IndraLab

Statements

MINDY4 affects EGFR

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MINDY4 increases the amount of EGFR.

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MINDY4 increases the amount of EGFR. 5 / 5

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"More interestingly, FAM188B re-expression could recover EGFR receptor levels that had been decreased by FAM188B knockdown."

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"In this regard, it is very intriguing that FAM188B knockdown decreased levels of total EGFR and p-EGFR in both attached and detached cells (XREF_FIG A, D)."

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"Interestingly, FAM188B knockdown downregulated EGFR protein levels in both attached and suspended cells regardless of EGFR mutation (XREF_FIG A)."

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"Intriguingly, si-FAM188B treatment increased EGFR mRNA levels but decreased its protein levels, which was reversed by treatment with the proteasomal inhibitor MG132, indicating that FAM188B regulates EGFR levels via the proteasomal pathway."

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"All these data suggest that FAM188B knockdown downregulates EGFR levels through the proteasome degradation pathway and inactivates multiple pathways involved in cell proliferation and survival."

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MINDY4 activates EGFR.

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MINDY4 activates EGFR. 3 / 3

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"FAM188B knockdown decreased the activities of several oncogenic proteins downstream of EGFR that are involved in anoikis resistance, including pAkt, pSrc, and pSTAT3, with little changes to their protein levels."

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"It is possible that EGFR downregulation induced by si-FAM188B results in inactivation of those signaling pathways, which are involved not only in the determination of anoikis resistance but also metastatic characteristics, including migration and invasion [XREF_BIBR]."

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"However, FAM188B knockdown decreased EGFR protein levels (XREF_FIG A)."

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MINDY4 decreases the amount of EGFR.

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MINDY4 decreases the amount of EGFR. 2 / 2

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"Interestingly, FAM188B knockdown did not decrease but rather increased EGFR mRNA levels (XREF_FIG B)."

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"Contrary to expectation, FAM188B knockdown upregulated EGFR mRNA levels (XREF_FIG B)."

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MINDY4 inhibits EGFR.

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MINDY4 inhibits EGFR. 1 / 1

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"FAM188B knockdown induced EGFR downregulation and inactivation of survival related signaling molecules, indicating that FAM188B could be a potential target to control tumor metastasis."

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MINDY4 affects cell growth

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MINDY4 activates cell growth. 9 / 9

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"FAM188B knockdown induced the inhibition of cell growth along with the downregulation of mRNA and protein levels of FOXM1 ."

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"In addition, FAM188B knockdown decreased cell growth in the 3D culture condition, which mimics in vivo conditions (XREF_FIG E)."

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"FAM188B knockdown induced cell growth inhibition due to an increase in apoptosis in colon cancer cell lines."

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"FAM188B was downregulated by si-RNA targeting FAM188B ( Figure 1B ) , and cell growth was significantly inhibited by FAM188B knockdown as assessed by 3 - ( 4,5 - dimethylthiazol-2-yl ) -5 - ( 3-carboxyme-thoxyphenyl ) -2 - ( 4-sulfophenyl ) -2 H-tetrazolium ( MTS ) assay in A549 , H1299 , and H1975 cells ( Figure 1C ) ."

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"FAM188B knockdown induced the inhibition of cell growth along with the downregulation of mRNA and protein levels of FOXM1."

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"FAM188B was downregulated by si-RNA targeting FAM188B (XREF_FIG B), and cell growth was significantly inhibited by FAM188B knockdown as assessed by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxyme-thoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay in A549, H1299, and H1975 cells (XREF_FIG C)."

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"In addition , FAM188B knockdown decreased cell growth in the 3D culture condition , which mimics in vivo conditions ( Figure 4E ) ."

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"Knockdown of FAM188B stimulated cell growth inhibition, through an increase of apoptosis in colon cancer cell lines.46 Proteomic analysis of FAM188B immunocomplexes identified p53 and USP7 as interaction partners of FAM188B."

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"Knockdown of FAM188B stimulated cell growth inhibition , through an increase of apoptosis in colon cancer cell lines.46 Proteomic analysis of FAM188B immunocomplexes identified p53 and USP7 as interaction partners of FAM188B ."

