IndraLab

Statements


MINDY1 affects YAP1
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MINDY1 binds YAP1.
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"We then made these deletion constructs in order to delineate the interaction between YAP and MINDY1."

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"The interaction between MINDY1 and YAP suggested that YAP might be a substrate of MINDY1, and therefore we evaluated the possibility of YAP deubiquitylation by MINDY1."

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"However, MINDY1 DUB activity promotes the proliferation of bladder cancer cells by stabilizing MINDY1 interaction partner YAP protein and critical transcriptional regulator of the Hippo pathway."
MINDY1 deubiquitinates YAP1.
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MINDY1 deubiquitinates YAP1. 4 / 4
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"MINDY1 deubiquitylates YAP."

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"Conversely, ectopic expression of MINDY1-WT, but not MINDY1 , markedly decreased YAP ubiquitylation in cells (Fig. 4B)."

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"Then, we examined MINDY1 deubiquitination activity on YAP in two common ubiquitination manners (K48-linked ubiquitination and K63-linked ubiquitination)."

"CONCLUSION: In general, our findings establish a previously undocumented catalytic role for <span class="match term0">MINDY1</span> as a deubiquitinating enzyme of <span class="match term1">YAP</span> and provides a possible target for the therapy of bladder cancer."
MINDY1 activates YAP1.
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MINDY1 activates YAP1. 4 / 4
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"MINDY1 promotes bladder cancer progression by stabilizing YAP."

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"It was found that depletion of MINDY1 decreased the YAP/TEAD-luciferase reporter gene activity (Fig. 1G, H)."

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"MINDY1 increases the stability of YAP."

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"Four nonoverlapping siRNA mixtures specific for each of the DUBs belonging to MINDY were transfected into T24 cells, it was found that silencing MINDY1 markedly decreased YAP (Fig. 1A)."
MINDY1 increases the amount of YAP1.
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MINDY1 increases the amount of YAP1. 3 / 3
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"Depletion of MINDY1 significantly decreased the YAP protein level and inhibited the Hippo signaling activity."

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"Depletion of MINDY1 decreased the YAP protein level and the expression of YAP/TEAD target genes in bladder cancer, including CTGF, ANKRD1 and CYR61."

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"We then tested whether ubiquitin–proteasome system (UPS) was required to YAP degradation induced by MINDY1 depletion, and found that MG132 largely recovered the decreased YAP expression induced by MINDY1 silence."
MINDY1 inhibits YAP1.
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MINDY1 inhibits YAP1. 2 / 2
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"Therefore, targeting MINDY1 may also provide a new means to inhibit tumor‐specific YAP activity."

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"The present study also demonstrated that MINDY1 removed the K48-linked ubiquitin chain from YAP, thus inhibiting proteasome-mediated YAP degradation."
MINDY1 decreases the amount of YAP1.
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MINDY1 decreases the amount of YAP1. 2 / 2
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"It was found that MINDY1 deletion dramatically decreased YAP protein level, and this effect could be reversed by addition of the proteasome inhibitor MG132 or overexpression of MINDY1-WT, but not its catalytically inactive mutant MINDY1 (Fig. 3A, B)."

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"Downregulation of MINDY1 disrupted the YAP stabilization and inhibited the expression of YAP downstream genes, such as CTGF, CYR61 and ANKRD1 in bladder cancer (88)."

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"32 OTUD7B and MINDY1 could promote breast cancer proliferation by stabilizing ERα in a deubiquitylation activity–dependent manner."

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"These results indicated that MINDY1 promoted bladder cancer cell proliferation, at least partially, via the regulation of YAP."

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"MINDY1 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha."

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"Our results demonstrated that depletion of MINDY1 significantly decreased cell proliferation and increased the population in G1 phases , indicating that MINDY1 may regulate G1 to S transition in bladder cancer cells ( Fig. 5A , B ) ."

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"MINDY1 depletion significantly decreased bladder cancer cell proliferation."

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"We also found that MINDY1 promoted cell proliferation through YAP ."

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"Further investigations revealed that MINDY1 promoted the proliferation and migration of breast cancer cells through ERα."

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"Our data further demonstrated that MINDY1 depletion dramatically decreased the proliferation bladder cancer cells."

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"These results demonstrated that MINDY1 promoted bladder cancer proliferation through increasing YAP stability."

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"It was found that MINDY1 depletion inhibited cell proliferation in both vehicle and estradiol treated conditions (Fig. 7A and Fig. S3A)."
MINDY1 affects ESR
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MINDY1 increases the amount of ESR.
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MINDY1 increases the amount of ESR. 5 / 5
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"MINDY1 depletion significantly reduced the expression of endogenous ERα target genes such as PS2, GREB1, and PDZK1 in the presence or absence of estrogen (Fig. 1C, D)."

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"We found that the decreased ERα expression induced by MINDY1 depletion could be largely recovered by addition of MG132, suggesting MINDY1 regulates ERα degradation through ubiquitin-proteasome system (UPS)."

