IndraLab

Statements

"ULBP4-NKG2D interaction can not only activate NK cell and NK-mediated cytotoxicity [ xref , xref , xref ], but also serve to stimulate the cytotoxicity of CD8+ T cell [ xref ], which suggests an influence of ULBP4 on both innate and adaptive immune responses."

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"It is intriguing that ULBP-4 and hMSH2 can also bind to NKG2D to induce the cytotoxicity of Vgamma9Vdelta2-T cells against tumor cells through TCR and NKG2D engagement."

28894450

RAET1E inhibits KLRK1.

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RAET1E inhibits KLRK1. 3 / 3

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"RAET1E2, a soluble isoform of the UL16 binding protein RAET1E produced by tumor cells, inhibits NKG2D mediated NK cytotoxicity."

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"In other words, RAET1E might impair NKG2D mediated NK cell cytotoxicity to tumors [XREF_BIBR]."

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"We previously reported that RAET1E2, a soluble isoform of the RAET1E (ULBP4), inhibits NKG2D mediated NK cytotoxicity."

19436053

RAET1E decreases the amount of KLRK1.

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RAET1E decreases the amount of KLRK1. 1 / 2

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"Moreover, co-culture-free soluble forms of ULBP4 splice variants (their alpha1 + alpha2 ectodomains) and RAET1G3 (soluble splice variant of RAET1G2) with NK cells down-regulated the cell surface expression of NKG2D."

18544572

RAET1E activates KLRK1.

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RAET1E activates KLRK1. 1 / 2

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"Indeed a soluble, secreted splicing variant of RAET1E has also been reported XREF_BIBR Therefore expression of soluble isoforms of RAET1G and RAET1E could allow cancer cells to produce soluble NKG2D ligand without the need for metalloproteinase activity."

19223974

RAET1E affects AS1

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RAET1E binds AS1. 7 / 7

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"According to both the data from GEPIA () and TCGA (), we unveiled that the expression of LINC01559, LINC00483, LINC01296, RAET1E-AS1 and PCED1B-AS1 was significantly high in STAD (stomach adenocarcinoma) tissues in contrast with normal gastric tissues (Fig. xref , Supplementary Fig. xref )."

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"We randomly selected hsa-miR-145-5p for further analysis; it had ceRNA relationships with four mRNAs (ITGB8, WNT11, BMPER, and RARRES3), two lncRNAs (RAET1E-AS1 and LOC102723591), and one circRNA (hsa_circ_0092630) (Fig. xref e)."

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"However, the role of the lncRNA RAET1E-AS1 in cell biology has not been explored."

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"Correlation analyses revealed that the expression levels of RAET1E-AS1, WNT11, and BMPER had significantly negative correlations with the expression level of hsa-miR-145-5p (Fig. xref g–i), while the other RNAs did not exhibit such relationships (Figure S xref C, D)."

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"Furthermore, the expression level of RAET1E-AS1 had a significantly positive correlation with the expression levels of WNT11 and BMPER (Fig. xref j, k)."

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"Finally, we found that overexpression of has-miR-145-5p in ASCs could significantly downregulated the expression levels of WNT11, BMPER, RAET1E-AS1, LOC102723591, and hsa_circ_0092630 (Fig. xref l)."

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"Moreover, we found that five lncRNAs (RAET1E-AS1, LOC102723591, LOC105373230, LOC112267883, and LINC02595) and five circRNAs (hsa_circ_0017534, hsa_circ_0092630, hsa_circ_0080906, hsa_circ_0075045, and hsa_circ_0080909) were significantly upregulated in O-ASCs, compared with Y-ASCs (Fig. xref c)."

34051854

KLRK1 affects RAET1E

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RAET1E binds KLRK1. 4 / 6

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No evidence text available

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No evidence text available

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"It is intriguing that ULBP-4 and hMSH2 can also bind to NKG2D to induce the cytotoxicity of Vgamma9Vdelta2-T cells against tumor cells through TCR and NKG2D engagement."

28894450

TGFB affects RAET1E

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TGFB decreases the amount of RAET1E.

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TGFB decreases the amount of RAET1E. 4 / 4

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"Additionally, transforming growth factor-beta (TGF-beta) selectively downregulates the expression of MICA, ULBP2, and ULBP4, but not MICB, ULBP1, or ULBP3, in malignant glioma cells [XREF_BIBR]."

