IndraLab

Statements


TGFB decreases the amount of RAET1E. 4 / 4
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"TGF-beta inhibits the transcription of MICA, ULBP2, and ULBP4 mRNA, whereas MICB, ULBP1, and ULBP3 mRNA levels remained unchanged."

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"Secretion of TGF-beta by NPC cells is well documented and is known to promote the progression and metastasis of NPC [XREF_BIBR, XREF_BIBR], herein ULBP4 expression may be also downregulated by TGF-beta on NPC cells."

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"Additionally, transforming growth factor-beta (TGF-beta) selectively downregulates the expression of MICA, ULBP2, and ULBP4, but not MICB, ULBP1, or ULBP3, in malignant glioma cells [XREF_BIBR]."

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"We further delineate two independent mechanisms that can explain these expression patterns : (i) transforming growth factor-beta (TGF-beta) is upregulated during malignant progression and selectively downregulates MICA, ULBP2 and ULBP4 expression, while MICB, ULBP1 and ULBP3 are unaffected."