IndraLab

Statements

USP10 inhibits G3BP1. 6 / 10
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"Furthermore, both the Caprin-1 GIM and USP10 GIM suppressed liquid–liquid phase separation (LLPS) of G3BP1, leading us to examine the effect of other domains of Caprin-1 on LLPS."
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"The GIM of USP10 drastically reduced the number and sizes of G3BP1 droplets (Fig. 3B), suggesting that the inhibitory effect of USP10 on G3BP1 LLPS is likely caused by the interaction between USP10 GIM and G3BP1."
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"USP10 may prevent G3BP from nucleating SG assembly by locking G3BP in a conformation that influences the NTF2 like domain and mediates or prevents G3BP oligomerization."
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"USP10 has been shown to inhibit SG nucleation by occupying G3BP (Kedersha et al., 2016)."
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"This unexpected finding may suggest that binding of the USP10-derived SLiM to NTF2 reduces the propensity of G3BP1 to enter condensates."
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"It is also possible that USP10 blocks the helicase function of G3BP, as helicase activity of some proteins, e.g., DDX6 and RCK, has been shown to be required for RNA granule assembly."
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