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"We further delineate two independent mechanisms that can explain these expression patterns : (i) transforming growth factor-beta (TGF-beta) is upregulated during malignant progression and selectively downregulates MICA, ULBP2 and ULBP4 expression, while MICB, ULBP1 and ULBP3 are unaffected."

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"TGF-beta inhibits the transcription of MICA, ULBP2, and ULBP4 mRNA, whereas MICB, ULBP1, and ULBP3 mRNA levels remained unchanged."

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"Secretion of TGF-beta by NPC cells is well documented and is known to promote the progression and metastasis of NPC [XREF_BIBR, XREF_BIBR], herein ULBP4 expression may be also downregulated by TGF-beta on NPC cells."

28159927

TGFB inhibits RAET1E.

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TGFB inhibits RAET1E. 1 / 1

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"Elevated TGF-β levels as detected in glioblastoma patients were also shown to affect the expression of NKG2DLs (104, 112): experimentally reduced TGF-β expression by glioma cells led to an increase of MICA, ULBP2, and ULBP4 transcripts and increased cell surface expression of MICA and ULBP2 as well as of a reduction of tumorigenicity in vivo (104, 112)."

31803194

TCR affects RAET1E

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TCR binds RAET1E. 4 / 4

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"ULBP4 also can bind to Vγ9Vδ2 TCR and thus induce the cytotoxic activity of Vγ9Vδ2T cells toward tumor cells through both TCR and NKG2D engagement ( xref )."

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"Of interest, the NKG2D ligand ULBP4 may bind to the TCR of some gammadelta T-cell subsets, and this may exacerbate their inhibition by neuroblastoma cells."

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"We also show that ULBP4 binds to a soluble chimeric protein containing TCRgamma9 and delta2 and activates TCR (-) Jurkat T cells transfected with TCRgamma9 and delta2."

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"They can be activated by γδ TCR ligands such as phosphoantigens, or by MHC-associated ligands of the activatory receptor killer cell lectin-like receptor subfamily K, member 1 (KLRK1, best known as NKG2D, such as MHC class I polypeptide-related sequence A (MICA), MICB, and various members of the UL16-binding protein (ULBP) family. γδ T cells also express killer-cell immunoglobulin-like receptors (KIRs), which can be either activatory or inhibitory, including killer cell immunoglobulin-like receptor, 2 domains, long cytoplasmic tail, 1 (KIR2DL1) xref and killer cell immunoglobulin-like receptor, 3 domains, long cytoplasmic tail, 1 (KIR3DL1). xref Tumors possess the ability to manipulate this balance to stimulate tolerance by inhibitory signals, including soluble NKG2D ligands, transforming growth factor β1 (TGFβ1), galectin 3 and prostaglandin E 2 (PGE 2 ) xref , xref , xref , xref Elevated circulating levels of sMICA, sMICB, and sULBP1 might be particularly active against effector γδ T cells, as the latter express high amounts of NKG2D. Of interest, the NKG2D ligand ULBP4 may bind to the TCR of some γδ T-cell subsets, and this may exacerbate their inhibition by neuroblastoma cells. xref "

24734216

Pirinixic acid affects RAET1E

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Pirinixic acid increases the amount of RAET1E. 3 / 3

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No evidence text available

23811191

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No evidence text available

11798191

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No evidence text available

20813756

RAET1E

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RAET1E binds.

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RAET1E binds RAET1E. 2 / 2

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hprd

No evidence text available

15240696

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No evidence text available

12732206

RAET1E translocates.

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RAET1E translocates from the cytoplasm to the plasma membrane. 1 / 1

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"In addition, we showed that HCQ did not affect the synthesis or degradation of ULBP4, but induced the translocation of ULBP4 from the cytoplasm to the cell membrane."

28339029

E2F1 affects RAET1E

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E2F1 activates RAET1E.

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E2F1 activates RAET1E. 2 / 2

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"To investigate whether E2F1 activates the Raet1e promoter reporter construct described in XREF_FIG, fibroblasts maintained in 0% serum were cotransfected with the reporter construct and increasing amounts of a pcDNA vector encoding E2F1."

