IndraLab

Statements


UCHL3 deubiquitinates RAD51. 7 / 7
1 | 6

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"UCHL3 deubiquitinates RAD51 thereby promoting the recruitment of RAD51 to DNA damage sites and augmenting DNA repair."

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"After DNA damages, UCHL3 is activated via phosphorylation by ATM and then deubiquitinates RAD51 promoting RAD51-BRCA2 interaction and proper HR repair [150]."

"UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2."

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"UCHL3 deubiquitylates RAD51 to promote the interaction between RAD51 and BRCA2 and HR repair [121]."

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"RAD51 deubiquitination by UCHL3 was observed both in vitro and in cellulo and shown to be critical for BRCA2-RAD51 interaction, RAD51 recruitment to DSB sites, foci formation, as well as RAD51 mediated D-loop formation [XREF_BIBR]."
| PMC

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"found that UCHL3 deubiquitinates RAD51 and subsequently facilitates RAD51-BRCA2 interaction, which is critical for homologous recombination (HR) and contributes to therapeutic resistance in breast cancer."

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"UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2."