IndraLab

Statements

RAET1E affects KLRK1
2 | 8 1
RAET1E binds KLRK1.
2 | 3 1
RAET1E binds KLRK1. 6 / 8
2 | 3 1
sparser
"ULBP4-NKG2D interaction can not only activate NK cell and NK-mediated cytotoxicity [ xref , xref , xref ], but also serve to stimulate the cytotoxicity of CD8+ T cell [ xref ], which suggests an influence of ULBP4 on both innate and adaptive immune responses."
28159927
hprd
No evidence text available
14508119
hprd
No evidence text available
12732206
reach
"In addition, the receptor–ligand analysis using the CellPhoneDB database illustrated that the strength of the interaction between NKG2DLs, including MICB (Micb) and RAET1E (Raet1e), of NP cells and the NKG2D of the identified other cells, was increased at 8 w post‐puncture (Figure 2G)."
38554394
reach
"RAET1E binds and activates NKG2D-expressing NK and CD8 T cells, with RAET family members typically absent on normal cells but overexpressed under stress."
39994453
reach
"It is intriguing that ULBP-4 and hMSH2 can also bind to NKG2D to induce the cytotoxicity of Vgamma9Vdelta2-T cells against tumor cells through TCR and NKG2D engagement."
28894450
RAET1E inhibits KLRK1.
| 3
RAET1E inhibits KLRK1. 3 / 3
| 3
reach
"In other words, RAET1E might impair NKG2D mediated NK cell cytotoxicity to tumors [XREF_BIBR]."
| PMC
reach
"RAET1E2, a soluble isoform of the UL16 binding protein RAET1E produced by tumor cells, inhibits NKG2D mediated NK cytotoxicity."
17470428
reach
"We previously reported that RAET1E2, a soluble isoform of the RAET1E (ULBP4), inhibits NKG2D mediated NK cytotoxicity."
19436053
RAET1E decreases the amount of KLRK1.
| 1
RAET1E decreases the amount of KLRK1. 1 / 2
| 1
reach
"Moreover, co-culture-free soluble forms of ULBP4 splice variants (their alpha1 + alpha2 ectodomains) and RAET1G3 (soluble splice variant of RAET1G2) with NK cells down-regulated the cell surface expression of NKG2D."
18544572
RAET1E activates KLRK1.
| 1
RAET1E activates KLRK1. 1 / 2
| 1
reach
"Indeed a soluble, secreted splicing variant of RAET1E has also been reported XREF_BIBR Therefore expression of soluble isoforms of RAET1G and RAET1E could allow cancer cells to produce soluble NKG2D ligand without the need for metalloproteinase activity."
19223974
Delta-actitoxin-Avd1a binds RAET1E. 10 / 12
| 12
sparser
"Pathways such as TNF-α Signaling via NF-κB exhibited downregulation of key genes (LIF, REL, RNF19B) and upregulation of NR4A1, with RAET1E-AS1 regulating multiple mRNAs."
41102192
sparser
"RAET1E-AS1 and LINC02145 were not expressed in this cell line, as confirmed in RNA-seq data of D425 cells in the CCMA database [ xref ] (expression 0 or < 1 CPM)."
39198884
sparser
"Moreover, we found that five lncRNAs (RAET1E-AS1, LOC102723591, LOC105373230, LOC112267883, and LINC02595) and five circRNAs (hsa_circ_0017534, hsa_circ_0092630, hsa_circ_0080906, hsa_circ_0075045, and hsa_circ_0080909) were significantly upregulated in O-ASCs, compared with Y-ASCs (Fig. xref c)."
34051854
sparser
"We randomly selected hsa-miR-145-5p for further analysis; it had ceRNA relationships with four mRNAs (ITGB8, WNT11, BMPER, and RARRES3), two lncRNAs (RAET1E-AS1 and LOC102723591), and one circRNA (hsa_circ_0092630) (Fig. xref e)."
34051854
sparser
"Correlation analyses revealed that the expression levels of RAET1E-AS1, WNT11, and BMPER had significantly negative correlations with the expression level of hsa-miR-145-5p (Fig. xref g–i), while the other RNAs did not exhibit such relationships (Figure S xref C, D)."
34051854
sparser
"Interestingly, transcriptome-neuroimaging association analysis demonstrated the correlations between regional rSC-FC coupling variations between MDD patients and HCs and α/β-hydrolase domain-containing 6 (ABHD6), β 1,3-N-acetylglucosaminyltransferase-9(β3GNT9), transmembrane protein 45B (TMEM45B), the correlation between regional dSC-FC coupling variations and retinoic acid early transcript 1E antisense RNA 1(RAET1E-AS1), and the correlations between regional iSC-FC coupling variations and ABHD6, β3GNT9, katanin-like 2 protein (KATNAL2)."
38971483
sparser
"Furthermore, the expression level of RAET1E-AS1 had a significantly positive correlation with the expression levels of WNT11 and BMPER (Fig. xref j, k)."
34051854
sparser
"Finally, we found that overexpression of has-miR-145-5p in ASCs could significantly downregulated the expression levels of WNT11, BMPER, RAET1E-AS1, LOC102723591, and hsa_circ_0092630 (Fig. xref l)."
34051854
sparser
"RAET1E-AS1 and LINC02145 were not expressed in this cell line, as confirmed in RNA-seq data of D425 cells in the CCMA database [ xref ] (expression 0 or < 1 CPM)."
39281885
sparser
"However, the role of the lncRNA RAET1E-AS1 in cell biology has not been explored."
34051854
KLRK1 affects RAET1E
2 | 3 1
RAET1E binds KLRK1. 6 / 8
2 | 3 1
sparser
"ULBP4-NKG2D interaction can not only activate NK cell and NK-mediated cytotoxicity [ xref , xref , xref ], but also serve to stimulate the cytotoxicity of CD8+ T cell [ xref ], which suggests an influence of ULBP4 on both innate and adaptive immune responses."
28159927
hprd
No evidence text available
14508119
hprd
No evidence text available
12732206
reach
"In addition, the receptor–ligand analysis using the CellPhoneDB database illustrated that the strength of the interaction between NKG2DLs, including MICB (Micb) and RAET1E (Raet1e), of NP cells and the NKG2D of the identified other cells, was increased at 8 w post‐puncture (Figure 2G)."