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"E2F1 was much less effective in activating a Raet1e reporter plasmid in which both putative E2F sites were mutated, indicating that E2F transcription factors directly bind and activate the Raet1e promoter construct (XREF_FIG, right)."

23166357

E2F1 binds RAET1E.

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RAET1E binds E2F1. 1 / 1

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"An investigation of the roles of factors known to regulate the cell cycle showed that E2F1–3, the activating E2F transcription factors, bind to the Raet1e promoter in vivo and transactivate the endogenous Raet1e gene as well as the Raet1e promoter in a reporter plasmid."

23298206

Reliable detection reagents affects RAET1E

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Reliable detection reagents activates RAET1E. 2 / 2

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eidos

"The lack of knowledge on ULBP4 is in part due to the scarcity of reliable detection reagents , since there are only a few `` ULBP4-specific '' antibodies commercially available with some even showing cross-reactivity to undefined antigen ( s ) on cells not containing ULBP4 transcripts [ 32 ] ."

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"Reply : For clarification , we amended the text as follows : '' The lack of knowledge on ULBP4 is in part due to the scarcity of reliable detection reagents , since there are only a few `` ULBP4-specific '' antibodies commercially available with some even showing cross-reactivity to undefined antigen ( s ) on cells not containing ULBP4 transcripts ( Zoller et al ., 2018 ) ."

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Paracetamol affects RAET1E

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Paracetamol decreases the amount of RAET1E. 2 / 2

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No evidence text available

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No evidence text available

17585979

Carbon nanotube affects RAET1E

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Carbon nanotube increases the amount of RAET1E.

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Carbon nanotube increases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

25554681

Carbon nanotube decreases the amount of RAET1E.

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Carbon nanotube decreases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

25620056

Butyric acid affects RAET1E

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Butyric acid activates RAET1E. 1 / 1

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"Consistent with these findings, we observed that the chemical HDAC inhibitor butyrate activated the WT Raet1e promoter (XREF_FIG)."

27874833

Butyric acid activates mutated RAET1E. 1 / 1

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"Interestingly, butyrate treatment failed to drive expression from the m18RE * mutant Raet1e promoter (XREF_FIG)."

27874833

Aflatoxin B1 affects RAET1E

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Aflatoxin B1 methylates RAET1E.

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Aflatoxin B1 methylates RAET1E. 1 / 1

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ctd

No evidence text available

27153756

Aflatoxin B1 increases the amount of RAET1E.

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Aflatoxin B1 increases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

22100608

ULBP3 affects RAET1E

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ULBP3 binds RAET1E. 1 / 1

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biogrid

No evidence text available

28514442

ULBP3 binds RAET1E and MICA. 1 / 1

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"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."

20536569

ULBP2 affects RAET1E

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ULBP2 binds RAET1E. 2 / 2

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No evidence text available

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"However, it is noteworthy that high expression of ULBP2 and ULBP4 has been paradoxically associated with poor prognosis in ovarian cancer, and it does not appear to be related to an increase of the shedding of these molecules ( xref , xref )."

24711808

RAET1G affects RAET1E

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RAET1E binds RAET1G. 2 / 2

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"Given the results of Cao et al.’s study and the fact that many isoforms were also stained during RAET1E and RAET1G IHC staining, it is possible that high RAET1E and RAET1G expression may be associated with poor prognosis."

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"Intriguingly, although the results of our multivariate analysis were not significant, in univariate analysis, high RAET1E or RAET1G expression was associated with poor disease-free survival (Table xref )."

25510288

RAET1E affects immune response

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RAET1E activates immune response. 2 / 2

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"Our results indicate that Letal promotes tumor immune surveillance by promoting the survival and intratumoral expansion of antitumor cytotoxic lymphocytes."

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"These results suggest that Letal delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes."

14508119

RAET1E affects cell population proliferation

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RAET1E activates cell population proliferation. 2 / 2

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"Here we show that immobilized soluble ULBP4 (rULBP4) induces the proliferation of human ovarian epithelial carcinoma- or colonic carcinoma derived Vdelta2 (+) T cells in vitro."

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"Simultaneous T-cell receptor activation and engagement of Letal stimulated proliferation of CD8 (+) cells and dramatically increased IL-2 and IFNgamma secretion."

