IndraLab

Statements

UCHL3 deubiquitinates XRCC5. 6 / 6
| 6
reach
"UCHL3 de-ubiquitinates and stabilises Ku80 which is required for Ku80 retention at DSBs [10]."
31769469
reach
"In addition, UCHL3 deubiquitinates and stabilizes TDP1 to promote the repair of TOP1-induced single-strand breaks , and UCHL3 also deubiquitinates KU80 to promote the retention of KU80 at DNA damage sites, thereby improving DNA repair by nonhomologous end joining (NHEJ) ."
37012254
reach
"UCHL3 enhances Ku80 chromatin binding and directly deubiquitylates Ku80."
30559450
reach
"Taken together, these data suggest that UCHL3 could enhance Ku chromatin retention upon DSB induction by deubiquitylating Ku80."
30559450
reach
"Conversely, the ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) can directly deubiquitylate Ku80."
40254688
reach
"Here we found that UCHL3, a deubiquitylating enzyme, interacts with and can directly deubiquitylate Ku80 in a catalytic activity dependent manner."
30559450