IndraLab

Statements


USP10 inhibits G3BP1. 3 / 7
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"This unexpected finding may suggest that binding of the USP10-derived SLiM to NTF2 reduces the propensity of G3BP1 to enter condensates."

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"It is also possible that USP10 blocks the helicase function of G3BP, as helicase activity of some proteins, e.g., DDX6 and RCK, has been shown to be required for RNA granule assembly."

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"USP10 may prevent G3BP from nucleating SG assembly by locking G3BP in a conformation that influences the NTF2 like domain and mediates or prevents G3BP oligomerization."