35005106

MINDY4 affects TP53

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MINDY4 inhibits TP53.

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MINDY4 inhibits TP53. 3 / 3

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"FAM188B silencing activates p53 and its downstream pathway."

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"Therefore, elevated expression of FAM188B in tumor tissues suggests that FAM188B would inhibit p53 activation and thereby provide tolerance against stressful conditions."

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"FAM188B knockdown increased p53 as well as Ser15 phosphorylated p53, and thus enhanced protein levels of p53 regulated genes, including p21, PUMA, and BAX, which are in the apoptosis pathway."

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MINDY4 decreases the amount of TP53.

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MINDY4 decreases the amount of TP53. 2 / 2

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"To determine how FAM188B knockdown enhances p53 protein levels, we identified FAM188B interacting proteins revealed by LC/MS-MS."

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"However, double silencing of USP7 and FAM188B restored the p53 level."

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MINDY4 binds TP53.

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TP53 binds MINDY4. 1 / 1

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"Interestingly, when we immunoprecipitated p53 proteins, we could observe that FAM188B as well as USP7 were in the p53 immunocomplexes, indicating that FAM188B forms a complex with p53."

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MINDY4 activates TP53.

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MINDY4 activates TP53. 1 / 1

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"These results suggest that FAM188B downregulation activates p53, and thus upregulates apoptosis related genes, including BAX, and PUMA, and leads to cell death."

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MINDY4 affects Neoplasm Metastasis

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MINDY4 activates Neoplasm Metastasis. 6 / 6

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"Here, we demonstrate that FAM188B knockdown sensitizes human lung cancer cell lines to anoikis upon cell detachment and inhibits lung metastasis in vivo."

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"FAM188B knockdown inhibits various metastatic characteristics and tumor metastasis ."

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"FAM188B knockdown inhibits various metastatic characteristics and tumor metastasis."

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"Here, we demonstrate that FAM188B knockdown makes lung cancer cells sensitive to anoikis and inhibits lung metastasis."

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"FAM188B Downregulation Sensitizes Lung Cancer Cells to Anoikis via EGFR Downregulation and Inhibits Tumor Metastasis In Vivo Simple Summary Cancer cells should acquire anoikis resistance for successful metastasis ."

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"FAM188B Downregulation Sensitizes Lung Cancer Cells to Anoikis via EGFR Downregulation and Inhibits Tumor Metastasis In Vivo ."

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MINDY4 affects apoptotic process

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MINDY4 inhibits apoptotic process.

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MINDY4 inhibits apoptotic process. 4 / 4

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"We also observed that FAM188B knockdown induced apoptosis in the suspension culture as determined by flow cytometry analysis of annexin V/PI stained cells (XREF_FIG D)."

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"There were increases in annexin V / PI-stained cells by si-FAM188B-treatment , indicating that FAM188B knockdown induces apoptosis ( Figure 1D and Figure S1A ) ."

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"We also observed that FAM188B knockdown induced apoptosis in the suspension culture as determined by flow cytometry analysis of annexin V / PI stained cells ( Figure 2D ) ."

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"There were increases in annexin V/PI stained cells by si-FAM188B-treatment, indicating that FAM188B knockdown induces apoptosis (XREF_FIG D and Figure S1A)."

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MINDY4 activates apoptotic process.

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MINDY4 activates apoptotic process. 1 / 1

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"These results suggest that FAM188B downregulation activates p53, and thus upregulates apoptosis related genes, including BAX, and PUMA, and leads to cell death."

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MINDY4 affects Neoplasm Invasiveness

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MINDY4 activates Neoplasm Invasiveness. 4 / 4

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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."

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"FAM188B knockdown significantly decreased both invasion (XREF_FIG A) and migration (XREF_FIG B) in three cell lines."

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"FAM188B knockdown significantly decreased both invasion ( Figure 4A ) and migration ( Figure 4B ) in three cell lines ."

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"FAM188B knockdown attenuated invasion, migration, adhesion, and wound closure (XREF_FIG A-D)."

