IndraLab

Statements


COPS5 deubiquitinates CTNNB1. 3 / 3
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"Collectively, the above results demonstrate that PDIA6 contributes to PC progression, which may be associated with CSN5 regulated deubiquitination of beta-catenin and PD-L1."

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"Meanwhile, our data indicate that knockdown of CSN5 dramatically increased the levels of β-catenin ubiquitination, while overexpression of SAPG5 significantly decrease the levels of β-catenin ubiquitination (Fig. 6o)."

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"Mechanistically, our results indicate that CSN5 can decrease beta-catenin ubiquitination to enhance the protein expression of SCARA5 in HCC cells."