IndraLab

Statements

UCHL3 deubiquitinates RAD51. 7 / 7
1 | 6
reach
"UCHL3 deubiquitinates RAD51 thereby promoting the recruitment of RAD51 to DNA damage sites and augmenting DNA repair."
31113933
reach
"After DNA damages, UCHL3 is activated via phosphorylation by ATM and then deubiquitinates RAD51 promoting RAD51-BRCA2 interaction and proper HR repair [150]."
28552167
ubibrowser
"UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2."
27941124
reach
"UCHL3 deubiquitylates RAD51 to promote the interaction between RAD51 and BRCA2 and HR repair [121]."
33990032
reach
"RAD51 deubiquitination by UCHL3 was observed both in vitro and in cellulo and shown to be critical for BRCA2-RAD51 interaction, RAD51 recruitment to DSB sites, foci formation, as well as RAD51 mediated D-loop formation [XREF_BIBR]."
| PMC
reach
"found that UCHL3 deubiquitinates RAD51 and subsequently facilitates RAD51-BRCA2 interaction, which is critical for homologous recombination (HR) and contributes to therapeutic resistance in breast cancer."
33585209
reach
"UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2."
27941124