14508119

RAET1E affects ULBP3

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ULBP3 binds RAET1E. 1 / 1

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biogrid

No evidence text available

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ULBP3 binds RAET1E and MICA. 1 / 1

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"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."

20536569

RAET1E affects ULBP2

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ULBP2 binds RAET1E. 2 / 2

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biogrid

No evidence text available

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RAET1E affects RAET1G

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RAET1E binds RAET1G. 2 / 2

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RAET1E affects CD8

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RAET1E activates CD8. 2 / 2

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"Simultaneous T-cell receptor activation and engagement of Letal stimulated proliferation of CD8 (+) cells and dramatically increased IL-2 and IFNgamma secretion."

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"As shown earlier, the intermediate cells had the highest expression of genes involved in co-stimulation and antigen presentation, but also genes involved in NK cell and CD8 T cell activation, such as MICB, RAET1E, RAET1G, RAET1L and ULBP3 were enriched on intermediate monocytes."

26650546

1,2-dichloroethane affects RAET1E

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1,2-dichloroethane decreases the amount of RAET1E. 2 / 2

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No evidence text available

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No evidence text available

28189721

(+)-JQ1 compound affects RAET1E

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(+)-JQ1 compound decreases the amount of RAET1E. 2 / 2

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No evidence text available

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No evidence text available

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Trichloroethene affects RAET1E

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Trichloroethene increases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

25549359

Transcription factor JUNB affects RAET1E

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Transcription factor JUNB decreases the amount of RAET1E. 1 / 1

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"The transcription of Raet1e was inhibited by the transcription factor JUNB in cell lines and mouse tissues XREF_BIBR."

19629084

Titanium dioxide affects RAET1E

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Titanium dioxide increases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

31298478

Sodium dodecyl sulfate affects RAET1E

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Sodium dodecyl sulfate decreases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

31734321

Silicon dioxide affects RAET1E

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Silicon dioxide decreases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

25895662

Signaling receptor activity affects RAET1E

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Signaling receptor activity activates RAET1E. 1 / 1

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"Simultaneous T-cell receptor activation and engagement of Letal stimulated proliferation of CD8 (+) cells and dramatically increased IL-2 and IFNgamma secretion."

14508119

Self-made mAb DUMO1 affects RAET1E

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Self-made mAb DUMO1 activates RAET1E. 1 / 1

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eidos

"In contrast , our self-made mAb DUMO1 specifically binds to ULBP4-transfected cell lines ( but not mock-transfected cells ) and recombinantly produced ULBP4 , but does not bind to cells that do NOT contain ULBP4 / RAET1E transcripts such as HepG2 cells or human monocytes ( see Zoller et al ., 2018 and our present manuscript ) ."

33556116

Rotenone affects RAET1E

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Rotenone decreases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

29955902

Resveratrol affects RAET1E

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Resveratrol increases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

31298478

Psmb9-a affects RAET1E

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Psmb9-a inhibits RAET1E. 1 / 1

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"EBV LMP2A reduces MICA and ULBP4 in lymphoblastoid cell lines and inhibits recognition by CD8+ T cells [XREF_BIBR], and this allows it to block its recognition and destruction by NK cells."

27077876

Propanal affects RAET1E

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Propanal increases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

26079696

Phosphatidylinositol affects RAET1E

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Phosphatidylinositol activates RAET1E. 1 / 1

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"To determine whether the ULBP4 protein is transmembrane or GPI linked, cells expressing the transiently transfected ULBP4 or MICB or ULBP3 were treated with phosphatidylinositol specific phospholipase[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

12732206

Jinfukang affects RAET1E

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Jinfukang increases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

27392435

Hsa-miR-8485 affects RAET1E

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Hsa-miR-8485 decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-7977 affects RAET1E

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Hsa-miR-7977 decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6847-3p affects RAET1E

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Hsa-miR-6847-3p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6821-5p affects RAET1E

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Hsa-miR-6821-5p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6811-3p affects RAET1E

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Hsa-miR-6811-3p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6733-3p affects RAET1E

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Hsa-miR-6733-3p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6514-3p affects RAET1E

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Hsa-miR-6514-3p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-5690 affects RAET1E

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Hsa-miR-5690 decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-557 affects RAET1E

