IndraLab

Statements

USP10 binds G3BP1 and CAPRIN1. 7 / 7
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sparser
"However, a recent study suggests that G3BP proteins interact with Caprin1 and USP10 but that they are mutually exclusive allowing the binding of these proteins to serve as a switch for SG formation depending on the binding partner interacting with G3BP1."
30595162
sparser
"However, it is important to note that the interactions between G3BP1 and USP10 or Caprin1 do not fully dictate SG disassembly or assembly, as two different laboratories recently demonstrated that the unstressed G3BP1 interactome significantly overlaps the interactome of G3BP1 during stress [ xref , xref ]."
30326201
sparser
"USP10 and Caprin1 antagonistically bind G3BP to regulate SG formation."
27022092
sparser
"Our results indicated that N expression abrogates G3BP1 interaction with the SG proteins CAPRIN1 and USP10 ( Figure 2C ), reinforcing the idea that N inhibits the formation of SGs in host cells by sequestering G3BPs away from their interacting SG-nucleating proteins."
34901782
sparser
"Rescue experiments using G3BP1 mutants show that phosphomimetic G3BP1-S149E fails to rescue SG formation, whereas G3BP1-F33W, a mutant unable to bind G3BP partner proteins Caprin1 or USP10, rescues SG formation."
27022092
sparser
"Therefore, although Caprin1 and USP10 both bind G3BP ( xref ; xref ), they have antagonistic effects on SGs."
27022092
sparser
"Interaction of Dengue RNA with stress granule proteins G3BP1, USP10 and caprin1 occurs at an adjacent unstructured region of the 3′ UTR ( xref )."
23290869