A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

MAP2K1 phosphorylates MAPK1. 10 / 131
32 1 | 13 39 44
rlimsp
"ERK2 phosphorylation by MEK1 was evaluated in the absence or presence of purified arrestins."
reach
"Activated Mek1 and Mek2 then phosphorylate their only known substrates, Erk1 and Erk2."
biopax:inoh
No evidence text available
reach
"In our MS data, we found that Mitogen activated protein kinase kinase 1 (MAP2K1), which can phosphorylate and activate ERK1 and ERK2, was increased by 95% in the cytosol."
reach
"MEK1 and MEK2 specifically phosphorylate the TEY motif of ERK1 and ERK2."
biopax:inoh
No evidence text available
rlimsp
"Expression of wild-type LC-PTP in 293T cells suppressed the phosphorylation of ERK2 by a mutant MEK1, which was constitutively active regardless of upstream activation signals."
reach
"In contrast, while the MEK1 and MEK2 inhibitor, U0126, prevented phosphorylation of ERK1 and ERK2, it had no effect on IGF-protection."
signor
"Mek1 as indicated by extensive phosphorylation of erk1 and erk2 during the initial 2 h of adipogenesis."
reach
"ERK2 phosphorylation by MEK1 was evaluated in the absence or presence of purified arrestins."
MAP2K1 phosphorylated on S222 and S218 phosphorylates MAPK1 on T185. 10 / 50
50 |
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
MAP2K1 phosphorylated on S222 and S218 phosphorylates MAPK1 on Y187. 10 / 50
50 |
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
biopax:pid
No evidence text available
MAP2K1 phosphorylates MAPK1 on Y187. 10 / 35
1 3 1 26 | 1 2 1
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
signor
"Mapk1 is phosphorylated by map2k1/mek1 and map2k2/mek2 on thr-185 and tyr-187 in response to external stimuli like insulin or ngf. Both phosphorylations are required for activity."
hprd
No evidence text available
hprd
No evidence text available
MAP2K1 phosphorylates MAPK1 on T185. 8 / 8
1 3 1 | 2 1
biopax:phosphositeplus
No evidence text available
sparser
"MEK1 and MEK2 phosphorylate ERK1 and ERK2 on T183 and Y185 residues within the TPY motif ."
signor
"Mapk1 is phosphorylated by map2k1/mek1 and map2k2/mek2 on thr-185 and tyr-187 in response to external stimuli like insulin or ngf. Both phosphorylations are required for activity."
reach
"As an example of text being converted into an executable model, consider the sentence " MEK1 phosphorylates ERK2 at threonine 185 and tyrosine 187 "."
biopax:pid
No evidence text available
sparser
"We used a mass spectrometry-based analysis of the undigested or tryptically digested protein to establish that MKK1 exclusively phosphorylates His 6 -ERK2 on Thr-183 and Tyr-185 within the activation loop."
biopax:pid
No evidence text available
biopax:pid
No evidence text available
Phosphorylated MAP2K1 phosphorylates MAPK1. 3 / 3
| 3
reach
"These enzymes are protein-serine and threonine kinases that catalyze the phosphorylation and activation of MEK1 and MEK2 which, in turn, catalyze the phosphorylation and activation of ERK1 and ERK2."
reach
"Within the cascade, the doubly phosphorylated MEK1 phosphorylates the extracellular-signal-regulated kinases ERK1 and ERK2 (XREF_FIG)."
reach
"Western blot analysis with an anti-phos-ERK antibody showed that the doubly phosphorylated MEK1 could robustly phosphorylate ERK2 in vitro as expected (XREF_FIG; full gels available in XREF_SUPPLEMENTARY)."
Modified MAP2K1 leads to the phosphorylation of MAPK1. 2 / 2
| 2
reach
"We also showed that silencing of MEK1 or MEK2 expression significantly reduces the extent of ERK1 and ERK2 activating phosphorylation."
reach
"In contrast, co-expression of MKK7 or MEK1 increased phosphorylation of JNK1 and ERK2, respectively (XREF_FIG)."
Kinase-active MAP2K1 phosphorylates MAPK1 on Y187. 2 / 2
2 |
bel
"The dual phosphorylation of Thr-183 and Tyr-185 in ERK2 is catalyzed by MAPK/ERK kinase 1 (MEK1)."
bel
"1378617;15592455;16094384;11971971;15972258;15935618"
Kinase-active MAP2K1 phosphorylates MAPK1 on T185. 2 / 2
2 |
bel
"The dual phosphorylation of Thr-183 and Tyr-185 in ERK2 is catalyzed by MAPK/ERK kinase 1 (MEK1)."
bel
"9166761;11971971;15935618"
MAP2K1 leads to the phosphorylation of MAPK1 on threonine. 1 / 1
| 1
reach
"In the cascade, enzymatically active Raf proteins phosphorylate and activate MEK1 and MEK2, dual specificity kinases that in turn phosphorylate ERK1 and ERK2 on threonine and tyrosine residues of their homologous TEY motif; only diphosphorylated ERK has elevated kinase activity (Anderson etal, 1990)."
MAP2K1 leads to the phosphorylation of mutated MAPK1. 1 / 1
| 1
reach
"MEK1 and MEK2 phosphorylate a majority of the ERK2 mutants."
MAP2K1 phosphorylated on S298, S222, and S218 phosphorylates MAPK1 on T185. 1 / 1
1 |
biopax:pid
No evidence text available
Mutated MAP2K1 phosphorylates MAPK1. 1 / 1
| 1
reach
"Expression of wild-type LC-PTP in 293T cells suppressed the phosphorylation of ERK2 by a mutant MEK1, which was constitutively active regardless of upstream activation signals."
MAP2K1 phosphorylated on S298, S222, and S218 phosphorylates MAPK1 on Y187. 1 / 1
1 |
biopax:pid
No evidence text available
MAP2K1 leads to the phosphorylation of MAPK1 on tyrosine. 1 / 1
| 1
reach
"In the cascade, enzymatically active Raf proteins phosphorylate and activate MEK1 and MEK2, dual specificity kinases that in turn phosphorylate ERK1 and ERK2 on threonine and tyrosine residues of their homologous TEY motif; only diphosphorylated ERK has elevated kinase activity (Anderson etal, 1990)."
MAP2K1 phosphorylated on an unknown residue and an unknown residue phosphorylates MAPK1. 1 / 1
1 |
biopax:panther
No evidence text available