IndraLab

Statements

MINDY4 affects EGFR

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MINDY4 increases the amount of EGFR.

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MINDY4 increases the amount of EGFR. 5 / 5

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"Intriguingly, si-FAM188B treatment increased EGFR mRNA levels but decreased its protein levels, which was reversed by treatment with the proteasomal inhibitor MG132, indicating that FAM188B regulates EGFR levels via the proteasomal pathway."

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"Interestingly, FAM188B knockdown downregulated EGFR protein levels in both attached and suspended cells regardless of EGFR mutation (XREF_FIG A)."

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"More interestingly, FAM188B re-expression could recover EGFR receptor levels that had been decreased by FAM188B knockdown."

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"All these data suggest that FAM188B knockdown downregulates EGFR levels through the proteasome degradation pathway and inactivates multiple pathways involved in cell proliferation and survival."

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"In this regard, it is very intriguing that FAM188B knockdown decreased levels of total EGFR and p-EGFR in both attached and detached cells (XREF_FIG A, D)."

33440835

MINDY4 activates EGFR.

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MINDY4 activates EGFR. 3 / 3

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"It is possible that EGFR downregulation induced by si-FAM188B results in inactivation of those signaling pathways, which are involved not only in the determination of anoikis resistance but also metastatic characteristics, including migration and invasion [XREF_BIBR]."

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"FAM188B knockdown decreased the activities of several oncogenic proteins downstream of EGFR that are involved in anoikis resistance, including pAkt, pSrc, and pSTAT3, with little changes to their protein levels."

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"However, FAM188B knockdown decreased EGFR protein levels (XREF_FIG A)."

33440835

MINDY4 decreases the amount of EGFR.

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MINDY4 decreases the amount of EGFR. 2 / 2

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"Contrary to expectation, FAM188B knockdown upregulated EGFR mRNA levels (XREF_FIG B)."

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"Interestingly, FAM188B knockdown did not decrease but rather increased EGFR mRNA levels (XREF_FIG B)."

33440835

MINDY4 inhibits EGFR.

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MINDY4 inhibits EGFR. 1 / 1

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"FAM188B knockdown induced EGFR downregulation and inactivation of survival related signaling molecules, indicating that FAM188B could be a potential target to control tumor metastasis."

33440835

MINDY4 affects TP53

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MINDY4 inhibits TP53.

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MINDY4 inhibits TP53. 3 / 3

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"FAM188B knockdown increased p53 as well as Ser15 phosphorylated p53, and thus enhanced protein levels of p53 regulated genes, including p21, PUMA, and BAX, which are in the apoptosis pathway."

29795372

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"Therefore, elevated expression of FAM188B in tumor tissues suggests that FAM188B would inhibit p53 activation and thereby provide tolerance against stressful conditions."

29795372

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"FAM188B silencing activates p53 and its downstream pathway."

29795372

MINDY4 binds TP53.

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MINDY4 binds TP53. 3 / 3

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"Interestingly, when we immunoprecipitated p53 proteins, we could observe that FAM188B as well as USP7 were in the p53 immunocomplexes, indicating that FAM188B forms a complex with p53."

29795372

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No evidence text available

29795372

MINDY4 decreases the amount of TP53.

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MINDY4 decreases the amount of TP53. 2 / 2

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"However, double silencing of USP7 and FAM188B restored the p53 level."

29795372

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"To determine how FAM188B knockdown enhances p53 protein levels, we identified FAM188B interacting proteins revealed by LC/MS-MS."

29795372

MINDY4 activates TP53.

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MINDY4 activates TP53. 1 / 1

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"These results suggest that FAM188B downregulation activates p53, and thus upregulates apoptosis related genes, including BAX, and PUMA, and leads to cell death."

29795372

MINDY4 affects cell growth

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MINDY4 activates cell growth. 8 / 8

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"FAM188B was downregulated by si-RNA targeting FAM188B (XREF_FIG B), and cell growth was significantly inhibited by FAM188B knockdown as assessed by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxyme-thoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay in A549, H1299, and H1975 cells (XREF_FIG C)."

33440835

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"FAM188B was downregulated by si-RNA targeting FAM188B ( Figure 1B ) , and cell growth was significantly inhibited by FAM188B knockdown as assessed by 3 - ( 4,5 - dimethylthiazol-2-yl ) -5 - ( 3-carboxyme-thoxyphenyl ) -2 - ( 4-sulfophenyl ) -2 H-tetrazolium ( MTS ) assay in A549 , H1299 , and H1975 cells ( Figure 1C ) ."

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"Knockdown of FAM188B stimulated cell growth inhibition , through an increase of apoptosis in colon cancer cell lines.46 Proteomic analysis of FAM188B immunocomplexes identified p53 and USP7 as interaction partners of FAM188B ."

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"In addition , FAM188B knockdown decreased cell growth in the 3D culture condition , which mimics in vivo conditions ( Figure 4E ) ."

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"In addition, FAM188B knockdown decreased cell growth in the 3D culture condition, which mimics in vivo conditions (XREF_FIG E)."

