IndraLab

Statements

TNIP1 affects TNFAIP3
15 2 | 1 20 87
TNIP1 binds TNFAIP3.
15 2 | 17 86
TNFAIP3 binds TNIP1. 10 / 108
15 2 | 15 70
biogrid
No evidence text available
32296183
sparser
"On the other hand, functional analysis of different ABIN-1 mutants has shown that ABIN-1 binding to A20 is not essential for its NF-κB inhibitory function [99] ."
22119011
biogrid
No evidence text available
11389905
sparser
"The role of ABIN1 in IL-17 signaling (e.g. whether and how ABIN1 and A20 cooperatively interact to inhibit NFκB activation as in TNF signaling) is less well defined; however, ABIN1 can inhibit IL-17 signaling independent of A20 ( xref )."
30543901
sparser
"Hence, ABIN1 binds to A20 in cells, and ABIN1 deficiency resembles A20 deficiency in several regards."
23059429
reach
"TNIP1 interacts with TNFAIP3 and may play a role in NF-kappaB inhibition together with TNFAIP3."
22087647
reach
"To further explore the underlying mechanisms of the interaction of TNFAIP3 and TNIP1, the HaploReg 4.1 online database was used to predict the functions of the two loci in silico."
32398022
sparser
"As a result, NF‐κB is liberated from suppressive conditions and is translocated into cellular nuclei for transcription of targeted genes. xref , xref Furthermore, TNIP1 also interacts with A20 (also known as TNFAIP3) and mediates the interaction of A20 with polyubiquitinated IKK‐γ. xref Previous studies have demonstrated that NF‐κB activity is inhibited by TNIP1 complexed with A20 and IKK through polyubiquitin binding, removing this polyubiquitin binding release NF‐κB and activating NF‐κB‐mediated signalling in pro‐inflammatory signalling pathways. xref , xref "
31691497
sparser
"TNFAIP2 may play a pro-angiogenic role, whereas TNFAIP3 interacts with TNIP1 and inhibits TNF-induced NFk-B-dependent gene expression by interfering with RIP- or TRAF2-mediated transactivation signal."
17324256
reach
"Notably, TNFAIP3, a binding partner of TNIP1, did not show significant evidence of association or interaction with TNIP1 (data not shown)."
23055271
TNFAIP3 binds TNIP1 and NFkappaB. 3 / 3
| 3
sparser
"Acute T-lymphocyte leukaemia is a form of haematological malignancy with abnormal activation of NF-κB pathway, which results in high expression of A20 and ABIN1, which constitute a negative feedback mechanism for the regulation of NF-κB activation."
29776374
sparser
"TNIP1 interacts with A20 (TNFAIP3) to negatively regulate NF-kappaB."
21750679
sparser
"A20 and TNIP1 (referred to as ABIN in that system) do not directly associate with NF-κB but they do decrease NF-κB-mediated transcription."
21967852
TNFAIP3 binds TNIP1 and A20. 2 / 2
| 2
reach
"The TNFAIP3 interacting protein 1, (TNIP1), also known as ABIN1, interacts with TNFAIP3 and A20 and promotes inhibition of NF-kappaB activity [XREF_BIBR, XREF_BIBR]."
23227085
reach
"Genetic studies have shown an association between multiple autoimmune diseases and TNFAIP3 (A20) and TNIP1 (ABIN1), both repressors of NF-kappaB and of IKBKE (IKKepsilon), which is an NF-kappaB activator."
23944604
TNFAIP3 binds TAX1BP1, TNIP1, and RNF11. 1 / 1
| 1
sparser
"It is also unclear what regulates the interactions between A20, TAX1BP1, ABIN1 and RNF11 during virus infection to assemble the A20 antiviral complex."
23308279
sparser
"Independent polymorphisms in TNFAIP3 are associated with rheumatoid arthritis, and systemic lupus erythematosus. xref – xref , xref TNIP1 is upregulated in psoriasis lesions and uninvolved versus normal skin from controls xref and the association of TNFAIP3 and TNIP1 with PsA needs to be examined."
19182814
IKBKG binds TNIP1 and TNFAIP3. 1 / 1
| 1
sparser
"Conversely, the interaction of A20 with IKKγ and ABIN-1 seems to be mediated by different domains in A20 [19] , further demonstrating that the homologous AHD2 region is not an A20 interaction domain."
