IndraLab

Statements

G3BP1 affects USP10
36 1 | 109 88
G3BP1 binds USP10.
36 1 | 88 83
USP10 binds G3BP1. 10 / 196
36 1 | 81 67
reach
"Resveratrol binds to G3BP1 and interrupts the G3BP1/USP10 interaction, releasing USP10 and promoting its deubiquitinating activity, increasing p53-mediated apoptosis in melanoma (Oi et al., 2015)."
34744708
sparser
"In addition, several viruses (Semliki Forest, Chikungunya, and herpes simplex) encode SG-inhibiting proteins that share the same binding motif (FGDF motif) within USP10 that binds to G3BP ( xref )."
30082464
biogrid
No evidence text available
36183834
biogrid
No evidence text available
36183834
biogrid
No evidence text available
29395067
sparser
"WDR68 is a protein composed of a sequence of four WD repeats and has been demonstrated to fulfil the role of a scaffold protein, including binding directly to HIPK2, MEKK1 and DYRK1A/B [ xref ] or facilitating the interaction between USP10 and G3BP1 [ xref ]."
40462101
biogrid
No evidence text available
19615732
biogrid
No evidence text available
29395067
sparser
"Through searching for protein–protein interaction (PPI) network and Gene Expression Profiling Interactive Analysis (GEPIA) website, we found that USP10 interacted with G3BP1, and that there was a positive correlation between G3BP1 mRNA expression and USP10 mRNA expression in OC."
34967276
sparser
"TAT-RasGAP 317–326 did not modulate binding of G3BP1 to USP10, stress granule formation or c-myc mRNA levels."
22205990
G3BP1 binds CAPRIN1 and USP10. 4 / 4
| 4
sparser
"USP10 and Caprin1 antagonistically bind G3BP to regulate SG formation."
27022092
sparser
"Therefore, although Caprin1 and USP10 both bind G3BP ( xref ; xref ), they have antagonistic effects on SGs."
27022092
sparser
"Rescue experiments using G3BP1 mutants show that phosphomimetic G3BP1-S149E fails to rescue SG formation, whereas G3BP1-F33W, a mutant unable to bind G3BP partner proteins Caprin1 or USP10, rescues SG formation."
27022092
sparser
"However, a recent study suggests that G3BP proteins interact with Caprin1 and USP10 but that they are mutually exclusive allowing the binding of these proteins to serve as a switch for SG formation depending on the binding partner interacting with G3BP1."
30595162
G3BP1 binds SH2D3C and USP10. 3 / 3
| 3
sparser
"It was recently identified that a common canonical sequence motif, FGDF, mediates binding of the nsP3 and USP10 proteins to G3BP ."
26410532
sparser
"The model might also explain the elimination of binding of both nsP3 and USP10 to G3BP upon mutation of the glycine residue to alanine, which would restrict flexibility and thus hinder adequate positioning of the phenylalanine side-chains in the FGDF motifs."
25658430
sparser
"Since the binding of nsP3 and USP10 to G3BP inhibits SGs, we hypothesized that ICP8 binding might do the same."
25658430
Mutated G3BP1 binds USP10. 2 / 2
| 2
reach
"Even the G3BP1 mutant that lacks the interaction region can still bind Caprin1 or USP10 to affect the formation of SGs (24)."
35935992
reach
"Even G3BP1 mutants lacking the RGG interaction region can bind caprin 1 and USP10 to affect SG formation (17, 18)."
38690262
G3BP1 binds G3BP2, CAPRIN1, and USP10. 2 / 2
| 2
sparser
"In addition, a proteomic analysis found that G3BP1, G3BP2, Caprin1 and USP10 interact with DENV RNA [ xref ], and it was reported that G3BP1, G3BP2 and Caprin1 regulate the translation of ISG mRNAs, thus protecting DENV replication from IFN-mediated antiviral effects [ xref ]."
27367717
sparser
"Additional experiments demonstrate that, in contrast to DDX6, the SG proteins G3BP1, G3BP2, Caprin1 and USP10 bind to the variable region (VR) in the 3' UTR."
21957497
G3BP1 binds G3BP2 and USP10. 1 / 1
| 1
sparser
"In addition, the variable sequences in the 3’UTR interact with stress granule (SG) proteins G3BP1, G3BP2, Caprin 1 and USP10 [ xref ]."