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"Knockdown of FAM188B stimulated cell growth inhibition, through an increase of apoptosis in colon cancer cell lines.46 Proteomic analysis of FAM188B immunocomplexes identified p53 and USP7 as interaction partners of FAM188B."

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"FAM188B knockdown induced the inhibition of cell growth along with the downregulation of mRNA and protein levels of FOXM1."

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"FAM188B knockdown induced cell growth inhibition due to an increase in apoptosis in colon cancer cell lines."

29795372

MINDY4 affects Neoplasm Invasiveness

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MINDY4 activates Neoplasm Invasiveness. 7 / 7

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"FAM188B promotes the growth, metastasis, and invasion of hepatocellular carcinoma by targeting the HRNPA1/PKM2 axis."

38844182

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"FAM188B knockdown significantly decreased both invasion (XREF_FIG A) and migration (XREF_FIG B) in three cell lines."

33440835

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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."

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"We further demonstrated that FAM188B knockdown inhibited cell proliferation, epithelial-mesenchymal transition, migration and invasion both in vitro and in vivo."

38844182

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"FAM188B knockdown attenuated invasion, migration, adhesion, and wound closure (XREF_FIG A-D)."

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"Therefore, we speculate that MINDY4 in PC enhances the invasion and migration of PC by inducing EMT.To further investigate the cancer-promoting mechanism of MINDY2 in PC, we identified ACTN4 as an interacting protein of MINDY2 by immunoprecipitation, mass spectrometry, and immunofluorescence co-localization."

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"FAM188B knockdown significantly decreased both invasion ( Figure 4A ) and migration ( Figure 4B ) in three cell lines ."

33440835

MINDY4 affects Neoplasm Metastasis

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MINDY4 activates Neoplasm Metastasis. 6 / 6

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"FAM188B promotes the growth, metastasis, and invasion of hepatocellular carcinoma by targeting the HRNPA1/PKM2 axis."

38844182

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"FAM188B knockdown inhibits various metastatic characteristics and tumor metastasis."

33440835

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"FAM188B Downregulation Sensitizes Lung Cancer Cells to Anoikis via EGFR Downregulation and Inhibits Tumor Metastasis In Vivo Simple Summary Cancer cells should acquire anoikis resistance for successful metastasis ."

33440835

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"Here, we demonstrate that FAM188B knockdown makes lung cancer cells sensitive to anoikis and inhibits lung metastasis."

33440835

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"FAM188B knockdown inhibits various metastatic characteristics and tumor metastasis ."

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"Here, we demonstrate that FAM188B knockdown sensitizes human lung cancer cell lines to anoikis upon cell detachment and inhibits lung metastasis in vivo."

33440835

MINDY4 affects apoptotic process

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MINDY4 inhibits apoptotic process.

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MINDY4 inhibits apoptotic process. 4 / 4

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"There were increases in annexin V/PI stained cells by si-FAM188B-treatment, indicating that FAM188B knockdown induces apoptosis (XREF_FIG D and Figure S1A)."

33440835

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"We also observed that FAM188B knockdown induced apoptosis in the suspension culture as determined by flow cytometry analysis of annexin V/PI stained cells (XREF_FIG D)."

33440835

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"We also observed that FAM188B knockdown induced apoptosis in the suspension culture as determined by flow cytometry analysis of annexin V / PI stained cells ( Figure 2D ) ."

33440835

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"There were increases in annexin V / PI-stained cells by si-FAM188B-treatment , indicating that FAM188B knockdown induces apoptosis ( Figure 1D and Figure S1A ) ."

33440835

MINDY4 activates apoptotic process.

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MINDY4 activates apoptotic process. 1 / 1

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"These results suggest that FAM188B downregulation activates p53, and thus upregulates apoptosis related genes, including BAX, and PUMA, and leads to cell death."

29795372

TP53 affects MINDY4

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TP53 binds MINDY4.

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MINDY4 binds TP53. 3 / 3

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"Interestingly, when we immunoprecipitated p53 proteins, we could observe that FAM188B as well as USP7 were in the p53 immunocomplexes, indicating that FAM188B forms a complex with p53."

29795372

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No evidence text available

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TP53 decreases the amount of MINDY4.

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TP53 decreases the amount of MINDY4. 1 / 1

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No evidence text available

MINDY4 affects FOXM1

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MINDY4 activates FOXM1.

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MINDY4 activates FOXM1. 3 / 3

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"More interestingly, FAM188B knockdown decreased FOXM1, an oncogenic transcription factor [XREF_BIBR], in both attached and suspended conditions (XREF_FIG D)."

33440835

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"More interestingly , FAM188B knockdown decreased FOXM1 , an oncogenic transcription factor [ 23 ] , in both attached and suspended conditions ( Figure 3D ) ."

33440835

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"Recently , we reported that FAM188B knockdown decreased levels of FOXM1 , an oncogenic transcription factor , with an increase in its ubiquitination in A549 cells [ 14 ] ."

33440835

MINDY4 deubiquitinates FOXM1.

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MINDY4 deubiquitinates FOXM1. 1 / 1

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"<span class="match term0">FAM188B</span> Interacts with <span class="match term1">FOXM1</span> and Regulates Stability via Deubiquitination"

33142744

Bisphenol A affects MINDY4

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Bisphenol A increases the amount of MINDY4.