38554394
reach
"RAET1E binds and activates NKG2D-expressing NK and CD8 T cells, with RAET family members typically absent on normal cells but overexpressed under stress."
39994453
reach
"It is intriguing that ULBP-4 and hMSH2 can also bind to NKG2D to induce the cytotoxicity of Vgamma9Vdelta2-T cells against tumor cells through TCR and NKG2D engagement."
28894450
TGFB affects RAET1E
| 6
TGFB decreases the amount of RAET1E.
| 5
TGFB decreases the amount of RAET1E. 5 / 5
| 5
reach
"Additionally, transforming growth factor-beta (TGF-beta) selectively downregulates the expression of MICA, ULBP2, and ULBP4, but not MICB, ULBP1, or ULBP3, in malignant glioma cells [XREF_BIBR]."
24885711
reach
"We further delineate two independent mechanisms that can explain these expression patterns : (i) transforming growth factor-beta (TGF-beta) is upregulated during malignant progression and selectively downregulates MICA, ULBP2 and ULBP4 expression, while MICB, ULBP1 and ULBP3 are unaffected."
16891318
reach
"TGF-beta inhibits the transcription of MICA, ULBP2, and ULBP4 mRNA, whereas MICB, ULBP1, and ULBP3 mRNA levels remained unchanged."
30813924
reach
"For example, the treatment of human melanoma cells with IFN-γ reduces MICA levels [21], and TGF-β downregulates the transcription of MICA, ULBP2, and ULBP4 in human malignant gliomas [22]."
37603573
reach
"Secretion of TGF-beta by NPC cells is well documented and is known to promote the progression and metastasis of NPC [XREF_BIBR, XREF_BIBR], herein ULBP4 expression may be also downregulated by TGF-beta on NPC cells."
28159927
TGFB inhibits RAET1E.
| 1
TGFB inhibits RAET1E. 1 / 1
| 1
reach
"Elevated TGF-β levels as detected in glioblastoma patients were also shown to affect the expression of NKG2DLs (104, 112): experimentally reduced TGF-β expression by glioma cells led to an increase of MICA, ULBP2, and ULBP4 transcripts and increased cell surface expression of MICA and ULBP2 as well as of a reduction of tumorigenicity in vivo (104, 112)."
31803194
ULBP2 affects RAET1E
2 | 1 1
RAET1E binds ULBP2. 4 / 4
2 | 1 1
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
sparser
"However, it is noteworthy that high expression of ULBP2 and ULBP4 has been paradoxically associated with poor prognosis in ovarian cancer, and it does not appear to be related to an increase of the shedding of these molecules ( xref , xref )."
24711808
reach
"RAET1E ∗ 002 was more associated RAET1H ∗ 002 and RAET1E ∗ 005 was associated with RAET1L ∗ 002."
23416094
TCR affects RAET1E
| 2 2
RAET1E binds TCR. 4 / 4
| 2 2
reach
"We also show that ULBP4 binds to a soluble chimeric protein containing TCRgamma9 and delta2 and activates TCR (-) Jurkat T cells transfected with TCRgamma9 and delta2."
19436053
sparser
"ULBP4 also can bind to Vγ9Vδ2 TCR and thus induce the cytotoxic activity of Vγ9Vδ2T cells toward tumor cells through both TCR and NKG2D engagement ( xref )."
25538706
sparser
"They can be activated by γδ TCR ligands such as phosphoantigens, or by MHC-associated ligands of the activatory receptor killer cell lectin-like receptor subfamily K, member 1 (KLRK1, best known as NKG2D, such as MHC class I polypeptide-related sequence A (MICA), MICB, and various members of the UL16-binding protein (ULBP) family. γδ T cells also express killer-cell immunoglobulin-like receptors (KIRs), which can be either activatory or inhibitory, including killer cell immunoglobulin-like receptor, 2 domains, long cytoplasmic tail, 1 (KIR2DL1) xref and killer cell immunoglobulin-like receptor, 3 domains, long cytoplasmic tail, 1 (KIR3DL1). xref Tumors possess the ability to manipulate this balance to stimulate tolerance by inhibitory signals, including soluble NKG2D ligands, transforming growth factor β1 (TGFβ1), galectin 3 and prostaglandin E 2 (PGE 2 ) xref , xref , xref , xref Elevated circulating levels of sMICA, sMICB, and sULBP1 might be particularly active against effector γδ T cells, as the latter express high amounts of NKG2D. Of interest, the NKG2D ligand ULBP4 may bind to the TCR of some γδ T-cell subsets, and this may exacerbate their inhibition by neuroblastoma cells. xref "
24734216
reach
"Of interest, the NKG2D ligand ULBP4 may bind to the TCR of some gammadelta T-cell subsets, and this may exacerbate their inhibition by neuroblastoma cells."
24734216
RAET1E affects ULBP2
2 | 1 1
RAET1E binds ULBP2. 4 / 4
2 | 1 1
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
sparser
"However, it is noteworthy that high expression of ULBP2 and ULBP4 has been paradoxically associated with poor prognosis in ovarian cancer, and it does not appear to be related to an increase of the shedding of these molecules ( xref , xref )."
24711808
reach
"RAET1E ∗ 002 was more associated RAET1H ∗ 002 and RAET1E ∗ 005 was associated with RAET1L ∗ 002."
23416094
RAET1E affects TCR
| 2 2
RAET1E binds TCR. 4 / 4
| 2 2
reach
"We also show that ULBP4 binds to a soluble chimeric protein containing TCRgamma9 and delta2 and activates TCR (-) Jurkat T cells transfected with TCRgamma9 and delta2."
19436053
sparser
"ULBP4 also can bind to Vγ9Vδ2 TCR and thus induce the cytotoxic activity of Vγ9Vδ2T cells toward tumor cells through both TCR and NKG2D engagement ( xref )."
