IndraLab

Statements

G3BP1 affects USP10
11 1 | 79 81
G3BP1 binds USP10.
11 1 | 63 77
USP10 binds G3BP1. 10 / 132
11 1 | 63 46
reach
"Therefore, although Caprin1 and USP10 both bind G3BP, they have antagonistic effects on SGs."
27022092
sparser
"Thus, studies were conducted to determine if Cif inhibits USP10 activity by stabilizing the interaction between USP10 and G3BP1, and by reducing the interaction between USP10 and CFTR."
21455491
reach
"Studies using USP10 mutants, including USP10/77 -792 and USP10/95-792, indicate that USP10 's interaction with G3BP1 is essential for inhibition of ROS dependent apoptosis and for USP10 incorporation into stress granules."
27974222
reach
"Resveratrol promotes the p53-mediated apoptosis of cancer cells by acting on the USP10-binding protein G3BP1 [36]."
35627217
reach
"To provide additional support for the immunoprecipitation studies demonstrating that Cif increases the interaction between G3BP1 and USP10 in the early endosomal compartment, we performed bimolecular fluorescence complementation (BiFC) studies."
21455491
sparser
"Cif stabilizes USP10 and G3BP1 interaction to inhibit USP10 activity."
21455491
sparser
"Interestingly, recent work has shown that the compound resveratrol can inhibit the interaction of G3BP with USP10 by binding to the NTF2-like domain of G3BP, thereby stimulating USP10 DUB activity and stabilization of p53 [ xref ]."
25658430
sparser
"TAT-RasGAP 317–326 did not modulate binding of G3BP1 to USP10, stress granule formation or c-myc mRNA levels."
22205990
sparser
"Thus, USP10 interaction with G3BP1 and the incorporation of USP10 into stress granules are dispensable for USP10 inhibition of cytokine deprivation-induced apoptosis in FL HSPCs."
27974222
reach
"USP10 and Caprin1 antagonistically bind G3BP to regulate SG formation."
27022092
USP10 binds G3BP1 and CAPRIN1. 7 / 7
| 7
sparser
"However, a recent study suggests that G3BP proteins interact with Caprin1 and USP10 but that they are mutually exclusive allowing the binding of these proteins to serve as a switch for SG formation depending on the binding partner interacting with G3BP1."
30595162
sparser
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [ xref , xref ]."
30326201
sparser
"USP10 and Caprin1 antagonistically bind G3BP to regulate SG formation."
27022092
sparser
"Our results indicated that N expression abrogates G3BP1 interaction with the SG proteins CAPRIN1 and USP10 ( Figure 2C ), reinforcing the idea that N inhibits the formation of SGs in host cells by sequestering G3BPs away from their interacting SG-nucleating proteins."
34901782
sparser
"Rescue experiments using G3BP1 mutants show that phosphomimetic G3BP1-S149E fails to rescue SG formation, whereas G3BP1-F33W, a mutant unable to bind G3BP partner proteins Caprin1 or USP10, rescues SG formation."
27022092
sparser
"Therefore, although Caprin1 and USP10 both bind G3BP ( xref ; xref ), they have antagonistic effects on SGs."
27022092
sparser
"Interaction of Dengue RNA with stress granule proteins G3BP1, USP10 and caprin1 occurs at an adjacent unstructured region of the 3′ UTR ( xref )."
23290869
USP10 binds G3BP2, G3BP1, and CAPRIN1. 6 / 6
| 6
sparser
"In addition, a proteomic analysis found that G3BP1, G3BP2, Caprin1 and USP10 interact with DENV RNA [ xref ], and it was reported that G3BP1, G3BP2 and Caprin1 regulate the translation of ISG mRNAs, thus protecting DENV replication from IFN-mediated antiviral effects [ xref ]."
27367717
sparser
"However, a role for the G3BP1 and G3BP2 interactions with CAPRIN1 and/or USP10 under chronic nutrient starvation has not yet been investigated."
30326201
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
31037644
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
31037644
sparser
"Additional experiments demonstrate that, in contrast to DDX6, the SG proteins G3BP1, G3BP2, Caprin1 and USP10 bind to the variable region (VR) in the 3' UTR."
21957497
sparser
"In addition, a proteomic analysis found that G3BP1, G3BP2, Caprin1 and USP10 interact with DENV RNA [171], and it was reported that G3BP1, G3BP2 and Caprin1 regulate the translation of ISG mRNAs, thus protecting DENV replication from IFN-mediated antiviral effects [172]."
