IndraLab

Statements

USP46 affects Histone_H2B
| 6
USP46 deubiquitinates Histone_H2B. 6 / 6
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reach
"Usp12 and Usp46 deubiquitinate both H2A and H2B and Uaf-1 is required for this reaction [XREF_BIBR]."
25962961
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"Joo et al. demonstrated that USP46 and USP12 containing fractions from HeLa cells can deubiquitinate histones H2A and H2B to control cell fate and gastrulation during Xenopus development [XREF_BIBR]."
23316392
reach
"In other species, USP46 deubiquitinates deubiquitinate histones H2A and H2B associated to USP12 and WDR48 proteins, reinforcing its epigenetic function [40]."
32078636
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"USP12 and USP46 prefer nucleosomal substrates and deubiquitinate both histone H2A and H2B in vitro and in vivo."
21183687
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"Both USP12 and USP46 deubiquitinate histone H2A and H2B, affecting Xenopus development (Joo et al., 2011), and, unlike USP1, these smaller USPs can simultaneously bind WDR20 in addition to WDR48 (Joo [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26388029
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"It has also been reported that USP12 and USP46 deubiquitinate histone H2A and H2B thereby playing a role in Xenopus development."
27650958
USP46 affects GRIA
| 6
USP46 deubiquitinates GRIA. 5 / 5
| 5
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"Together, these data reveal a conserved mechanism where USP46 deubiquitinates AMPARs at synapses to protect them from degradation and promote their recycling to the cell surface to affect synapse function."
29302259
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"Endogenous USP46 suppresses AMPAR ubiquitination in neurons."
26077708
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"We found that USP46 suppressed AMPAR ubiquitination leading to an increase in receptor protein amount as well as in receptor synaptic localization."
26077708
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"Given the same type of deubiquitinating enzyme (USP46) is able to deubiquitinate AMPA receptors, and knockdown of USP46 elevated AMPA receptor ubiquitination and reduced AMPA receptor expression in hi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29501527
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"USP46 over-expression leads to a reduction in AMPAR ubiquitination, whereas knockdown of USP46 by either siRNAs or shRNAs causes a significant increase in AMPAR ubiquitination."
26077708
USP46 deubiquitinates GRIA on K48. 1 / 1
| 1
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"In contrast, Huo et al. (2015) showed that USP46 preferentially deubiquitinates AMPARs with Lys63- but not Lys48-linked chains in HEK293 cells, suggesting that USP46 chain specificity is controlled by other factors in vivo."
29302259
USP46 affects GLR1.1
| 5
USP46 deubiquitinates GLR1.1. 5 / 5
| 5
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"These findings suggest that USP-46 functions to deubiquitinate GLR-1 and to protect the receptor from degradation."
23316392
reach
"These data support a model in which USP-46 promotes GLR-1 abundance at synapses by deubiquitinating GLR-1 and preventing its degradation in the lysosome."
21273419
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"The abundance of GLR-1 (4KR), a mutant receptor which can not be ubiquitinated, is unaffected in usp-46 loss-of-function mutants leading to a model where USP-46 deubiquitinates GLR-1 to regulate its abundance."
29302259
reach
"Second, we tested whether the amount of ubiquitinated GLR-1 is increased in usp-46 mutant animals, as would be expected if USP-46 deubiquitinates GLR-1."
21273419
reach
"These data demonstrate that USP-46 promotes the deubiquitination of GLR-1, which in turn increases the abundance of GLR-1 in the VNC."
21273419
USP46 affects GRIA1
1 | 3
USP46 deubiquitinates GRIA1. 4 / 4
1 | 3
reach
"Mammalian USP46 can deubiquitinate both GluA1 and GluA2 subunits and protect AMPARs from degradation (Huo et al., 2015)."
29302259
reach
"We observed that USP46 is able to deubiquitinate not only GluA1 but also GluA2, indicating a relative stringency in contrast to the distinct E3 ligases that are employed for GluA1 and GluA2."
26077708
reach
"Mammalian USP46 can deubiquitinate both GluA1 and GluA2 subunits and protect AMPARs from degradation."
29302259
ubibrowser
"This Editorial Highlight discusses the relevance of a study published in the current issue of Journal of Neurochemistry, in which the authors Huo and collaborators now identified ubiquitin-specific peptidase 46 (USP46) as a specific AMPAR deubiquitinase."