25538706
sparser
"They can be activated by γδ TCR ligands such as phosphoantigens, or by MHC-associated ligands of the activatory receptor killer cell lectin-like receptor subfamily K, member 1 (KLRK1, best known as NKG2D, such as MHC class I polypeptide-related sequence A (MICA), MICB, and various members of the UL16-binding protein (ULBP) family. γδ T cells also express killer-cell immunoglobulin-like receptors (KIRs), which can be either activatory or inhibitory, including killer cell immunoglobulin-like receptor, 2 domains, long cytoplasmic tail, 1 (KIR2DL1) xref and killer cell immunoglobulin-like receptor, 3 domains, long cytoplasmic tail, 1 (KIR3DL1). xref Tumors possess the ability to manipulate this balance to stimulate tolerance by inhibitory signals, including soluble NKG2D ligands, transforming growth factor β1 (TGFβ1), galectin 3 and prostaglandin E 2 (PGE 2 ) xref , xref , xref , xref Elevated circulating levels of sMICA, sMICB, and sULBP1 might be particularly active against effector γδ T cells, as the latter express high amounts of NKG2D. Of interest, the NKG2D ligand ULBP4 may bind to the TCR of some γδ T-cell subsets, and this may exacerbate their inhibition by neuroblastoma cells. xref "
24734216
reach
"Of interest, the NKG2D ligand ULBP4 may bind to the TCR of some gammadelta T-cell subsets, and this may exacerbate their inhibition by neuroblastoma cells."
24734216
RAET1E affects CSF2
| 4
RAET1E activates CSF2.
| 3
RAET1E activates CSF2. 3 / 3
| 3
reach
"Soluble ULBP4 (sULBP4) was significantly elevated in the CSF of female MS patients compared to controls and male MS patients [81]."
38139373
reach
"Therefore, we investigated whether soluble ULBP4, which is elevated in the CSF from female patients with MS, has an impact on CD8 T lymphocyte functions."
34873031
reach
"The data suggest that a soluble form of ULBP4, which is enriched in the CSF of female patients with MS, can enhance the production of GM-CSF and IFNγ by activated human CD8 T lymphocytes."
34873031
RAET1E increases the amount of CSF2.
| 1
RAET1E increases the amount of CSF2. 1 / 1
| 1
reach
"The addition of soluble ULBP4 to human CD8 T lymphocytes activated with anti-CD3 (Figure 4C) significantly increased the secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IFNγ (Figure 4, C and D), 2 key inflammatory cytokines."
34873031
Pirinixic acid affects RAET1E
3 |
Pirinixic acid increases the amount of RAET1E. 3 / 3
3 |
ctd
No evidence text available
20813756
ctd
No evidence text available
11798191
ctd
No evidence text available
23811191
Paracetamol affects RAET1E
3 |
Paracetamol decreases the amount of RAET1E.
2 |
Paracetamol decreases the amount of RAET1E. 2 / 2
2 |
ctd
No evidence text available
17585979
ctd
No evidence text available
22230336
Paracetamol increases the amount of RAET1E.
1 |
Paracetamol increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
33387578
Aflatoxin B1 affects RAET1E
3 |
Aflatoxin B1 increases the amount of RAET1E.
2 |
Aflatoxin B1 increases the amount of RAET1E. 2 / 2
2 |
ctd
No evidence text available
32234424
ctd
No evidence text available
22100608
Aflatoxin B1 methylates RAET1E.
1 |
Aflatoxin B1 methylates RAET1E. 1 / 1
1 |
ctd
No evidence text available
27153756
ULBP3 affects RAET1E
2 | 1
RAET1E binds ULBP3. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
MICA binds ULBP3 and RAET1E. 1 / 1
| 1
sparser
"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."
20536569
RAET1E
2 | 1
RAET1E binds.
2 |
RAET1E binds RAET1E. 2 / 2
2 |
hprd
No evidence text available
15240696
hprd
No evidence text available
12732206
RAET1E translocates.
| 1
RAET1E translocates from the cytoplasm to the plasma membrane. 1 / 1
| 1
sparser
"In addition, we showed that HCQ did not affect the synthesis or degradation of ULBP4, but induced the translocation of ULBP4 from the cytoplasm to the cell membrane."
28339029
RAET1E affects ULBP3
2 | 1
RAET1E binds ULBP3. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
MICA binds ULBP3 and RAET1E. 1 / 1
| 1
sparser
"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."
20536569
E2F1 affects RAET1E
| 2 1
E2F1 activates RAET1E.
| 2
E2F1 activates RAET1E. 2 / 2
| 2
reach
"To investigate whether E2F1 activates the Raet1e promoter reporter construct described in XREF_FIG, fibroblasts maintained in 0% serum were cotransfected with the reporter construct and increasing amounts of a pcDNA vector encoding E2F1."
23166357
reach
"E2F1 was much less effective in activating a Raet1e reporter plasmid in which both putative E2F sites were mutated, indicating that E2F transcription factors directly bind and activate the Raet1e promoter construct (XREF_FIG, right)."
23166357
E2F1 binds RAET1E.
| 1
E2F1 binds RAET1E. 1 / 1
| 1
sparser
"An investigation of the roles of factors known to regulate the cell cycle showed that E2F1–3, the activating E2F transcription factors, bind to the Raet1e promoter in vivo and transactivate the endogenous Raet1e gene as well as the Raet1e promoter in a reporter plasmid."
23298206
Trichloroethene affects RAET1E
2 |
Trichloroethene increases the amount of RAET1E.
1 |
Trichloroethene increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
25549359
Trichloroethene decreases the amount of RAET1E.
1 |
Trichloroethene decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
33387578
Titanium dioxide affects RAET1E
2 |
Titanium dioxide increases the amount of RAET1E. 2 / 2
2 |
ctd
No evidence text available
35295148
ctd
No evidence text available
31298478
Reliable detection reagents affects RAET1E
| 2
Reliable detection reagents activates RAET1E. 2 / 2
| 2
eidos
"Reply : For clarification , we amended the text as follows : '' The lack of knowledge on ULBP4 is in part due to the scarcity of reliable detection reagents , since there are only a few `` ULBP4-specific '' antibodies commercially available with some even showing cross-reactivity to undefined antigen ( s ) on cells not containing ULBP4 transcripts ( Zoller et al ., 2018 ) ."
33556116
eidos
"The lack of knowledge on ULBP4 is in part due to the scarcity of reliable detection reagents , since there are only a few `` ULBP4-specific '' antibodies commercially available with some even showing cross-reactivity to undefined antigen ( s ) on cells not containing ULBP4 transcripts [ 32 ] ."