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MINDY4 is modified

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MINDY4 is phosphorylated on S162. 1 / 1

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hprd

No evidence text available

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MINDY4 is phosphorylated on S476. 1 / 1

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hprd

No evidence text available

18452278

MINDY4 is phosphorylated on T167. 1 / 1

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hprd

No evidence text available

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MINDY4 affects cell adhesion

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MINDY4 activates cell adhesion. 3 / 3

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"In addition, cell adhesion was also retarded in cells treated with si-FAM188B (XREF_FIG C)."

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"FAM188B knockdown attenuated invasion, migration, adhesion, and wound closure (XREF_FIG A-D)."

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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."

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MINDY4 affects FOXM1

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MINDY4 activates FOXM1. 3 / 3

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"More interestingly , FAM188B knockdown decreased FOXM1 , an oncogenic transcription factor [ 23 ] , in both attached and suspended conditions ( Figure 3D ) ."

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"More interestingly, FAM188B knockdown decreased FOXM1, an oncogenic transcription factor [XREF_BIBR], in both attached and suspended conditions (XREF_FIG D)."

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"Recently , we reported that FAM188B knockdown decreased levels of FOXM1 , an oncogenic transcription factor , with an increase in its ubiquitination in A549 cells [ 14 ] ."

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MINDY4 affects BIRC5

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MINDY4 activates BIRC5.

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MINDY4 activates BIRC5. 2 / 2

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"FAM188B knockdown decreased levels of Survivin , which is an anti-apoptotic protein that plays a critical role in anoikis resistance [ 14 ] ."

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"FAM188B knockdown also resulted in downregulation of Survivin and cell cycle-related proteins , which are direct targets of FOXM1 ."

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MINDY4 increases the amount of BIRC5.

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MINDY4 increases the amount of BIRC5. 1 / 1

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"FAM188B knockdown decreased levels of Survivin, which is an anti-apoptotic protein that plays a critical role in anoikis resistance [XREF_BIBR]."

33440835

Bisphenol A affects MINDY4

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Bisphenol A increases the amount of MINDY4.

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Bisphenol A increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

30816183

Bisphenol A decreases the amount of MINDY4.

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Bisphenol A decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

25181051

Aflatoxin B1 affects MINDY4

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Aflatoxin B1 methylates MINDY4.

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Aflatoxin B1 methylates MINDY4. 1 / 1

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ctd

No evidence text available

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Aflatoxin B1 demethylates MINDY4.

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Aflatoxin B1 demethylates MINDY4. 1 / 1

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ctd

No evidence text available

30157460

TP53 affects MINDY4

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TP53 decreases the amount of MINDY4.

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TP53 decreases the amount of MINDY4. 1 / 1

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biopax:msigdb

No evidence text available

TP53 binds MINDY4.

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TP53 binds MINDY4. 1 / 1

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"Interestingly, when we immunoprecipitated p53 proteins, we could observe that FAM188B as well as USP7 were in the p53 immunocomplexes, indicating that FAM188B forms a complex with p53."

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MINDY4 affects wound closure

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MINDY4 activates wound closure. 2 / 2

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"FAM188B knockdown decreased wound closure in all three cell lines ( Figure 4D ) ."

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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."

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MINDY4 affects migration

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MINDY4 activates migration. 2 / 2

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"FAM188B knockdown significantly decreased both invasion ( Figure 4A ) and migration ( Figure 4B ) in three cell lines ."

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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."

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MINDY4 affects lung metastasis

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MINDY4 activates lung metastasis. 2 / 2

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"Here , we demonstrate that FAM188B knockdown sensitizes human lung cancer cell lines to anoikis upon cell detachment and inhibits lung metastasis in vivo ."

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"Here , we demonstrate that FAM188B knockdown makes lung cancer cells sensitive to anoikis and inhibits lung metastasis ."

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MINDY4 affects cell death

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MINDY4 activates cell death. 2 / 2

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"These results suggest that FAM188B downregulation activates p53, and thus upregulates apoptosis related genes, including BAX, and PUMA, and leads to cell death."