12586352
TNIP1 binds TNIP2, IKBKG, and TNFAIP3. 1 / 1
| 1
sparser
"A similar redundancy of the zinc fingers could be demonstrated for A20’s ability to bind to ABIN-1, ABIN-2, TXBP151, IKKγ, and A20 itself."
11389905
sparser
"Association of TNFAIP3 , ETS1 and TNIP1 with SLE."
22087647
TNFAIP3 binds ETS1 and TNIP1. 1 / 1
| 1
sparser
"Our replication study confirmed the association of TNFAIP3 , ETS1 and TNIP1 with SLE susceptibility in a southwestern Chinese population."
22087647
TNFAIP3 binds TAX1BP1 and TNIP1. 1 / 1
| 1
sparser
"For instance, A20, TAX1BP1 and ABIN1 form an inducible complex that restricts antiviral signaling and IFN-β production in response to virus infection ( xref , xref ) ( xref )."
22435550
TNIP1 binds TNFAIP3 and NLRP1. 1 / 1
| 1
sparser
"Besides psoriasis, the TNIP1 and TNFAIP3 gene have been associated with systemic lupus erythematosus (SLE) [ xref , xref ]."
26046540
TNFAIP3 binds cooH, CXXC1, and TNIP1. 1 / 1
| 1
sparser
"Therefore, the ability of A20 to block TNF-mediated NF-κB activation is likely to involve the binding of the NF-κB inhibitory protein ABIN to the COOH-terminal zinc finger domain of A20."
10385526
BLNK binds TNIP1, THSD1, TNFAIP3, and TNIP1. 1 / 1
| 1
sparser
"The interaction between A20 and TNIP1, mediated by the ABIN-homology domain 1 (AHD1) domain of TNIP1 [ xref ], promotes negative regulation of MAPK activation as well as NF- κ B-mediated gene transcription downstream of TNFR and TLRs [ xref , xref ]."
30402506
TNFAIP3 binds TNIP1 and TFRC. 1 / 1
| 1
sparser
"A20/ABIN1-mediated TfR1 reduction of macrophages is associated with extracellular HCVcc concentrations."
26382585
TNIP1 binds TNIP2, TNFAIP3, and CXXC1. 1 / 1
| 1
sparser
"Yeast two-hybrid studies revealed the binding of the zinc finger domain of A20 with two novel proteins, named ABIN-1 (previously called ABIN, for A20-binding inhibitor of NF-κB activation) and ABIN-2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12586352
NLRP1 binds TNFAIP3, TNIP1, and ETS1. 1 / 1
| 1
sparser
"12 Zhong H, Li XL, Li M et al. (2011) Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population."
25522798
TNIP1 activates TNFAIP3.
| 1 2
TNIP1 activates TNFAIP3. 3 / 3
| 1 2
reach
"Previous studies have demonstrated that ABIN1 mediated anti-inflammatory mechanisms are A20 and TNFAIP3 dependent."
32843955
eidos
"Similar to the loss of A20 , the loss of ABIN1 ( tnip1 - / - ) may lead to embryonic lethality ( 89 ) ."
31312197
reach
"The pro-necroptotic effect of CYLD on RIPK1 K63/M1 ubiquitination is opposed by the TNFAIP3 interacting protein 1 (TNIP1)/TNF alpha-induced protein 3 (TNFAIP3, also known as A20) complex, which interacts with M1 chains and prevents their removal [65]."
36551253
TNIP1 inhibits TNFAIP3.
| 1 1
TNIP1 inhibits TNFAIP3. 2 / 2
| 1 1
sparser
"ABIN-1 inhibits IL-17R signaling independently of A20."
30761389
reach
"ABIN1 attenuated inflammatory responses and colitis by regulating A20 and TNFAIP3 activities."
32843955
TNFAIP3 affects TNIP1
15 2 | 18 87
TNFAIP3 binds TNIP1.
15 2 | 17 86
TNFAIP3 binds TNIP1. 10 / 108
15 2 | 15 70
biogrid
No evidence text available
32296183
sparser
"On the other hand, functional analysis of different ABIN-1 mutants has shown that ABIN-1 binding to A20 is not essential for its NF-κB inhibitory function [99] ."
