IndraLab

Statements

MINDY4 affects EGFR
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MINDY4 increases the amount of EGFR.
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MINDY4 increases the amount of EGFR. 5 / 5
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"Intriguingly, si-FAM188B treatment increased EGFR mRNA levels but decreased its protein levels, which was reversed by treatment with the proteasomal inhibitor MG132, indicating that FAM188B regulates EGFR levels via the proteasomal pathway."
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"Interestingly, FAM188B knockdown downregulated EGFR protein levels in both attached and suspended cells regardless of EGFR mutation (XREF_FIG A)."
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"More interestingly, FAM188B re-expression could recover EGFR receptor levels that had been decreased by FAM188B knockdown."
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"All these data suggest that FAM188B knockdown downregulates EGFR levels through the proteasome degradation pathway and inactivates multiple pathways involved in cell proliferation and survival."
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"In this regard, it is very intriguing that FAM188B knockdown decreased levels of total EGFR and p-EGFR in both attached and detached cells (XREF_FIG A, D)."
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MINDY4 activates EGFR.
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MINDY4 activates EGFR. 3 / 3
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"It is possible that EGFR downregulation induced by si-FAM188B results in inactivation of those signaling pathways, which are involved not only in the determination of anoikis resistance but also metastatic characteristics, including migration and invasion [XREF_BIBR]."
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"FAM188B knockdown decreased the activities of several oncogenic proteins downstream of EGFR that are involved in anoikis resistance, including pAkt, pSrc, and pSTAT3, with little changes to their protein levels."
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"However, FAM188B knockdown decreased EGFR protein levels (XREF_FIG A)."
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MINDY4 decreases the amount of EGFR.
| 2
MINDY4 decreases the amount of EGFR. 2 / 2
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"Contrary to expectation, FAM188B knockdown upregulated EGFR mRNA levels (XREF_FIG B)."
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"Interestingly, FAM188B knockdown did not decrease but rather increased EGFR mRNA levels (XREF_FIG B)."
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MINDY4 inhibits EGFR.
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MINDY4 inhibits EGFR. 1 / 1
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"FAM188B knockdown induced EGFR downregulation and inactivation of survival related signaling molecules, indicating that FAM188B could be a potential target to control tumor metastasis."
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MINDY4 affects TP53
2 | 7
MINDY4 inhibits TP53.
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MINDY4 inhibits TP53. 3 / 3
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"FAM188B knockdown increased p53 as well as Ser15 phosphorylated p53, and thus enhanced protein levels of p53 regulated genes, including p21, PUMA, and BAX, which are in the apoptosis pathway."
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"Therefore, elevated expression of FAM188B in tumor tissues suggests that FAM188B would inhibit p53 activation and thereby provide tolerance against stressful conditions."
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"FAM188B silencing activates p53 and its downstream pathway."
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MINDY4 binds TP53.
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MINDY4 binds TP53. 1 / 3
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"Interestingly, when we immunoprecipitated p53 proteins, we could observe that FAM188B as well as USP7 were in the p53 immunocomplexes, indicating that FAM188B forms a complex with p53."
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MINDY4 decreases the amount of TP53.
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MINDY4 decreases the amount of TP53. 2 / 2
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"However, double silencing of USP7 and FAM188B restored the p53 level."
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"To determine how FAM188B knockdown enhances p53 protein levels, we identified FAM188B interacting proteins revealed by LC/MS-MS."
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MINDY4 activates TP53.
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MINDY4 activates TP53. 1 / 1
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"These results suggest that FAM188B downregulation activates p53, and thus upregulates apoptosis related genes, including BAX, and PUMA, and leads to cell death."
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MINDY4 affects cell growth
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MINDY4 activates cell growth. 8 / 8
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"FAM188B was downregulated by si-RNA targeting FAM188B (XREF_FIG B), and cell growth was significantly inhibited by FAM188B knockdown as assessed by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxyme-thoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay in A549, H1299, and H1975 cells (XREF_FIG C)."
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"FAM188B was downregulated by si-RNA targeting FAM188B ( Figure 1B ) , and cell growth was significantly inhibited by FAM188B knockdown as assessed by 3 - ( 4,5 - dimethylthiazol-2-yl ) -5 - ( 3-carboxyme-thoxyphenyl ) -2 - ( 4-sulfophenyl ) -2 H-tetrazolium ( MTS ) assay in A549 , H1299 , and H1975 cells ( Figure 1C ) ."