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"FAM188B downregulation leads to cell death in vitro."

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MINDY4 affects STAT3

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MINDY4 activates STAT3. 2 / 2

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"Intriguingly, FAM188B knockdown inactivated Src, Akt, and STAT3, not only in suspension but also in attached cells (XREF_FIG D)."

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"STAT3 activation was dramatically reduced by FAM188B knockdown (XREF_FIG D), and consistently phospho-STAT3 immunostaining decreased in the FAM188B-knockdown lung tumor tissue."

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MINDY4 affects Cell Survival

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MINDY4 activates Cell Survival. 2 / 2

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"FAM188B enhances cell survival via interaction with USP7."

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"FAM188B knockdown decreased cell viability in lung cancer cells."

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Tris(1,3-dichloro-2-propyl)phosphate affects MINDY4

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Tris(1,3-dichloro-2-propyl)phosphate decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

26179874

Thioacetamide affects MINDY4

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Thioacetamide increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

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Tetrachloromethane affects MINDY4

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Tetrachloromethane increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

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Sunitinib affects MINDY4

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Sunitinib decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

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Sodium arsenite affects MINDY4

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Sodium arsenite decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

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Silicon dioxide affects MINDY4

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Silicon dioxide increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

25895662

SiFAM188B affects MINDY4

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SiFAM188B decreases the amount of MINDY4. 1 / 1

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"FAM188B protein levels were also reduced by siFAM188B, as determined by western blot."

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Si-RNA targeting FAM188B affects MINDY4

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Si-RNA targeting FAM188B inhibits MINDY4. 1 / 1

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Methapyrilene affects MINDY4

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Methapyrilene methylates MINDY4. 1 / 1

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ctd

No evidence text available

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Hsa-miR-484 affects MINDY4

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Hsa-miR-484 decreases the amount of MINDY4. 1 / 1

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biopax:mirtarbase

No evidence text available

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Doxycycline affects MINDY4

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Doxycycline activates MINDY4. 1 / 1

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"Doxycycline induced FAM188B short hairpin RNA (shRNA), which led to FAM188B downregulation."

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Dichloroacetic acid affects MINDY4

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Dichloroacetic acid increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

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Cytarabine affects MINDY4

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Cytarabine decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

21198554

Benzo[e]pyrene affects MINDY4

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Benzo[e]pyrene methylates MINDY4. 1 / 1

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ctd

No evidence text available

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All-trans-retinoic acid affects MINDY4

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All-trans-retinoic acid decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

23724009

Aflatoxin B2 affects MINDY4

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Aflatoxin B2 methylates MINDY4. 1 / 1

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ctd

No evidence text available

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Acrylamide affects MINDY4

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Acrylamide decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

28959563

Vehicle Emissions affects MINDY4

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Vehicle Emissions methylates MINDY4. 1 / 1

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ctd

No evidence text available

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USP7 affects MINDY4

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USP7 binds MINDY4. 1 / 1

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"In our study, however, the amount of FAM188B bound USP7 dramatically increased upon FAM188B overexpression in HCT-116 cells."

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TRIM56 affects MINDY4

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TRIM56 binds MINDY4. 1 / 1

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biogrid

No evidence text available

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NFKBIL1 affects MINDY4

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MINDY4 binds NFKBIL1. 1 / 1

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biogrid

No evidence text available

27173435

MINDY4 affects various metastatic characteristics

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MINDY4 activates various metastatic characteristics. 1 / 1

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eidos

"FAM188B knockdown inhibits various metastatic characteristics and tumor metastasis ."

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MINDY4 affects tumor proteins

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MINDY4 activates tumor proteins. 1 / 1

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"FAM188B knockdown reduced the levels of tumor proteins such as EGFR and FOXM1 , suggesting that FAM188B may be a potential target controlling tumor malignancies ."

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MINDY4 affects total p-EGFR

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MINDY4 activates total p-EGFR. 1 / 1

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"In this regard , it is very intriguing that FAM188B knockdown decreased levels of total EGFR and p-EGFR in both attached and detached cells ( Figure 3A , D ) ."

