IndraLab

Statements

MINDY1 activates YAP protein. 4 / 4
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"Depletion of MINDY1 decreased the YAP protein level and the expression of YAP / TEAD target genes in bladder cancer , including CTGF , ANKRD1 and CYR61 ."
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"We then depleted MINDY1 with two non-overlapping siRNAs separately in T24 and UMUC3 cells to further validate the function of MINDY1 in regulating YAP , as shown in Fig. 1B , C , MINDY1 depletion significantly decreased the YAP protein levels without influence on the expression of YAP mRNA ."
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"Depletion of MINDY1 significantly decreased the YAP protein level and inhibited the Hippo signaling activity ."
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"A In the presence of the proteasome inhibitor MG132 , depletion of MINDY1 did not further decrease the YAP protein level ."
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