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Hsa-miR-557 decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-512-5p affects RAET1E

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Hsa-miR-512-5p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-510-5p affects RAET1E

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Hsa-miR-510-5p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-507 affects RAET1E

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Hsa-miR-507 decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-450b-5p affects RAET1E

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Hsa-miR-450b-5p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4302 affects RAET1E

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Hsa-miR-4302 decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4284 affects RAET1E

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Hsa-miR-4284 decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4276 affects RAET1E

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Hsa-miR-4276 decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-3680-3p affects RAET1E

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Hsa-miR-3680-3p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-33b-5p affects RAET1E

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Hsa-miR-33b-5p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-33a-5p affects RAET1E

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Hsa-miR-33a-5p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-24-3p affects RAET1E

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Hsa-miR-24-3p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-214-5p affects RAET1E

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Hsa-miR-214-5p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-129-5p affects RAET1E

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Hsa-miR-129-5p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-1268b affects RAET1E

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Hsa-miR-1268b decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-1268a affects RAET1E

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Hsa-miR-1268a decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-124-3p affects RAET1E

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Hsa-miR-124-3p decreases the amount of RAET1E. 1 / 1

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biopax:mirtarbase

No evidence text available

18668037

Glycoprotein affects RAET1E

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Glycoprotein binds RAET1E. 1 / 1

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"Unlike ULBP1 and ULBP2, ULBP4 is not bound by the name-giving HCMV glycoprotein UL16 [ xref , xref ], and therefore ULBP4 can be considered as a misnomer."

33556116

Formaldehyde affects RAET1E

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Formaldehyde increases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

27664576

Fenofibrate affects RAET1E

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Fenofibrate increases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

11798191

Endosulfan affects RAET1E

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Endosulfan increases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

29391264

Dichloroacetic acid affects RAET1E

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Dichloroacetic acid increases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

28962523

Dibenz[a,h]anthracene affects RAET1E

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Dibenz[a,h]anthracene decreases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

26377693

Clofibrate affects RAET1E

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Clofibrate increases the amount of RAET1E. 1 / 1

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➶

ctd

No evidence text available

17585979

Avobenzone affects RAET1E

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Avobenzone decreases the amount of RAET1E. 1 / 1

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ctd

No evidence text available

31016361

Arsenite(3-) affects RAET1E

1 |

Arsenite(3-) demethylates RAET1E. 1 / 1

1 |

➶

ctd

No evidence text available

23974009

Aluminium atom affects RAET1E

1 |

Aluminium atom decreases the amount of RAET1E. 1 / 1

1 |

➶

ctd

No evidence text available

21298039

Vgamma9Vdelta2 affects RAET1E

| 1

Vgamma9Vdelta2 activates RAET1E. 1 / 1

| 1

➶

reach

"Overexpression of the NKG2D ligands ULBP1 and ULBP4 by hematological and epithelial tumors, respectively, drives efficient cytotoxic responses by Vgamma9Vdelta2 T-cells."

29867961

ULBP3 affects MICA

| 1

ULBP3 binds RAET1E and MICA. 1 / 1

| 1

➶

sparser

"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."

20536569

TNFSF9 affects RAET1E

1 |

TNFSF9 binds RAET1E. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

TFF2 affects RAET1E

| 1

TFF2 inhibits RAET1E. 1 / 1

| 1

➶

reach

"The Raet1e promoter is repressed by HDAC3 in an Sp dependent manner."

27874833

TCRgamma9 affects RAET1E

| 1

RAET1E binds TCRgamma9. 1 / 1

| 1

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reach

"The NKG2D ligand ULBP4 binds to TCRgamma9 and delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D."

19436053

SDK2 affects RAET1E

1 |

RAET1E binds SDK2. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RYK affects RAET1E

1 |

RYK binds RAET1E. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects δ

| 1

RAET1E activates δ. 1 / 1

| 1

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reach

"Overexpression of the ULBP1 and ULBP4 on the leukemia, lymphoma and epithelial tumors, respectively, induces cytotoxicity of Vγ9Vδ2 T cells to tumor cells [42]."

