IndraLab

Statements


MINDY4 inhibits TP53. 3 / 3
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"Therefore, elevated expression of FAM188B in tumor tissues suggests that FAM188B would inhibit p53 activation and thereby provide tolerance against stressful conditions."

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"FAM188B silencing activates p53 and its downstream pathway."

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"FAM188B knockdown increased p53 as well as Ser15 phosphorylated p53, and thus enhanced protein levels of p53 regulated genes, including p21, PUMA, and BAX, which are in the apoptosis pathway."