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Bisphenol A increases the amount of MINDY4. 2 / 2

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ctd

No evidence text available

35817127

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No evidence text available

30816183

Bisphenol A decreases the amount of MINDY4.

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Bisphenol A decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

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USP7 affects MINDY4

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MINDY4 binds USP7. 3 / 3

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No evidence text available

29795372

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"In our study, however, the amount of FAM188B bound USP7 dramatically increased upon FAM188B overexpression in HCT-116 cells."

29795372

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biogrid

No evidence text available

29795372

MINDY4 is modified

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MINDY4 is phosphorylated on S162. 1 / 1

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hprd

No evidence text available

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MINDY4 is phosphorylated on S476. 1 / 1

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hprd

No evidence text available

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MINDY4 is phosphorylated on T167. 1 / 1

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hprd

No evidence text available

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MINDY4 affects cell adhesion

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MINDY4 activates cell adhesion. 3 / 3

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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."

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"In addition, cell adhesion was also retarded in cells treated with si-FAM188B (XREF_FIG C)."

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"FAM188B knockdown attenuated invasion, migration, adhesion, and wound closure (XREF_FIG A-D)."

33440835

MINDY4 affects USP7

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MINDY4 binds USP7. 3 / 3

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biogrid

No evidence text available

29795372

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"In our study, however, the amount of FAM188B bound USP7 dramatically increased upon FAM188B overexpression in HCT-116 cells."

29795372

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biogrid

No evidence text available

29795372

Thioacetamide affects MINDY4

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Thioacetamide increases the amount of MINDY4.

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Thioacetamide increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

23411599

Thioacetamide decreases the amount of MINDY4.

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Thioacetamide decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

34492290

Sodium arsenite affects MINDY4

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Sodium arsenite decreases the amount of MINDY4. 2 / 2

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No evidence text available

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No evidence text available

29301061

Cadmium dichloride affects MINDY4

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Cadmium dichloride increases the amount of MINDY4. 2 / 2

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ctd

No evidence text available

37325564

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No evidence text available

38568856

Aflatoxin B1 affects MINDY4

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Aflatoxin B1 methylates MINDY4.

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Aflatoxin B1 methylates MINDY4. 1 / 1

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ctd

No evidence text available

27153756

Aflatoxin B1 demethylates MINDY4.

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Aflatoxin B1 demethylates MINDY4. 1 / 1

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ctd

No evidence text available

30157460

MINDY4 affects wound closure

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MINDY4 activates wound closure. 2 / 2

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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."

33440835

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"FAM188B knockdown decreased wound closure in all three cell lines ( Figure 4D ) ."

33440835

MINDY4 affects migration

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MINDY4 activates migration. 2 / 2

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"FAM188B knockdown significantly decreased both invasion ( Figure 4A ) and migration ( Figure 4B ) in three cell lines ."

33440835

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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."

33440835

MINDY4 affects lung metastasis

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MINDY4 activates lung metastasis. 2 / 2

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"Here , we demonstrate that FAM188B knockdown sensitizes human lung cancer cell lines to anoikis upon cell detachment and inhibits lung metastasis in vivo ."

33440835

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"Here , we demonstrate that FAM188B knockdown makes lung cancer cells sensitive to anoikis and inhibits lung metastasis ."

33440835

MINDY4 affects cell population proliferation

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MINDY4 activates cell population proliferation. 2 / 2

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"Experiments showed that the function of Circ-FAM188B-103aa in chicken myogenesis was the same as that of its host gene transcript, FAM188B, which enhanced proliferation but restricted differentiation of chicken SMSCs [117]."

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"We further demonstrated that FAM188B knockdown inhibited cell proliferation, epithelial-mesenchymal transition, migration and invasion both in vitro and in vivo."

38844182

MINDY4 affects cell death

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MINDY4 activates cell death. 2 / 2

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"FAM188B downregulation leads to cell death in vitro."

29795372

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"These results suggest that FAM188B downregulation activates p53, and thus upregulates apoptosis related genes, including BAX, and PUMA, and leads to cell death."

29795372

MINDY4 affects Ubiquitin

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MINDY4 inhibits Ubiquitin.

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MINDY4 inhibits Ubiquitin. 1 / 1

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"FAM188B may inhibit ubiquitin-mediated degradation of hnRNPA1 through deubiquitination."

38844182

MINDY4 activates Ubiquitin.

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MINDY4 activates Ubiquitin. 1 / 1

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"The upregulation of a probable ubiquitin carboxy-terminal hydrolase (FAM188b) in algal-fed sponges as compared with aposymbiotic and bacterial fed sponges is notable (figs."

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MINDY4 affects STAT3

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MINDY4 activates STAT3. 2 / 2

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"STAT3 activation was dramatically reduced by FAM188B knockdown (XREF_FIG D), and consistently phospho-STAT3 immunostaining decreased in the FAM188B-knockdown lung tumor tissue."

33440835

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"Intriguingly, FAM188B knockdown inactivated Src, Akt, and STAT3, not only in suspension but also in attached cells (XREF_FIG D)."

