINDY1 decreases the amount of TEAD.

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MINDY1 decreases the amount of TEAD. 1 / 1

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"Depletion of MINDY1 decreased the YAP protein level and the expression of YAP and TEAD target genes in bladder cancer, including CTGF, ANKRD1 and CYR61."

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MINDY1 affects RNF126

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RNF126 binds MINDY1. 2 / 2

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biogrid

No evidence text available

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biogrid

No evidence text available

26186194

MINDY1 affects LSM8

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LSM8 binds MINDY1. 2 / 2

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biogrid

No evidence text available

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hprd

No evidence text available

15231747

MINDY1 affects CHIA

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CHIA binds MINDY1. 2 / 2

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biogrid

No evidence text available

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biogrid

No evidence text available

28514442

LSM8 affects MINDY1

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LSM8 binds MINDY1. 2 / 2

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biogrid

No evidence text available

15231747

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hprd

No evidence text available

15231747

LEF1 affects MINDY1

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LEF1 decreases the amount of MINDY1. 2 / 2

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

FOXO4 affects MINDY1

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FOXO4 decreases the amount of MINDY1. 2 / 2

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

CHIA affects MINDY1

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CHIA binds MINDY1. 2 / 2

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biogrid

No evidence text available

26186194

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biogrid

No evidence text available

28514442

Trimethyltin chloride affects MINDY1

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Trimethyltin chloride increases the amount of MINDY1. 1 / 1

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ctd

No evidence text available

23000284

Sulforaphane affects MINDY1

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Sulforaphane decreases the amount of MINDY1. 1 / 1

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ctd

No evidence text available

31838189

Nickel monoxide affects MINDY1

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Nickel monoxide increases the amount of MINDY1. 1 / 1

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ctd

No evidence text available

19167457

Mutation T335 aspartate affects MINDY1

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Mutation T335 aspartate inhibits MINDY1. 1 / 1

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"To our surprise , the mutation of T335 to aspartate also abolishes MINDY1 activity ( Figure 4D ) ."

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Methotrexate affects MINDY1

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Methotrexate increases the amount of MINDY1. 1 / 1

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ctd

No evidence text available

17400583

Lentivirus-based shRNA decelerated bladder tumor growth affects MINDY1

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Lentivirus-based shRNA decelerated bladder tumor growth inhibits MINDY1. 1 / 1

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"Our data showed that MINDY1 depletion by lentivirus-based shRNA decelerated bladder tumor growth ( Fig. 5F , G ) ."

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Leflunomide affects MINDY1

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Leflunomide decreases the amount of MINDY1. 1 / 1

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ctd

No evidence text available

28988120

Jinfukang affects MINDY1

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Jinfukang increases the amount of MINDY1. 1 / 1

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ctd

No evidence text available

27392435

Hsa-miR-8062 affects MINDY1

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Hsa-miR-8062 decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-7151-3p affects MINDY1

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Hsa-miR-7151-3p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-6832-5p affects MINDY1

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Hsa-miR-6832-5p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6807-5p affects MINDY1

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Hsa-miR-6807-5p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-6778-3p affects MINDY1

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Hsa-miR-6778-3p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-6747-3p affects MINDY1

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Hsa-miR-6747-3p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-6727-3p affects MINDY1

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Hsa-miR-6727-3p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-6513-3p affects MINDY1

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Hsa-miR-6513-3p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-6504-3p affects MINDY1

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Hsa-miR-6504-3p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-5096 affects MINDY1

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Hsa-miR-5096 decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-5095 affects MINDY1

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Hsa-miR-5095 decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-483-5p affects MINDY1

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Hsa-miR-483-5p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4740-3p affects MINDY1

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Hsa-miR-4740-3p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-4722-3p affects MINDY1

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Hsa-miR-4722-3p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-4700-3p affects MINDY1

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Hsa-miR-4700-3p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-4465 affects MINDY1