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"Besides, MINDY1 depletion decreased ERα protein level in both estrogen and vehicle conditions (Fig. S1C)."

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"It was found that depletion of MINDY1 by siRNAs significantly decreased ERα protein level."

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"It is found that ERα protein level and ERα signaling activity were significantly inhibited by MINDY1 depletion."
MINDY1 activates ESR.
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MINDY1 activates ESR. 5 / 5
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"Importantly, the catalytically inactive mutant of MINDY1 (C137A) lost the ability in modulating ERα, indicating that MINDY1 promoted ERα stability through its enzymatically active site."

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"We observed that MINDY1 depletion significantly decreased ERα (Fig. S1A)."

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"It was observed that MINDY1 depletion inhibited the activity of ERα-luciferase reporter gene both in the presence or absence of estrogen (Fig. 1E, F)."

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"Consistently, Overexpression of MINDY1 significantly enhanced ERα transcriptional activity (Fig. S1D)."

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"To further identify MINDY1 promoted ERα-positive breast cancer cell proliferation and migration by increasing ERα stabilization, we ectopic expressed ERα in MINDY1 knockdown MCF-7 cells."
MINDY1 deubiquitinates ESR.
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MINDY1 leads to the deubiquitination of ESR. 3 / 3
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"As show in Fig. 6A, MINDY1 depletion significantly increased ERα ubiquitylation in MCF-7 cells."

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"We observed that MINDY1 reduced ERα ubiquitylation in MCF-7 cells in a dose-dependent manner (Fig. 6C)."

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"Furthermore, MINDY1 reduced the ubiquitylation of ERα induced by the E3 ligase TRIM8 (Fig. 6D) [26]."
MINDY1 binds ESR.
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"Endogenous MINDY1 and ERα from lysates of MCF-7 cells were co-immunoprecipitated, suggesting the interaction of MINDY1 and ERα in the physiological condition (Fig. 4B)."

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"The Co-IP experiment demonstrated that endogenous MINDY1 and ERα from lysates of MCF-7 cells were co-immunoprecipitated, indicating the interaction of MINDY1 and ERα in the physiological condition."

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"GST-pull-down assay confirmed the direct interaction between MINDY1 and ERα."
MINDY1 affects ESR1
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MINDY1 binds ESR1.
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MINDY1 binds ESR1. 4 / 4
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"GST-pull-down assay confirmed the direct interaction between MINDY1 and ERα."

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"The Co-IP experiment demonstrated that endogenous MINDY1 and ERα from lysates of MCF-7 cells were co-immunoprecipitated, indicating the interaction of MINDY1 and ERα in the physiological condition."

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"MINDY1 interacted with ERα protein and enhanced its stability via removing the K48-linked ubiquitin chain from ERα."

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"MINDY1 interacted with ERα and increased its stabilization through removing the K48-linked ubiquitin from ERα."
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MINDY1 deubiquitinates ESR1.
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MINDY1 deubiquitinates ESR1. 3 / 3
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"Specifically, MINDY1 associated with the N-terminal of ERalpha via its catalytic domain, thus inhibiting K48-specific poly-ubiquitination process on ERalpha protein."

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"MINDY1 deubiquitylates ERalpha."

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"MINDY1 interacted with ERalpha, thereby mediating the deubiquitination of ERalpha and increased its stability in a deubiquitylation activity-dependent manner."
MINDY1 increases the amount of ESR1.
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MINDY1 increases the amount of ESR1. 1 / 1
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"MINDY1 depletion significantly decreased the ERalpha protein level and ERalpha signaling activity in breast cancer cells."
MINDY1 activates ESR1.
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MINDY1 activates ESR1. 1 / 1
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"MINDY1 depletion inhibits ERalpha signaling pathway activity."
ESR1 affects MINDY1
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ESR1 binds MINDY1.
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MINDY1 binds ESR1. 4 / 4
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"GST-pull-down assay confirmed the direct interaction between MINDY1 and ERα."

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"The Co-IP experiment demonstrated that endogenous MINDY1 and ERα from lysates of MCF-7 cells were co-immunoprecipitated, indicating the interaction of MINDY1 and ERα in the physiological condition."

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"MINDY1 interacted with ERα protein and enhanced its stability via removing the K48-linked ubiquitin chain from ERα."

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"MINDY1 interacted with ERα and increased its stabilization through removing the K48-linked ubiquitin from ERα."
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ESR1 inhibits MINDY1.
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ESR1 inhibits MINDY1. 1 / 1
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"Finally, overexpression of ERalpha could rescue the MINDY1 depletion-induced growth inhibition both in vitro and in vivo, suggesting that MINDY1 promotes breast carcinogenesis through increasing ERalpha stability."
ESR1 decreases the amount of MINDY1.
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ESR1 decreases the amount of MINDY1. 1 / 1
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Bisphenol A increases the amount of MINDY1.
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Bisphenol A increases the amount of MINDY1. 3 / 3
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Bisphenol A decreases the amount of MINDY1.
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Bisphenol A decreases the amount of MINDY1. 3 / 3
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YAP1 affects MINDY1
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YAP1 binds MINDY1.
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"We then made these deletion constructs in order to delineate the interaction between YAP and MINDY1."