33440835

MINDY4 affects PKM2

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MINDY4 activates PKM2. 2 / 2

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"Mechanistically, FAM188B knockdown significantly inhibited the hnRNPA1/PKM2 pathway in HCC cells."

38844182

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"FAM188B promotes the growth, metastasis, and invasion of hepatocellular carcinoma by targeting the HRNPA1/PKM2 axis."

38844182

MINDY4 affects HNRNPA1

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MINDY4 deubiquitinates HNRNPA1.

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MINDY4 leads to the deubiquitination of HNRNPA1. 1 / 1

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"In conclusion, FAM188B promotes HCC progression by enhancing the deubiquitination of hnRNPA1 and subsequently activating the hnRNPA1/PKM2 pathway."

38844182

MINDY4 activates HNRNPA1.

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MINDY4 activates HNRNPA1. 1 / 1

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"Mechanistically, FAM188B knockdown significantly inhibited the hnRNPA1/PKM2 pathway in HCC cells."

38844182

MINDY4 affects Cell Survival

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MINDY4 activates Cell Survival. 2 / 2

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"FAM188B knockdown decreased cell viability in lung cancer cells."

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"FAM188B enhances cell survival via interaction with USP7."

29795372

MINDY4 affects BIRC5

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MINDY4 increases the amount of BIRC5.

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MINDY4 increases the amount of BIRC5. 1 / 1

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"FAM188B knockdown decreased levels of Survivin, which is an anti-apoptotic protein that plays a critical role in anoikis resistance [XREF_BIBR]."

33440835

MINDY4 activates BIRC5.

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MINDY4 activates BIRC5. 1 / 1

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"FAM188B knockdown decreased levels of Survivin , which is an anti-apoptotic protein that plays a critical role in anoikis resistance [ 14 ] ."

33440835

Acrylamide affects MINDY4

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Acrylamide decreases the amount of MINDY4. 2 / 2

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ctd

No evidence text available

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No evidence text available

32763439

Tris(1,3-dichloro-2-propyl)phosphate affects MINDY4

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Tris(1,3-dichloro-2-propyl)phosphate decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

26179874

Triptonide affects MINDY4

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Triptonide decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

33045310

Trichloroethene affects MINDY4

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Trichloroethene increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

33387578

Tetrachloromethane affects MINDY4

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Tetrachloromethane increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

31150632

Temozolomide affects MINDY4

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Temozolomide increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

31758290

Sunitinib affects MINDY4

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Sunitinib decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

31533062

Sulfadimethoxine affects MINDY4

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Sulfadimethoxine increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

30047161

Sorafenib affects MINDY4

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Sorafenib decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

39786591

Silicon dioxide affects MINDY4

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Silicon dioxide increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

25895662

SiFAM188B affects MINDY4

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SiFAM188B decreases the amount of MINDY4. 1 / 1

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"FAM188B protein levels were also reduced by siFAM188B, as determined by western blot."

29795372

Si-RNA targeting FAM188B affects MINDY4

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Si-RNA targeting FAM188B inhibits MINDY4. 1 / 1

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eidos

33440835

Rotenone affects MINDY4

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Rotenone decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

39786591

Perfluorooctane-1-sulfonic acid affects MINDY4

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Perfluorooctane-1-sulfonic acid increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

36331819

Perfluorohexanesulfonic acid affects MINDY4

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Perfluorohexanesulfonic acid increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

37995155

Paracetamol affects MINDY4

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Paracetamol decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

33387578

Methimazole affects MINDY4

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Methimazole increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

30047161

Methapyrilene affects MINDY4

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Methapyrilene methylates MINDY4. 1 / 1

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ctd

No evidence text available

30157460

Epoxiconazole affects MINDY4

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Epoxiconazole decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

35436446

Doxycycline affects MINDY4

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Doxycycline activates MINDY4. 1 / 1

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"Doxycycline induced FAM188B short hairpin RNA (shRNA), which led to FAM188B downregulation."

29795372

Dichloroacetic acid affects MINDY4

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Dichloroacetic acid increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

28962523

Cytarabine affects MINDY4

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Cytarabine decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

21198554

Chlordecone affects MINDY4

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Chlordecone increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

33711761

Cadmium atom affects MINDY4

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Cadmium atom increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

37325564

Bis(2-ethylhexyl) phthalate affects MINDY4

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Bis(2-ethylhexyl) phthalate increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

34319233

Beta-D-glucose affects MINDY4

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Beta-D-glucose increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

36331819

Benzo[e]pyrene affects MINDY4

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Benzo[e]pyrene methylates MINDY4. 1 / 1

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ctd

No evidence text available

30157460

Benzo[a]pyrene affects MINDY4

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Benzo[a]pyrene demethylates MINDY4. 1 / 1

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ctd

No evidence text available

27901495

Antirheumatic drug affects MINDY4

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Antirheumatic drug increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

24449571

Amitrole affects MINDY4

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Amitrole increases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

30047161

All-trans-retinoic acid affects MINDY4

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All-trans-retinoic acid decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