33070015
CAPRIN1 binds USP10, TIAL1, TIA1, and G3BP1. 1 / 1
| 1
sparser
"The recruitment mode is thought to be as follows: Caprin1, USP10, TIAR, and TIA-1 interact with G3BP-1 which binds to σNS via its RNA recognition (RRM) and an arginine/glycine-rich (RGG) motifs."
31681621
USP10 binds RIT2, FMR1, USP10, G3BP1, and FMR1. 1 / 1
| 1
reach
"Future examinations of Fmr1 transcripts and translation efficiency may yield valuable insights.Another intriguing aspect of Fmr1/FMRP is that, despite the elevated total protein level of Fmr1, the presence of the Usp10-rin-Fmr1/USP10-G3BP1-FMRP complex prevents Fmr1/FMRP from binding to porin/VDAC, resulting in localized depletion at the ERMCS."
39863576
G3BP1 binds USP10 and NUFIP2. 1 / 1
| 1
sparser
"Interestingly, our previous map of human protein complexes ( xref ) suggests that the known complex of G3BP, CAPRIN, and USP10 ( xref ) also physically interacts with NUFIP2, leading us to suggest the name CapGUN (i.e., CAPRIN1, G3BP2, USP10, NUFIP2)."
31665645
USP10 binds Integrins and G3BP1. 1 / 1
| 1
reach
"Connecting G3BP to integrins is the finding that G3BP knockdown inhibits Scr/FAK/ERK signaling, and human lung cancer cell migration and invasion, suggesting a USP10/integrin/G3BP complex and coordination between these proteins (Zhang et al., 2013)."
37562219
G3BP1 binds NUTF2, CAPRIN1, and USP10. 1 / 1
| 1
sparser
"This motif is responsible for competitive binding of USP10 to the NTF2 domain of G3BP1 and displacement of caprin-1 ( xref )."
32989041
USP10 binds G3BP1 and FMR1. 1 / 1
| 1
reach
"In accordance with prior findings, the USP10-G3BP1-FMRP complex shows weak binding affinity with RPL7a, ZNF598, PELO, ASCC3, ABCE1, NEMF, and RAPTOR, while exhibiting strong binding affinity with RPS10, MFN1, MFN2, DRP1, and RICTOR (Supplementary Fig. 15k)."
39863576
Cycle inhibiting factor (Cif) binds USP10 and G3BP1. 1 / 1
| 1
sparser
"Treatment of co-transfected (YN-USP10 and YC-G3BP1) airway epithelial cells with Cif-containing OMV resulted in an increase in BiFC signal, confirming an increased (4.35±0.30 fold) interaction between USP10 and G3BP1 in the presence of Cif ( xref ) compared to cells treated with control (Cif mutant OMV)."
21455491
USP10 binds RIT2, USP10, and G3BP1. 1 / 1
| 1
reach
"The Usp10-rin/USP10-G3BP1 complex is mechanistically associated with ERMCS and regulates Ca transfer to mitochondria by affecting its assembly."
39863576
HCT116 binds G3BP1 and USP10. 1 / 1
| 1
sparser
"As expected, the interaction between G3BP1 and USP10 decreased in HCT116 cells treated with resveratrol ( xref )."
24998844
USP10 binds G3BP1 and NTF2L domain. 1 / 1
| 1
reach
"The first IDR of the SARS‐CoV‐2 N protein contains a USP10‐like ΦxFG SLiM (Figure 2G) (Kruse et al. 2021), which binds within the G3BP1 NTF2L domain with high affinity (Table 2) and within the four main residues in the same fashion as USP10 or SFV nsP3 SLiM (Biswal et al. 2022), (Table 1), (Figure 2H)."
40170442
G3BP1 binds USP10 and TP53. 1 / 1
| 1
sparser
"Disruption of the interaction of p53 with USP10 by G3BP1 interference leads to suppression of p53 deubiquitination."
24998844
G3BP1 inhibits USP10.
| 19 5
G3BP1 inhibits USP10. 10 / 23
| 16 5
reach
"Conversely, G3BP is inhibited when binding to peptidase USP10."
28746877
reach
"One of the reported functions of G3BP1 is to bind to and inhibit USP10 XREF_BIBR."
22205990
reach
"In a steady-state, G3BP1 inhibits the antioxidant activity of USP10."
35782985
reach
"Notably, siRNA mediated knockdown of G3BP1 significantly increased the abundance of CFTR, most likely because endogenous G3BP1 inhibits USP10 (XREF_FIG)."
