IndraLab

Statements

MAP2K1 phosphorylates MAPK1. 10 / 131
4 1 | 62 49 13
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"For example, MEK1 and MEK2 phosphorylate ERK1 and ERK2 in the cellular * Corresponding author."
8634328
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"Note that MEK1 fully phosphorylated MAPK and Erk2 by 2 h. PKG and MAPK placed approximately one molecule phosphate onto each molecule of preferred substrate, CK II was somewhat less efficient, incorpo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12576052
sparser
"In the second model arrestin can act as a true scaffold, bringing both MEK1 and ERK2 into close proximity to each other, thereby facilitating the phosphorylation of ERK2 by MEK1."
22174878
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"Raf-1 then activates MEK1, which phosphorylates ERK1 and ERK2."
23608617
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"MAPK signaling is enhanced by receptor tyrosine kinases, integrins, and G-protein coupled receptors; MAP2K1 phosphorylates ERK1 and ERK2 [ xref ]."
32703450
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"Next, we tested whether arrestin binding affects ERK2 phosphorylation by MEK1."
22174878
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"Mek1 and Mek2 mediate the phosphorylation of Erk1 and Erk2, which also form dimers XREF_BIBR."
24937142
sparser
"Within the cascade, the doubly phosphorylated MEK1 phosphorylates the extracellular-signal-regulated kinases ERK1 and ERK2 ( xref )."
26350765
rlimsp
"Expression of wild-type LC-PTP in 293T cells suppressed the phosphorylation of ERK2 by a mutant MEK1, which was constitutively active regardless of upstream activation signals. No suppression of the phosphorylation was observed by LC-PTPCS, a catalytically inactive mutant."
10415025
sparser
"We here show that the MEK1-dependent phosphorylation of ERK2 is involved in NTHi-induced CXCL2 up-regulation in the SLFs."
22379036
MAP2K1 phosphorylated on S218 and S222 phosphorylates MAPK1 on Y205. 10 / 41
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MAP2K1 phosphorylates MAPK1 on Y187. 10 / 34
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hprd
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19651622
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18691976
rlimsp
"The dual phosphorylation of Thr-183 and Tyr-185 in ERK2 is catalyzed by MAPK/ERK kinase 1 (MEK1)."
12082107
hprd
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19415658
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hprd
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16153436
phosphoelm
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11971971
MAP2K1 phosphorylated on S218 and S222 phosphorylates MAPK1 on Y187. 9 / 9
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7559390
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9032297
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10998418
MAP2K1 phosphorylated on S218 and S222 phosphorylates MAPK1 on T185. 9 / 9
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10998418
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9765155
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7559390
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9032297
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12952943
MAP2K1 phosphorylates MAPK1 on T185. 6 / 6
1 1 | 2 2
signor
"Mapk1 is phosphorylated by map2k1/mek1 and map2k2/mek2 on thr-185 and tyr-187 in response to external stimuli like insulin or ngf. Both phosphorylations are required for activity."
11971971
reach
"MEK1 and MEK2 phosphorylate ERK1 and ERK2 on T183 and Y185 residues within the TPY motif (Crews et al., 1992b; Seger et al., 1992; Zheng & Guan, 1993b)."
11337027
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"We used a mass spectrometry-based analysis of the undigested or tryptically digested protein to establish that MKK1 exclusively phosphorylates His 6 -ERK2 on Thr-183 and Tyr-185 within the activation loop."
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biopax:phosphositeplus
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sparser
"MEK1 and MEK2 phosphorylate ERK1 and ERK2 on T183 and Y185 residues within the TPY motif ."
11337027
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"As an example of text being converted into an executable model, consider the sentence " MEK1 phosphorylates ERK2 at threonine 185 and tyrosine 187 "."
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MAP2K1 phosphorylates MAPK1 on Y205. 3 / 3
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Phosphorylated MAP2K1 phosphorylates MAPK1. 3 / 3
| 3
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"Western blot analysis with an anti-phos-ERK antibody showed that the doubly phosphorylated MEK1 could robustly phosphorylate ERK2 in vitro as expected (XREF_FIG; full gels available in XREF_SUPPLEMENTARY)."
26350765
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"Within the cascade, the doubly phosphorylated MEK1 phosphorylates the extracellular-signal-regulated kinases ERK1 and ERK2 (XREF_FIG)."
26350765
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"These enzymes are protein-serine and threonine kinases that catalyze the phosphorylation and activation of MEK1 and MEK2 which, in turn, catalyze the phosphorylation and activation of ERK1 and ERK2."
30118796
Kinase-active MAP2K1 phosphorylates MAPK1 on T185. 2 / 2
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bel
"9166761;11971971;15935618"
15212693
bel
"The dual phosphorylation of Thr-183 and Tyr-185 in ERK2 is catalyzed by MAPK/ERK kinase 1 (MEK1)."
12082107
Modified MAP2K1 leads to the phosphorylation of MAPK1. 2 / 2
| 2
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"We also showed that silencing of MEK1 or MEK2 expression significantly reduces the extent of ERK1 and ERK2 activating phosphorylation."
19014680
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"In contrast, co-expression of MKK7 or MEK1 increased phosphorylation of JNK1 and ERK2, respectively (XREF_FIG)."
21602844
Kinase-active MAP2K1 phosphorylates MAPK1 on Y187. 2 / 2
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bel
"1378617;15592455;16094384;11971971;15972258;15935618"
15212693
bel
"The dual phosphorylation of Thr-183 and Tyr-185 in ERK2 is catalyzed by MAPK/ERK kinase 1 (MEK1)."
12082107
MAP2K1 phosphorylated on S218, S222, and S298 phosphorylates MAPK1 on Y187. 1 / 1
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biopax:pid
No evidence text available
12876277
Mutated MAP2K1 phosphorylates MAPK1. 1 / 1
| 1
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"Expression of wild-type LC-PTP in 293T cells suppressed the phosphorylation of ERK2 by a mutant MEK1, which was constitutively active regardless of upstream activation signals."
10415025
MAP2K1 phosphorylated on an unknown residue and an unknown residue phosphorylates MAPK1. 1 / 1
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biopax:panther
No evidence text available
MAP2K1 leads to the phosphorylation of MAPK1 on tyrosine. 1 / 1
| 1
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"In the cascade, enzymatically active Raf proteins phosphorylate and activate MEK1 and MEK2, dual specificity kinases that in turn phosphorylate ERK1 and ERK2 on threonine and tyrosine residues of their homologous TEY motif; only diphosphorylated ERK has elevated kinase activity (Anderson etal, 1990)."
24489118
MAP2K1 phosphorylated on S218, S222, and S298 phosphorylates MAPK1 on T185. 1 / 1
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biopax:pid
No evidence text available
12876277
MAP2K1 leads to the phosphorylation of MAPK1 on threonine. 1 / 1
| 1
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"In the cascade, enzymatically active Raf proteins phosphorylate and activate MEK1 and MEK2, dual specificity kinases that in turn phosphorylate ERK1 and ERK2 on threonine and tyrosine residues of their homologous TEY motif; only diphosphorylated ERK has elevated kinase activity (Anderson etal, 1990)."
24489118
MAP2K1 leads to the phosphorylation of mutated MAPK1. 1 / 1
| 1
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"MEK1 and MEK2 phosphorylate a majority of the ERK2 mutants."
8939908