23724009

Vehicle Emissions affects MINDY4

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Vehicle Emissions methylates MINDY4. 1 / 1

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ctd

No evidence text available

25560391

USP9X affects MINDY4

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MINDY4 binds USP9X. 1 / 1

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biogrid

No evidence text available

29795372

UBR5 affects MINDY4

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MINDY4 binds UBR5. 1 / 1

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biogrid

No evidence text available

29795372

UBE2H affects MINDY4

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UBE2H binds MINDY4. 1 / 1

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biogrid

No evidence text available

38113892

UBC affects MINDY4

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UBC binds MINDY4. 1 / 1

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biogrid

No evidence text available

29576527

Tobacco Smoke Pollution affects MINDY4

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Tobacco Smoke Pollution decreases the amount of MINDY4. 1 / 1

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ctd

No evidence text available

33660061

TUBB6 affects MINDY4

1 |

MINDY4 binds TUBB6. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

TRIM56 affects MINDY4

1 |

MINDY4 binds TRIM56. 1 / 1

1 |

➶

biogrid

No evidence text available

27173435

TRIM21 affects MINDY4

1 |

MINDY4 binds TRIM21. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

TOP2A affects MINDY4

1 |

MINDY4 binds TOP2A. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

TIMM50 affects MINDY4

1 |

MINDY4 binds TIMM50. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

TCOF1 affects MINDY4

1 |

MINDY4 binds TCOF1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

Smoke affects MINDY4

1 |

Smoke decreases the amount of MINDY4. 1 / 1

1 |

➶

ctd

No evidence text available

34520756

SSBP1 affects MINDY4

1 |

MINDY4 binds SSBP1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

SRRM2 affects MINDY4

1 |

MINDY4 binds SRRM2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

SNRPA1 affects MINDY4

1 |

MINDY4 binds SNRPA1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

SF3B4 affects MINDY4

1 |

MINDY4 binds SF3B4. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

SF3B1 affects MINDY4

1 |

MINDY4 binds SF3B1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

SERBP1 affects MINDY4

1 |

MINDY4 binds SERBP1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

RUVBL2 affects MINDY4

1 |

MINDY4 binds RUVBL2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

RPS6 affects MINDY4

1 |

MINDY4 binds RPS6. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

RPLP2 affects MINDY4

1 |

MINDY4 binds RPLP2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

RPL4 affects MINDY4

1 |

MINDY4 binds RPL4. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

RPL22 affects MINDY4

1 |

MINDY4 binds RPL22. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

RPL21 affects MINDY4

1 |

MINDY4 binds RPL21. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

RPL14 affects MINDY4

1 |

MINDY4 binds RPL14. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

RPL13A affects MINDY4

1 |

MINDY4 binds RPL13A. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

RPL10 affects MINDY4

1 |

MINDY4 binds RPL10. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

RHOT2 affects MINDY4

1 |

RHOT2 binds MINDY4. 1 / 1

1 |

➶

biogrid

No evidence text available

32877691

RAD50 affects MINDY4

1 |

MINDY4 binds RAD50. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

Particulate Matter affects MINDY4

1 |

Particulate Matter increases the amount of MINDY4. 1 / 1

1 |

➶

ctd

No evidence text available

29883952

PRPF8 affects MINDY4

1 |

MINDY4 binds PRPF8. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

PRPF19 affects MINDY4

1 |

MINDY4 binds PRPF19. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

PPP6C affects MINDY4

1 |

MINDY4 binds PPP6C. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

PPP2R1A affects MINDY4

1 |

MINDY4 binds PPP2R1A. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

PPIB affects MINDY4

1 |

MINDY4 binds PPIB. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

POLR2B affects MINDY4

1 |

MINDY4 binds POLR2B. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

PJA2 affects MINDY4

1 |

MINDY4 binds PJA2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

PCM1 affects MINDY4

1 |

MINDY4 binds PCM1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

PCB138 affects MINDY4

1 |

PCB138 decreases the amount of MINDY4. 1 / 1

1 |

➶

ctd

No evidence text available

23829299

NPM1 affects MINDY4

1 |

MINDY4 binds NPM1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

NFKBIL1 affects MINDY4

1 |

MINDY4 binds NFKBIL1. 1 / 1

1 |

➶

biogrid

No evidence text available

27173435

MIR484 affects MINDY4

1 |

MIR484 decreases the amount of MINDY4. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

MINDY4 affects various metastatic characteristics

| 1

MINDY4 activates various metastatic characteristics. 1 / 1

| 1

➶

eidos

"FAM188B knockdown inhibits various metastatic characteristics and tumor metastasis ."

33440835

MINDY4 affects tumor proteins

| 1

MINDY4 activates tumor proteins. 1 / 1

| 1

➶

eidos

"FAM188B knockdown reduced the levels of tumor proteins such as EGFR and FOXM1 , suggesting that FAM188B may be a potential target controlling tumor malignancies ."

33440835

MINDY4 affects total p-EGFR

| 1

MINDY4 activates total p-EGFR. 1 / 1

| 1

➶

eidos

"In this regard , it is very intriguing that FAM188B knockdown decreased levels of total EGFR and p-EGFR in both attached and detached cells ( Figure 3A , D ) ."

