IndraLab

Statements

MINDY4 activates EGFR. 3 / 3
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reach
"FAM188B knockdown decreased the activities of several oncogenic proteins downstream of EGFR that are involved in anoikis resistance, including pAkt, pSrc, and pSTAT3, with little changes to their protein levels."
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"It is possible that EGFR downregulation induced by si-FAM188B results in inactivation of those signaling pathways, which are involved not only in the determination of anoikis resistance but also metastatic characteristics, including migration and invasion [XREF_BIBR]."
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"However, FAM188B knockdown decreased EGFR protein levels (XREF_FIG A)."
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