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COPS5 leads to the deubiquitination of MDM2. 2 / 2

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"In addition, overexpression of COPS5 lead to reduced MDM2 self-ubiquitination and nuclear export of p53, which caused a dysregulation of Mdm2-P53 axis (46–49)."

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"The protein CSN5, a part of the COP9 signalosome and a regulator of cell cycle proteins such as p27, has been shown to increase p53 proteasomal degradation by promoting p53 nuclear export and decreasing MDM2 auto-ubiquitination and degradation XREF_BIBR."

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IndraLab

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COPS5 leads to the deubiquitination of MDM2. 2 / 2

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