27367717
USP10 binds G3BP2, G3BP1, and EIF2AK2. 4 / 4
| 4
sparser
"Validation of the mass spectrometry data confirmed the interaction of NCAP with G3BP1, G3BP2, YTHDF3, USP10 and PKR."
34780058
sparser
"NCAP showed specific interaction with the SG proteins G3BP1, G3BP2, YTHDF3, USP10 and PKR, and translocated to SGs following oxidative stress and heat shock."
34780058
sparser
"NCAP interacts with SG proteins. (A) Interaction of NCAP with G3BP1, G3BP2, YTHDF3, USP10 and PKR."
34780058
sparser
"Fig. 4: NCAP interacts with SG proteins. (A) Interaction of NCAP with G3BP1, G3BP2, YTHDF3, USP10 and PKR."
34780058
USP10 binds SH2D3C and G3BP1. 3 / 3
| 3
sparser
"Since the binding of nsP3 and USP10 to G3BP inhibits SGs, we hypothesized that ICP8 binding might do the same."
25658430
sparser
"It was recently identified that a common canonical sequence motif, FGDF, mediates binding of the nsP3 and USP10 proteins to G3BP ."
26410532
sparser
"The model might also explain the elimination of binding of both nsP3 and USP10 to G3BP upon mutation of the glycine residue to alanine, which would restrict flexibility and thus hinder adequate positioning of the phenylalanine side-chains in the FGDF motifs."
25658430
SQSTM1 binds USP10 and G3BP1. 2 / 2
| 2
sparser
"G3BP1 interacts with p62 and USP10 to inhibit protein aggregation."
34526993
sparser
"G3BP1 interacted with p62 and USP10 and inhibited p62/USP10-induced protein aggregation."
31501480
TP53 binds USP10 and G3BP1. 2 / 2
| 2
sparser
"Disruption of the interaction of p53 with USP10 by G3BP1 interference leads to suppression of p53 deubiquitination."
24998844
sparser
"Disruption of the interaction of p53 with USP10 by G3BP1 interference leads to the suppression of p53 deubiquitination."
24998844
USP10 binds G3BP2 and G3BP1. 1 / 1
| 1
sparser
"In addition, the variable sequences in the 3’UTR interact with stress granule (SG) proteins G3BP1, G3BP2, Caprin 1 and USP10 [ xref ]."
33070015
TIA1 binds TIAL1, USP10, G3BP1, and CAPRIN1. 1 / 1
| 1
sparser
"The recruitment mode is thought to be as follows: Caprin1, USP10, TIAR, and TIA-1 interact with G3BP-1 which binds to σNS via its RNA recognition (RRM) and an arginine/glycine-rich (RGG) motifs."
31681621
USP10 binds G3BP1 and CAPRIN1. 1 / 1
| 1
sparser
"Caprin-1 and ubiquitin specific peptidase 10 (USP10) interact with G3BP1, facilitating and suppressing SG formation, respectively."
36279435
USP10 binds NUFIP2 and G3BP1. 1 / 1
| 1
sparser
"Interestingly, our previous map of human protein complexes ( xref ) suggests that the known complex of G3BP, CAPRIN, and USP10 ( xref ) also physically interacts with NUFIP2, leading us to suggest the name CapGUN (i.e., CAPRIN1, G3BP2, USP10, NUFIP2)."
31665645
USP10 binds NUTF2, G3BP1, and CAPRIN1. 1 / 1
| 1
sparser
"This motif is responsible for competitive binding of USP10 to the NTF2 domain of G3BP1 and displacement of caprin-1 ( xref )."
32989041
USP10 binds G3BP1 and cycle inhibiting factor (Cif). 1 / 1
| 1
sparser
"Treatment of co-transfected (YN-USP10 and YC-G3BP1) airway epithelial cells with Cif-containing OMV resulted in an increase in BiFC signal, confirming an increased (4.35±0.30 fold) interaction between USP10 and G3BP1 in the presence of Cif ( xref ) compared to cells treated with control (Cif mutant OMV)."
21455491
USP10 binds G3BP1 and HCT116. 1 / 1
| 1
sparser
"As expected, the interaction between G3BP1 and USP10 decreased in HCT116 cells treated with resveratrol ( xref )."
24998844
G3BP1 inhibits USP10.
| 15 4
G3BP1 inhibits USP10. 10 / 18
| 12 4
reach
"It should be remarked that G3BP1 is also a perturbator for the PD-VPs USP10 [91], GiGYF2 [99], EIF4G1 [100], and TIAL1 [101]."