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MINDY4 affects signaling receptor activity

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MINDY4 activates signaling receptor activity. 1 / 1

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"More interestingly , FAM188B re-expression could recover EGFR receptor levels that had been decreased by FAM188B knockdown ( Figure S3A ) ."

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MINDY4 affects several oncogenic proteins

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MINDY4 activates several oncogenic proteins. 1 / 1

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"FAM188B knockdown decreased the activities of several oncogenic proteins downstream of EGFR that are involved in anoikis resistance , including pAkt , pSrc , and pSTAT3 , with little changes to their protein levels ."

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MINDY4 affects overall ubiquitination p53 immunocomplexes p53

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MINDY4 activates overall ubiquitination p53 immunocomplexes p53. 1 / 1

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"Knockdown of FAM188B led to an overall decrease in ubiquitination of p53 immunocomplexes and p53 , further implicating USP7 in p53 deubiquitination.46 USP7 and the cell cycle E3 ubiquitin-protein ligase CHFR is a checkpoint protein with FHA and RING domains and a member of the RING family and it is known as a mitotic checkpoint ."

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MINDY4 affects metastatic features

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MINDY4 activates metastatic features. 1 / 1

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"We tested whether knockdown of FAM188B inhibits these metastatic features in three lung cancer cell lines ."

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MINDY4 affects metastatic characteristics

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MINDY4 activates metastatic characteristics. 1 / 1

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"Moreover , FAM188B downregulation reduced metastatic characteristics , such as cell adhesion , invasion , and migration , as well as growth in 3D culture conditions ."

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MINDY4 affects messenger RNA

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MINDY4 inhibits messenger RNA. 1 / 1

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"Contrary to expectation , FAM188B knockdown upregulated EGFR mRNA levels ( Figure 3B ) ."

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MINDY4 affects member RING family

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MINDY4 inhibits member RING family. 1 / 1

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eidos

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MINDY4 affects inactivation survival-related signaling molecules

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MINDY4 activates inactivation survival-related signaling molecules. 1 / 1

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"FAM188B knockdown induced EGFR downregulation and inactivation of survival-related signaling molecules , indicating that FAM188B could be a potential target to control tumor metastasis ."

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MINDY4 affects implicating USP7 deubiquitination.46 USP7 cell cycle E3 ubiquitin-protein ligase CHFR is checkpoint protein RING domains

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MINDY4 inhibits implicating USP7 deubiquitination.46 USP7 cell cycle E3 ubiquitin-protein ligase CHFR is checkpoint protein RING domains. 1 / 1

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eidos

35005106

MINDY4 affects growth lung cancer cell lines

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MINDY4 activates growth lung cancer cell lines. 1 / 1

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"Consistent with a previous report using colon cancer cells [ 13 ] , FAM188B knockdown inhibited the growth of lung cancer cell lines regardless of whether they were expressing wild type or mutant EGFR ( Figure 1C , D ) ."

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MINDY4 affects growth lung cancer cell lines soft agar

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MINDY4 activates growth lung cancer cell lines soft agar. 1 / 1

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eidos

"In addition , FAM188B knockdown decreased the growth of lung cancer cell lines in soft agar ( Figure 1F ) , and FAM188B knockdown sensitized cells to anoikis when cells were in suspension ( Figure 2C , D ) ."

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MINDY4 affects growth 3D culture

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MINDY4 activates growth 3D culture. 1 / 1

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"Moreover , FAM188B downregulation reduced metastatic characteristics , such as cell adhesion , invasion , and migration , as well as growth in 3D culture conditions ."

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MINDY4 affects colony soft agar

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MINDY4 activates colony soft agar. 1 / 1

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"Furthermore , although there were some variations in the ability to form colonies among the cell lines , FAM188B knockdown decreased colony formation in soft agar conditions , which is a measure of anchorage-independent growth ( Figure 1F ) ."

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MINDY4 affects colonies

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MINDY4 activates colonies. 1 / 1

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"Knockdown of FAM188B not only decreased the sizes of colonies but also altered the shape of growth when they were grown in 3D culture ( Figure 4E ) ."