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"Knockdown of FAM188B stimulated cell growth inhibition , through an increase of apoptosis in colon cancer cell lines.46 Proteomic analysis of FAM188B immunocomplexes identified p53 and USP7 as interaction partners of FAM188B ."
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"In addition , FAM188B knockdown decreased cell growth in the 3D culture condition , which mimics in vivo conditions ( Figure 4E ) ."
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"In addition, FAM188B knockdown decreased cell growth in the 3D culture condition, which mimics in vivo conditions (XREF_FIG E)."
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"Knockdown of FAM188B stimulated cell growth inhibition, through an increase of apoptosis in colon cancer cell lines.46 Proteomic analysis of FAM188B immunocomplexes identified p53 and USP7 as interaction partners of FAM188B."
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"FAM188B knockdown induced the inhibition of cell growth along with the downregulation of mRNA and protein levels of FOXM1."
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"FAM188B knockdown induced cell growth inhibition due to an increase in apoptosis in colon cancer cell lines."
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"FAM188B promotes the growth, metastasis, and invasion of hepatocellular carcinoma by targeting the HRNPA1/PKM2 axis."
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"FAM188B knockdown significantly decreased both invasion (XREF_FIG A) and migration (XREF_FIG B) in three cell lines."
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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."
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"We further demonstrated that FAM188B knockdown inhibited cell proliferation, epithelial-mesenchymal transition, migration and invasion both in vitro and in vivo."
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"FAM188B knockdown attenuated invasion, migration, adhesion, and wound closure (XREF_FIG A-D)."
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"Therefore, we speculate that MINDY4 in PC enhances the invasion and migration of PC by inducing EMT.To further investigate the cancer-promoting mechanism of MINDY2 in PC, we identified ACTN4 as an interacting protein of MINDY2 by immunoprecipitation, mass spectrometry, and immunofluorescence co-localization."
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"FAM188B knockdown significantly decreased both invasion ( Figure 4A ) and migration ( Figure 4B ) in three cell lines ."
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MINDY4 affects Neoplasm Metastasis
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MINDY4 activates Neoplasm Metastasis. 6 / 6
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"FAM188B promotes the growth, metastasis, and invasion of hepatocellular carcinoma by targeting the HRNPA1/PKM2 axis."
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"FAM188B knockdown inhibits various metastatic characteristics and tumor metastasis."
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"FAM188B Downregulation Sensitizes Lung Cancer Cells to Anoikis via EGFR Downregulation and Inhibits Tumor Metastasis In Vivo Simple Summary Cancer cells should acquire anoikis resistance for successful metastasis ."
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"Here, we demonstrate that FAM188B knockdown makes lung cancer cells sensitive to anoikis and inhibits lung metastasis."
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"FAM188B knockdown inhibits various metastatic characteristics and tumor metastasis ."
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"Here, we demonstrate that FAM188B knockdown sensitizes human lung cancer cell lines to anoikis upon cell detachment and inhibits lung metastasis in vivo."
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MINDY4 affects apoptotic process
| 2 3
MINDY4 inhibits apoptotic process.
| 2 2
MINDY4 inhibits apoptotic process. 4 / 4
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"There were increases in annexin V/PI stained cells by si-FAM188B-treatment, indicating that FAM188B knockdown induces apoptosis (XREF_FIG D and Figure S1A)."
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"We also observed that FAM188B knockdown induced apoptosis in the suspension culture as determined by flow cytometry analysis of annexin V/PI stained cells (XREF_FIG D)."
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"We also observed that FAM188B knockdown induced apoptosis in the suspension culture as determined by flow cytometry analysis of annexin V / PI stained cells ( Figure 2D ) ."
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"There were increases in annexin V / PI-stained cells by si-FAM188B-treatment , indicating that FAM188B knockdown induces apoptosis ( Figure 1D and Figure S1A ) ."
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MINDY4 activates apoptotic process.
| 1
MINDY4 activates apoptotic process. 1 / 1
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"These results suggest that FAM188B downregulation activates p53, and thus upregulates apoptosis related genes, including BAX, and PUMA, and leads to cell death."
