IndraLab

Statements

UCHL3 affects RAD51
1 | 6
UCHL3 deubiquitinates RAD51. 7 / 7
1 | 6
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"UCHL3 deubiquitinates RAD51 thereby promoting the recruitment of RAD51 to DNA damage sites and augmenting DNA repair."
31113933
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"After DNA damages, UCHL3 is activated via phosphorylation by ATM and then deubiquitinates RAD51 promoting RAD51-BRCA2 interaction and proper HR repair [150]."
28552167
ubibrowser
"UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2."
27941124
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"UCHL3 deubiquitylates RAD51 to promote the interaction between RAD51 and BRCA2 and HR repair [121]."
33990032
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"RAD51 deubiquitination by UCHL3 was observed both in vitro and in cellulo and shown to be critical for BRCA2-RAD51 interaction, RAD51 recruitment to DSB sites, foci formation, as well as RAD51 mediated D-loop formation [XREF_BIBR]."
| PMC
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"found that UCHL3 deubiquitinates RAD51 and subsequently facilitates RAD51-BRCA2 interaction, which is critical for homologous recombination (HR) and contributes to therapeutic resistance in breast cancer."
33585209
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"UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2."
27941124
UCHL3 affects XRCC5
| 4
UCHL3 deubiquitinates XRCC5. 4 / 4
| 4
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"Taken together, these data suggest that UCHL3 could enhance Ku chromatin retention upon DSB induction by deubiquitylating Ku80."
30559450
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"UCHL3 de-ubiquitinates and stabilises Ku80 which is required for Ku80 retention at DSBs [10]."
31769469
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"Here we found that UCHL3, a deubiquitylating enzyme, interacts with and can directly deubiquitylate Ku80 in a catalytic activity dependent manner."
30559450
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"UCHL3 enhances Ku80 chromatin binding and directly deubiquitylates Ku80."
30559450
UCHL3 affects COPS5
| 4
UCHL3 deubiquitinates COPS5. 4 / 4
| 4
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"To address this question, we firstly performed an in vitro deubiquitination assay, which clearly demonstrated that UCHL3 can deubiquitinate COPS5 in vitro."
28583475
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"These results imply that UCHL3 physically interacts with COPS5 and deubiquitinates COPS5.Given that UCHL3 can deubiquitinate COPS5, we speculate that UCHL3 could affect cellular levels of COPS5."
28583475
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"Given that UCHL3 interacts with COPS5 in IFN signaling and UCHL3 is a deubiquitinase, we question whether UCHL3 promotes COPS5 deubiquitination."
28583475
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"Furthermore, we demonstrate that UCHL3 as a deubiquitinase can deubiquitinate COPS5, thereby upregulating COPS5 levels and protein stability (Figs. 4 and 5)."
28583475
UCHL3 affects AHR
| 3
UCHL3 deubiquitinates AHR. 3 / 3
| 3
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"As expected, the ability of UCHL3 to deubiquitinate AhR was almost completely abrogated by TCID treatment (Fig. 7a)."
32546741
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"WT UCHL3, but not UCHL3-C95S, significantly reduced AhR protein polyubiquitination (Fig. 6f), whereas the other mutants did not decrease AhR polyubiquitination."
32546741
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"Second, UCHL3 reduces AhR polyubiquitination and enhances AhR protein stabilization in a DUB activity-dependent manner, and this ability could be inhibited by TCID, a UCHL3 inhibitor."
32546741
UCHL3 affects TRAF2
| 2
UCHL3 leads to the deubiquitination of TRAF2. 2 / 2
| 2
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"The elevated UCHL3 facilitates carcinogenesis and enhances inflammation by deubiquitinating and stabilizing TNF Receptor Associated Factor 2 (TRAF2)."
33585209
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"UCHL3 was found to activate NF-kappaB signalling by deubiquitinating and stabilizing TRAF2, leading to tumourigenesis."
