IndraLab

Statements


UCHL3 deubiquitinates XRCC5. 4 / 4
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"Taken together, these data suggest that UCHL3 could enhance Ku chromatin retention upon DSB induction by deubiquitylating Ku80."

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"UCHL3 de-ubiquitinates and stabilises Ku80 which is required for Ku80 retention at DSBs [10]."

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"Here we found that UCHL3, a deubiquitylating enzyme, interacts with and can directly deubiquitylate Ku80 in a catalytic activity dependent manner."

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"UCHL3 enhances Ku80 chromatin binding and directly deubiquitylates Ku80."