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USP7 affects MINDY4
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MINDY4 binds USP7. 1 / 3
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"In our study, however, the amount of FAM188B bound USP7 dramatically increased upon FAM188B overexpression in HCT-116 cells."
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TP53 affects MINDY4
2 | 1
MINDY4 binds TP53. 1 / 3
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"Interestingly, when we immunoprecipitated p53 proteins, we could observe that FAM188B as well as USP7 were in the p53 immunocomplexes, indicating that FAM188B forms a complex with p53."
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MINDY4 affects cell adhesion
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MINDY4 activates cell adhesion. 3 / 3
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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."
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"In addition, cell adhesion was also retarded in cells treated with si-FAM188B (XREF_FIG C)."
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"FAM188B knockdown attenuated invasion, migration, adhesion, and wound closure (XREF_FIG A-D)."
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MINDY4 affects USP7
2 | 1
MINDY4 binds USP7. 1 / 3
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"In our study, however, the amount of FAM188B bound USP7 dramatically increased upon FAM188B overexpression in HCT-116 cells."
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MINDY4 affects FOXM1
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MINDY4 activates FOXM1. 3 / 3
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"More interestingly, FAM188B knockdown decreased FOXM1, an oncogenic transcription factor [XREF_BIBR], in both attached and suspended conditions (XREF_FIG D)."
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"More interestingly , FAM188B knockdown decreased FOXM1 , an oncogenic transcription factor [ 23 ] , in both attached and suspended conditions ( Figure 3D ) ."
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"Recently , we reported that FAM188B knockdown decreased levels of FOXM1 , an oncogenic transcription factor , with an increase in its ubiquitination in A549 cells [ 14 ] ."
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MINDY4 affects wound closure
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MINDY4 activates wound closure. 2 / 2
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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."
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"FAM188B knockdown decreased wound closure in all three cell lines ( Figure 4D ) ."
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MINDY4 affects migration
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MINDY4 activates migration. 2 / 2
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"FAM188B knockdown significantly decreased both invasion ( Figure 4A ) and migration ( Figure 4B ) in three cell lines ."
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"FAM188B knockdown attenuated invasion , migration , adhesion , and wound closure ( Figure 4A-D ) ."
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MINDY4 affects lung metastasis
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MINDY4 activates lung metastasis. 2 / 2
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"Here , we demonstrate that FAM188B knockdown sensitizes human lung cancer cell lines to anoikis upon cell detachment and inhibits lung metastasis in vivo ."
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"Here , we demonstrate that FAM188B knockdown makes lung cancer cells sensitive to anoikis and inhibits lung metastasis ."
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"Experiments showed that the function of Circ-FAM188B-103aa in chicken myogenesis was the same as that of its host gene transcript, FAM188B, which enhanced proliferation but restricted differentiation of chicken SMSCs [117]."
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"We further demonstrated that FAM188B knockdown inhibited cell proliferation, epithelial-mesenchymal transition, migration and invasion both in vitro and in vivo."
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MINDY4 affects cell death
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MINDY4 activates cell death. 2 / 2
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"FAM188B downregulation leads to cell death in vitro."
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"These results suggest that FAM188B downregulation activates p53, and thus upregulates apoptosis related genes, including BAX, and PUMA, and leads to cell death."
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MINDY4 affects Ubiquitin
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MINDY4 inhibits Ubiquitin.
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MINDY4 inhibits Ubiquitin. 1 / 1
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"FAM188B may inhibit ubiquitin-mediated degradation of hnRNPA1 through deubiquitination."
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MINDY4 activates Ubiquitin.
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MINDY4 activates Ubiquitin. 1 / 1
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"The upregulation of a probable ubiquitin carboxy-terminal hydrolase (FAM188b) in algal-fed sponges as compared with aposymbiotic and bacterial fed sponges is notable (figs."
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MINDY4 affects STAT3
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MINDY4 activates STAT3. 2 / 2
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"STAT3 activation was dramatically reduced by FAM188B knockdown (XREF_FIG D), and consistently phospho-STAT3 immunostaining decreased in the FAM188B-knockdown lung tumor tissue."
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"Intriguingly, FAM188B knockdown inactivated Src, Akt, and STAT3, not only in suspension but also in attached cells (XREF_FIG D)."