21455491
sparser
"However, oxidative and nitrosative stress induce SGs formation which cause USP10 to induce ataxia-telangiectasia-mutated protein (ATM) phosphorylation which suppresses the inhibition of USP10 by G3BP1, thereby reducing ROS production and apoptosis ( xref , xref )."
37124566
reach
"Surprisingly, the human homolog of Bre5, G3BP1, inhibits the activity of USP10, at least in vitro, indicating that cofactors can either restrict or enhance protease activity."
16325574
reach
"Here we describe in vitro analysis of the G3BP1 affinities, and show that substitution of G3BP1 residues F15 or F33 to tryptophan reduces affinity for both the USP10 and Caprin1 motif peptides."
| DOI
sparser
"Anisonov et al. [ xref ] also found that USP10 is inhibited by G3BP1 in a mechanism similar to that for NUP62, which indicates an analogous cascading route from SARS-CoV-2 to PD for this protein."
34066091
sparser
"Notably, siRNA-mediated knockdown of G3BP1 significantly increased the abundance of CFTR, most likely because endogenous G3BP1 inhibits USP10 ( xref )."
21455491
reach
"It should be remarked that G3BP1 is also a perturbator for the PD-VPs USP10 [91], GiGYF2 [99], EIF4G1 [100], and TIAL1 [101]."
34066091
G3BP1 bound to USP10 inhibits USP10. 3 / 3
| 3
reach
"Second, in U2OS bladder cancer cells, the interaction between G3BP1 and USP10 inactivates the deubiquitinating enzyme activity of USP10 XREF_BIBR."
21455491
reach
"G3BP1 binds to USP10 and therefore disrupts the interaction of USP10 with p53, leading to suppression of p53 deubiquitination."
24998844
reach
"G3BP1 binds to USP10 and inhibits the deubiquitination activity of USP10."
24998844
G3BP1 activates USP10.
| 2
G3BP1 activates USP10. 2 / 2
| 2
reach
"However, oxidative and nitrosative stress induce SGs formation which cause USP10 to induce ataxia-telangiectasia-mutated protein (ATM) phosphorylation which suppresses the inhibition of USP10 by G3BP1, thereby reducing ROS production and apoptosis (4, 34)."
37124566
reach
"Interestingly G3BP1 modulates USP10 deubiquitinase activity, as well as interacts and co-localizes with HCV NS5B protein and RNA to modulate HCV replication."
23141719
USP10 affects G3BP1
36 1 | 99 83
USP10 binds G3BP1.
36 1 | 88 83
USP10 binds G3BP1. 10 / 196
36 1 | 81 67
reach
"Resveratrol binds to G3BP1 and interrupts the G3BP1/USP10 interaction, releasing USP10 and promoting its deubiquitinating activity, increasing p53-mediated apoptosis in melanoma (Oi et al., 2015)."
34744708
sparser
"In addition, several viruses (Semliki Forest, Chikungunya, and herpes simplex) encode SG-inhibiting proteins that share the same binding motif (FGDF motif) within USP10 that binds to G3BP ( xref )."
30082464
biogrid
No evidence text available
36183834
biogrid
No evidence text available
36183834
biogrid
No evidence text available
29395067
sparser
"WDR68 is a protein composed of a sequence of four WD repeats and has been demonstrated to fulfil the role of a scaffold protein, including binding directly to HIPK2, MEKK1 and DYRK1A/B [ xref ] or facilitating the interaction between USP10 and G3BP1 [ xref ]."
40462101
biogrid
No evidence text available
19615732
biogrid
No evidence text available
29395067
sparser
"Through searching for protein–protein interaction (PPI) network and Gene Expression Profiling Interactive Analysis (GEPIA) website, we found that USP10 interacted with G3BP1, and that there was a positive correlation between G3BP1 mRNA expression and USP10 mRNA expression in OC."
34967276
sparser
"TAT-RasGAP 317–326 did not modulate binding of G3BP1 to USP10, stress granule formation or c-myc mRNA levels."
22205990
G3BP1 binds CAPRIN1 and USP10. 4 / 4
| 4
sparser
"USP10 and Caprin1 antagonistically bind G3BP to regulate SG formation."
27022092
sparser
"Therefore, although Caprin1 and USP10 both bind G3BP ( xref ; xref ), they have antagonistic effects on SGs."
27022092
sparser
"Rescue experiments using G3BP1 mutants show that phosphomimetic G3BP1-S149E fails to rescue SG formation, whereas G3BP1-F33W, a mutant unable to bind G3BP partner proteins Caprin1 or USP10, rescues SG formation."