32413966

RAET1E affects transcription, DNA-templated

| 1

RAET1E inhibits transcription, DNA-templated. 1 / 1

| 1

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reach

"It remains unclear, however, whether AP-1 acts directly on the Raet1e gene to repress transcription or by an indirect mechanism that alters Raet1e transcription or mRNA stability."

23298206

RAET1E affects soluble 35-kDa protein

| 1

RAET1E activates soluble 35-kDa protein. 1 / 1

| 1

➶

eidos

"RAET1E belongs to a ligand family for NKG2D in humans and can produce a soluble , 35-kDa protein ( named RAET1E2 ) in tumor cells ."

| PMC

RAET1E affects pspA

| 1

RAET1E activates pspA. 1 / 1

| 1

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reach

"RAET1E belongs to a ligand family for NKG2D in humans and can produce a soluble, 35-kDa protein (named RAET1E2) in tumor cells."

| PMC

RAET1E affects luciferase reporter construct

| 1

RAET1E activates luciferase reporter construct. 1 / 1

| 1

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reach

"E2F overexpression was sufficient to activate endogenous Raet1 genes in cells as well as a luciferase reporter construct driven by the Raet1e promoter."

24507156

RAET1E affects glycoprotein

| 1

Glycoprotein binds RAET1E. 1 / 1

| 1

➶

sparser

"Unlike ULBP1 and ULBP2, ULBP4 is not bound by the name-giving HCMV glycoprotein UL16 [ xref , xref ], and therefore ULBP4 can be considered as a misnomer."

33556116

RAET1E affects atherosclerosis modifier locus Ath11 10b

| 1

RAET1E activates atherosclerosis modifier locus Ath11 10b. 1 / 1

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reach

"Altered expression of Raet1e, a major histocompatibility complex class 1 like molecule, underlies the atherosclerosis modifier locus Ath11 10b."

23948654

RAET1E affects adverse response

| 1

RAET1E activates adverse response. 1 / 1

| 1

➶

eidos

"We then transiently knocked down the expression of Raet1e via siRNA inUbr5 - / -4 T1 tumor ( Figure 5b ) , which , when implanted in mice , caused a partial reversal of the inhibited growth of the parental tumor ( Figure 5c ) , but did not alter thein vitro growth rates ( Figure S1E ) , suggesting that higher Raet1e expression may mediate an adverse response against the tumor and that UBR5 deficiency in tumor cells may generate immunogens that attract anti-tumor responses.Upregulated proteins inUbr5 - / -4 T1 tumor.Potential immunogens and interacting partners controlled by UBR5 ."

32363114

RAET1E affects TNFSF9

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TNFSF9 binds RAET1E. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects TCRgamma9

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RAET1E binds TCRgamma9. 1 / 1

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reach

"The NKG2D ligand ULBP4 binds to TCRgamma9 and delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D."

19436053

RAET1E affects T cell-mediated cytotoxicity tumor cells.18Decreased Raet1e

| 1

RAET1E activates T cell-mediated cytotoxicity tumor cells.18Decreased Raet1e. 1 / 1

| 1

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eidos

"It has been shown to function as a ligand for both TCRgamma9delta2and NKG2D through which Raet1e induces T cell-mediated cytotoxicity to tumor cells.18Decreased Raet1e expression is a poor prognostic marker in nasopharyngeal carcinoma ,19 whereas high expression of Raet1e is an indicator of good prognosis in cervical cancer.20We first confirmed the MS finding of Raet1e 's overexpression by Western blot in WT and inUbr5 - / - cells treated with the proteasome inhibitor MG132 ( Figure 5a ) , which also indicated that Raet1e protein level was indeed regulated by a proteasome-mediated mechanism ."

32363114

RAET1E affects SDK2

1 |

RAET1E binds SDK2. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects RYK

1 |

RYK binds RAET1E. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects RAE1

| 1

RAET1E increases the amount of RAE1. 1 / 1

| 1

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reach

"Although E2F sites in the Raet1e promoter have been shown to drive RAE-1 expression during proliferation, these sites were dispensable for activation of the Raet1e promoter by m18 (XREF_FIG)."

27874833

RAET1E affects RAB3B

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RAET1E binds RAB3B. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects PODXL2

1 |

RAET1E binds PODXL2. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects Neoplasms

| 1

RAET1E activates Neoplasms. 1 / 1

| 1

➶

eidos

"Ligands for NKG2D include MICA , ULBP4 , and ULBP1 , which are implicated in NKG2D mediated recognition of multiple cancers 8, 9 ."