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"The interaction between MINDY1 and YAP suggested that YAP might be a substrate of MINDY1, and therefore we evaluated the possibility of YAP deubiquitylation by MINDY1."

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"However, MINDY1 DUB activity promotes the proliferation of bladder cancer cells by stabilizing MINDY1 interaction partner YAP protein and critical transcriptional regulator of the Hippo pathway."
YAP1 inhibits MINDY1.
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YAP1 inhibits MINDY1. 1 / 1
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"Increased YAP expression reverses the effect of MINDY1 depletion ."
UBC affects MINDY1
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Pirinixic acid increases the amount of MINDY1.
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Pirinixic acid increases the amount of MINDY1. 2 / 2
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Pirinixic acid decreases the amount of MINDY1.
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Pirinixic acid decreases the amount of MINDY1. 1 / 1
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Pirinixic acid activates MINDY1.
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MYB affects MINDY1
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MYB decreases the amount of MINDY1. 4 / 4
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MINDY1 affects YAP protein
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MINDY1 activates YAP protein. 4 / 4
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"Depletion of MINDY1 decreased the YAP protein level and the expression of YAP / TEAD target genes in bladder cancer , including CTGF , ANKRD1 and CYR61 ."

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"We then depleted MINDY1 with two non-overlapping siRNAs separately in T24 and UMUC3 cells to further validate the function of MINDY1 in regulating YAP , as shown in Fig. 1B , C , MINDY1 depletion significantly decreased the YAP protein levels without influence on the expression of YAP mRNA ."

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"A In the presence of the proteasome inhibitor MG132 , depletion of MINDY1 did not further decrease the YAP protein level ."

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"Depletion of MINDY1 significantly decreased the YAP protein level and inhibited the Hippo signaling activity ."

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"These results demonstrated that MINDY1 promoted bladder cancer proliferation through increasing YAP stability ."

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"50 In BE and 10.13039 / 100005820EAC , MINDY1 was identified in a set of 90 genes significantly predicting disease progression by distinguishing 10.13039 / 100005820EAC progressors from patients with non-dysplastic BE.51 Moreover , MINDY-1 was found to promote bladder cancer progression by stabilizing YAP ,52 a key tumorigenesis pathway member that can also be induced by conjugated bile acids in 10.13039 / 100005820EAC ."

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"Our data suggest that MINDY1 may drive bladder cancer progression via YAP expression ."

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"MINDY1 promotes bladder cancer progression by stabilizing YAP Background Bladder cancer is one of the most commonly diagnosed urological malignant tumor ."
MINDY1 affects CD274
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MINDY1 deubiquitinates CD274.
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MINDY1 leads to the deubiquitination of CD274. 2 / 2
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"MINDY1 was found to directly interact with PD-L1, with MINDY1 gene knockdown promoting PD-L1 ubiquitination and MINDY1 overexpression inhibiting PD-L1 ubiquitination."

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"In conclusion, MINDY1 inhibits the malignant progression of liver cancer by inhibiting PD-L1 ubiquitination and mediating immune escape."
MINDY1 ubiquitinates CD274.
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MINDY1 leads to the ubiquitination of CD274. 1 / 1
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"The potential role of MINDY1 in inhibiting the stemness of liver cancer cells by deubiquitinating PD-L1 has not yet been reported."
MINDY1 increases the amount of CD274.
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MINDY1 increases the amount of CD274. 1 / 1
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"Study on the mechanism of liver cancer immune escape mediated by MINDY1 through regulation of PD-L1 ubiquitination level."
RNF126 affects MINDY1
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MINDY1 affects bladder cancer cell
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MINDY1 activates bladder cancer cell. 3 / 3
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"MINDY1 depletion inhibits bladder cancer cell proliferation ."

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"These results indicated that MINDY1 promoted bladder cancer cell proliferation , at least partially , via the regulation of YAP ."

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"MINDY1 depletion significantly decreased bladder cancer cell proliferation ."
MINDY1 affects RNF126
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MINDY1 affects Neoplasms
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MINDY1 activates Neoplasms.
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"Then, we used xenograft mice models to further investigated if MINDY1 promoted tumor growth in vivo."

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"Knockdown of MINDY1 significantly inhibited tumor growth in vivo, while the restoration of YAP expression abolished the inhibition induced by MINDY1 depletion (Fig. 6E)."
MINDY1 inhibits Neoplasms.
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"Therefore, targeting MINDY1 may also provide a new means to inhibit tumor‐specific YAP activity."
MINDY1 affects CHIA
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ESR affects MINDY1
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"Endogenous MINDY1 and ERα from lysates of MCF-7 cells were co-immunoprecipitated, suggesting the interaction of MINDY1 and ERα in the physiological condition (Fig. 4B)."

