IndraLab

Statements

OTUD1 affects SMAD7
1 | 4
OTUD1 deubiquitinates SMAD7. 5 / 5
1 | 4
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"Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7"
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"OTUD1 deubiquitinates SMAD7 and sustains SMAD7 stability."
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"Further investigation reveals that OTUD1 directly deubiquitinates the TGF-beta pathway inhibitor SMAD7 and prevents its degradation."
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"To demonstrate that OTUD1 can directly deubiquitinate SMAD7, we performed in vitro deubiquitination assays."
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"This confirms that OTUD1 deubiquitinates SMAD7 in vitro."
29235476
OTUD1 affects TP53
1 | 1 2
OTUD1 deubiquitinates TP53. 4 / 4
1 | 1 2
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"OTUD1, OTUD5 and USP11 directly deubiquitinating p53 and functional proteins were required for p53 stabilization [XREF_BIBR - XREF_BIBR]."
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"Our results showed that OTUD1 deubiquitinated p53 and that functional OTUD1 was required for p53 stabilization."
28216291
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"Our results showed that OTUD1 deubiquitinated p53 and that functional OTUD1 was required for p53 stabilization."
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"Review"
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OTUD1 affects STAT3
| 2
OTUD1 deubiquitinates STAT3. 2 / 2
| 2
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"Mechanistically, OTUD1 bounds to the SH2 domain of STAT3 and causes deubiquitination of STAT3."
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"Conclusion: Cardiomyocyte OTUD1 promotes pathological cardiac remodeling and dysfunction by deubiquitinating STAT3."
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OTUD1 affects SMAD3
| 2
OTUD1 deubiquitinates SMAD3. 2 / 2
| 2
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"Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3."
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"Our findings demonstrate that endothelial OTUD1 promotes Ang II-induced vascular remodeling by deubiquitinating SMAD3."
36579465
OTUD1 affects Aurora-A
| 2
OTUD1 deubiquitinates Aurora-A. 2 / 2
| 2
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"Only OTUD1 and OTUD6A induced the deubiquitination of Aurora-A (XREF_FIG a)."
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"OTUD1, one of the final candidate DUBs for Aurora-A, bound to and deubiquitinated Aurora-A but its interaction with endogenous Aurora-A was much weaker than OTUD6A."
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OTUD1 affects TYK2
| 1
OTUD1 leads to the deubiquitination of TYK2. 1 / 1
| 1
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"In line with this, OTUD1 deficiency in both primary macrophages (Fig. 5b) and MEFs (Supplementary information, Fig. S5d), as well as A549 cells (Supplementary information, Fig. S5e), markedly improved Tyk2 ubiquitination levels, whereas OTUD1 overexpression inhibited Tyk2 ubiquitination (Fig. 5c; Supplementary information, Fig. S5f)."
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OTUD1 affects TGFB
| 1
OTUD1 deubiquitinates TGFB. 1 / 1
| 1
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"Further investigation reveals that OTUD1 directly deubiquitinates the TGF-beta pathway inhibitor SMAD7 and prevents its degradation."
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OTUD1 affects SMURF1
| 1
OTUD1 leads to the deubiquitination of SMURF1. 1 / 1
| 1
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"Furthermore, OTUD1 induced upregulation of the E3 ubiquitin ligase Smurf1 by deubiquitinating Smurf1, and Smurf1 degraded MAVS in MDBK cells in a ubiquitination dependent manner, ultimately inhibiting IFN-I production."
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OTUD1 affects PRDX4
| 1
OTUD1 deubiquitinates PRDX4. 1 / 1
| 1
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"Mechanistically, OTUD1 deubiquitinates peroxiredoxin 4 (PRDX4), protecting it from endoplasmic reticulum (ER)-associated degradation."
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OTUD1 affects MAVS/TRAF3/TRAF6
| 1
OTUD1 leads to the deubiquitination of MAVS/TRAF3/TRAF6. 1 / 1
| 1
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"And overexpression of OTUD1 promoted K48 linked ubiquitination of MAVS/TRAF3/TRAF6 (XREF_SUPPLEMENTARY), suggesting that OTUD1 promotes ubiquitination and degradation of MAVS/TRAF3/TRAF6."
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OTUD1 affects MAVS
| 1
OTUD1 leads to the deubiquitination of MAVS. 1 / 1
| 1
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"Furthermore, OTUD1 induced upregulation of the E3 ubiquitin ligase Smurf1 by deubiquitinating Smurf1, and Smurf1 degraded MAVS in MDBK cells in a ubiquitination dependent manner, ultimately inhibiting IFN-I production."
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OTUD1 affects KLF4
| 1
OTUD1 deubiquitinates KLF4. 1 / 1
| 1
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"OTUD1 was positively correlated with KLF4 and stabilized KLF4 at protein level by deubiquitinating KLF4."
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OTUD1 affects CFH
| 1
OTUD1 deubiquitinates CFH. 1 / 1
| 1
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"These results indicated that the deubiquitinase OTUD1, which was upregulated by VE-822, inhibited the progression of LUAD in vitro and in vivo by deubiquitinating and stabilizing FHL1."
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OTUD1 affects CARD9
| 1
OTUD1 deubiquitinates CARD9. 1 / 1
| 1
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"OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9."
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OTUD1 affects ART4
| 1
OTUD1 leads to the deubiquitination of ART4. 1 / 1
| 1
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"The level of Art4-OTUD1 fusion in ubp2Delta ubp15Delta cells, however, was nearly identical to that in WT cells (XREF_FIG, lanes 5 and 6, and C), suggesting that OTUD1 efficiently prevents Art4 hype-r-ubiquitination."
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