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MINDY4 affects PKM2
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MINDY4 activates PKM2. 2 / 2
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"Mechanistically, FAM188B knockdown significantly inhibited the hnRNPA1/PKM2 pathway in HCC cells."
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"FAM188B promotes the growth, metastasis, and invasion of hepatocellular carcinoma by targeting the HRNPA1/PKM2 axis."
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MINDY4 affects HNRNPA1
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MINDY4 deubiquitinates HNRNPA1.
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MINDY4 leads to the deubiquitination of HNRNPA1. 1 / 1
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"In conclusion, FAM188B promotes HCC progression by enhancing the deubiquitination of hnRNPA1 and subsequently activating the hnRNPA1/PKM2 pathway."
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MINDY4 activates HNRNPA1.
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MINDY4 activates HNRNPA1. 1 / 1
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"Mechanistically, FAM188B knockdown significantly inhibited the hnRNPA1/PKM2 pathway in HCC cells."
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MINDY4 affects Cell Survival
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"FAM188B knockdown decreased cell viability in lung cancer cells."
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"FAM188B enhances cell survival via interaction with USP7."
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MINDY4 affects BIRC5
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MINDY4 increases the amount of BIRC5.
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MINDY4 increases the amount of BIRC5. 1 / 1
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"FAM188B knockdown decreased levels of Survivin, which is an anti-apoptotic protein that plays a critical role in anoikis resistance [XREF_BIBR]."
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MINDY4 activates BIRC5.
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MINDY4 activates BIRC5. 1 / 1
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"FAM188B knockdown decreased levels of Survivin , which is an anti-apoptotic protein that plays a critical role in anoikis resistance [ 14 ] ."
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SiFAM188B affects MINDY4
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SiFAM188B decreases the amount of MINDY4. 1 / 1
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"FAM188B protein levels were also reduced by siFAM188B, as determined by western blot."
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Si-RNA targeting FAM188B affects MINDY4
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Si-RNA targeting FAM188B inhibits MINDY4. 1 / 1
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"FAM188B was downregulated by si-RNA targeting FAM188B ( Figure 1B ) , and cell growth was significantly inhibited by FAM188B knockdown as assessed by 3 - ( 4,5 - dimethylthiazol-2-yl ) -5 - ( 3-carboxyme-thoxyphenyl ) -2 - ( 4-sulfophenyl ) -2 H-tetrazolium ( MTS ) assay in A549 , H1299 , and H1975 cells ( Figure 1C ) ."
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Doxycycline affects MINDY4
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Doxycycline activates MINDY4. 1 / 1
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"Doxycycline induced FAM188B short hairpin RNA (shRNA), which led to FAM188B downregulation."
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MINDY4 affects various metastatic characteristics
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MINDY4 activates various metastatic characteristics. 1 / 1
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"FAM188B knockdown inhibits various metastatic characteristics and tumor metastasis ."
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MINDY4 affects tumor proteins
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MINDY4 activates tumor proteins. 1 / 1
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"FAM188B knockdown reduced the levels of tumor proteins such as EGFR and FOXM1 , suggesting that FAM188B may be a potential target controlling tumor malignancies ."
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MINDY4 affects total p-EGFR
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MINDY4 activates total p-EGFR. 1 / 1
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"In this regard , it is very intriguing that FAM188B knockdown decreased levels of total EGFR and p-EGFR in both attached and detached cells ( Figure 3A , D ) ."
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"More interestingly , FAM188B re-expression could recover EGFR receptor levels that had been decreased by FAM188B knockdown ( Figure S3A ) ."
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MINDY4 affects several oncogenic proteins
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MINDY4 activates several oncogenic proteins. 1 / 1
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"FAM188B knockdown decreased the activities of several oncogenic proteins downstream of EGFR that are involved in anoikis resistance , including pAkt , pSrc , and pSTAT3 , with little changes to their protein levels ."
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MINDY4 affects overall ubiquitination p53 immunocomplexes p53
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MINDY4 activates overall ubiquitination p53 immunocomplexes p53. 1 / 1
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"Knockdown of FAM188B led to an overall decrease in ubiquitination of p53 immunocomplexes and p53 , further implicating USP7 in p53 deubiquitination.46 USP7 and the cell cycle E3 ubiquitin-protein ligase CHFR is a checkpoint protein with FHA and RING domains and a member of the RING family and it is known as a mitotic checkpoint ."