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"The Co-IP experiment demonstrated that endogenous MINDY1 and ERα from lysates of MCF-7 cells were co-immunoprecipitated, indicating the interaction of MINDY1 and ERα in the physiological condition."

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"GST-pull-down assay confirmed the direct interaction between MINDY1 and ERα."
CHIA affects MINDY1
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Sodium arsenate increases the amount of MINDY1.
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Sodium arsenate increases the amount of MINDY1. 1 / 1
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Sodium arsenate decreases the amount of MINDY1.
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Sodium arsenate decreases the amount of MINDY1. 1 / 1
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Paracetamol decreases the amount of MINDY1. 2 / 2
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Folic acid affects MINDY1
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Folic acid increases the amount of MINDY1.
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Folic acid increases the amount of MINDY1. 1 / 1
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Folic acid decreases the amount of MINDY1.
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Folic acid decreases the amount of MINDY1. 1 / 1
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Arsenic atom increases the amount of MINDY1.
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Arsenic atom increases the amount of MINDY1. 1 / 1
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Arsenic atom decreases the amount of MINDY1.
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Arsenic atom decreases the amount of MINDY1. 1 / 1
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Tobacco Smoke Pollution increases the amount of MINDY1.
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Tobacco Smoke Pollution increases the amount of MINDY1. 1 / 1
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Tobacco Smoke Pollution decreases the amount of MINDY1.
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Tobacco Smoke Pollution decreases the amount of MINDY1. 1 / 1
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SEL1L3 affects MINDY1
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"Depletion of MINDY1 induced G1 phases cell cycle arrest, indicating that MINDY1 was involved in the G1 to S transition of ERα-positive breast cancer cells (Fig. 7B)."

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"In addition, MINDY1 depletion led to growth inhibition and cell cycle arrest of ERalpha-positive breast cancer cells."
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"Depletion of MINDY1 significantly decreased the YAP protein level and inhibited the Hippo signaling activity ."

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"MINDY1 depletion inhibits Hippo signaling pathway activity."
MINDY1 affects bladder cancer cells
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MINDY1 activates bladder cancer cells. 2 / 2
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"Our study demonstrated that MINDY1 could promote bladder cancer cells proliferation in vitro and in vivo ."