22119011
biogrid
No evidence text available
11389905
sparser
"The role of ABIN1 in IL-17 signaling (e.g. whether and how ABIN1 and A20 cooperatively interact to inhibit NFκB activation as in TNF signaling) is less well defined; however, ABIN1 can inhibit IL-17 signaling independent of A20 ( xref )."
30543901
sparser
"Hence, ABIN1 binds to A20 in cells, and ABIN1 deficiency resembles A20 deficiency in several regards."
23059429
reach
"TNIP1 interacts with TNFAIP3 and may play a role in NF-kappaB inhibition together with TNFAIP3."
22087647
reach
"To further explore the underlying mechanisms of the interaction of TNFAIP3 and TNIP1, the HaploReg 4.1 online database was used to predict the functions of the two loci in silico."
32398022
sparser
"As a result, NF‐κB is liberated from suppressive conditions and is translocated into cellular nuclei for transcription of targeted genes. xref , xref Furthermore, TNIP1 also interacts with A20 (also known as TNFAIP3) and mediates the interaction of A20 with polyubiquitinated IKK‐γ. xref Previous studies have demonstrated that NF‐κB activity is inhibited by TNIP1 complexed with A20 and IKK through polyubiquitin binding, removing this polyubiquitin binding release NF‐κB and activating NF‐κB‐mediated signalling in pro‐inflammatory signalling pathways. xref , xref "
31691497
sparser
"TNFAIP2 may play a pro-angiogenic role, whereas TNFAIP3 interacts with TNIP1 and inhibits TNF-induced NFk-B-dependent gene expression by interfering with RIP- or TRAF2-mediated transactivation signal."
17324256
reach
"Notably, TNFAIP3, a binding partner of TNIP1, did not show significant evidence of association or interaction with TNIP1 (data not shown)."
23055271
TNFAIP3 binds TNIP1 and NFkappaB. 3 / 3
| 3
sparser
"Acute T-lymphocyte leukaemia is a form of haematological malignancy with abnormal activation of NF-κB pathway, which results in high expression of A20 and ABIN1, which constitute a negative feedback mechanism for the regulation of NF-κB activation."
29776374
sparser
"TNIP1 interacts with A20 (TNFAIP3) to negatively regulate NF-kappaB."
21750679
sparser
"A20 and TNIP1 (referred to as ABIN in that system) do not directly associate with NF-κB but they do decrease NF-κB-mediated transcription."
21967852
TNFAIP3 binds TNIP1 and A20. 2 / 2
| 2
reach
"The TNFAIP3 interacting protein 1, (TNIP1), also known as ABIN1, interacts with TNFAIP3 and A20 and promotes inhibition of NF-kappaB activity [XREF_BIBR, XREF_BIBR]."
23227085
reach
"Genetic studies have shown an association between multiple autoimmune diseases and TNFAIP3 (A20) and TNIP1 (ABIN1), both repressors of NF-kappaB and of IKBKE (IKKepsilon), which is an NF-kappaB activator."
23944604
TNFAIP3 binds TAX1BP1, TNIP1, and RNF11. 1 / 1
| 1
sparser
"It is also unclear what regulates the interactions between A20, TAX1BP1, ABIN1 and RNF11 during virus infection to assemble the A20 antiviral complex."
23308279
sparser
"Independent polymorphisms in TNFAIP3 are associated with rheumatoid arthritis, and systemic lupus erythematosus. xref – xref , xref TNIP1 is upregulated in psoriasis lesions and uninvolved versus normal skin from controls xref and the association of TNFAIP3 and TNIP1 with PsA needs to be examined."
19182814
IKBKG binds TNIP1 and TNFAIP3. 1 / 1
| 1
sparser
"Conversely, the interaction of A20 with IKKγ and ABIN-1 seems to be mediated by different domains in A20 [19] , further demonstrating that the homologous AHD2 region is not an A20 interaction domain."
12586352
TNIP1 binds TNIP2, IKBKG, and TNFAIP3. 1 / 1
| 1
sparser
"A similar redundancy of the zinc fingers could be demonstrated for A20’s ability to bind to ABIN-1, ABIN-2, TXBP151, IKKγ, and A20 itself."
11389905
sparser
"Association of TNFAIP3 , ETS1 and TNIP1 with SLE."
22087647
TNFAIP3 binds ETS1 and TNIP1. 1 / 1
| 1
sparser
"Our replication study confirmed the association of TNFAIP3 , ETS1 and TNIP1 with SLE susceptibility in a southwestern Chinese population."