33556116
Cadmium dichloride decreases the amount of RAET1E. 2 / 2
2 |
ctd
No evidence text available
33453195
ctd
No evidence text available
38568856
Butyrate affects RAET1E
| 2
Butyrate activates RAET1E. 1 / 1
| 1
reach
"Consistent with these findings, we observed that the chemical HDAC inhibitor butyrate activated the WT Raet1e promoter (XREF_FIG)."
27874833
Butyrate activates mutated RAET1E. 1 / 1
| 1
reach
"Interestingly, butyrate treatment failed to drive expression from the m18RE * mutant Raet1e promoter (XREF_FIG)."
27874833
Benzo[a]pyrene affects RAET1E
2 |
Benzo[a]pyrene increases the amount of RAET1E.
1 |
Benzo[a]pyrene increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
32234424
Benzo[a]pyrene demethylates RAET1E.
1 |
Benzo[a]pyrene demethylates RAET1E. 1 / 1
1 |
ctd
No evidence text available
27901495
TNFSF9 affects RAET1E
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RAET1E binds TNFSF9. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
SDK2 affects RAET1E
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RAET1E binds SDK2. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
RYK affects RAET1E
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RAET1E binds RYK. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
RAET1G affects RAET1E
| 2
RAET1E binds RAET1G. 2 / 2
| 2
sparser
"Intriguingly, although the results of our multivariate analysis were not significant, in univariate analysis, high RAET1E or RAET1G expression was associated with poor disease-free survival (Table  xref )."
25510288
sparser
"Given the results of Cao et al.’s study and the fact that many isoforms were also stained during RAET1E and RAET1G IHC staining, it is possible that high RAET1E and RAET1G expression may be associated with poor prognosis."
25510288
RAET1E affects immune response
| 2
RAET1E activates immune response. 2 / 2
| 2
reach
"Our results indicate that Letal promotes tumor immune surveillance by promoting the survival and intratumoral expansion of antitumor cytotoxic lymphocytes."
15026360
reach
"These results suggest that Letal delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes."
14508119
reach
"Simultaneous T-cell receptor activation and engagement of Letal stimulated proliferation of CD8 (+) cells and dramatically increased IL-2 and IFNgamma secretion."
14508119
reach
"Here we show that immobilized soluble ULBP4 (rULBP4) induces the proliferation of human ovarian epithelial carcinoma- or colonic carcinoma derived Vdelta2 (+) T cells in vitro."
19436053
RAET1E affects TNFSF9
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RAET1E binds TNFSF9. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
RAET1E affects SDK2
2 |
RAET1E binds SDK2. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
RAET1E affects RYK
2 |
RAET1E binds RYK. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
RAET1E affects RAET1G
| 2
RAET1E binds RAET1G. 2 / 2
| 2
sparser
"Intriguingly, although the results of our multivariate analysis were not significant, in univariate analysis, high RAET1E or RAET1G expression was associated with poor disease-free survival (Table  xref )."
25510288
sparser
"Given the results of Cao et al.’s study and the fact that many isoforms were also stained during RAET1E and RAET1G IHC staining, it is possible that high RAET1E and RAET1G expression may be associated with poor prognosis."
25510288
RAET1E affects RAB3B
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RAET1E binds RAB3B. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
RAET1E affects PODXL2
2 |
RAET1E binds PODXL2. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
RAET1E affects NRN1
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RAET1E binds NRN1. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
RAET1E affects NKG2DL
| 2
RAET1E increases the amount of NKG2DL. 2 / 2
| 2
reach
"Also, TIL but not PBL from paired patients, expressed MICA, ULBP3 and ULBP4 on their cell surface, suggesting that local mechanisms operating in the TME might trigger NKG2DL expression on TIL."
35936986
reach
"An analysis of the expression of NKG2DLs on lymphoid cells revealed that TIL, but not PBL from either ccRCC patients or HD, expressed MICA (Figures 4 A and b), ULBP3 (Figures 4 C and d) and ULBP4 (Figures 4 E and f), suggesting that the TME promotes NKG2DL expression on TIL."
35936986
RAET1E affects NCR3LG1
2 |
RAET1E binds NCR3LG1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
RAET1E affects MFAP3
2 |
RAET1E binds MFAP3. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
RAET1E affects IGDCC4
2 |
RAET1E binds IGDCC4. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
RAET1E affects IFNGR1
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RAET1E binds IFNGR1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
RAET1E affects GOLIM4
2 |
RAET1E binds GOLIM4. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
RAET1E affects FGFR2
2 |
RAET1E binds FGFR2. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
RAET1E affects FGFR1
2 |
RAET1E binds FGFR1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
RAET1E affects CD8
| 2
RAET1E activates CD8. 2 / 2
| 2
reach
"Simultaneous T-cell receptor activation and engagement of Letal stimulated proliferation of CD8 (+) cells and dramatically increased IL-2 and IFNgamma secretion."
14508119
reach
"As shown earlier, the intermediate cells had the highest expression of genes involved in co-stimulation and antigen presentation, but also genes involved in NK cell and CD8 T cell activation, such as MICB, RAET1E, RAET1G, RAET1L and ULBP3 were enriched on intermediate monocytes."
26650546
RAET1E affects ALG11
2 |
RAET1E binds ALG11. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
RAB3B affects RAET1E
2 |
RAET1E binds RAB3B. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
PODXL2 affects RAET1E
2 |
RAET1E binds PODXL2. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
Nanotubes, Carbon increases the amount of RAET1E.
1 |
Nanotubes, Carbon increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
25554681
Nanotubes, Carbon decreases the amount of RAET1E.