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Hsa-miR-4465 decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-4433b-3p affects MINDY1

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Hsa-miR-4433b-3p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-4433a-3p affects MINDY1

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Hsa-miR-4433a-3p decreases the amount of MINDY1. 1 / 1

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biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-4279 affects MINDY1

1 |

Hsa-miR-4279 decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-411-5p affects MINDY1

1 |

Hsa-miR-411-5p decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-3653-5p affects MINDY1

1 |

Hsa-miR-3653-5p decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-26b-5p affects MINDY1

1 |

Hsa-miR-26b-5p decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-26a-5p affects MINDY1

1 |

Hsa-miR-26a-5p decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-1976 affects MINDY1

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Hsa-miR-1976 decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

27292025

Hsa-miR-193b-5p affects MINDY1

1 |

Hsa-miR-193b-5p decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-1303 affects MINDY1

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Hsa-miR-1303 decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-1297 affects MINDY1

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Hsa-miR-1297 decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

27292025

Gossypol acetic acid affects MINDY1

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Gossypol acetic acid decreases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

29938581

Formaldehyde affects MINDY1

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Formaldehyde increases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Flutamide affects MINDY1

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Flutamide increases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

24136188

Endoplasmic reticulum affects MINDY1

| 1

Endoplasmic reticulum inhibits MINDY1. 1 / 1

| 1

➶

reach

"Finally, overexpression of ERα could rescue the MINDY1 depletion-induced growth inhibition both in vitro and in vivo, suggesting that MINDY1 promotes breast carcinogenesis through increasing ERα stability."

34645792

Dimethyl-4-toluidine affects MINDY1

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Dimethyl-4-toluidine decreases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

27638505

Dibutyl phthalate affects MINDY1

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Dibutyl phthalate increases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

21266533

Cyclosporin A affects MINDY1

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Cyclosporin A decreases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

20106945

Clofibrate affects MINDY1

1 |

Clofibrate decreases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

17585979

Cisplatin affects MINDY1

1 |

Cisplatin increases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

27392435

Cadmium atom affects MINDY1

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Cadmium atom decreases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

23369406

Atrazine affects MINDY1

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Atrazine increases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

25929836

All-trans-retinoic acid affects MINDY1

1 |

All-trans-retinoic acid increases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

23724009

Tobacco Smoke Pollution affects MINDY1

1 |

Tobacco Smoke Pollution increases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

22363418

TFAP4 affects MINDY1

1 |

TFAP4 decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

TCF4 affects MINDY1

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TCF4 decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

STAT6 affects MINDY1

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STAT6 decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

STAT5A affects MINDY1

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STAT5A decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

STAT1 affects MINDY1

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STAT1 decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

SLC45A2 affects MINDY1

1 |

SLC45A2 binds MINDY1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

SEL1L3 affects MINDY1

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MINDY1 binds SEL1L3. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RUNX1 affects MINDY1

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RUNX1 decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

REPIN1 affects MINDY1

1 |

REPIN1 decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

Pentosan Sulfuric Polyester affects MINDY1

1 |

Pentosan Sulfuric Polyester increases the amount of MINDY1. 1 / 1

1 |

➶

ctd

No evidence text available

28973697

PAX4 affects MINDY1

1 |

PAX4 decreases the amount of MINDY1. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

MINDY1 is modified

1 |

MINDY1 is phosphorylated on S441. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

MINDY1 affects validate function MINDY1 regulating YAP

| 1

MINDY1 inhibits validate function MINDY1 regulating YAP. 1 / 1

| 1

➶

eidos

34315490

MINDY1 affects ubiquitinated-YAP

| 1

MINDY1 decreases the amount of ubiquitinated-YAP. 1 / 1

| 1

➶

reach

"Depletion of MINDY1 significantly increased the level of ubiquitinated-YAP in T24 cells (Fig. 4A)."

