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G3BP1 inhibits USP10. 21 / 23
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"In a steady-state, G3BP1 inhibits the antioxidant activity of USP10."
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"Notably, siRNA mediated knockdown of G3BP1 significantly increased the abundance of CFTR, most likely because endogenous G3BP1 inhibits USP10 (XREF_FIG)."
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"One of the reported functions of G3BP1 is to bind to and inhibit USP10 XREF_BIBR."
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"However, oxidative and nitrosative stress induce SGs formation which cause USP10 to induce ataxia-telangiectasia-mutated protein (ATM) phosphorylation which suppresses the inhibition of USP10 by G3BP1, thereby reducing ROS production and apoptosis ( xref , xref )."
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"Surprisingly, the human homolog of Bre5, G3BP1, inhibits the activity of USP10, at least in vitro, indicating that cofactors can either restrict or enhance protease activity."
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"Here we describe in vitro analysis of the G3BP1 affinities, and show that substitution of G3BP1 residues F15 or F33 to tryptophan reduces affinity for both the USP10 and Caprin1 motif peptides."
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"Anisonov et al. [ xref ] also found that USP10 is inhibited by G3BP1 in a mechanism similar to that for NUP62, which indicates an analogous cascading route from SARS-CoV-2 to PD for this protein."
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"Notably, siRNA-mediated knockdown of G3BP1 significantly increased the abundance of CFTR, most likely because endogenous G3BP1 inhibits USP10 ( xref )."
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"It should be remarked that G3BP1 is also a perturbator for the PD-VPs USP10 [91], GiGYF2 [99], EIF4G1 [100], and TIAL1 [101]."
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"Anisonov et al. [91] also found that USP10 is inhibited by G3BP1 in a mechanism similar to that for NUP62, which indicates an analogous cascading route from SARS-CoV-2 to PD for this protein."
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"discovered the interaction of G3BP1 with ubiquitin specific protease 10 (USP10), and they concluded that G3BP1 might restrict the deubiquitinating activity of USP10."
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"Conversely, G3BP is inhibited when binding to peptidase USP10."
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"G3BP1 disrupts the interaction of USP10 with p53."
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"Under physiological conditions, excessive G3BP1 is able to inhibit the antioxidant activity of USP10 to maintain ROS homeostasis."
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"However, upon exposure to external stress such as high concentrations of hydrogen peroxide [65], the inhibition of USP10 by G3BP1 is abrogated and USP10 is induced to phosphorylate by ataxia-telangiectasia-mutated protein (ATM) or activated by ATM-phosphorylated protein, thereby reducing ROS production and apoptosis [64]."
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"Under physiological conditions, excessive G3BP1 inhibits the antioxidant activity of USP10 and elevates ROS steady-state."
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"Taken together, these results suggested that G3BP1 inhibits p62/USP10-induced protein aggregation, whereas G3BP2 attenuates such a G3BP1 inhibition by competing G3BP1-interaction with p62 and/or USP10 (Fig. 8c)."
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"In contrast, while ubiquitination of G3BP1 has not been reported, G3BP1 inhibits the deubiquitinase activity of USP10 ."
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"In airway epithelial cells treated with the CFTR inhibitory factor (Cif), the Ras GTPase-activating protein-binding protein 1 (G3BP1) inhibits the ubiquitin-specific protease USP10."
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"However, upon exposure to external stress such as high concentrations of hydrogen peroxide [ xref ], the inhibition of USP10 by G3BP1 is abrogated and USP10 is induced to phosphorylate by ataxia-telangiectasia-mutated protein (ATM) or activated by ATM-phosphorylated protein, thereby reducing ROS production and apoptosis [ xref ]."
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"It appears therefore that the FGDF mediated G3BP and USP10 complex is mutually inhibitory, with G3BP inhibiting the DUB activity of USP10 and USP10 inhibiting the SG nucleating function of G3BP."
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