1 |
Nanotubes, Carbon decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
25620056
NRN1 affects RAET1E
2 |
RAET1E binds NRN1. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
NCR3LG1 affects RAET1E
2 |
RAET1E binds NCR3LG1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
MFAP3 affects RAET1E
2 |
RAET1E binds MFAP3. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
IGDCC4 affects RAET1E
2 |
RAET1E binds IGDCC4. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
IFNGR1 affects RAET1E
2 |
RAET1E binds IFNGR1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
GOLIM4 affects RAET1E
2 |
RAET1E binds GOLIM4. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
FGFR2 affects RAET1E
2 |
RAET1E binds FGFR2. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
FGFR1 affects RAET1E
2 |
RAET1E binds FGFR1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
ALG11 affects RAET1E
2 |
RAET1E binds ALG11. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
17beta-estradiol affects RAET1E
2 |
17beta-estradiol decreases the amount of RAET1E. 2 / 2
2 |
ctd
No evidence text available
39298647
ctd
No evidence text available
30165855
1,2-dichloroethane decreases the amount of RAET1E. 2 / 2
2 |
ctd
No evidence text available
28960355
ctd
No evidence text available
28189721
(+)-JQ1 compound affects RAET1E
2 |
(+)-JQ1 compound decreases the amount of RAET1E. 2 / 2
2 |
ctd
No evidence text available
26752646
ctd
No evidence text available
24796395
Δ affects RAET1E
| 1
Δ activates RAET1E. 1 / 1
| 1
reach
"Other human γδT cells recognize stress-induced MIC, ULBP4, or endothelial protein C receptor."
35381143
Triptonide affects RAET1E
1 |
Triptonide increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
33045310
Transcription factor JUNB decreases the amount of RAET1E. 1 / 1
| 1
reach
"The transcription of Raet1e was inhibited by the transcription factor JUNB in cell lines and mouse tissues XREF_BIBR."
19629084
Sodium dodecyl sulfate decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
31734321
Sodium arsenite affects RAET1E
1 |
Sodium arsenite increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
37682722
Silicon dioxide affects RAET1E
1 |
Silicon dioxide decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
25895662
Signaling receptor activity activates RAET1E. 1 / 1
| 1
reach
"Simultaneous T-cell receptor activation and engagement of Letal stimulated proliferation of CD8 (+) cells and dramatically increased IL-2 and IFNgamma secretion."
14508119
Self-made mAb DUMO1 affects RAET1E
| 1
Self-made mAb DUMO1 activates RAET1E. 1 / 1
| 1
eidos
"In contrast , our self-made mAb DUMO1 specifically binds to ULBP4-transfected cell lines ( but not mock-transfected cells ) and recombinantly produced ULBP4 , but does not bind to cells that do NOT contain ULBP4 / RAET1E transcripts such as HepG2 cells or human monocytes ( see Zoller et al ., 2018 and our present manuscript ) ."
33556116
Rotenone affects RAET1E
1 |
Rotenone decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
29955902
RhULBP4 affects RAET1E
| 1
RhULBP4 inhibits RAET1E. 1 / 1
| 1
reach
"We also confirmed the specificity of ULBP4 detection as preabsorption of the anti-ULBP4 antibody with the rhULBP4 abolished ULBP4 detection from protein lysates (data not shown)."
34873031
Resveratrol affects RAET1E
1 |
Resveratrol decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
31298478
Psmb9-a affects RAET1E
| 1
Psmb9-a inhibits RAET1E. 1 / 1
| 1
reach
"EBV LMP2A reduces MICA and ULBP4 in lymphoblastoid cell lines and inhibits recognition by CD8+ T cells [XREF_BIBR], and this allows it to block its recognition and destruction by NK cells."
27077876
Propanal affects RAET1E
1 |
Propanal increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
26079696
reach
"To determine whether the ULBP4 protein is transmembrane or GPI linked, cells expressing the transiently transfected ULBP4 or MICB or ULBP3 were treated with phosphatidylinositol specific phospholipase[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12732206
Perfluorooctane-1-sulfonic acid increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
36331819
Jinfukang affects RAET1E
1 |
Jinfukang increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
27392435
Hsa-mir-4302 affects RAET1E
1 |
Hsa-mir-4302 decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-mir-4284 affects RAET1E
1 |
Hsa-mir-4284 decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-mir-4276 affects RAET1E
1 |
Hsa-mir-4276 decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-mir-1268b affects RAET1E
1 |
Hsa-mir-1268b decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-8485 affects RAET1E
1 |
Hsa-miR-8485 decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-7977 affects RAET1E
1 |
Hsa-miR-7977 decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6847-3p affects RAET1E
1 |
Hsa-miR-6847-3p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6821-5p affects RAET1E
1 |
Hsa-miR-6821-5p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6811-3p affects RAET1E
1 |
Hsa-miR-6811-3p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6733-3p affects RAET1E
1 |
Hsa-miR-6733-3p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-6514-3p affects RAET1E
1 |
Hsa-miR-6514-3p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-5690 affects RAET1E
1 |
Hsa-miR-5690 decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-512-5p affects RAET1E
1 |
Hsa-miR-512-5p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-510-5p affects RAET1E
1 |
Hsa-miR-510-5p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-450b-5p affects RAET1E
1 |
Hsa-miR-450b-5p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-3680-3p affects RAET1E
1 |
Hsa-miR-3680-3p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-33b-5p affects RAET1E
1 |
Hsa-miR-33b-5p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-33a-5p affects RAET1E
1 |
Hsa-miR-33a-5p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-24-3p affects RAET1E
1 |
Hsa-miR-24-3p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-214-5p affects RAET1E
1 |
Hsa-miR-214-5p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-129-5p affects RAET1E
1 |
Hsa-miR-129-5p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
Hsa-miR-124-3p affects RAET1E
1 |
Hsa-miR-124-3p decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18668037
Glycoprotein affects RAET1E
| 1
RAET1E binds glycoprotein. 1 / 1
| 1
sparser
"Unlike ULBP1 and ULBP2, ULBP4 is not bound by the name-giving HCMV glycoprotein UL16 [ xref , xref ], and therefore ULBP4 can be considered as a misnomer."