34315490

MINDY1 affects tumor growth

| 1

MINDY1 activates tumor growth. 1 / 1

| 1

➶

eidos

"Knockdown of MINDY1 significantly inhibited tumor growth in vivo , while the restoration of YAP expression abolished the inhibition induced by MINDY1 depletion ( Fig. 6E ) ."

34315490

MINDY1 affects transcripts CTGF CYR61 ANKRD1

| 1

MINDY1 activates transcripts CTGF CYR61 ANKRD1. 1 / 1

| 1

➶

eidos

"We then examined the expression of YAP target genes ( CTGF , CYR61 and ANKRD1 ) and found that depletion of MINDY1 dramatically decreased the transcripts of CTGF , CYR61 and ANKRD1 ( Fig. 1E , F ) ."

34315490

MINDY1 affects signal transduction

| 1

MINDY1 activates signal transduction. 1 / 1

| 1

➶

reach

"MINDY1 depletion inhibits ERalpha signaling pathway activity."

34645792

MINDY1 affects proteasome-mediated YAP

| 1

MINDY1 inhibits proteasome-mediated YAP. 1 / 1

| 1

➶

eidos

"The present study also demonstrated that MINDY1 removed the K48-linked ubiquitin chain from YAP , thus inhibiting proteasome-mediated YAP degradation ."

34315490

MINDY1 affects population G1 phases

| 1

MINDY1 inhibits population G1 phases. 1 / 1

| 1

➶

eidos

34315490

MINDY1 affects fluorescent cleavage products

| 1

MINDY1 activates fluorescent cleavage products. 1 / 1

| 1

➶

eidos

"However , we observe that both MINDY1 and MINDY2 rapidly produce a range of fluorescent cleavage products that lie between Ub1 and Ub7 , suggesting endo-activity as the DUB can cleave anywhere within the polyUb chain , resulting in the formation of chains of all intermediate lengths as products ( Figures 6C and 6D ) ."

34529927

MINDY1 affects clone capability UMUC3 cells

| 1

MINDY1 activates clone capability UMUC3 cells. 1 / 1

| 1

➶

eidos

"The results of clone formation assay revealed that MINDY1 depletion dramatically decreased the clone formation capability in T24 and UMUC3 cells ( Fig. 5C ) ."

34315490

MINDY1 affects cell migration

| 1

MINDY1 activates cell migration. 1 / 1

| 1

➶

reach

"Furthermore, wound-healing assay revealed that depletion of MINDY1 significantly decreased the cell migration ability (Fig. 7F)."

34645792

MINDY1 affects cell bladder cancer cells

| 1

MINDY1 activates cell bladder cancer cells. 1 / 1

| 1

➶

eidos

"A MINDY1 depletion inhibited cell proliferation in bladder cancer cells ."

34315490

MINDY1 affects breast cancer cell

| 1

MINDY1 activates breast cancer cell. 1 / 1

| 1

➶

eidos

"Correction to : MINDY1 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha ."

35087032

MINDY1 affects apoptotic process

| 1

MINDY1 inhibits apoptotic process. 1 / 1

| 1

➶

reach

"The results showed that the combination treatment of silencing MINDY1 expression and tamoxifen induced more obvious inhibitory effects and apoptosis in MCF-7 cells (Fig. S3B, C)."

34645792

MINDY1 affects YAP stability

| 1

MINDY1 activates YAP stability. 1 / 1

| 1

➶

eidos

"MINDY1 increases YAP stability ."

34315490

MINDY1 affects YAP protein stability

| 1

MINDY1 activates YAP protein stability. 1 / 1

| 1

➶

eidos

"Furthermore , MINDY1 could increase YAP protein stability by removing K48-linked Ub chains Supplementary Information ."

34315490

MINDY1 affects YAP TEAD-luciferase reporter

| 1

MINDY1 activates YAP TEAD-luciferase reporter. 1 / 1

| 1

➶

eidos

"It was found that depletion of MINDY1 decreased the YAP / TEAD-luciferase reporter gene activity ( Fig. 1G , H ) ."