33440835

MINDY4 affects signaling receptor activity

| 1

MINDY4 activates signaling receptor activity. 1 / 1

| 1

➶

eidos

"More interestingly , FAM188B re-expression could recover EGFR receptor levels that had been decreased by FAM188B knockdown ( Figure S3A ) ."

33440835

MINDY4 affects several oncogenic proteins

| 1

MINDY4 activates several oncogenic proteins. 1 / 1

| 1

➶

eidos

"FAM188B knockdown decreased the activities of several oncogenic proteins downstream of EGFR that are involved in anoikis resistance , including pAkt , pSrc , and pSTAT3 , with little changes to their protein levels ."

33440835

MINDY4 affects overall ubiquitination p53 immunocomplexes p53

| 1

MINDY4 activates overall ubiquitination p53 immunocomplexes p53. 1 / 1

| 1

➶

eidos

"Knockdown of FAM188B led to an overall decrease in ubiquitination of p53 immunocomplexes and p53 , further implicating USP7 in p53 deubiquitination.46 USP7 and the cell cycle E3 ubiquitin-protein ligase CHFR is a checkpoint protein with FHA and RING domains and a member of the RING family and it is known as a mitotic checkpoint ."

35005106

MINDY4 affects metastatic features

| 1

MINDY4 activates metastatic features. 1 / 1

| 1

➶

eidos

"We tested whether knockdown of FAM188B inhibits these metastatic features in three lung cancer cell lines ."

33440835

MINDY4 affects metastatic characteristics

| 1

MINDY4 activates metastatic characteristics. 1 / 1

| 1

➶

eidos

"Moreover , FAM188B downregulation reduced metastatic characteristics , such as cell adhesion , invasion , and migration , as well as growth in 3D culture conditions ."

33440835

MINDY4 affects messenger RNA

| 1

MINDY4 inhibits messenger RNA. 1 / 1

| 1

➶

eidos

"Contrary to expectation , FAM188B knockdown upregulated EGFR mRNA levels ( Figure 3B ) ."

33440835

MINDY4 affects member RING family

| 1

MINDY4 inhibits member RING family. 1 / 1

| 1

➶

eidos

35005106

MINDY4 affects inactivation survival-related signaling molecules

| 1

MINDY4 activates inactivation survival-related signaling molecules. 1 / 1

| 1

➶

eidos

"FAM188B knockdown induced EGFR downregulation and inactivation of survival-related signaling molecules , indicating that FAM188B could be a potential target to control tumor metastasis ."

33440835

MINDY4 affects implicating USP7 deubiquitination.46 USP7 cell cycle E3 ubiquitin-protein ligase CHFR is checkpoint protein RING domains

| 1

MINDY4 inhibits implicating USP7 deubiquitination.46 USP7 cell cycle E3 ubiquitin-protein ligase CHFR is checkpoint protein RING domains. 1 / 1

| 1

➶

eidos

35005106

MINDY4 affects hydrolase

| 1

MINDY4 activates hydrolase. 1 / 1

| 1

➶

reach

"The upregulation of a probable ubiquitin carboxy-terminal hydrolase (FAM188b) in algal-fed sponges as compared with aposymbiotic and bacterial fed sponges is notable (figs."

34791195

MINDY4 affects growth lung cancer cell lines

| 1

MINDY4 activates growth lung cancer cell lines. 1 / 1

| 1

➶

eidos

"Consistent with a previous report using colon cancer cells [ 13 ] , FAM188B knockdown inhibited the growth of lung cancer cell lines regardless of whether they were expressing wild type or mutant EGFR ( Figure 1C , D ) ."

33440835

MINDY4 affects growth lung cancer cell lines soft agar

| 1

MINDY4 activates growth lung cancer cell lines soft agar. 1 / 1

| 1

➶

eidos

"In addition , FAM188B knockdown decreased the growth of lung cancer cell lines in soft agar ( Figure 1F ) , and FAM188B knockdown sensitized cells to anoikis when cells were in suspension ( Figure 2C , D ) ."

33440835

MINDY4 affects growth 3D culture

| 1

MINDY4 activates growth 3D culture. 1 / 1

| 1

➶

eidos

"Moreover , FAM188B downregulation reduced metastatic characteristics , such as cell adhesion , invasion , and migration , as well as growth in 3D culture conditions ."

33440835

MINDY4 affects epithelial to mesenchymal transition

| 1

MINDY4 activates epithelial to mesenchymal transition. 1 / 1

| 1

➶

reach

"We further demonstrated that FAM188B knockdown inhibited cell proliferation, epithelial-mesenchymal transition, migration and invasion both in vitro and in vivo."

38844182

MINDY4 affects colony soft agar

| 1

MINDY4 activates colony soft agar. 1 / 1

| 1

➶

eidos

"Furthermore , although there were some variations in the ability to form colonies among the cell lines , FAM188B knockdown decreased colony formation in soft agar conditions , which is a measure of anchorage-independent growth ( Figure 1F ) ."