34234868

RAET1E affects NRN1

1 |

RAET1E binds NRN1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects NKG2D-mediated NK cell cytotoxicity

| 1

RAET1E inhibits NKG2D-mediated NK cell cytotoxicity. 1 / 1

| 1

➶

eidos

"In other words , RAET1E might impair NKG2D-mediated NK cell cytotoxicity to tumors [ 43 ] ."

| PMC

RAET1E affects NCR3LG1

1 |

RAET1E binds NCR3LG1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects Major Histocompatibility Complex Class 1

| 1

RAET1E activates Major Histocompatibility Complex Class 1. 1 / 1

| 1

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reach

"Altered Expression of Raet1e, a Major Histocompatibility Complex Class 1 Like Molecule, Underlies the Atherosclerosis Modifier Locus Ath11 10b."

23948654

RAET1E affects MICA

| 1

ULBP3 binds RAET1E and MICA. 1 / 1

| 1

➶

sparser

"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."

20536569

RAET1E affects MFAP3

1 |

RAET1E binds MFAP3. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects IGDCC4

1 |

IGDCC4 binds RAET1E. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects IFNGR1

1 |

RAET1E binds IFNGR1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects GOLIM4

1 |

GOLIM4 binds RAET1E. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects FGFR2

1 |

RAET1E binds FGFR2. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects FGFR1

1 |

RAET1E binds FGFR1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects FAS

| 1

RAET1E decreases the amount of FAS. 1 / 1

| 1

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reach

"Letal also down-regulated the expression of Fas in CD8+ cells and rendered them resistant to Fas ligand induced apoptosis."

15026360

RAET1E affects EPHA7

1 |

RAET1E binds EPHA7. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects E2F1

| 1

RAET1E binds E2F1. 1 / 1

| 1

➶

sparser

23298206

RAET1E affects E2F

| 1

E2F binds RAET1E. 1 / 1

| 1

➶

sparser

"Collectively, the data demonstrate that E2F transcription factors bind and transactivate the Raet1e promoter, play an important role in supporting Raet1 transcription in proliferating cells, and function potentially redundantly in driving Raet1 transcription."

23166357

RAET1E affects DUMO1

| 1

RAET1E binds DUMO1. 1 / 1

| 1

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reach

"While ULBP4 specific pAb and mAb 709116 bound ststULBP4_im and ULBP4 transfectants similarly to DUMO1, we did not detect binding of mAb 6E6 neither to ststULBP_im nor to the ULBP4 transfectants by flow cytometry, although mAb 6E6 brightly detected denatured ststULBP4 in immunoblotting (data not shown)."

29651291

RAET1E affects Atherosclerosis Modifier Locus Ath11 10b

| 1

RAET1E activates Atherosclerosis Modifier Locus Ath11 10b. 1 / 1

| 1

➶

reach

"Altered Expression of Raet1e, a Major Histocompatibility Complex Class 1 Like Molecule, Underlies the Atherosclerosis Modifier Locus Ath11 10b."

23948654

RAET1E affects ARL8B

1 |

RAET1E binds ARL8B. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects ALG11

1 |

RAET1E binds ALG11. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

RAET1E affects 4-aminobenzoic acid

| 1

4-aminobenzoic acid binds RAET1E. 1 / 1

| 1

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reach

29651291

RAB3B affects RAET1E

1 |

RAET1E binds RAB3B. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

PODXL2 affects RAET1E

1 |

RAET1E binds PODXL2. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

PAMP affects RAET1E

| 1

PAMP increases the amount of RAET1E. 1 / 1

| 1

➶

reach

"Collectively, the presented data exclude that ULBP4 is expressed by human monocytes under normal conditions and upon activation by PAMP."

33556116

RAET1E is modified

| 1

RAET1E is glycosylated. 1 / 1

| 1

➶

sparser

"Position 82 is polymorphic and occupied either by asparagine (stULBP4) or tyrosine (Uniprot reference sequence at), and therefore ULBP4 glycosylation can be expected to be variable within the human population with potential consequences for expression and detection."

