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MINDY1 increases the amount of ESR. 5 / 5
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"We found that the decreased ERα expression induced by MINDY1 depletion could be largely recovered by addition of MG132, suggesting MINDY1 regulates ERα degradation through ubiquitin-proteasome system (UPS)."
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"Besides, MINDY1 depletion decreased ERα protein level in both estrogen and vehicle conditions (Fig. S1C)."
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"It was found that depletion of MINDY1 by siRNAs significantly decreased ERα protein level."
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"MINDY1 depletion significantly reduced the expression of endogenous ERα target genes such as PS2, GREB1, and PDZK1 in the presence or absence of estrogen (Fig. 1C, D)."
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"It is found that ERα protein level and ERα signaling activity were significantly inhibited by MINDY1 depletion."
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