IndraLab

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UCHL3 deubiquitinates FOXM1. 3 / 3
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"Furthermore, knockdown of UCHL3 increased FOXM1 ubiquitination, which enhanced FOXM1 turnover and promoted pancreatic cancer cells ' sensitivity to gemcitabine."
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"Our results demonstrate that <span class="match term0">UCHL3</span> deubiquitinated and stabilized <span class="match term1">FOXM1</span>, thereby potentiating proliferation, migration, and invasion of pancreatic cancer cells."
31598398
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"Deubiquitination of FOXM1 by UCHL3 was also shown to promote pancreatic cancer progression and gemcitabine resistance."
33680951