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UCHL3 deubiquitinates AHR. 6 / 6
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"In addition, UCHL3 promotes the proliferation and stem cell traits of NSCLC cells by deubiquitinating Aryl hydrocarbon receptor (AhR) (90)."
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"WT UCHL3, but not UCHL3-C95S, significantly reduced AhR protein polyubiquitination (Fig. 6f), whereas the other mutants did not decrease AhR polyubiquitination."
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"As expected, the ability of UCHL3 to deubiquitinate AhR was almost completely abrogated by TCID treatment (Fig. 7a)."
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"Second, UCHL3 reduces AhR polyubiquitination and enhances AhR protein stabilization in a DUB activity-dependent manner, and this ability could be inhibited by TCID, a UCHL3 inhibitor."
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"Moreover, UCHL3 in non-small cell lung cancers promotes stem-like characteristics and potent tumorigenic capacity by deubiquitinating the aryl hydrocarbon receptor [28]."
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"The results indicated that UCHL3 knockdown led to augmented ubiquitination of endogenous AhR protein while UCHL3 up-regulation led to the opposite (Fig. 2H)."
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