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MINDY1 deubiquitinates YAP1. 4 / 4
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"MINDY1 deubiquitylates YAP."
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"Conversely, ectopic expression of MINDY1-WT, but not MINDY1 , markedly decreased YAP ubiquitylation in cells (Fig. 4B)."
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"Then, we examined MINDY1 deubiquitination activity on YAP in two common ubiquitination manners (K48-linked ubiquitination and K63-linked ubiquitination)."
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"CONCLUSION: In general, our findings establish a previously undocumented catalytic role for <span class="match term0">MINDY1</span> as a deubiquitinating enzyme of <span class="match term1">YAP</span> and provides a possible target for the therapy of bladder cancer."
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