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MINDY4 affects metastatic features
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MINDY4 activates metastatic features. 1 / 1
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"We tested whether knockdown of FAM188B inhibits these metastatic features in three lung cancer cell lines ."
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MINDY4 affects metastatic characteristics
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MINDY4 activates metastatic characteristics. 1 / 1
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"Moreover , FAM188B downregulation reduced metastatic characteristics , such as cell adhesion , invasion , and migration , as well as growth in 3D culture conditions ."
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MINDY4 affects messenger RNA
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"Contrary to expectation , FAM188B knockdown upregulated EGFR mRNA levels ( Figure 3B ) ."
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MINDY4 affects member RING family
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MINDY4 inhibits member RING family. 1 / 1
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"Knockdown of FAM188B led to an overall decrease in ubiquitination of p53 immunocomplexes and p53 , further implicating USP7 in p53 deubiquitination.46 USP7 and the cell cycle E3 ubiquitin-protein ligase CHFR is a checkpoint protein with FHA and RING domains and a member of the RING family and it is known as a mitotic checkpoint ."
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MINDY4 affects inactivation survival-related signaling molecules
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MINDY4 activates inactivation survival-related signaling molecules. 1 / 1
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"FAM188B knockdown induced EGFR downregulation and inactivation of survival-related signaling molecules , indicating that FAM188B could be a potential target to control tumor metastasis ."
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MINDY4 affects implicating USP7 deubiquitination.46 USP7 cell cycle E3 ubiquitin-protein ligase CHFR is checkpoint protein RING domains
| 1
MINDY4 inhibits implicating USP7 deubiquitination.46 USP7 cell cycle E3 ubiquitin-protein ligase CHFR is checkpoint protein RING domains. 1 / 1
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"Knockdown of FAM188B led to an overall decrease in ubiquitination of p53 immunocomplexes and p53 , further implicating USP7 in p53 deubiquitination.46 USP7 and the cell cycle E3 ubiquitin-protein ligase CHFR is a checkpoint protein with FHA and RING domains and a member of the RING family and it is known as a mitotic checkpoint ."
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MINDY4 affects hydrolase
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MINDY4 activates hydrolase. 1 / 1
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"The upregulation of a probable ubiquitin carboxy-terminal hydrolase (FAM188b) in algal-fed sponges as compared with aposymbiotic and bacterial fed sponges is notable (figs."
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MINDY4 affects growth lung cancer cell lines
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MINDY4 activates growth lung cancer cell lines. 1 / 1
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"Consistent with a previous report using colon cancer cells [ 13 ] , FAM188B knockdown inhibited the growth of lung cancer cell lines regardless of whether they were expressing wild type or mutant EGFR ( Figure 1C , D ) ."
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MINDY4 affects growth lung cancer cell lines soft agar
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MINDY4 activates growth lung cancer cell lines soft agar. 1 / 1
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"In addition , FAM188B knockdown decreased the growth of lung cancer cell lines in soft agar ( Figure 1F ) , and FAM188B knockdown sensitized cells to anoikis when cells were in suspension ( Figure 2C , D ) ."
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MINDY4 affects growth 3D culture
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MINDY4 activates growth 3D culture. 1 / 1
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"Moreover , FAM188B downregulation reduced metastatic characteristics , such as cell adhesion , invasion , and migration , as well as growth in 3D culture conditions ."
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MINDY4 activates epithelial to mesenchymal transition. 1 / 1
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"We further demonstrated that FAM188B knockdown inhibited cell proliferation, epithelial-mesenchymal transition, migration and invasion both in vitro and in vivo."
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MINDY4 affects colony soft agar
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MINDY4 activates colony soft agar. 1 / 1
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"Furthermore , although there were some variations in the ability to form colonies among the cell lines , FAM188B knockdown decreased colony formation in soft agar conditions , which is a measure of anchorage-independent growth ( Figure 1F ) ."
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MINDY4 affects colonies
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MINDY4 activates colonies. 1 / 1
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"Knockdown of FAM188B not only decreased the sizes of colonies but also altered the shape of growth when they were grown in 3D culture ( Figure 4E ) ."
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MINDY4 affects cell aggregate
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MINDY4 activates cell aggregate. 1 / 1
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"However , FAM188B knockdown inhibited cell aggregate formation in all three cell lines with an increase in dead cells stained by PI and shown in red ( Figure 2C ) ."
