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Phosphorylated MAP2K1 phosphorylates MAPK1. 3 / 3
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"Western blot analysis with an anti-phos-ERK antibody showed that the doubly phosphorylated MEK1 could robustly phosphorylate ERK2 in vitro as expected (XREF_FIG; full gels available in XREF_SUPPLEMENTARY)."
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"Within the cascade, the doubly phosphorylated MEK1 phosphorylates the extracellular-signal-regulated kinases ERK1 and ERK2 (XREF_FIG)."
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"These enzymes are protein-serine and threonine kinases that catalyze the phosphorylation and activation of MEK1 and MEK2 which, in turn, catalyze the phosphorylation and activation of ERK1 and ERK2."
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