29651291

NRN1 affects RAET1E

1 |

RAET1E binds NRN1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

NCR3LG1 affects RAET1E

1 |

RAET1E binds NCR3LG1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

MKN45 cells HKHP affects RAET1E

| 1

MKN45 cells HKHP activates RAET1E. 1 / 1

| 1

➶

eidos

"Stimulation of MKN45 cells with HKHP increased MICA , ULBP4 ( another NKG2DL ) , and TLR4 at the protein and transcriptional levels ."

33928707

MICA affects ULBP3

| 1

ULBP3 binds RAET1E and MICA. 1 / 1

| 1

➶

sparser

"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."

20536569

MFAP3 affects RAET1E

1 |

RAET1E binds MFAP3. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

IGDCC4 affects RAET1E

1 |

IGDCC4 binds RAET1E. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

IFNGR1 affects RAET1E

1 |

RAET1E binds IFNGR1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

HDAC3 affects RAET1E

| 1

HDAC3 inhibits RAET1E. 1 / 1

| 1

➶

reach

"The Raet1e promoter is repressed by HDAC3 in an Sp dependent manner."

27874833

GRB2 affects KLRK1, MICA, MICB, PIK3R1, RAET1E, TYROBP, ULBP1, and ULBP3

| 1

TYROBP binds ULBP1, ULBP3, RAET1E, KLRK1, GRB2, MICA, MICB, and PIK3R1. 1 / 1

| 1

➶

sparser

"Protein–protein interaction analysis showed that the top 10 proteins associated with the HCST included TYROBP, KLRC4, MICA, MICB, ULBP3, ULBP1, RAET1E, GRB2, KLRK1, and PIK3R1, which are mainly involved in the immune response and tumorigenesis."

33968730

GOLIM4 affects RAET1E

1 |

GOLIM4 binds RAET1E. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

FGFR2 affects RAET1E

1 |

RAET1E binds FGFR2. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

FGFR1 affects RAET1E

1 |

RAET1E binds FGFR1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

EPHA7 affects RAET1E

1 |

RAET1E binds EPHA7. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

EC 3.5.1.98 (histone deacetylase) inhibitor affects RAET1E

| 1

EC 3.5.1.98 (histone deacetylase) inhibitor inhibits RAET1E. 1 / 1

| 1

➶

reach

"Consistent with these findings, we observed that the chemical HDAC inhibitor butyrate activated the WT Raet1e promoter (XREF_FIG)."

27874833

E2F affects RAET1E

| 1

E2F binds RAET1E. 1 / 1

| 1

➶

sparser

23166357

Dietary Fats affects RAET1E

1 |

Dietary Fats increases the amount of RAET1E. 1 / 1

1 |

➶

ctd

No evidence text available

25016146

DUMO1 affects RAET1E

| 1

RAET1E binds DUMO1. 1 / 1

| 1

➶

reach

29651291

DKK1 affects RAET1E

| 1

DKK1 inhibits RAET1E. 1 / 1

| 1

➶

reach

"DKK1 knockdown in H2087-LCC cells increased the expression of NK cell activating ligands ULBP1, ULBP2, ULBP4, and ULBP5 and death signal receptors."

27015306

CYP19A1 affects CYP3A4, EBPL, FGF4, KLF2, MASP1, MMP20, NUAK1, PTPN2, RAET1E, SERPINE2, and SOX18

| 1

SOX18 binds NUAK1, RAET1E, EBPL, CYP19A1, CYP3A4, FGF4, KLF2, MASP1, SERPINE2, PTPN2, and MMP20. 1 / 1

| 1

➶

sparser

"FGF4, CYP19A1, PTPN2, CYP3A4, SERPINE2, SOX18, MMP20, MASP1, KLF2, ERP44, NUAK1 and RAET1E are directly associated with SCC."

29805591

CRNDE affects RAET1E

| 1

CRNDE decreases the amount of RAET1E. 1 / 1

| 1

➶

reach

"The results showed that knockdown of CRNDE increased DUSP5, CDKN1A, EMP1, RAET1E, and CDKN2B expression, but decreased RPL23A, EIF4E2, QPRT, ACSS1, and APCDD1 expression (XREF_FIG)."

28796262