33440835

MINDY4 affects colonies

| 1

MINDY4 activates colonies. 1 / 1

| 1

➶

eidos

"Knockdown of FAM188B not only decreased the sizes of colonies but also altered the shape of growth when they were grown in 3D culture ( Figure 4E ) ."

33440835

MINDY4 affects cell aggregate

| 1

MINDY4 activates cell aggregate. 1 / 1

| 1

➶

eidos

"However , FAM188B knockdown inhibited cell aggregate formation in all three cell lines with an increase in dead cells stained by PI and shown in red ( Figure 2C ) ."

33440835

MINDY4 affects apoptosis signaling

| 1

MINDY4 inhibits apoptosis signaling. 1 / 1

| 1

➶

eidos

"FAM188B knockdown induced increased caspase 3 activation , as assessed by its cleavage , and thus increased PARP cleavage ( Figure S1B ) , indicating activation of apoptosis signaling by FAM188B knockdown ."

33440835

MINDY4 affects annexin

| 1

MINDY4 inhibits annexin. 1 / 1

| 1

➶

reach

"In addition, FAM188B knockdown increased the population of annexin V/PI stained cells."

29795372

MINDY4 affects activation of cysteine-type endopeptidase activity involved in apoptotic process

| 1

MINDY4 inhibits activation of cysteine-type endopeptidase activity involved in apoptotic process. 1 / 1

| 1

➶

eidos

33440835

MINDY4 affects USP9X

1 |

MINDY4 binds USP9X. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects UBR5

1 |

MINDY4 binds UBR5. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects UBE2H

1 |

UBE2H binds MINDY4. 1 / 1

1 |

➶

biogrid

No evidence text available

38113892

MINDY4 affects UBC

1 |

UBC binds MINDY4. 1 / 1

1 |

➶

biogrid

No evidence text available

29576527

MINDY4 affects TUBB6

1 |

MINDY4 binds TUBB6. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects TRIM56

1 |

MINDY4 binds TRIM56. 1 / 1

1 |

➶

biogrid

No evidence text available

27173435

MINDY4 affects TRIM21

1 |

MINDY4 binds TRIM21. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects TOP2A

1 |

MINDY4 binds TOP2A. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects TIMM50

1 |

MINDY4 binds TIMM50. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects TCOF1

1 |

MINDY4 binds TCOF1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects STAT3 activation

| 1

MINDY4 activates STAT3 activation. 1 / 1

| 1

➶

eidos

"STAT3 activation was dramatically reduced by FAM188B knockdown ( Figure 3D ) , and consistently phospho-STAT3 immunostaining decreased in the FAM188B-knockdown lung tumor tissue ( Figure S4B ) ."

33440835

MINDY4 affects SSBP1

1 |

MINDY4 binds SSBP1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects SRRM2

1 |

MINDY4 binds SRRM2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects SRC

| 1

MINDY4 activates SRC. 1 / 1

| 1

➶

reach

"Intriguingly, FAM188B knockdown inactivated Src, Akt, and STAT3, not only in suspension but also in attached cells (XREF_FIG D)."

33440835

MINDY4 affects SNRPA1

1 |

MINDY4 binds SNRPA1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects SF3B4

1 |

MINDY4 binds SF3B4. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects SF3B1

1 |

MINDY4 binds SF3B1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects SERBP1

1 |

MINDY4 binds SERBP1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects RUVBL2

1 |

MINDY4 binds RUVBL2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects RPS6

1 |

MINDY4 binds RPS6. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects RPLP2

1 |

MINDY4 binds RPLP2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects RPL4

1 |

MINDY4 binds RPL4. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects RPL22

1 |

MINDY4 binds RPL22. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects RPL21

1 |

MINDY4 binds RPL21. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects RPL14

1 |

MINDY4 binds RPL14. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects RPL13A

1 |

MINDY4 binds RPL13A. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects RPL10

1 |

MINDY4 binds RPL10. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects RHOT2

1 |

RHOT2 binds MINDY4. 1 / 1

1 |

➶

biogrid

No evidence text available

32877691

MINDY4 affects RAD50

1 |

MINDY4 binds RAD50. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects Pancreatic Neoplasms

| 1

MINDY4 activates Pancreatic Neoplasms. 1 / 1

| 1

➶

reach

37207150

MINDY4 affects PTK2

| 1

MINDY4 leads to the phosphorylation of PTK2. 1 / 1

| 1

➶

reach

"FAK activation is also important for anoikis resistance [XREF_BIBR], and FAK phosphorylation was reduced by FAM188B knockdown (XREF_FIG D)."