22087647
TNFAIP3 binds TAX1BP1 and TNIP1. 1 / 1
| 1
sparser
"For instance, A20, TAX1BP1 and ABIN1 form an inducible complex that restricts antiviral signaling and IFN-β production in response to virus infection ( xref , xref ) ( xref )."
22435550
TNIP1 binds TNFAIP3 and NLRP1. 1 / 1
| 1
sparser
"Besides psoriasis, the TNIP1 and TNFAIP3 gene have been associated with systemic lupus erythematosus (SLE) [ xref , xref ]."
26046540
TNFAIP3 binds cooH, CXXC1, and TNIP1. 1 / 1
| 1
sparser
"Therefore, the ability of A20 to block TNF-mediated NF-κB activation is likely to involve the binding of the NF-κB inhibitory protein ABIN to the COOH-terminal zinc finger domain of A20."
10385526
BLNK binds TNIP1, THSD1, TNFAIP3, and TNIP1. 1 / 1
| 1
sparser
"The interaction between A20 and TNIP1, mediated by the ABIN-homology domain 1 (AHD1) domain of TNIP1 [ xref ], promotes negative regulation of MAPK activation as well as NF- κ B-mediated gene transcription downstream of TNFR and TLRs [ xref , xref ]."
30402506
TNFAIP3 binds TNIP1 and TFRC. 1 / 1
| 1
sparser
"A20/ABIN1-mediated TfR1 reduction of macrophages is associated with extracellular HCVcc concentrations."
26382585
TNIP1 binds TNIP2, TNFAIP3, and CXXC1. 1 / 1
| 1
sparser
"Yeast two-hybrid studies revealed the binding of the zinc finger domain of A20 with two novel proteins, named ABIN-1 (previously called ABIN, for A20-binding inhibitor of NF-κB activation) and ABIN-2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12586352
NLRP1 binds TNFAIP3, TNIP1, and ETS1. 1 / 1
| 1
sparser
"12 Zhong H, Li XL, Li M et al. (2011) Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population."
25522798
TNFAIP3 ubiquitinates TNIP1.
| 1
TNFAIP3 ubiquitinates TNIP1. 1 / 1
| 1
sparser
"As proposed for RIPK1, other E3 ligases such as Itch or RNF11 may be involved in A20-dependent ABIN-1 or A20 ubiquitination and degradation [ xref , xref ]."
35099607
TNFAIP3 inhibits TNIP1.
| 1
TNFAIP3 inhibits TNIP1. 1 / 1
| 1
reach
"For instance, mutations in tumor necrosis factor alpha-induced protein 3 or A20 (TNFAIP3) can trigger incorrect degradation and termination of pro-inflammatory responses.47 TNFAIP3 interacting protein 1 (TNIP1) has been described as another key repressor of inflammatory signaling and a potential factor in multiple autoimmune disorders."
36483271
NFKBIA affects NFkappaB, REL, TNF, TNFAIP3, TNIP1, and TRAF3IP2
| 1
TNIP1 binds TNFAIP3, TRAF3IP2, NFKBIA, REL, TNF, and NFkappaB. 1 / 1
| 1
sparser
"TNIP1 , TNFAIP3 , TRAF3IP2 , NFKBIA , and REL are associated with the TNF-α pathway and activation of NF-κB; while IL23R , IL12B , IL23A , and TYK2 are associated with activation of the Th17 pathway."
22577363
sparser
"Association of TNFAIP3 , ETS1 and TNIP1 with SLE."
22087647
IKBKG affects TNIP2
| 1
TNIP1 binds TNIP2, IKBKG, and TNFAIP3. 1 / 1
| 1
sparser
"A similar redundancy of the zinc fingers could be demonstrated for A20’s ability to bind to ABIN-1, ABIN-2, TXBP151, IKKγ, and A20 itself."
11389905
IKBKG affects TNFAIP3, and TNIP1
| 1
IKBKG binds TNIP1 and TNFAIP3. 1 / 1
| 1
sparser
"Conversely, the interaction of A20 with IKKγ and ABIN-1 seems to be mediated by different domains in A20 [19] , further demonstrating that the homologous AHD2 region is not an A20 interaction domain."