33556116
Formaldehyde affects RAET1E
1 |
Formaldehyde increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
27664576
Fenofibrate affects RAET1E
1 |
Fenofibrate increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
11798191
Endosulfan affects RAET1E
1 |
Endosulfan increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
29391264
Diisononyl 1,2-cyclohexanedicarboxylic acid decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
31605871
Dichloroacetic acid increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
28962523
Dibenz[a,h]anthracene decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
26377693
Deltamethrin affects RAET1E
1 |
Deltamethrin decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
37019170
Crocidolite asbestos increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
29279043
Clofibrate affects RAET1E
1 |
Clofibrate increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
17585979
Bisphenol A affects RAET1E
1 |
Bisphenol A increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
32156529
Beta-D-glucose affects RAET1E
1 |
Beta-D-glucose increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
36331819
Avobenzone affects RAET1E
1 |
Avobenzone decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
31016361
Arsenite(3-) affects RAET1E
1 |
Arsenite(3-) demethylates RAET1E. 1 / 1
1 |
ctd
No evidence text available
23974009
Aluminium atom affects RAET1E
1 |
Aluminium atom decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
21298039
Aldehydo-D-glucose increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
39613055
Vgamma9Vdelta2 affects RAET1E
| 1
Vgamma9Vdelta2 activates RAET1E. 1 / 1
| 1
reach
"Overexpression of the NKG2D ligands ULBP1 and ULBP4 by hematological and epithelial tumors, respectively, drives efficient cytotoxic responses by Vgamma9Vdelta2 T-cells."
29867961
ULBP3 affects MICA
| 1
MICA binds ULBP3 and RAET1E. 1 / 1
| 1
sparser
"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."
20536569
Tobacco Smoke Pollution decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
33660061
TCRgamma9 affects RAET1E
| 1
RAET1E binds TCRgamma9. 1 / 1
| 1
reach
"The NKG2D ligand ULBP4 binds to TCRgamma9 and delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D."
19436053
SP affects RAET1E
| 1
SP inhibits RAET1E. 1 / 1
| 1
reach
"The Raet1e promoter is repressed by HDAC3 in an Sp dependent manner."
27874833
RAET1E affects δ
| 1
RAET1E activates δ. 1 / 1
| 1
reach
"Overexpression of the ULBP1 and ULBP4 on the leukemia, lymphoma and epithelial tumors, respectively, induces cytotoxicity of Vγ9Vδ2 T cells to tumor cells [42]."
32413966
RAET1E affects soluble 35-kDa protein
| 1
RAET1E activates soluble 35-kDa protein. 1 / 1
| 1
eidos
"RAET1E belongs to a ligand family for NKG2D in humans and can produce a soluble , 35-kDa protein ( named RAET1E2 ) in tumor cells ."
| PMC
RAET1E affects pspA
| 1
RAET1E activates pspA. 1 / 1
| 1
reach
"RAET1E belongs to a ligand family for NKG2D in humans and can produce a soluble, 35-kDa protein (named RAET1E2) in tumor cells."
| PMC
RAET1E affects luciferase reporter construct
| 1
RAET1E activates luciferase reporter construct. 1 / 1
| 1
reach
"E2F overexpression was sufficient to activate endogenous Raet1 genes in cells as well as a luciferase reporter construct driven by the Raet1e promoter."
24507156
RAET1E affects glycoprotein
| 1
RAET1E binds glycoprotein. 1 / 1
| 1
sparser
"Unlike ULBP1 and ULBP2, ULBP4 is not bound by the name-giving HCMV glycoprotein UL16 [ xref , xref ], and therefore ULBP4 can be considered as a misnomer."
33556116
RAET1E affects adverse response
| 1
RAET1E activates adverse response. 1 / 1
| 1
eidos
"We then transiently knocked down the expression of Raet1e via siRNA inUbr5 - / -4 T1 tumor ( Figure 5b ) , which , when implanted in mice , caused a partial reversal of the inhibited growth of the parental tumor ( Figure 5c ) , but did not alter thein vitro growth rates ( Figure S1E ) , suggesting that higher Raet1e expression may mediate an adverse response against the tumor and that UBR5 deficiency in tumor cells may generate immunogens that attract anti-tumor responses.Upregulated proteins inUbr5 - / -4 T1 tumor.Potential immunogens and interacting partners controlled by UBR5 ."
32363114
RAET1E affects TCRgamma9
| 1
RAET1E binds TCRgamma9. 1 / 1
| 1
reach
"The NKG2D ligand ULBP4 binds to TCRgamma9 and delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D."
19436053
RAET1E affects T cell-mediated cytotoxicity tumor cells.18Decreased Raet1e
| 1
RAET1E activates T cell-mediated cytotoxicity tumor cells.18Decreased Raet1e. 1 / 1
| 1
eidos
"It has been shown to function as a ligand for both TCRgamma9delta2and NKG2D through which Raet1e induces T cell-mediated cytotoxicity to tumor cells.18Decreased Raet1e expression is a poor prognostic marker in nasopharyngeal carcinoma ,19 whereas high expression of Raet1e is an indicator of good prognosis in cervical cancer.20We first confirmed the MS finding of Raet1e 's overexpression by Western blot in WT and inUbr5 - / - cells treated with the proteasome inhibitor MG132 ( Figure 5a ) , which also indicated that Raet1e protein level was indeed regulated by a proteasome-mediated mechanism ."
32363114
RAET1E affects RAE1
| 1
RAET1E increases the amount of RAE1. 1 / 1
| 1
reach
"Although E2F sites in the Raet1e promoter have been shown to drive RAE-1 expression during proliferation, these sites were dispensable for activation of the Raet1e promoter by m18 (XREF_FIG)."
27874833
RAET1E affects PCDH1
1 |
RAET1E binds PCDH1. 1 / 1
1 |
biogrid
No evidence text available
33961781
RAET1E affects Neoplasms
| 1
RAET1E activates Neoplasms. 1 / 1
| 1
eidos
"Ligands for NKG2D include MICA , ULBP4 , and ULBP1 , which are implicated in NKG2D mediated recognition of multiple cancers 8, 9 ."
34234868
RAET1E affects NKG2D-mediated NK cell cytotoxicity
| 1
RAET1E inhibits NKG2D-mediated NK cell cytotoxicity. 1 / 1
| 1
eidos
"In other words , RAET1E might impair NKG2D-mediated NK cell cytotoxicity to tumors [ 43 ] ."
| PMC
RAET1E affects Major Histocompatibility Complex Class 1
| 1
RAET1E activates Major Histocompatibility Complex Class 1. 1 / 1
| 1
reach
"Altered Expression of Raet1e, a Major Histocompatibility Complex Class 1 Like Molecule, Underlies the Atherosclerosis Modifier Locus Ath11 10b."
