IndraLab

Statements

UCHL3 deubiquitinates TDP1. 2 / 2
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"In addition, UCHL3 deubiquitinates and stabilizes TDP1 to promote the repair of TOP1-induced single-strand breaks , and UCHL3 also deubiquitinates KU80 to promote the retention of KU80 at DNA damage sites, thereby improving DNA repair by nonhomologous end joining (NHEJ) ."
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"In contrast, UCHL3 is downregulated in spinocerebellar ataxia with axonal neuropathy (SCAN1), causing elevated levels of TDP1 ubiquitylation and faster turnover rate."
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