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MINDY1 activates ESR. 5 / 5
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"To further identify MINDY1 promoted ERα-positive breast cancer cell proliferation and migration by increasing ERα stabilization, we ectopic expressed ERα in MINDY1 knockdown MCF-7 cells."
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"Importantly, the catalytically inactive mutant of MINDY1 (C137A) lost the ability in modulating ERα, indicating that MINDY1 promoted ERα stability through its enzymatically active site."
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"Consistently, Overexpression of MINDY1 significantly enhanced ERα transcriptional activity (Fig. S1D)."
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"We observed that MINDY1 depletion significantly decreased ERα (Fig. S1A)."
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"It was observed that MINDY1 depletion inhibited the activity of ERα-luciferase reporter gene both in the presence or absence of estrogen (Fig. 1E, F)."
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