33440835

MINDY4 affects PRPF8

1 |

MINDY4 binds PRPF8. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects PRPF19

1 |

MINDY4 binds PRPF19. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects PPP6C

1 |

MINDY4 binds PPP6C. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects PPP2R1A

1 |

MINDY4 binds PPP2R1A. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects PPIB

1 |

MINDY4 binds PPIB. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects POLR2B

1 |

MINDY4 binds POLR2B. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects PJA2

1 |

MINDY4 binds PJA2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects PCM1

1 |

MINDY4 binds PCM1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects PARP cleavage

| 1

MINDY4 inhibits PARP cleavage. 1 / 1

| 1

➶

eidos

33440835

MINDY4 affects NPM1

1 |

MINDY4 binds NPM1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects NFKBIL1

1 |

MINDY4 binds NFKBIL1. 1 / 1

1 |

➶

biogrid

No evidence text available

27173435

MINDY4 affects LRPPRC

1 |

MINDY4 binds LRPPRC. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects KRT9

1 |

MINDY4 binds KRT9. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects KRT6A

1 |

MINDY4 binds KRT6A. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects KRT3

1 |

MINDY4 binds KRT3. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects KRT2

1 |

MINDY4 binds KRT2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects KRT15

1 |

MINDY4 binds KRT15. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects KRT13

1 |

MINDY4 binds KRT13. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects KRT10

1 |

MINDY4 binds KRT10. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects KRT1

1 |

MINDY4 binds KRT1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects KIF7

1 |

MINDY4 binds KIF7. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects KIF11

1 |

MINDY4 binds KIF11. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects IFT57

1 |

MINDY4 binds IFT57. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects IFT172

1 |

MINDY4 binds IFT172. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects HYCC1

| 1

MINDY4 activates HYCC1. 1 / 1

| 1

➶

reach

"Mechanistically, FAM188B knockdown significantly inhibited the hnRNPA1/PKM2 pathway in HCC cells."

38844182

MINDY4 affects HSPA9

1 |

MINDY4 binds HSPA9. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects HRNPA1

| 1

MINDY4 activates HRNPA1. 1 / 1

| 1

➶

reach

"FAM188B promotes the growth, metastasis, and invasion of hepatocellular carcinoma by targeting the HRNPA1/PKM2 axis."

38844182

MINDY4 affects HNRNPF

1 |

MINDY4 binds HNRNPF. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects GTF3C1

1 |

MINDY4 binds GTF3C1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects Figure

| 1

MINDY4 inhibits Figure-S1A. 1 / 1

| 1

➶

reach

"There were increases in annexin V/PI stained cells by si-FAM188B-treatment, indicating that FAM188B knockdown induces apoptosis (XREF_FIG D and Figure S1A)."

33440835

MINDY4 affects FAK phosphorylation

| 1

MINDY4 activates FAK phosphorylation. 1 / 1

| 1

➶

eidos

"FAK activation is also important for anoikis resistance [ 22 ] , and FAK phosphorylation was reduced by FAM188B knockdown ( Figure 3D ) ."

33440835

MINDY4 affects ELP1

1 |

MINDY4 binds ELP1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects EIF3H

1 |

MINDY4 binds EIF3H. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects EIF3E

1 |

MINDY4 binds EIF3E. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects EIF3B

1 |

MINDY4 binds EIF3B. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects EIF3A

1 |

MINDY4 binds EIF3A. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects EGFR receptor

| 1

MINDY4 increases the amount of EGFR receptor. 1 / 1

| 1

➶

reach

"More interestingly, FAM188B re-expression could recover EGFR receptor levels that had been decreased by FAM188B knockdown."

33440835

MINDY4 affects EEF1G

1 |

MINDY4 binds EEF1G. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects DSP

1 |

MINDY4 binds DSP. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects DHRS2

1 |

MINDY4 binds DHRS2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects DDX39A

1 |

DDX39A binds MINDY4. 1 / 1

1 |

➶

biogrid

No evidence text available

32393512

MINDY4 affects Carcinoma, Hepatocellular

| 1

MINDY4 activates Carcinoma, Hepatocellular. 1 / 1

| 1

➶

reach

"FAM188B promotes the growth, metastasis, and invasion of hepatocellular carcinoma by targeting the HRNPA1/PKM2 axis."

38844182

MINDY4 affects CTR9

1 |

MINDY4 binds CTR9. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects CCT8

1 |

MINDY4 binds CCT8. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects CCT2

1 |

MINDY4 binds CCT2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects BICD1

1 |

BICD1 binds MINDY4. 1 / 1

1 |

➶

biogrid

No evidence text available

28718761

MINDY4 affects BAG2

1 |

MINDY4 binds BAG2. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects ANAPC7

1 |

MINDY4 binds ANAPC7. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects ANAPC1

1 |

MINDY4 binds ANAPC1. 1 / 1

1 |

➶

biogrid

No evidence text available

29795372

MINDY4 affects AKT

| 1

MINDY4 activates AKT. 1 / 1

| 1

➶

reach

"Intriguingly, FAM188B knockdown inactivated Src, Akt, and STAT3, not only in suspension but also in attached cells (XREF_FIG D)."

33440835

MINDY4 affects AGMAT

1 |

MINDY4 binds AGMAT. 1 / 1

1 |

➶

biogrid

No evidence text available

27173435

MINDY4 affects 3D

| 1

MINDY4 inhibits 3D. 1 / 1

| 1

➶

reach

"Moreover, FAM188B downregulation reduced metastatic characteristics, such as cell adhesion, invasion, and migration, as well as growth in 3D culture conditions."

33440835