IndraLab

Statements

UCHL3 deubiquitinates AHR. 3 / 3
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"As expected, the ability of UCHL3 to deubiquitinate AhR was almost completely abrogated by TCID treatment (Fig. 7a)."
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"WT UCHL3, but not UCHL3-C95S, significantly reduced AhR protein polyubiquitination (Fig. 6f), whereas the other mutants did not decrease AhR polyubiquitination."
32546741
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"Second, UCHL3 reduces AhR polyubiquitination and enhances AhR protein stabilization in a DUB activity-dependent manner, and this ability could be inhibited by TCID, a UCHL3 inhibitor."
32546741