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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MAP2K1 leads to the phosphorylation of MAPK1 on threonine. 1 / 1

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"In the cascade, enzymatically active Raf proteins phosphorylate and activate MEK1 and MEK2, dual specificity kinases that in turn phosphorylate ERK1 and ERK2 on threonine and tyrosine residues of their homologous TEY motif; only diphosphorylated ERK has elevated kinase activity (Anderson etal, 1990)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...