IndraLab

Statements

COPS5 deubiquitinates CTNNB1. 6 / 6
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"Those data indicated that PDIA6 promoted CSN5 protein expression and further inhibited the ubiquitination of β-catenin and PD-L1."
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"Both ubiquitin-specific peptidase 7 (USP7) and COP9 signalosome subunit 5 (CSN5) mediate the deubiquitination and stabilization of β-catenin, thus promoting PDAC proliferation (Li et al., 2020a; Ma et al., 2021)."
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"Meanwhile, our data indicate that knockdown of CSN5 dramatically increased the levels of β-catenin ubiquitination, while overexpression of SAPG5 significantly decrease the levels of β-catenin ubiquitination (Fig. 6o)."
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"Mechanistically, our results indicate that CSN5 can decrease beta-catenin ubiquitination to enhance the protein expression of SCARA5 in HCC cells."
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"Furthermore, CSN5 was reported to inhibit the ubiquitination of PD-L1 and β-catenin [16,38], which was confirmed in the present study."
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"Collectively, the above results demonstrate that PDIA6 contributes to PC progression, which may be associated with CSN5-regulated deubiquitination of beta-catenin and PD-L1."
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