IndraLab

Statements

G3BP1 binds CAPRIN1 and USP10. 4 / 4
| 4
sparser
"However, a recent study suggests that G3BP proteins interact with Caprin1 and USP10 but that they are mutually exclusive allowing the binding of these proteins to serve as a switch for SG formation depending on the binding partner interacting with G3BP1."
30595162
sparser
"USP10 and Caprin1 antagonistically bind G3BP to regulate SG formation."
27022092
sparser
"Therefore, although Caprin1 and USP10 both bind G3BP ( xref ; xref ), they have antagonistic effects on SGs."
27022092
sparser
"Rescue experiments using G3BP1 mutants show that phosphomimetic G3BP1-S149E fails to rescue SG formation, whereas G3BP1-F33W, a mutant unable to bind G3BP partner proteins Caprin1 or USP10, rescues SG formation."
27022092