IndraLab

Statements

MINDY4 increases the amount of EGFR. 5 / 5
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"Intriguingly, si-FAM188B treatment increased EGFR mRNA levels but decreased its protein levels, which was reversed by treatment with the proteasomal inhibitor MG132, indicating that FAM188B regulates EGFR levels via the proteasomal pathway."
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"Interestingly, FAM188B knockdown downregulated EGFR protein levels in both attached and suspended cells regardless of EGFR mutation (XREF_FIG A)."
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"More interestingly, FAM188B re-expression could recover EGFR receptor levels that had been decreased by FAM188B knockdown."
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"All these data suggest that FAM188B knockdown downregulates EGFR levels through the proteasome degradation pathway and inactivates multiple pathways involved in cell proliferation and survival."
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"In this regard, it is very intriguing that FAM188B knockdown decreased levels of total EGFR and p-EGFR in both attached and detached cells (XREF_FIG A, D)."
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