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"Our data further demonstrated that MINDY1 depletion dramatically decreased the proliferation bladder cancer cells ."
MINDY1 affects SEL1L3
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MINDY1 affects MINDY1
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MINDY1 deubiquitinates MINDY1.
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MINDY1 leads to the deubiquitination of MINDY1. 1 / 1
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"MINDY1 was found to directly interact with PD-L1, with MINDY1 gene knockdown promoting PD-L1 ubiquitination and MINDY1 overexpression inhibiting PD-L1 ubiquitination."
MINDY1 decreases the amount of MINDY1.
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MINDY1 decreases the amount of MINDY1. 1 / 1
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"MINDY1 was found to directly interact with PD-L1, with MINDY1 gene knockdown promoting PD-L1 ubiquitination and MINDY1 overexpression inhibiting PD-L1 ubiquitination."
MINDY1 affects MANSC1
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MINDY1 affects LSM8
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MINDY1 affects KDELR1
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MINDY1 affects KCNA10
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MINDY1 affects GRTP1
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MINDY1 affects GMCL1
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MANSC1 affects MINDY1
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LSM8 affects MINDY1
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LEF1 affects MINDY1
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LEF1 decreases the amount of MINDY1. 2 / 2
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KDELR1 affects MINDY1
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KCNA10 affects MINDY1
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GRTP1 affects MINDY1
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GMCL1 affects MINDY1
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FOXO4 affects MINDY1
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FOXO4 decreases the amount of MINDY1. 2 / 2
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17beta-estradiol increases the amount of MINDY1.
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17beta-estradiol increases the amount of MINDY1. 1 / 1
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17beta-estradiol decreases the amount of MINDY1.
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17beta-estradiol decreases the amount of MINDY1. 1 / 1
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4,4'-sulfonyldiphenol increases the amount of MINDY1. 2 / 2
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Valproic acid decreases the amount of MINDY1. 1 / 1
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Urethane affects MINDY1
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Urethane increases the amount of MINDY1. 1 / 1
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Tungsten affects MINDY1
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Tungsten decreases the amount of MINDY1. 1 / 1
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Trimethyltin chloride increases the amount of MINDY1. 1 / 1
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Thiram affects MINDY1
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Thiram decreases the amount of MINDY1. 1 / 1
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Thioacetamide increases the amount of MINDY1. 1 / 1
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Sulforaphane decreases the amount of MINDY1. 1 / 1
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Sorafenib affects MINDY1
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Sorafenib increases the amount of MINDY1. 1 / 1
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Sodium dichromate increases the amount of MINDY1. 1 / 1
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Sodium arsenite decreases the amount of MINDY1. 1 / 1
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Perfluorononanoic acid decreases the amount of MINDY1. 1 / 1
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Okadaic acid decreases the amount of MINDY1. 1 / 1
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Nickel monoxide increases the amount of MINDY1. 1 / 1
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Monochloropropanediol decreases the amount of MINDY1. 1 / 1
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Methotrexate increases the amount of MINDY1. 1 / 1
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Methidathion decreases the amount of MINDY1. 1 / 1
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Lentivirus-based shRNA decelerated bladder tumor growth affects MINDY1
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Lentivirus-based shRNA decelerated bladder tumor growth inhibits MINDY1. 1 / 1
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"Our data showed that MINDY1 depletion by lentivirus-based shRNA decelerated bladder tumor growth ( Fig. 5F , G ) ."
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Leflunomide decreases the amount of MINDY1. 1 / 1
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Jinfukang affects MINDY1
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Jinfukang increases the amount of MINDY1. 1 / 1
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Hsa-mir-4465 decreases the amount of MINDY1. 1 / 1
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Hsa-mir-4279 decreases the amount of MINDY1. 1 / 1
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Hsa-miR-8062 decreases the amount of MINDY1. 1 / 1
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Hsa-miR-7151-3p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-6832-5p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-6807-5p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-6778-3p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-6747-3p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-6727-3p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-6513-3p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-6504-3p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-5096 decreases the amount of MINDY1. 1 / 1
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Hsa-miR-5095 decreases the amount of MINDY1. 1 / 1
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Hsa-miR-483-5p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-4740-3p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-4722-3p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-4700-3p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-4433b-3p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-4433a-3p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-411-5p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-3653-5p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-26b-5p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-26a-5p decreases the amount of MINDY1. 1 / 1
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Hsa-miR-193b-5p decreases the amount of MINDY1. 1 / 1
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Gossypol acetic acid decreases the amount of MINDY1. 1 / 1
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Formaldehyde increases the amount of MINDY1. 1 / 1
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Folpet affects MINDY1
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Folpet increases the amount of MINDY1. 1 / 1
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Flutamide affects MINDY1
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Flutamide increases the amount of MINDY1. 1 / 1
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Fenthion affects MINDY1
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Fenthion decreases the amount of MINDY1. 1 / 1
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Dimethyl-4-toluidine decreases the amount of MINDY1. 1 / 1
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Dibutyl phthalate increases the amount of MINDY1. 1 / 1
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Deltamethrin increases the amount of MINDY1. 1 / 1
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Cyclosporin A decreases the amount of MINDY1. 1 / 1
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Crocidolite asbestos decreases the amount of MINDY1. 1 / 1
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Copper(II) chloride decreases the amount of MINDY1. 1 / 1
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No evidence text available
Clofibrate affects MINDY1
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Clofibrate decreases the amount of MINDY1. 1 / 1
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No evidence text available
Cisplatin affects MINDY1
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Cisplatin increases the amount of MINDY1. 1 / 1
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No evidence text available
Caffeine affects MINDY1
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Caffeine phosphorylates MINDY1. 1 / 1
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No evidence text available
1 |
Cadmium atom decreases the amount of MINDY1. 1 / 1
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No evidence text available
1 |
Bisphenol F increases the amount of MINDY1. 1 / 1
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No evidence text available
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1 |

No evidence text available
Atrazine affects MINDY1
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Atrazine increases the amount of MINDY1. 1 / 1
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No evidence text available
Aristolochic acid A increases the amount of MINDY1. 1 / 1
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No evidence text available
All-trans-retinoic acid increases the amount of MINDY1. 1 / 1
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No evidence text available
1 |
Afuresertib increases the amount of MINDY1. 1 / 1
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No evidence text available
Abrine affects MINDY1
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Abrine decreases the amount of MINDY1. 1 / 1
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No evidence text available
ZP3 affects MINDY1
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1 |

No evidence text available
YTHDC1 affects MINDY1
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1 |

No evidence text available
TSPAN16 affects MINDY1
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No evidence text available
TMEM74 affects MINDY1
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1 |

No evidence text available
TMEM63C affects MINDY1
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No evidence text available
TMEM31 affects MINDY1
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1 |