34066091
reach
"G3BP1 disrupts the interaction of USP10 with p53."
24998844
sparser
"Anisonov et al. [91] also found that USP10 is inhibited by G3BP1 in a mechanism similar to that for NUP62, which indicates an analogous cascading route from SARS-CoV-2 to PD for this protein."
34066091
reach
"Surprisingly, the human homolog of Bre5, G3BP1, inhibits the activity of USP10, at least in vitro, indicating that cofactors can either restrict or enhance protease activity."
16325574
reach
"Notably, siRNA mediated knockdown of G3BP1 significantly increased the abundance of CFTR, most likely because endogenous G3BP1 inhibits USP10 (XREF_FIG)."
21455491
reach
"It appears therefore that the FGDF mediated G3BP and USP10 complex is mutually inhibitory, with G3BP inhibiting the DUB activity of USP10 and USP10 inhibiting the SG nucleating function of G3BP."
25658430
sparser
"In airway epithelial cells treated with the CFTR inhibitory factor (Cif), the Ras GTPase-activating protein-binding protein 1 (G3BP1) inhibits the ubiquitin-specific protease USP10."
28392259
reach
"discovered the interaction of G3BP1 with ubiquitin specific protease 10 (USP10), and they concluded that G3BP1 might restrict the deubiquitinating activity of USP10."
24998844
reach
"Taken together, these results suggested that G3BP1 inhibits p62/USP10-induced protein aggregation, whereas G3BP2 attenuates such a G3BP1 inhibition by competing G3BP1-interaction with p62 and/or USP10 (Fig. 8c)."
31501480
sparser
"Anisonov et al. [ xref ] also found that USP10 is inhibited by G3BP1 in a mechanism similar to that for NUP62, which indicates an analogous cascading route from SARS-CoV-2 to PD for this protein."
34066091
G3BP1 bound to USP10 inhibits USP10. 3 / 3
| 3
reach
"G3BP1 binds to USP10 and therefore disrupts the interaction of USP10 with p53, leading to suppression of p53 deubiquitination."
24998844
reach
"Second, in U2OS bladder cancer cells, the interaction between G3BP1 and USP10 inactivates the deubiquitinating enzyme activity of USP10 XREF_BIBR."
21455491
reach
"G3BP1 binds to USP10 and inhibits the deubiquitination activity of USP10."
24998844
G3BP1 activates USP10.
| 1
G3BP1 activates USP10. 1 / 1
| 1
reach
"Interestingly G3BP1 modulates USP10 deubiquitinase activity, as well as interacts and co-localizes with HCV NS5B protein and RNA to modulate HCV replication."
23141719
USP10 affects G3BP1
11 1 | 68 77
USP10 binds G3BP1.
11 1 | 63 77
USP10 binds G3BP1. 10 / 132
11 1 | 63 46
reach
"Therefore, although Caprin1 and USP10 both bind G3BP, they have antagonistic effects on SGs."
27022092
sparser
"Thus, studies were conducted to determine if Cif inhibits USP10 activity by stabilizing the interaction between USP10 and G3BP1, and by reducing the interaction between USP10 and CFTR."
21455491
reach
"Studies using USP10 mutants, including USP10/77 -792 and USP10/95-792, indicate that USP10 's interaction with G3BP1 is essential for inhibition of ROS dependent apoptosis and for USP10 incorporation into stress granules."
27974222
reach
"Resveratrol promotes the p53-mediated apoptosis of cancer cells by acting on the USP10-binding protein G3BP1 [36]."
35627217
reach
"To provide additional support for the immunoprecipitation studies demonstrating that Cif increases the interaction between G3BP1 and USP10 in the early endosomal compartment, we performed bimolecular fluorescence complementation (BiFC) studies."
21455491
sparser
"Cif stabilizes USP10 and G3BP1 interaction to inhibit USP10 activity."
21455491
sparser
"Interestingly, recent work has shown that the compound resveratrol can inhibit the interaction of G3BP with USP10 by binding to the NTF2-like domain of G3BP, thereby stimulating USP10 DUB activity and stabilization of p53 [ xref ]."
25658430
sparser
"TAT-RasGAP 317–326 did not modulate binding of G3BP1 to USP10, stress granule formation or c-myc mRNA levels."
22205990
sparser
"Thus, USP10 interaction with G3BP1 and the incorporation of USP10 into stress granules are dispensable for USP10 inhibition of cytokine deprivation-induced apoptosis in FL HSPCs."
27974222
reach
"USP10 and Caprin1 antagonistically bind G3BP to regulate SG formation."