34315490

MINDY1 affects YAP TEAD target bladder cancer including CTGF ANKRD1 CYR61

| 1

MINDY1 activates YAP TEAD target bladder cancer including CTGF ANKRD1 CYR61. 1 / 1

| 1

➶

eidos

"Depletion of MINDY1 decreased the YAP protein level and the expression of YAP / TEAD target genes in bladder cancer , including CTGF , ANKRD1 and CYR61 ."

34315490

MINDY1 affects Ub5

| 1

MINDY1 inhibits Ub5. 1 / 1

| 1

➶

reach

"Furthermore, mutating residues at equivalent positions in MINDY1 also inhibit cleavage of Ub5 (Figures S6F and S6G)."

34529927

MINDY1 affects TEAD-luciferase reporter gene

| 1

MINDY1 activates TEAD-luciferase reporter gene. 1 / 1

| 1

➶

reach

"It was found that depletion of MINDY1 decreased the YAP/TEAD-luciferase reporter gene activity (Fig. 1G, H)."

34315490

MINDY1 affects SLC45A2

1 |

SLC45A2 binds MINDY1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

MINDY1 affects SEL1L3

1 |

MINDY1 binds SEL1L3. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

MINDY1 affects MANSC1

1 |

MANSC1 binds MINDY1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

MINDY1 affects KDELR1

1 |

MINDY1 binds KDELR1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

MINDY1 affects KCNA10

1 |

MINDY1 binds KCNA10. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

MINDY1 affects Hippo signaling bladder cancer cells

| 1

MINDY1 activates Hippo signaling bladder cancer cells. 1 / 1

| 1

➶

eidos

"MINDY1 depletion decreases Hippo signaling activity in bladder cancer cells ."

34315490

MINDY1 affects HERC2

1 |

MINDY1 binds HERC2. 1 / 1

1 |

➶

biogrid

No evidence text available

26186194

MINDY1 affects GRTP1

1 |

GRTP1 binds MINDY1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

MINDY1 affects GMCL1

1 |

GMCL1 binds MINDY1. 1 / 1

1 |

➶

biogrid

No evidence text available

25416956

MINDY1 affects DNA biosynthetic process

| 1

MINDY1 activates DNA biosynthetic process. 1 / 1

| 1

➶

reach

"Our results indicated that MINDY1 depletion inhibited the DNA synthesis of MCF-7 and T47D cells (Fig. 7D, E)."

34645792

MINDY1 affects CCN2

| 1

MINDY1 activates CCN2. 1 / 1

| 1

➶

reach

"We then examined the expression of YAP target genes (CTGF, CYR61 and ANKRD1) and found that depletion of MINDY1 dramatically decreased the transcripts of CTGF, CYR61 and ANKRD1 (Fig. 1E, F)."

34315490

MINDY1 affects CCN1

| 1

MINDY1 activates CCN1. 1 / 1

| 1

➶

reach

"We then examined the expression of YAP target genes (CTGF, CYR61 and ANKRD1) and found that depletion of MINDY1 dramatically decreased the transcripts of CTGF, CYR61 and ANKRD1 (Fig. 1E, F)."

34315490

MINDY1 affects ANKRD1

| 1

MINDY1 activates ANKRD1. 1 / 1

| 1

➶

reach

"We then examined the expression of YAP target genes (CTGF, CYR61 and ANKRD1) and found that depletion of MINDY1 dramatically decreased the transcripts of CTGF, CYR61 and ANKRD1 (Fig. 1E, F)."

34315490

MINDY1 S321A mutation affects MINDY1

| 1

MINDY1 S321A mutation activates MINDY1. 1 / 1

| 1

➶

eidos

"However , to our surprise , MINDY1 S321A mutation did not abolish activity , but instead resulted in a modest increase in MINDY1 activity ( Figure 4B ) ."

34529927