No evidence text available
TFAP4 affects MINDY1
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TFAP4 decreases the amount of MINDY1. 1 / 1
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No evidence text available
TCF4 affects MINDY1
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TCF4 decreases the amount of MINDY1. 1 / 1
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No evidence text available
SV2C affects MINDY1
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No evidence text available
STAT6 affects MINDY1
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STAT6 decreases the amount of MINDY1. 1 / 1
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No evidence text available
STAT5A affects MINDY1
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STAT5A decreases the amount of MINDY1. 1 / 1
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No evidence text available
STAT1 affects MINDY1
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STAT1 decreases the amount of MINDY1. 1 / 1
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No evidence text available
SLC45A2 affects MINDY1
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No evidence text available
RUNX1 affects MINDY1
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RUNX1 decreases the amount of MINDY1. 1 / 1
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No evidence text available
RPS27A affects MINDY1
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No evidence text available
RIGI affects MINDY1
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1 |

No evidence text available
RGS9BP affects MINDY1
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1 |

No evidence text available
REPIN1 affects MINDY1
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REPIN1 decreases the amount of MINDY1. 1 / 1
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No evidence text available
Pentosan Sulfuric Polyester increases the amount of MINDY1. 1 / 1
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No evidence text available
Particulate Matter increases the amount of MINDY1. 1 / 1
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No evidence text available
PTCHD3 affects MINDY1
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No evidence text available
PIGH affects MINDY1
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No evidence text available
PAX4 affects MINDY1
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PAX4 decreases the amount of MINDY1. 1 / 1
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No evidence text available
OR6M1 affects MINDY1
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No evidence text available
OR5H1 affects MINDY1
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No evidence text available
OR2G6 affects MINDY1
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1 |

No evidence text available
OR1A2 affects MINDY1
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No evidence text available
OR10S1 affects MINDY1
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No evidence text available
MINDY1 is modified
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MINDY1 is phosphorylated on S441. 1 / 1
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No evidence text available
Nitrates affects MINDY1
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Nitrates increases the amount of MINDY1. 1 / 1
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No evidence text available
NRSN1 affects MINDY1
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No evidence text available
MIR1976 affects MINDY1
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MIR1976 decreases the amount of MINDY1. 1 / 1
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No evidence text available
MIR1303 affects MINDY1
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MIR1303 decreases the amount of MINDY1. 1 / 1
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No evidence text available
MIR1297 affects MINDY1
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MIR1297 decreases the amount of MINDY1. 1 / 1
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No evidence text available
MINDY1 affects validate function MINDY1 regulating YAP
| 1
MINDY1 inhibits validate function MINDY1 regulating YAP. 1 / 1
| 1

eidos
"We then depleted MINDY1 with two non-overlapping siRNAs separately in T24 and UMUC3 cells to further validate the function of MINDY1 in regulating YAP , as shown in Fig. 1B , C , MINDY1 depletion significantly decreased the YAP protein levels without influence on the expression of YAP mRNA ."
MINDY1 affects ubiquitinated-YAP
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MINDY1 decreases the amount of ubiquitinated-YAP. 1 / 1
| 1

reach
"Depletion of MINDY1 significantly increased the level of ubiquitinated-YAP in T24 cells (Fig. 4A)."
MINDY1 affects tumor growth
| 1
MINDY1 activates tumor growth. 1 / 1
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eidos
"Knockdown of MINDY1 significantly inhibited tumor growth in vivo , while the restoration of YAP expression abolished the inhibition induced by MINDY1 depletion ( Fig. 6E ) ."
MINDY1 affects transcripts CTGF CYR61 ANKRD1
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MINDY1 activates transcripts CTGF CYR61 ANKRD1. 1 / 1
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eidos
"We then examined the expression of YAP target genes ( CTGF , CYR61 and ANKRD1 ) and found that depletion of MINDY1 dramatically decreased the transcripts of CTGF , CYR61 and ANKRD1 ( Fig. 1E , F ) ."

reach
"MINDY1 depletion inhibits ERalpha signaling pathway activity."
MINDY1 affects proteasome-mediated YAP
| 1
MINDY1 inhibits proteasome-mediated YAP. 1 / 1
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eidos
"The present study also demonstrated that MINDY1 removed the K48-linked ubiquitin chain from YAP , thus inhibiting proteasome-mediated YAP degradation ."
MINDY1 affects population G1 phases
| 1
MINDY1 inhibits population G1 phases. 1 / 1
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eidos
"Our results demonstrated that depletion of MINDY1 significantly decreased cell proliferation and increased the population in G1 phases , indicating that MINDY1 may regulate G1 to S transition in bladder cancer cells ( Fig. 5A , B ) ."
MINDY1 affects clone capability UMUC3 cells
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MINDY1 activates clone capability UMUC3 cells. 1 / 1
| 1

eidos
"The results of clone formation assay revealed that MINDY1 depletion dramatically decreased the clone formation capability in T24 and UMUC3 cells ( Fig. 5C ) ."
| 1

reach
"Furthermore, wound-healing assay revealed that depletion of MINDY1 significantly decreased the cell migration ability (Fig. 7F)."
MINDY1 affects cell bladder cancer cells
| 1
MINDY1 activates cell bladder cancer cells. 1 / 1
| 1

eidos
"A MINDY1 depletion inhibited cell proliferation in bladder cancer cells ."
MINDY1 affects breast cancer cell
| 1
MINDY1 activates breast cancer cell. 1 / 1
| 1

eidos
"Correction to : MINDY1 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha ."

