IndraLab

Statements

COPS5 affects CD274
1 | 17
COPS5 deubiquitinates CD274. 10 / 18
1 | 17
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"Although PD-L1 had notable basal ubiquitination, CSN5 abolished ubiquitination of PD-L1 (XREF_FIG)."
27866850
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"However, our results suggested that CSN5 directly deubiquitinates and stabilizes PD-L1 in cancer cells to escape from immune surveillance."
27866850
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"CSN5 in turn, prevents the ubiquitination of PD-L1, hinders its degradation and as a result enhances tumor escape from immunosurveillance."
29765155
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"Then, the results demonstrated that PD-L1 ubiquitination and downregulation of PD-L1 induced by GOLM1-KD was abolished by CSN5 overexpression (Fig. 3g, h)."
34795203
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"Another inhibitor, curcumin (XREF_FIG E), inhibits a JAMM DUB CSN5 that deubiquitinates and stabilizes PD-L1, thereby destabilizing PD-L1 in various cancers [XREF_BIBR, XREF_BIBR]."
33466790
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"Next we asked whether CSN5 deubiquitinates PD-L1 to increase protein stabilization."
27866850
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"Moreover, CSN5 modulated the deubiquitination and stability of PD-L1."
31802034
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"CSN5 directly deubiquitinates and stabilizes PD-L1 in cancer cells to escape from immune surveillance XREF_BIBR."
33354502
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"CSN5 then binds to and deubiquitinates PD-L1, thus enhancing expression of PD-L1."
| PMC
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"In addition, Lim et al. found that TNF-α upregulates the expression of ubiquitin enzyme CSN5, which reduces the ubiquitination of PD-L1 and stabilizes its expression (41)."
34367136
COPS5 affects CTNNB1
| 3
COPS5 deubiquitinates CTNNB1. 3 / 3
| 3
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"Collectively, the above results demonstrate that PDIA6 contributes to PC progression, which may be associated with CSN5 regulated deubiquitination of beta-catenin and PD-L1."
34325342
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"Meanwhile, our data indicate that knockdown of CSN5 dramatically increased the levels of β-catenin ubiquitination, while overexpression of SAPG5 significantly decrease the levels of β-catenin ubiquitination (Fig. 6o)."
30249289
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"Mechanistically, our results indicate that CSN5 can decrease beta-catenin ubiquitination to enhance the protein expression of SCARA5 in HCC cells."
29189991
COPS5 affects BRSK2
| 3
COPS5 leads to the deubiquitination of BRSK2. 3 / 3
| 3
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"We provided the evidence that Jab1 promoted the ubiquitination and degradation of BRSK2."
22609399
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"Moreover, Jab1 promotes polyubiquitination and degradation of BRSK2."
22609399
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"Intriguingly, Jab1 promoted the ubiquitination and proteasome dependent degradation of BRSK2."
22609399
COPS5 affects PEA15
| 1 1
COPS5 deubiquitinates PEA15. 2 / 2
| 1 1
trips
"Here, we report that in response to DNA damage, COPS5 deubiquitinates and stabilizes PEA15 in an ATM kinase-dependent manner."
24710276
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"Here, we report that in response to DNA damage, COPS5 deubiquitinates and stabilizes PEA15 in an ATM kinase dependent manner."
24710276
COPS5 affects ZEB1
| 1
COPS5 deubiquitinates ZEB1. 1 / 1
| 1
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"CSN5 deubiquitinates ZEB1 by interacting with it directly, which increases ZEB1 stability [XREF_BIBR, XREF_BIBR]."
33808323
COPS5 affects TP53
| 1
COPS5 leads to the deubiquitination of TP53. 1 / 1
| 1
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"The protein CSN5, a part of the COP9 signalosome and a regulator of cell cycle proteins such as p27, has been shown to increase p53 proteasomal degradation by promoting p53 nuclear export and decreasing MDM2 auto-ubiquitination and degradation XREF_BIBR."
23885265
COPS5 affects STK11
| 1
COPS5 deubiquitinates STK11. 1 / 1
| 1
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"Mechanistically, we found that CSN5 directly interacted and deubiquitinated LKB1 for its stabilization in cardiomyocytes."
30710502
COPS5 affects SNAIL
| 1
COPS5 leads to the deubiquitination of SNAIL. 1 / 1
| 1
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"COPS5 has also reported to suppress the SNAIL ubiquitination by inhibiting the binding of SNAIL with beta-Trcp, an E3 ligase [XREF_BIBR]."
29755680
COPS5 affects SNAI2
1 |
COPS5 deubiquitinates SNAI2. 1 / 1
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ubibrowser
"In this study, we identified COP9 signalosome subunit 5 (COPS5) as a deubiquitinating enzyme of SNAIL by using siRNA library screening."
29755680
COPS5 affects SNAI1
| 1
COPS5 deubiquitinates SNAI1. 1 / 1
| 1
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"For instance, deubiquitination of HSP70 and Snail by CSN5 were reported to modulate exosomal protein sorting and to enhance cancer cell invasion and migration, respectively."
27866850
COPS5 affects SMAD4
| 1
COPS5 leads to the deubiquitination of SMAD4. 1 / 1
| 1
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"Binding of Jab1 induces the ubiquitination and degradation of Smad4."
22335355
COPS5 affects Parkinson Disease
| 1
COPS5 leads to the deubiquitination of Parkinson Disease on L1. 1 / 1
| 1
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"CSN5 inhibits the ubiquitination and degradation of PD‐L1."
29992764
COPS5 affects MDM2
| 1
COPS5 leads to the deubiquitination of MDM2. 1 / 1
| 1
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"The protein CSN5, a part of the COP9 signalosome and a regulator of cell cycle proteins such as p27, has been shown to increase p53 proteasomal degradation by promoting p53 nuclear export and decreasing MDM2 auto-ubiquitination and degradation XREF_BIBR."
23885265
COPS5 affects HSPA
| 1
COPS5 deubiquitinates HSPA. 1 / 1
| 1
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"For instance, deubiquitination of HSP70 and Snail by CSN5 were reported to modulate exosomal protein sorting and to enhance cancer cell invasion and migration, respectively."
27866850
COPS5 affects CUL4A
1 |
COPS5 deubiquitinates CUL4A. 1 / 1
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ubibrowser
"Figure 4|in vitro deneddylation assay also demonstrated that CSN could de-ubiquitinat Cul4a"
12732143
COPS5 affects CDKN1B
| 1
COPS5 leads to the deubiquitination of CDKN1B. 1 / 1
| 1
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"P27 ubiquitination and degradation is enhanced by JAB1 binding as well as by phosphorylation on Thr187."
16365885
COPS5 affects 14-3-3sigma
| 1
COPS5 leads to the deubiquitination of 14-3-3sigma. 1 / 1
| 1
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"Further analysis showed that COPS5 and LASP1 synergistically interact to stimulate the ubiquitination and degradation of 14-3-3sigma and promote colorectal cancer progression via PI3K and Akt dependent signaling pathway."
29226323