26237995
USP46 affects Histone
| 3
USP46 deubiquitinates Histone-H2A. 3 / 3
| 3
reach
"Joo et al. demonstrated that USP46 and USP12 containing fractions from HeLa cells can deubiquitinate histones H2A and H2B to control cell fate and gastrulation during Xenopus development [XREF_BIBR]."
23316392
reach
"Several DUBs have been implicated in histone deubiquitination, including USP3, USP12, USP22, and USP46, which deubiquitinate both histones H2A and histones H2B [XREF_BIBR]."
33327527
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"In other species, USP46 deubiquitinates deubiquitinate histones H2A and H2B associated to USP12 and WDR48 proteins, reinforcing its epigenetic function [40]."
32078636
USP46 affects GRIA2
| 3
USP46 deubiquitinates GRIA2. 3 / 3
| 3
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"Mammalian USP46 can deubiquitinate both GluA1 and GluA2 subunits and protect AMPARs from degradation."
29302259
reach
"We observed that USP46 is able to deubiquitinate not only GluA1 but also GluA2, indicating a relative stringency in contrast to the distinct E3 ligases that are employed for GluA1 and GluA2."
26077708
reach
"Mammalian USP46 can deubiquitinate both GluA1 and GluA2 subunits and protect AMPARs from degradation (Huo et al., 2015)."
29302259
USP46 affects PHLPP1
1 | 1
Modified USP46 leads to the deubiquitination of PHLPP1. 1 / 1
| 1
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"Overexpression of WT USP46 significantly decreased the amount of ubiquitination of PHLPP1 both basally and after MG-132 treatment, while the catalytically inactive mutant USP46 had no effect (XREF_FIG)."
22391563
USP46 deubiquitinates PHLPP1. 1 / 1
1 |
ubibrowser
"SP1 [137] and USP46 [138] are other DUBs known to deubiquitinate PHLPP1"
25121098
USP46 affects AR
1 | 1
USP46 deubiquitinates AR. 2 / 2
1 | 1
reach
"Furthermore, overexpressed USP46 was able to deubiquitinate AR, similarly to our previous observations for USP12 [XREF_BIBR]."
29861848
ubibrowser
"Here we report that the novel small molecule anti-androgen, galeterone targets USP12 and USP46, two highly homologous deubiquitinating enzymes that control the AR-AKT-MDM2-P53 signalling pathway."
29861848
USP46 affects histones H2B
| 1
USP46 deubiquitinates histones H2B. 1 / 1
| 1
reach
"Several DUBs have been implicated in histone deubiquitination, including USP3, USP12, USP22, and USP46, which deubiquitinate both histones H2A and histones H2B [XREF_BIBR]."
33327527
reach
"It will be important in the future to test if USP46 functions in GABA neurons and whether it directly deubiquitinates components of the GABA system.WDR proteins are involved in protein-protein interactions that mediate diverse cellular processes."
29302259
USP46 affects WDR48
| 1
USP46 deubiquitinates WDR48. 1 / 1
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"Usp12 and Usp46 deubiquitinate both H2A and H2B and Uaf-1 is required for this reaction [XREF_BIBR]."
25962961
USP46 affects USP46
| 1
USP46 deubiquitinates USP46. 1 / 1
| 1
reach
"Given the same type of deubiquitinating enzyme (USP46) is able to deubiquitinate AMPA receptors, and knockdown of USP46 elevated AMPA receptor ubiquitination and reduced AMPA receptor expression in hi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29501527
USP46 affects Lys63-
| 1
USP46 deubiquitinates Lys63- on K48. 1 / 1
| 1
reach
"In contrast, Huo et al. (2015) showed that USP46 preferentially deubiquitinates AMPARs with Lys63- but not Lys48-linked chains in HEK293 cells, suggesting that USP46 chain specificity is controlled by other factors in vivo."
29302259
USP46 affects H2BC21
1 |
USP46 deubiquitinates H2BC21. 1 / 1
1 |
ubibrowser
"Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46."
21183687
USP46 affects H2AC20
1 |
USP46 deubiquitinates H2AC20. 1 / 1
1 |
ubibrowser
"Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46."
21183687
USP46 affects GAD1
1 |
USP46 deubiquitinates GAD1. 1 / 1
1 |
ubibrowser
No evidence text available
USP46 affects AMPA receptors
| 1
USP46 deubiquitinates AMPA receptors. 1 / 1
| 1
reach
"Given the same type of deubiquitinating enzyme (USP46) is able to deubiquitinate AMPA receptors, and knockdown of USP46 elevated AMPA receptor ubiquitination and reduced AMPA receptor expression in hi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29501527