reach
"The results showed that the combination treatment of silencing MINDY1 expression and tamoxifen induced more obvious inhibitory effects and apoptosis in MCF-7 cells (Fig. S3B, C)."
MINDY1 affects ZP3
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No evidence text available
MINDY1 affects YTHDC1
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No evidence text available
MINDY1 affects YAP stability
| 1
MINDY1 activates YAP stability. 1 / 1
| 1

eidos
"MINDY1 increases YAP stability ."
MINDY1 affects YAP protein stability
| 1
MINDY1 activates YAP protein stability. 1 / 1
| 1

eidos
"Furthermore , MINDY1 could increase YAP protein stability by removing K48-linked Ub chains Supplementary Information ."
MINDY1 affects YAP TEAD-luciferase reporter
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MINDY1 activates YAP TEAD-luciferase reporter. 1 / 1
| 1

eidos
"It was found that depletion of MINDY1 decreased the YAP / TEAD-luciferase reporter gene activity ( Fig. 1G , H ) ."
MINDY1 affects YAP TEAD target bladder cancer including CTGF ANKRD1 CYR61
| 1
MINDY1 activates YAP TEAD target bladder cancer including CTGF ANKRD1 CYR61. 1 / 1
| 1

eidos
"Depletion of MINDY1 decreased the YAP protein level and the expression of YAP / TEAD target genes in bladder cancer , including CTGF , ANKRD1 and CYR61 ."
MINDY1 affects Ub5
| 1
MINDY1 inhibits Ub5. 1 / 1
| 1

reach
"Furthermore, mutating residues at equivalent positions in MINDY1 also inhibit cleavage of Ub5 (Figures S6F and S6G)."
MINDY1 affects TSPAN16
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No evidence text available
MINDY1 affects TMEM74
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1 |

No evidence text available
MINDY1 affects TMEM63C
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No evidence text available
MINDY1 affects TMEM31
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1 |

No evidence text available
MINDY1 affects TEAD-luciferase reporter gene
| 1
MINDY1 activates TEAD-luciferase reporter gene. 1 / 1
| 1

reach
"It was found that depletion of MINDY1 decreased the YAP/TEAD-luciferase reporter gene activity (Fig. 1G, H)."
MINDY1 affects TEAD
| 1
MINDY1 increases the amount of TEAD. 1 / 1
| 1

reach
"Depletion of MINDY1 decreased the YAP protein level and the expression of YAP/TEAD target genes in bladder cancer, including CTGF, ANKRD1 and CYR61."
MINDY1 affects SV2C
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No evidence text available
MINDY1 affects SLC45A2
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No evidence text available
MINDY1 affects RPS27A
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1 |

No evidence text available
MINDY1 affects RIGI
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1 |

No evidence text available
MINDY1 affects RGS9BP
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1 |

No evidence text available
MINDY1 affects PTCHD3
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1 |

No evidence text available
MINDY1 affects PIGH
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1 |

No evidence text available
MINDY1 affects OR6M1
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1 |

No evidence text available
MINDY1 affects OR5H1
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1 |

No evidence text available
MINDY1 affects OR2G6
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1 |

No evidence text available
MINDY1 affects OR1A2
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1 |

No evidence text available
MINDY1 affects OR10S1
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1 |

No evidence text available
MINDY1 affects NRSN1
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1 |

No evidence text available
MINDY1 affects LMBR1L
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1 |

No evidence text available
MINDY1 affects INS
| 1
MINDY1 inhibits INS. 1 / 1
| 1

reach
"We found that MINDY1 knockdown enhances insulin-stimulated glucose uptake in rat myotubes."
MINDY1 affects Hippo signaling bladder cancer cells
| 1
MINDY1 activates Hippo signaling bladder cancer cells. 1 / 1
| 1

eidos
"MINDY1 depletion decreases Hippo signaling activity in bladder cancer cells ."
MINDY1 affects HERC2
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1 |

No evidence text available
MINDY1 affects FBXW12
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1 |

No evidence text available
MINDY1 affects FBXO22
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1 |

No evidence text available

reach
"Our results indicated that MINDY1 depletion inhibited the DNA synthesis of MCF-7 and T47D cells (Fig. 7D, E)."
MINDY1 affects DDI2
| 1
| 1

reach
"Interactors enriched on K48 Ub3 over K48 Ub2 included UbBPs with previously reported specificity for longer Ub chains: ZFAND2B/AIRAPL (18), ATXN3 (62, 63, 83), and MINDY1 (20), which bind 3, 3, and 4 Ub moieties, respectively, and DDI2/Ddi1 in yeast (58)."
MINDY1 affects DDI1
| 1
| 1

reach
"Interactors enriched on K48 Ub3 over K48 Ub2 included UbBPs with previously reported specificity for longer Ub chains: ZFAND2B/AIRAPL (18), ATXN3 (62, 63, 83), and MINDY1 (20), which bind 3, 3, and 4 Ub moieties, respectively, and DDI2/Ddi1 in yeast (58)."
MINDY1 affects DAZAP2
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1 |