27022092
sparser
"However, a recent study suggests that G3BP proteins interact with Caprin1 and USP10 but that they are mutually exclusive allowing the binding of these proteins to serve as a switch for SG formation depending on the binding partner interacting with G3BP1."
30595162
G3BP1 binds SH2D3C and USP10. 3 / 3
| 3
sparser
"It was recently identified that a common canonical sequence motif, FGDF, mediates binding of the nsP3 and USP10 proteins to G3BP ."
26410532
sparser
"The model might also explain the elimination of binding of both nsP3 and USP10 to G3BP upon mutation of the glycine residue to alanine, which would restrict flexibility and thus hinder adequate positioning of the phenylalanine side-chains in the FGDF motifs."
25658430
sparser
"Since the binding of nsP3 and USP10 to G3BP inhibits SGs, we hypothesized that ICP8 binding might do the same."
25658430
Mutated G3BP1 binds USP10. 2 / 2
| 2
reach
"Even the G3BP1 mutant that lacks the interaction region can still bind Caprin1 or USP10 to affect the formation of SGs (24)."
35935992
reach
"Even G3BP1 mutants lacking the RGG interaction region can bind caprin 1 and USP10 to affect SG formation (17, 18)."
38690262
G3BP1 binds G3BP2, CAPRIN1, and USP10. 2 / 2
| 2
sparser
"In addition, a proteomic analysis found that G3BP1, G3BP2, Caprin1 and USP10 interact with DENV RNA [ xref ], and it was reported that G3BP1, G3BP2 and Caprin1 regulate the translation of ISG mRNAs, thus protecting DENV replication from IFN-mediated antiviral effects [ xref ]."
27367717
sparser
"Additional experiments demonstrate that, in contrast to DDX6, the SG proteins G3BP1, G3BP2, Caprin1 and USP10 bind to the variable region (VR) in the 3' UTR."
21957497
G3BP1 binds G3BP2 and USP10. 1 / 1
| 1
sparser
"In addition, the variable sequences in the 3’UTR interact with stress granule (SG) proteins G3BP1, G3BP2, Caprin 1 and USP10 [ xref ]."
33070015
CAPRIN1 binds USP10, TIAL1, TIA1, and G3BP1. 1 / 1
| 1
sparser
"The recruitment mode is thought to be as follows: Caprin1, USP10, TIAR, and TIA-1 interact with G3BP-1 which binds to σNS via its RNA recognition (RRM) and an arginine/glycine-rich (RGG) motifs."
31681621
USP10 binds RIT2, FMR1, USP10, G3BP1, and FMR1. 1 / 1
| 1
reach
"Future examinations of Fmr1 transcripts and translation efficiency may yield valuable insights.Another intriguing aspect of Fmr1/FMRP is that, despite the elevated total protein level of Fmr1, the presence of the Usp10-rin-Fmr1/USP10-G3BP1-FMRP complex prevents Fmr1/FMRP from binding to porin/VDAC, resulting in localized depletion at the ERMCS."
39863576
G3BP1 binds USP10 and NUFIP2. 1 / 1
| 1
sparser
"Interestingly, our previous map of human protein complexes ( xref ) suggests that the known complex of G3BP, CAPRIN, and USP10 ( xref ) also physically interacts with NUFIP2, leading us to suggest the name CapGUN (i.e., CAPRIN1, G3BP2, USP10, NUFIP2)."
31665645
USP10 binds Integrins and G3BP1. 1 / 1
| 1
reach
"Connecting G3BP to integrins is the finding that G3BP knockdown inhibits Scr/FAK/ERK signaling, and human lung cancer cell migration and invasion, suggesting a USP10/integrin/G3BP complex and coordination between these proteins (Zhang et al., 2013)."
37562219
G3BP1 binds NUTF2, CAPRIN1, and USP10. 1 / 1
| 1
sparser
"This motif is responsible for competitive binding of USP10 to the NTF2 domain of G3BP1 and displacement of caprin-1 ( xref )."
32989041
USP10 binds G3BP1 and FMR1. 1 / 1
| 1
reach
"In accordance with prior findings, the USP10-G3BP1-FMRP complex shows weak binding affinity with RPL7a, ZNF598, PELO, ASCC3, ABCE1, NEMF, and RAPTOR, while exhibiting strong binding affinity with RPS10, MFN1, MFN2, DRP1, and RICTOR (Supplementary Fig. 15k)."