27022092
USP10 binds G3BP1 and CAPRIN1. 7 / 7
| 7
sparser
"However, a recent study suggests that G3BP proteins interact with Caprin1 and USP10 but that they are mutually exclusive allowing the binding of these proteins to serve as a switch for SG formation depending on the binding partner interacting with G3BP1."
30595162
sparser
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [ xref , xref ]."
30326201
sparser
"USP10 and Caprin1 antagonistically bind G3BP to regulate SG formation."
27022092
sparser
"Our results indicated that N expression abrogates G3BP1 interaction with the SG proteins CAPRIN1 and USP10 ( Figure 2C ), reinforcing the idea that N inhibits the formation of SGs in host cells by sequestering G3BPs away from their interacting SG-nucleating proteins."
34901782
sparser
"Rescue experiments using G3BP1 mutants show that phosphomimetic G3BP1-S149E fails to rescue SG formation, whereas G3BP1-F33W, a mutant unable to bind G3BP partner proteins Caprin1 or USP10, rescues SG formation."
27022092
sparser
"Therefore, although Caprin1 and USP10 both bind G3BP ( xref ; xref ), they have antagonistic effects on SGs."
27022092
sparser
"Interaction of Dengue RNA with stress granule proteins G3BP1, USP10 and caprin1 occurs at an adjacent unstructured region of the 3′ UTR ( xref )."
23290869
USP10 binds G3BP2, G3BP1, and CAPRIN1. 6 / 6
| 6
sparser
"In addition, a proteomic analysis found that G3BP1, G3BP2, Caprin1 and USP10 interact with DENV RNA [ xref ], and it was reported that G3BP1, G3BP2 and Caprin1 regulate the translation of ISG mRNAs, thus protecting DENV replication from IFN-mediated antiviral effects [ xref ]."
27367717
sparser
"However, a role for the G3BP1 and G3BP2 interactions with CAPRIN1 and/or USP10 under chronic nutrient starvation has not yet been investigated."
30326201
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al.2017); SeV Trailer RNA captures TIAR from SG (Iseni et al.2002); West Nile Virus (WNV) and Dengue virus (DENV) 3′-end viral genome captures TIA-1/TIAR (Li et al.2002; Emara and Brinton 2007; Xia et al.2015); DENV 3′-UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al.2011; Reineke et al.2015); JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al.2011)."
31037644
sparser
"ZIKV infection induces the redistribution of TIAR to the viral RNA replication sites (Hou et al. 2017) ; SeV Trailer RNA captures TIAR from SG (Iseni et al. 2002) ; West Nile Virus (WNV) and Dengue virus (DENV) 3 0 -end viral genome captures TIA-1/TIAR (Li et al. 2002; Emara and Brinton 2007; Xia et al. 2015) ; DENV 3 0 -UTR interacts with G3BP1, G3BP2, Caprin1 and USP10 (Ward et al. 2011; Reineke et al. 2015) ; JEV recruits G3BP and USP10 to the perinuclear region through the interaction of JEV core protein with Caprin-1, a SG-associated cellular factor (Ward et al. 2011) ."
31037644
sparser
"Additional experiments demonstrate that, in contrast to DDX6, the SG proteins G3BP1, G3BP2, Caprin1 and USP10 bind to the variable region (VR) in the 3' UTR."
21957497
sparser
"In addition, a proteomic analysis found that G3BP1, G3BP2, Caprin1 and USP10 interact with DENV RNA [171], and it was reported that G3BP1, G3BP2 and Caprin1 regulate the translation of ISG mRNAs, thus protecting DENV replication from IFN-mediated antiviral effects [172]."
27367717
USP10 binds G3BP2, G3BP1, and EIF2AK2. 4 / 4
| 4
sparser
"Validation of the mass spectrometry data confirmed the interaction of NCAP with G3BP1, G3BP2, YTHDF3, USP10 and PKR."
34780058
sparser
"NCAP showed specific interaction with the SG proteins G3BP1, G3BP2, YTHDF3, USP10 and PKR, and translocated to SGs following oxidative stress and heat shock."
34780058
sparser
"NCAP interacts with SG proteins. (A) Interaction of NCAP with G3BP1, G3BP2, YTHDF3, USP10 and PKR."
34780058
sparser
"Fig. 4: NCAP interacts with SG proteins. (A) Interaction of NCAP with G3BP1, G3BP2, YTHDF3, USP10 and PKR."
34780058
USP10 binds SH2D3C and G3BP1. 3 / 3
| 3
sparser
"Since the binding of nsP3 and USP10 to G3BP inhibits SGs, we hypothesized that ICP8 binding might do the same."