23948654
RAET1E affects MICA
| 1
MICA binds ULBP3 and RAET1E. 1 / 1
| 1
sparser
"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."
20536569
RAET1E affects Interferon
| 1
RAET1E activates Interferon. 1 / 1
| 1
reach
"The data suggest that a soluble form of ULBP4, which is enriched in the CSF of female patients with MS, can enhance the production of GM-CSF and IFNγ by activated human CD8 T lymphocytes."
34873031
RAET1E affects FDH
| 1
RAET1E binds FDH. 1 / 1
| 1
sparser
"Blocking one of these pathways could only induce minor inhibitory effect on degranulation of Vγ9Vδ2 T cells and cytotoxicity to EL4-ULBP4 + cells, but almost completely inhibited IFNγ production by Vγ9Vδ2 T cells."
35603176
RAET1E affects FAS
| 1
RAET1E decreases the amount of FAS. 1 / 1
| 1
reach
"Letal also down-regulated the expression of Fas in CD8+ cells and rendered them resistant to Fas ligand induced apoptosis."
15026360
RAET1E affects ERBB2
1 |
ERBB2 binds RAET1E. 1 / 1
1 |
biogrid
No evidence text available
39499777
RAET1E affects EPHA7
1 |
RAET1E binds EPHA7. 1 / 1
1 |
biogrid
No evidence text available
28514442
RAET1E affects E2F1
| 1
E2F1 binds RAET1E. 1 / 1
| 1
sparser
"An investigation of the roles of factors known to regulate the cell cycle showed that E2F1–3, the activating E2F transcription factors, bind to the Raet1e promoter in vivo and transactivate the endogenous Raet1e gene as well as the Raet1e promoter in a reporter plasmid."
23298206
RAET1E affects E2F
| 1
E2F binds RAET1E. 1 / 1
| 1
sparser
"Collectively, the data demonstrate that E2F transcription factors bind and transactivate the Raet1e promoter, play an important role in supporting Raet1 transcription in proliferating cells, and function potentially redundantly in driving Raet1 transcription."
23166357
RAET1E affects DUMO1
| 1
RAET1E binds DUMO1. 1 / 1
| 1
reach
"While ULBP4 specific pAb and mAb 709116 bound ststULBP4_im and ULBP4 transfectants similarly to DUMO1, we did not detect binding of mAb 6E6 neither to ststULBP_im nor to the ULBP4 transfectants by flow cytometry, although mAb 6E6 brightly detected denatured ststULBP4 in immunoblotting (data not shown)."
29651291
reach
"It remains unclear, however, whether AP-1 acts directly on the Raet1e gene to repress transcription or by an indirect mechanism that alters Raet1e transcription or mRNA stability."
23298206
RAET1E affects Atherosclerosis Modifier Locus Ath11 10b
| 1
RAET1E activates Atherosclerosis Modifier Locus Ath11 10b. 1 / 1
| 1
reach
"Altered Expression of Raet1e, a Major Histocompatibility Complex Class 1 Like Molecule, Underlies the Atherosclerosis Modifier Locus Ath11 10b."
23948654
RAET1E affects AS
| 1
AS binds RAET1E. 1 / 1
| 1
sparser
"Reduction of the lncRNA RAET1E-AS indicated that less miRNA sponges were free to interact with miR-145-5p, therefore, overexpression of miRNAs could promote cell proliferation and rejuvenate cellular senescence."
40251826
RAET1E affects ARL8B
1 |
RAET1E binds ARL8B. 1 / 1
1 |
biogrid
No evidence text available
28514442
RAET1E affects APEX1
1 |
APEX1 binds RAET1E. 1 / 1
1 |
biogrid
No evidence text available
28986522
4-ammoniobenzoate binds RAET1E. 1 / 1
| 1
reach
"While ULBP4 specific pAb and mAb 709116 bound ststULBP4_im and ULBP4 transfectants similarly to DUMO1, we did not detect binding of mAb 6E6 neither to ststULBP_im nor to the ULBP4 transfectants by flow cytometry, although mAb 6E6 brightly detected denatured ststULBP4 in immunoblotting (data not shown)."
29651291
Pathogen-Associated Molecular Pattern Molecules affects RAET1E
| 1
Pathogen-Associated Molecular Pattern Molecules increases the amount of RAET1E. 1 / 1
| 1
reach
"Collectively, the presented data exclude that ULBP4 is expressed by human monocytes under normal conditions and upon activation by PAMP."
33556116
Particulate Matter decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
36857595
PCDH1 affects RAET1E
1 |
RAET1E binds PCDH1. 1 / 1
1 |
biogrid
No evidence text available
33961781
RAET1E is modified
| 1
RAET1E is glycosylated. 1 / 1
| 1
sparser
"Position 82 is polymorphic and occupied either by asparagine (stULBP4) or tyrosine (Uniprot reference sequence at), and therefore ULBP4 glycosylation can be expected to be variable within the human population with potential consequences for expression and detection."
29651291
Nicotine affects RAET1E
1 |
Nicotine increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
23825647
MKN45 cells HKHP affects RAET1E
| 1
MKN45 cells HKHP activates RAET1E. 1 / 1
| 1
eidos
"Stimulation of MKN45 cells with HKHP increased MICA , ULBP4 ( another NKG2DL ) , and TLR4 at the protein and transcriptional levels ."
33928707
MIR557 affects RAET1E
1 |
MIR557 decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
MIR507 affects RAET1E
1 |
MIR507 decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
MIR1268A affects RAET1E
1 |
MIR1268A decreases the amount of RAET1E. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23824327
MICB affects RAET1E
| 1
MICB decreases the amount of RAET1E. 1 / 1
| 1
reach
"Also in accordance with our data, it was shown that the LMP2A latency protein of EBV, which activates signaling pathways to promote the proliferation of latently infected cells, induces MICA and MICB expression at the transcriptional level, while, on the other hand, reducing the cell-surface expression of both MIC proteins and ULBP4 through mechanisms that have not been identified as yet (30, 48)."