39863576
Cycle inhibiting factor (Cif) binds USP10 and G3BP1. 1 / 1
| 1
sparser
"Treatment of co-transfected (YN-USP10 and YC-G3BP1) airway epithelial cells with Cif-containing OMV resulted in an increase in BiFC signal, confirming an increased (4.35±0.30 fold) interaction between USP10 and G3BP1 in the presence of Cif ( xref ) compared to cells treated with control (Cif mutant OMV)."
21455491
USP10 binds RIT2, USP10, and G3BP1. 1 / 1
| 1
reach
"The Usp10-rin/USP10-G3BP1 complex is mechanistically associated with ERMCS and regulates Ca transfer to mitochondria by affecting its assembly."
39863576
HCT116 binds G3BP1 and USP10. 1 / 1
| 1
sparser
"As expected, the interaction between G3BP1 and USP10 decreased in HCT116 cells treated with resveratrol ( xref )."
24998844
USP10 binds G3BP1 and NTF2L domain. 1 / 1
| 1
reach
"The first IDR of the SARS‐CoV‐2 N protein contains a USP10‐like ΦxFG SLiM (Figure 2G) (Kruse et al. 2021), which binds within the G3BP1 NTF2L domain with high affinity (Table 2) and within the four main residues in the same fashion as USP10 or SFV nsP3 SLiM (Biswal et al. 2022), (Table 1), (Figure 2H)."
40170442
G3BP1 binds USP10 and TP53. 1 / 1
| 1
sparser
"Disruption of the interaction of p53 with USP10 by G3BP1 interference leads to suppression of p53 deubiquitination."
24998844
USP10 inhibits G3BP1.
| 7
USP10 inhibits G3BP1. 6 / 10
| 6
reach
"Furthermore, both the Caprin-1 GIM and USP10 GIM suppressed liquid–liquid phase separation (LLPS) of G3BP1, leading us to examine the effect of other domains of Caprin-1 on LLPS."
36279435
reach
"The GIM of USP10 drastically reduced the number and sizes of G3BP1 droplets (Fig. 3B), suggesting that the inhibitory effect of USP10 on G3BP1 LLPS is likely caused by the interaction between USP10 GIM and G3BP1."
36279435
reach
"USP10 may prevent G3BP from nucleating SG assembly by locking G3BP in a conformation that influences the NTF2 like domain and mediates or prevents G3BP oligomerization."
27821493
reach
"USP10 has been shown to inhibit SG nucleation by occupying G3BP (Kedersha et al., 2016)."
34432484
reach
"This unexpected finding may suggest that binding of the USP10-derived SLiM to NTF2 reduces the propensity of G3BP1 to enter condensates."
37161291
reach
"It is also possible that USP10 blocks the helicase function of G3BP, as helicase activity of some proteins, e.g., DDX6 and RCK, has been shown to be required for RNA granule assembly."
27821493
USP10 bound to G3BP1 inhibits G3BP1. 1 / 1
| 1
reach
"USP10, another binding partner of G3BP1 [58], negatively regulates SGs assembly by masking the RNA multivalent binding site of G3BP1 [71]."
37906632
USP10 decreases the amount of G3BP1.
| 1
USP10 decreases the amount of G3BP1. 1 / 3
| 1
reach
"However, USP10 KD also reduces expression of G3BP1 and G3BP2 (to 58% and 77% of control values, respectively; XREF_FIG), suggesting that the SG inhibition caused by USP10 KD may be caused by reduced levels of G3BP."
27022092
USP10 deubiquitinates G3BP1.
| 2
USP10 deubiquitinates G3BP1. 2 / 2
| 2
reach
"In contrast, other deubiquitinases such as USP10, which is reported to mediate G3BP2/G3BP1 deubiquitination has no correlation with G3BP2R468me2 under our system [7]."
36878903
reach
"hnRNPA2B1 interacts with many core SG proteins, including G3BP1, G3BP2, USP10, and Caprin-1; USP10 can deubiquitinate G3BP1; and hnRNPA2B1 depletion attenuates the G3BP1-USP10/Caprin-1 interaction but elevates the G3BP1 ubiquitination level under arsenite treatment."
38363675
USP10 activates G3BP1.
| 1
USP10 activates G3BP1. 1 / 1
| 1
reach
"We next found that USP10 coordinately promotes tumor progression with G3BP1."
34967276