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MINDY4 affects apoptosis signaling
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MINDY4 inhibits apoptosis signaling. 1 / 1
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"FAM188B knockdown induced increased caspase 3 activation , as assessed by its cleavage , and thus increased PARP cleavage ( Figure S1B ) , indicating activation of apoptosis signaling by FAM188B knockdown ."
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MINDY4 affects annexin
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MINDY4 inhibits annexin. 1 / 1
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"In addition, FAM188B knockdown increased the population of annexin V/PI stained cells."
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MINDY4 inhibits activation of cysteine-type endopeptidase activity involved in apoptotic process. 1 / 1
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"FAM188B knockdown induced increased caspase 3 activation , as assessed by its cleavage , and thus increased PARP cleavage ( Figure S1B ) , indicating activation of apoptosis signaling by FAM188B knockdown ."
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MINDY4 affects STAT3 activation
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MINDY4 activates STAT3 activation. 1 / 1
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"STAT3 activation was dramatically reduced by FAM188B knockdown ( Figure 3D ) , and consistently phospho-STAT3 immunostaining decreased in the FAM188B-knockdown lung tumor tissue ( Figure S4B ) ."
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MINDY4 affects SRC
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MINDY4 activates SRC. 1 / 1
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"Intriguingly, FAM188B knockdown inactivated Src, Akt, and STAT3, not only in suspension but also in attached cells (XREF_FIG D)."
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"Therefore, we speculate that MINDY4 in PC enhances the invasion and migration of PC by inducing EMT.To further investigate the cancer-promoting mechanism of MINDY2 in PC, we identified ACTN4 as an interacting protein of MINDY2 by immunoprecipitation, mass spectrometry, and immunofluorescence co-localization."
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MINDY4 affects PTK2
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MINDY4 leads to the phosphorylation of PTK2. 1 / 1
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"FAK activation is also important for anoikis resistance [XREF_BIBR], and FAK phosphorylation was reduced by FAM188B knockdown (XREF_FIG D)."
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MINDY4 affects PARP cleavage
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MINDY4 inhibits PARP cleavage. 1 / 1
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"FAM188B knockdown induced increased caspase 3 activation , as assessed by its cleavage , and thus increased PARP cleavage ( Figure S1B ) , indicating activation of apoptosis signaling by FAM188B knockdown ."
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MINDY4 affects HYCC1
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MINDY4 activates HYCC1. 1 / 1
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"Mechanistically, FAM188B knockdown significantly inhibited the hnRNPA1/PKM2 pathway in HCC cells."
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MINDY4 affects HRNPA1
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MINDY4 activates HRNPA1. 1 / 1
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"FAM188B promotes the growth, metastasis, and invasion of hepatocellular carcinoma by targeting the HRNPA1/PKM2 axis."
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MINDY4 affects Figure
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MINDY4 inhibits Figure-S1A. 1 / 1
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"There were increases in annexin V/PI stained cells by si-FAM188B-treatment, indicating that FAM188B knockdown induces apoptosis (XREF_FIG D and Figure S1A)."
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MINDY4 affects FAK phosphorylation
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MINDY4 activates FAK phosphorylation. 1 / 1
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"FAK activation is also important for anoikis resistance [ 22 ] , and FAK phosphorylation was reduced by FAM188B knockdown ( Figure 3D ) ."
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MINDY4 affects EGFR receptor
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MINDY4 increases the amount of EGFR receptor. 1 / 1
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"More interestingly, FAM188B re-expression could recover EGFR receptor levels that had been decreased by FAM188B knockdown."
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MINDY4 activates Carcinoma, Hepatocellular. 1 / 1
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"FAM188B promotes the growth, metastasis, and invasion of hepatocellular carcinoma by targeting the HRNPA1/PKM2 axis."
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MINDY4 affects AKT
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MINDY4 activates AKT. 1 / 1
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"Intriguingly, FAM188B knockdown inactivated Src, Akt, and STAT3, not only in suspension but also in attached cells (XREF_FIG D)."
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MINDY4 affects 3D
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MINDY4 inhibits 3D. 1 / 1
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"Moreover, FAM188B downregulation reduced metastatic characteristics, such as cell adhesion, invasion, and migration, as well as growth in 3D culture conditions."
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