IndraLab

Statements

COPS5 deubiquitinates CD274. 18 / 18
1 | 17
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"Although PD-L1 had notable basal ubiquitination, CSN5 abolished ubiquitination of PD-L1 (XREF_FIG)."
27866850
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"However, our results suggested that CSN5 directly deubiquitinates and stabilizes PD-L1 in cancer cells to escape from immune surveillance."
27866850
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"CSN5 in turn, prevents the ubiquitination of PD-L1, hinders its degradation and as a result enhances tumor escape from immunosurveillance."
29765155
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"Then, the results demonstrated that PD-L1 ubiquitination and downregulation of PD-L1 induced by GOLM1-KD was abolished by CSN5 overexpression (Fig. 3g, h)."
34795203
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"Another inhibitor, curcumin (XREF_FIG E), inhibits a JAMM DUB CSN5 that deubiquitinates and stabilizes PD-L1, thereby destabilizing PD-L1 in various cancers [XREF_BIBR, XREF_BIBR]."
33466790
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"Next we asked whether CSN5 deubiquitinates PD-L1 to increase protein stabilization."
27866850
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"Moreover, CSN5 modulated the deubiquitination and stability of PD-L1."
31802034
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"CSN5 directly deubiquitinates and stabilizes PD-L1 in cancer cells to escape from immune surveillance XREF_BIBR."
33354502
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"CSN5 then binds to and deubiquitinates PD-L1, thus enhancing expression of PD-L1."
| PMC
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"In addition, Lim et al. found that TNF-α upregulates the expression of ubiquitin enzyme CSN5, which reduces the ubiquitination of PD-L1 and stabilizes its expression (41)."
34367136
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"Jab1 and COPS5 reduces PD-L1 ubiquitination and stabilizes it."
29535627
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"Deubiquitination and Stabilization of PD-L1 by CSN5"
27866850
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"Collectively, the above results demonstrate that PDIA6 contributes to PC progression, which may be associated with CSN5 regulated deubiquitination of beta-catenin and PD-L1."
34325342
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"COP9 signalosome complex subunit 5 (CSN5), a JAMM family DUB, deubiquitinates and stabilizes PD-L1, thereby escaping T cell mediated immune surveillance."
33466790
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"Deubiquitination and Stabilization of PD-L1 by CSN5."
27866850
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"TNF-alpha within the tumor microenvironment stabilizes PD-L1 expression by means of COP9 signalosome 5 (CSN5) that directly deubiquitinates PD-L1 and impedes degradation of PD-L1."
33298250
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"Aside from inhibiting ubiquitination, CSN5 further deubiquitinates PD-L1 directly."
27866850
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"CSN5 deubiquitinates PD-L1 thereby preventing its proteasomal degradation."
32486375