No evidence text available
MINDY1 affects CTLA4
1 |
1 |

No evidence text available
MINDY1 affects CRYAA
1 |
1 |

No evidence text available
MINDY1 affects CNGA4
1 |
1 |

No evidence text available
MINDY1 affects CHRNB1
1 |
1 |

No evidence text available
MINDY1 affects CD1D
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1 |

No evidence text available
MINDY1 affects CCN2
| 1
MINDY1 activates CCN2. 1 / 1
| 1

reach
"We then examined the expression of YAP target genes (CTGF, CYR61 and ANKRD1) and found that depletion of MINDY1 dramatically decreased the transcripts of CTGF, CYR61 and ANKRD1 (Fig. 1E, F)."
MINDY1 affects CCN1
| 1
MINDY1 activates CCN1. 1 / 1
| 1

reach
"We then examined the expression of YAP target genes (CTGF, CYR61 and ANKRD1) and found that depletion of MINDY1 dramatically decreased the transcripts of CTGF, CYR61 and ANKRD1 (Fig. 1E, F)."
MINDY1 affects BTBD6
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No evidence text available
MINDY1 affects ANKRD1
| 1
MINDY1 activates ANKRD1. 1 / 1
| 1

reach
"We then examined the expression of YAP target genes (CTGF, CYR61 and ANKRD1) and found that depletion of MINDY1 dramatically decreased the transcripts of CTGF, CYR61 and ANKRD1 (Fig. 1E, F)."
MEIS1 affects MINDY1
1 |
MEIS1 decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
LMBR1L affects MINDY1
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1 |

No evidence text available
HNF1A affects MINDY1
1 |
HNF1A decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
HERC2 affects MINDY1
1 |
1 |

No evidence text available
1 |
Gentamicins decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
GABPB2 affects MINDY1
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GABPB2 decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
GABPA affects MINDY1
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GABPA decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
FR900359 affects MINDY1
1 |
FR900359 dephosphorylates MINDY1. 1 / 1
1 |

No evidence text available
FOXJ1 affects MINDY1
1 |
FOXJ1 decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
FBXW12 affects MINDY1
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1 |

No evidence text available
FBXO22 affects MINDY1
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1 |

No evidence text available
ETV7 affects MINDY1
1 |
ETV7 decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
ETV4 affects MINDY1
1 |
ETV4 decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
ELK1 affects MINDY1
1 |
ELK1 decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
DDI2 affects MINDY1
| 1
| 1

reach
"Interactors enriched on K48 Ub3 over K48 Ub2 included UbBPs with previously reported specificity for longer Ub chains: ZFAND2B/AIRAPL (18), ATXN3 (62, 63, 83), and MINDY1 (20), which bind 3, 3, and 4 Ub moieties, respectively, and DDI2/Ddi1 in yeast (58)."
DDI1 affects MINDY1
| 1
| 1

reach
"Interactors enriched on K48 Ub3 over K48 Ub2 included UbBPs with previously reported specificity for longer Ub chains: ZFAND2B/AIRAPL (18), ATXN3 (62, 63, 83), and MINDY1 (20), which bind 3, 3, and 4 Ub moieties, respectively, and DDI2/Ddi1 in yeast (58)."
DDE affects MINDY1
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DDE decreases the amount of MINDY1. 1 / 1
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No evidence text available
DAZAP2 affects MINDY1
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1 |

No evidence text available
CUX1 affects MINDY1
1 |
CUX1 decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
CTLA4 affects MINDY1
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1 |

No evidence text available
CRYAA affects MINDY1
1 |
1 |

No evidence text available
CNGA4 affects MINDY1
1 |
1 |

No evidence text available
CHRNB1 affects MINDY1
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1 |

No evidence text available
CEBPA affects MINDY1
1 |
CEBPA decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
CD1D affects MINDY1
1 |
1 |

No evidence text available
BTBD6 affects MINDY1
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1 |

No evidence text available
Acrylamide affects MINDY1
1 |
Acrylamide decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
4-hydroxyphenyl retinamide increases the amount of MINDY1. 1 / 1
1 |

No evidence text available

No evidence text available
2-hydroxypropanoic acid decreases the amount of MINDY1. 1 / 1
1 |

No evidence text available
1 |

No evidence text available

No evidence text available

No evidence text available
1-phenylpropan-2-amine increases the amount of MINDY1. 1 / 1
1 |

No evidence text available
1,2-dimethylhydrazine increases the amount of MINDY1. 1 / 1
1 |

No evidence text available