39676862
MICA affects ULBP3
| 1
MICA binds ULBP3 and RAET1E. 1 / 1
| 1
sparser
"However, UL16 is unable to bind to MICA, ULBP3, and ULBP4."
20536569
Luminex Discovery Assay affects RAET1E
| 1
Luminex Discovery Assay activates RAET1E. 1 / 1
| 1
reach
"To measure the quantity of different soluble NKG2D ligands in cell culture supernatants and serum samples, we used multiplexed ELISAs, namely, the Human Luminex Discovery Assay (R&D Systems), which allows quantitation of MIC-A, MIC-B, ULBP-1, ULBP-2/5/6, ULBP-3, and ULBP-4."
38653235
HDAC3 affects RAET1E
| 1
HDAC3 inhibits RAET1E. 1 / 1
| 1
reach
"The Raet1e promoter is repressed by HDAC3 in an Sp dependent manner."
27874833
Glyphosate affects RAET1E
1 |
Glyphosate increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
33713393
Glioma affects RAET1E
| 1
Glioma increases the amount of RAET1E. 1 / 1
| 1
reach
"Treatment of glioma cells with the catalytic LSD1 inhibitors tranylcypromine (TCP) or GSK LSD1 was able to increase MICB and ULBP4 expression, enhancing human NK-cell mediated lysis of the target cells (137)."
37090711
GRB2 affects KLRK1, MICA, MICB, PIK3R1, RAET1E, TYROBP, ULBP1, and ULBP3
| 1
TYROBP binds MICA, MICB, ULBP3, ULBP1, RAET1E, GRB2, KLRK1, and PIK3R1. 1 / 1
| 1
sparser
"Protein–protein interaction analysis showed that the top 10 proteins associated with the HCST included TYROBP, KLRC4, MICA, MICB, ULBP3, ULBP1, RAET1E, GRB2, KLRK1, and PIK3R1, which are mainly involved in the immune response and tumorigenesis."
33968730
FDH affects RAET1E
| 1
RAET1E binds FDH. 1 / 1
| 1
sparser
"Blocking one of these pathways could only induce minor inhibitory effect on degranulation of Vγ9Vδ2 T cells and cytotoxicity to EL4-ULBP4 + cells, but almost completely inhibited IFNγ production by Vγ9Vδ2 T cells."
35603176
EZH2 affects RAET1E
| 1
EZH2 decreases the amount of RAET1E. 1 / 1
| 1
reach
"Therefore, the inhibition of EZH2 leads to HCC cell eradication via NKs by upregulating expression of ULBP3 and ULBP4 in tumor cells."
37928272
ERBB2 affects RAET1E
1 |
ERBB2 binds RAET1E. 1 / 1
1 |
biogrid
No evidence text available
39499777
EPHA7 affects RAET1E
1 |
RAET1E binds EPHA7. 1 / 1
1 |
biogrid
No evidence text available
28514442
reach
"Consistent with these findings, we observed that the chemical HDAC inhibitor butyrate activated the WT Raet1e promoter (XREF_FIG)."
27874833
E2F affects RAET1E
| 1
E2F binds RAET1E. 1 / 1
| 1
sparser
"Collectively, the data demonstrate that E2F transcription factors bind and transactivate the Raet1e promoter, play an important role in supporting Raet1 transcription in proliferating cells, and function potentially redundantly in driving Raet1 transcription."
23166357
Dietary Fats affects RAET1E
1 |
Dietary Fats increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
25016146
DUMO1 affects RAET1E
| 1
RAET1E binds DUMO1. 1 / 1
| 1
reach
"While ULBP4 specific pAb and mAb 709116 bound ststULBP4_im and ULBP4 transfectants similarly to DUMO1, we did not detect binding of mAb 6E6 neither to ststULBP_im nor to the ULBP4 transfectants by flow cytometry, although mAb 6E6 brightly detected denatured ststULBP4 in immunoblotting (data not shown)."
29651291
CYP19A1 affects CYP3A4, EBPL, FGF4, KLF2, MASP1, MMP20, NUAK1, PTPN2, RAET1E, SERPINE2, and SOX18
| 1
sparser
"FGF4, CYP19A1, PTPN2, CYP3A4, SERPINE2, SOX18, MMP20, MASP1, KLF2, ERP44, NUAK1 and RAET1E are directly associated with SCC."
29805591
CRNDE affects RAET1E
| 1
CRNDE decreases the amount of RAET1E. 1 / 1
| 1
reach
"The results showed that knockdown of CRNDE increased DUSP5, CDKN1A, EMP1, RAET1E, and CDKN2B expression, but decreased RPL23A, EIF4E2, QPRT, ACSS1, and APCDD1 expression (XREF_FIG)."
28796262
CD8 affects RAET1E
| 1
CD8 activates RAET1E. 1 / 1
| 1
reach
"In addition, Letal induced the killing of cancer cells by CD8 (+) and NK cells."
14508119
AS affects RAET1E
| 1
AS binds RAET1E. 1 / 1
| 1
sparser
"Reduction of the lncRNA RAET1E-AS indicated that less miRNA sponges were free to interact with miR-145-5p, therefore, overexpression of miRNAs could promote cell proliferation and rejuvenate cellular senescence."
40251826
ARL8B affects RAET1E
1 |
RAET1E binds ARL8B. 1 / 1
1 |
biogrid
No evidence text available
28514442
APEX1 affects RAET1E
1 |
APEX1 binds RAET1E. 1 / 1
1 |
biogrid
No evidence text available
28986522
4-hydroxyphenyl 4-isopropoxyphenylsulfone decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
39298647
4-hydroxynon-2-enal increases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
19191707
4-ammoniobenzoate binds RAET1E. 1 / 1
| 1
reach
"While ULBP4 specific pAb and mAb 709116 bound ststULBP4_im and ULBP4 transfectants similarly to DUMO1, we did not detect binding of mAb 6E6 neither to ststULBP_im nor to the ULBP4 transfectants by flow cytometry, although mAb 6E6 brightly detected denatured ststULBP4 in immunoblotting (data not shown)."
29651291
2-hydroxypropanoic acid decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
30851411
4,4'-sulfonyldiphenol decreases the amount of RAET1E. 1 / 1
1 |
ctd
No evidence text available
39298647