31477831
UCHL3 affects TDP1
| 2
UCHL3 leads to the deubiquitination of TDP1. 1 / 1
| 1
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"In contrast, UCHL3 is downregulated in spinocerebellar ataxia with axonal neuropathy (SCAN1), causing elevated levels of TDP1 ubiquitylation and faster turnover rate."
29898404
Modified UCHL3 leads to the deubiquitination of TDP1. 1 / 1
| 1
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"Overexpression of UCHL3, but not a catalytically inactive mutant, suppresses TDP1 ubiquitylation and turnover rate."
29898404
UCHL3 affects HELLS
| 2
UCHL3 deubiquitinates HELLS. 2 / 2
| 2
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"UCHL3 deubiquitinates chromatin modifier lymphoid-specific helicase (LSH)."
34405018
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"UCHL3 deubiquitinates chromatin modifier lymphoid-specific helicase (LSH)."
34405018
UCHL3 affects FOXM1
| 2
UCHL3 deubiquitinates FOXM1. 2 / 2
| 2
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"Furthermore, knockdown of UCHL3 increased FOXM1 ubiquitination, which enhanced FOXM1 turnover and promoted pancreatic cancer cells ' sensitivity to gemcitabine."
31598398
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"Deubiquitination of FOXM1 by UCHL3 was also shown to promote pancreatic cancer progression and gemcitabine resistance."
33680951
UCHL3 affects VIM
| 1
UCHL3 leads to the deubiquitination of VIM. 1 / 1
| 1
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"Vimentin was identified as a potential de-ubiquitination substrate of UCHL3 and UCHL3 interacted with and promoted the de-ubiquitination of Vimentin, enhancing its stability."
36969045
UCHL3 affects STUB1
| 1
UCHL3 deubiquitinates STUB1. 1 / 1
| 1
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"No other tested DUB behaved in a similar manner : USP5 deubiquitinated Ub-CHIP in an unregulated manner, while UCHL-1 and UCHL-3 did not deubiquitinate Ub-CHIP under any conditions (XREF_FIG)."
21855799
UCHL3 affects SMAD1
1 |
UCHL3 deubiquitinates SMAD1. 1 / 1
1 |
ubibrowser
"Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation."
21453705
UCHL3 affects RAD51B
1 |
UCHL3 deubiquitinates RAD51B. 1 / 1
1 |
ubibrowser
"Mechanistically, in response to DNA damage, the deubiquitinase UCHL3 is phosphorylated and activated by ATM. UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2."
27941124
UCHL3 affects Polyubiquitin
| 1
UCHL3 deubiquitinates Polyubiquitin 1 / 1
| 1
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"UCH-L3 physically interacts with Smad1 and stabilizes it by deubiquitylating its polyubiquitin."
30123285
UCHL3 affects PPARG
| 1
UCHL3 deubiquitinates PPARG. 1 / 1
| 1
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"In addition, recombinant UCHL3 failed to deubiquitinate PPARgamma in vitro (XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY), indicating that UCHL3 modulates PPARgamma activity by an indirect mechanism, either through its ubiquitin hydrolase or its deneddylase activity."
22679485
UCHL3 affects MCL1
| 1
UCHL3 deubiquitinates MCL1. 1 / 1
| 1
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"Cdu1, but not the control enzyme UCH-L3 strongly deubiquitinated Mcl-1 (XREF_FIG)."
28347402
UCHL3 affects GARS1
| 1
UCHL3 deubiquitinates GARS1. 1 / 1
| 1
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"Importantly, UCH-L3 deubiquitylates Smad1 and enhances osteoblast differentiation [73]."
30123285
UCHL3 affects BRD4
| 1
UCHL3 leads to the deubiquitination of BRD4. 1 / 1
| 1
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"Consistently, ubiquitination assay showed knockdown of UCHL3 promoted the poly-ubiquitination of BRD4 (Fig. 3e)."
34290255