12586352
IKBKG affects OPTN, TNFAIP3, TNIP1, TNIP2, and polyubiquitin
| 1
IKBKG binds OPTN, TNIP1, TNIP2, TNFAIP3, and polyubiquitin. 1 / 1
| 1
sparser
"The majority of the identified interactors are known from previous work to bind polyubiquitin, including proteins known to modulate NF-κB signaling through their polyubiquitin binding such as NEMO, op[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19285159
ETS1 affects TNFAIP3, and TNIP1
| 1
TNFAIP3 binds ETS1 and TNIP1. 1 / 1
| 1
sparser
"Our replication study confirmed the association of TNFAIP3 , ETS1 and TNIP1 with SLE susceptibility in a southwestern Chinese population."
22087647
ETS1 affects NLRP1, TNFAIP3, and TNIP1
| 1
NLRP1 binds TNFAIP3, TNIP1, and ETS1. 1 / 1
| 1
sparser
"12 Zhong H, Li XL, Li M et al. (2011) Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population."
25522798
sparser
"Association of TNFAIP3 , ETS1 and TNIP1 with SLE."
22087647
CXXC1 affects cooH
| 1
TNFAIP3 binds cooH, CXXC1, and TNIP1. 1 / 1
| 1
sparser
"Therefore, the ability of A20 to block TNF-mediated NF-κB activation is likely to involve the binding of the NF-κB inhibitory protein ABIN to the COOH-terminal zinc finger domain of A20."
10385526
CXXC1 affects TNIP2
| 1
TNIP1 binds TNIP2, TNFAIP3, and CXXC1. 1 / 1
| 1
sparser
"Yeast two-hybrid studies revealed the binding of the zinc finger domain of A20 with two novel proteins, named ABIN-1 (previously called ABIN, for A20-binding inhibitor of NF-κB activation) and ABIN-2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12586352
CXXC1 affects TNFAIP3, TNIP1, and cooH
| 1
TNFAIP3 binds cooH, CXXC1, and TNIP1. 1 / 1
| 1
sparser
"Therefore, the ability of A20 to block TNF-mediated NF-κB activation is likely to involve the binding of the NF-κB inhibitory protein ABIN to the COOH-terminal zinc finger domain of A20."
10385526
CXXC1 affects TNFAIP3, TNIP1, and TNIP2
| 1
TNIP1 binds TNIP2, TNFAIP3, and CXXC1. 1 / 1
| 1
sparser
"Yeast two-hybrid studies revealed the binding of the zinc finger domain of A20 with two novel proteins, named ABIN-1 (previously called ABIN, for A20-binding inhibitor of NF-κB activation) and ABIN-2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12586352
BLNK affects TNIP1
| 1
BLNK binds TNIP1, THSD1, TNFAIP3, and TNIP1. 1 / 1
| 1
sparser
"The interaction between A20 and TNIP1, mediated by the ABIN-homology domain 1 (AHD1) domain of TNIP1 [ xref ], promotes negative regulation of MAPK activation as well as NF- κ B-mediated gene transcription downstream of TNFR and TLRs [ xref , xref ]."
30402506
BLK affects FCGR2B, HLA-DRB1, IRF5, STAT4, TNFAIP3, TNFSF13, and TNIP1
| 1
sparser
"Nonetheless, Koga and colleagues in 2011 evaluated 282 Japanese SLE patients and 222 healthy controls in order to assess the cumulative number of risk alleles associated with SNPs of HLA-DRB1, IRF5, STAT4, BLK, TNFAIP3, TNIP1, FCGR2B, and TNFSF13 genes."
26798662
IRF5 binds BLK, STAT4, TNFAIP3, SPP1, TNIP1, ETS1, and Lupus Erythematosus, Systemic. 1 / 1
| 1
sparser
"The present study was conducted to determine whether the 7 candidate genes IRF5 , BLK , STAT4 , TNFAIP3 , SPP1 , TNIP1 and ETS1 were associated with childhood-onset SLE in the Japanese population."
24023622
sparser
"Independent polymorphisms in TNFAIP3 are associated with rheumatoid arthritis, and systemic lupus erythematosus. xref – xref , xref TNIP1 is upregulated in psoriasis lesions and uninvolved versus normal skin from controls xref and the association of TNFAIP3 and TNIP1 with PsA needs to be examined."
19182814
AMBP affects COG6, PTPN6, SPATA2, TNFAIP3, and TNIP1
| 1
sparser
"Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population."
26738398