25658430
sparser
"It was recently identified that a common canonical sequence motif, FGDF, mediates binding of the nsP3 and USP10 proteins to G3BP ."
26410532
sparser
"The model might also explain the elimination of binding of both nsP3 and USP10 to G3BP upon mutation of the glycine residue to alanine, which would restrict flexibility and thus hinder adequate positioning of the phenylalanine side-chains in the FGDF motifs."
25658430
SQSTM1 binds USP10 and G3BP1. 2 / 2
| 2
sparser
"G3BP1 interacts with p62 and USP10 to inhibit protein aggregation."
34526993
sparser
"G3BP1 interacted with p62 and USP10 and inhibited p62/USP10-induced protein aggregation."
31501480
TP53 binds USP10 and G3BP1. 2 / 2
| 2
sparser
"Disruption of the interaction of p53 with USP10 by G3BP1 interference leads to suppression of p53 deubiquitination."
24998844
sparser
"Disruption of the interaction of p53 with USP10 by G3BP1 interference leads to the suppression of p53 deubiquitination."
24998844
USP10 binds G3BP2 and G3BP1. 1 / 1
| 1
sparser
"In addition, the variable sequences in the 3’UTR interact with stress granule (SG) proteins G3BP1, G3BP2, Caprin 1 and USP10 [ xref ]."
33070015
TIA1 binds TIAL1, USP10, G3BP1, and CAPRIN1. 1 / 1
| 1
sparser
"The recruitment mode is thought to be as follows: Caprin1, USP10, TIAR, and TIA-1 interact with G3BP-1 which binds to σNS via its RNA recognition (RRM) and an arginine/glycine-rich (RGG) motifs."
31681621
USP10 binds G3BP1 and CAPRIN1. 1 / 1
| 1
sparser
"Caprin-1 and ubiquitin specific peptidase 10 (USP10) interact with G3BP1, facilitating and suppressing SG formation, respectively."
36279435
USP10 binds NUFIP2 and G3BP1. 1 / 1
| 1
sparser
"Interestingly, our previous map of human protein complexes ( xref ) suggests that the known complex of G3BP, CAPRIN, and USP10 ( xref ) also physically interacts with NUFIP2, leading us to suggest the name CapGUN (i.e., CAPRIN1, G3BP2, USP10, NUFIP2)."
31665645
USP10 binds NUTF2, G3BP1, and CAPRIN1. 1 / 1
| 1
sparser
"This motif is responsible for competitive binding of USP10 to the NTF2 domain of G3BP1 and displacement of caprin-1 ( xref )."
32989041
USP10 binds G3BP1 and cycle inhibiting factor (Cif). 1 / 1
| 1
sparser
"Treatment of co-transfected (YN-USP10 and YC-G3BP1) airway epithelial cells with Cif-containing OMV resulted in an increase in BiFC signal, confirming an increased (4.35±0.30 fold) interaction between USP10 and G3BP1 in the presence of Cif ( xref ) compared to cells treated with control (Cif mutant OMV)."
21455491
USP10 binds G3BP1 and HCT116. 1 / 1
| 1
sparser
"As expected, the interaction between G3BP1 and USP10 decreased in HCT116 cells treated with resveratrol ( xref )."
24998844
USP10 inhibits G3BP1.
| 3
USP10 inhibits G3BP1. 3 / 7
| 3
reach
"This unexpected finding may suggest that binding of the USP10-derived SLiM to NTF2 reduces the propensity of G3BP1 to enter condensates."
37161291
reach
"It is also possible that USP10 blocks the helicase function of G3BP, as helicase activity of some proteins, e.g., DDX6 and RCK, has been shown to be required for RNA granule assembly."
27821493
reach
"USP10 may prevent G3BP from nucleating SG assembly by locking G3BP in a conformation that influences the NTF2 like domain and mediates or prevents G3BP oligomerization."
27821493
USP10 decreases the amount of G3BP1.
| 1
USP10 decreases the amount of G3BP1. 1 / 3
| 1
reach
"However, USP10 KD also reduces expression of G3BP1 and G3BP2 (to 58% and 77% of control values, respectively; XREF_FIG), suggesting that the SG inhibition caused by USP10 KD may be caused by reduced levels of G3BP."
27022092
USP10 activates G3BP1.
| 1
USP10 activates G3BP1. 1 / 1
| 1
reach
"We next found that USP10 coordinately promotes tumor progression with G3BP1."
34967276