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MINDY4 affects cell cycle-related proteins

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MINDY4 activates cell cycle-related proteins. 1 / 1

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"FAM188B knockdown also resulted in downregulation of Survivin and cell cycle-related proteins , which are direct targets of FOXM1 ."

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MINDY4 affects cell aggregate

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MINDY4 activates cell aggregate. 1 / 1

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"However , FAM188B knockdown inhibited cell aggregate formation in all three cell lines with an increase in dead cells stained by PI and shown in red ( Figure 2C ) ."

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MINDY4 affects apoptosis signaling

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MINDY4 inhibits apoptosis signaling. 1 / 1

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"FAM188B knockdown induced increased caspase 3 activation , as assessed by its cleavage , and thus increased PARP cleavage ( Figure S1B ) , indicating activation of apoptosis signaling by FAM188B knockdown ."

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MINDY4 affects annexin

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MINDY4 inhibits annexin. 1 / 1

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"In addition, FAM188B knockdown increased the population of annexin V/PI stained cells."

29795372

MINDY4 affects activation of cysteine-type endopeptidase activity involved in apoptotic process

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MINDY4 inhibits activation of cysteine-type endopeptidase activity involved in apoptotic process. 1 / 1

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eidos

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MINDY4 affects USP7

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USP7 binds MINDY4. 1 / 1

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"In our study, however, the amount of FAM188B bound USP7 dramatically increased upon FAM188B overexpression in HCT-116 cells."

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MINDY4 affects TRIM56

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TRIM56 binds MINDY4. 1 / 1

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biogrid

No evidence text available

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MINDY4 affects STAT3 activation

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MINDY4 activates STAT3 activation. 1 / 1

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eidos

"STAT3 activation was dramatically reduced by FAM188B knockdown ( Figure 3D ) , and consistently phospho-STAT3 immunostaining decreased in the FAM188B-knockdown lung tumor tissue ( Figure S4B ) ."

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MINDY4 affects SRC

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MINDY4 activates SRC. 1 / 1

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"Intriguingly, FAM188B knockdown inactivated Src, Akt, and STAT3, not only in suspension but also in attached cells (XREF_FIG D)."

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MINDY4 affects PTK2

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MINDY4 leads to the phosphorylation of PTK2. 1 / 1

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"FAK activation is also important for anoikis resistance [XREF_BIBR], and FAK phosphorylation was reduced by FAM188B knockdown (XREF_FIG D)."

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MINDY4 affects PARP cleavage

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MINDY4 inhibits PARP cleavage. 1 / 1

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eidos

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MINDY4 affects NFKBIL1

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MINDY4 binds NFKBIL1. 1 / 1

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biogrid

No evidence text available

27173435

MINDY4 affects Figure

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MINDY4 inhibits Figure-S1A. 1 / 1

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"There were increases in annexin V/PI stained cells by si-FAM188B-treatment, indicating that FAM188B knockdown induces apoptosis (XREF_FIG D and Figure S1A)."

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MINDY4 affects FAK phosphorylation

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MINDY4 activates FAK phosphorylation. 1 / 1

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"FAK activation is also important for anoikis resistance [ 22 ] , and FAK phosphorylation was reduced by FAM188B knockdown ( Figure 3D ) ."

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MINDY4 affects EGFR receptor

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MINDY4 increases the amount of EGFR receptor. 1 / 1

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"More interestingly, FAM188B re-expression could recover EGFR receptor levels that had been decreased by FAM188B knockdown."

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MINDY4 affects AKT

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MINDY4 activates AKT. 1 / 1

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"Intriguingly, FAM188B knockdown inactivated Src, Akt, and STAT3, not only in suspension but also in attached cells (XREF_FIG D)."

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MINDY4 affects AGMAT

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AGMAT binds MINDY4. 1 / 1

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biogrid

No evidence text available

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MINDY4 affects 3D

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MINDY4 inhibits 3D. 1 / 1

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"Moreover, FAM188B downregulation reduced metastatic characteristics, such as cell adhesion, invasion, and migration, as well as growth in 3D culture conditions."

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