IndraLab

Statements

TNIP1 affects TNFAIP3
8 2 | 1 22 74
TNIP1 binds TNFAIP3.
8 2 | 20 73
TNFAIP3 binds TNIP1. 10 / 87
8 2 | 13 58
sparser
"From the reported “NF-kB signaling” pathway, the genes coding for the interacting TNFAIP3 and TNIP1 molecules form Cluster 4, marked by their enrichment in interleukin and NF-kB GO terms."
31260503
sparser
"These findings are unexpected because A20 and ABIN-1 are binding partners considered to function together, in which case the predicted outcome would be that deleting one would be sufficient to ablate the activity of the other."
29934322
sparser
"45,46 ABIN1 and A20 directly interact, and A20-mediated deubiquitination and degradation of NEMO and subsequent NF-κB inhibition are ABIN1 dependent."
28935578
sparser
"Prior studies suggested that ABIN-1 binds A20, a potent restrictor of TNF-induced NFkB signaling, and that ABIN-1 inhibits NFkB signaling ( xref , xref )."
19060883
sparser
"Possibly, ABIN-1 binding to the A20 C-terminus may exert additional effects, such as shielding the MALT1 recognition motif of A20, which could protect A20 from MALT1-catalyzed inactivation."
35099607
sparser
"Although this may seem counterintuitive given the role of MCPIP1 in restricting inflammation, it is common for feedback inhibitors like TNFAIP3 and TNIP1 to be associated with inflammation ( xref )."
27920272
sparser
"Recently a genome-wide association study (GWAS) reported association of TNIP1 (5q32-q33.1) as well as TNFAIP3 SNPs with psoriasis in the Caucasian populations [ xref ]."
20849588
reach
"Notably, TNFAIP3, a binding partner of TNIP1, did not show significant evidence of association or interaction with TNIP1 (data not shown)."
23055271
sparser
"Collectively, these data demonstrate the importance of the ABIN1 UBD domain, which mediates the ABIN1-A20 axis, at limiting RIPK1 activation-dependent cell death during embryonic development."
35430614
reach
"Significant gene gene interaction between TNIP1 and TNFAIP3 was detected neither in SLE nor RA."
20849588
TNFAIP3 binds TNIP1 and IKBKG. 4 / 4
| 3 1
reach
"ABIN-1 binds to NEMO and IKKgamma and co-operates with A20 in inhibiting NF-kappaB."
16684768
sparser
"Conversely, the interaction of A20 with IKKγ and ABIN-1 seems to be mediated by different domains in A20 [19] , further demonstrating that the homologous AHD2 region is not an A20 interaction domain."
12586352
reach
"ABIN-1 binds to NEMO, facilitating A20 mediated removal of polyubiquitin chains from NEMO, and preventing NF-kappaB activation XREF_BIBR - XREF_BIBR."
20010814
reach
"6 ABIN1, A20, and NEMO were, later, demonstrated to interact as a complex; 14 supporting the hypothesis that ABIN1 may cooperatively bind with A20 and NEMO to alter the ubiquitination status of NEMO."
26097105
NFkappaB binds TNFAIP3 and TNIP1. 3 / 3
| 3
sparser
"A20 and TNIP1 (referred to as ABIN in that system) do not directly associate with NF-κB but they do decrease NF-κB-mediated transcription."
21967852
sparser
"TNIP1 interacts with A20 (TNFAIP3) to negatively regulate NF-kappaB."
21750679
sparser
"Acute T-lymphocyte leukaemia is a form of haematological malignancy with abnormal activation of NF-κB pathway, which results in high expression of A20 and ABIN1, which constitute a negative feedback mechanism for the regulation of NF-κB activation."
29776374
TNFAIP3 binds TNFAIP3 and TNIP1. 2 / 2
| 2
reach
"The TNFAIP3 interacting protein 1, (TNIP1), also known as ABIN1, interacts with TNFAIP3 and A20 and promotes inhibition of NF-kappaB activity [XREF_BIBR, XREF_BIBR]."
23227085
reach
"Genetic studies have shown an association between multiple autoimmune diseases and TNFAIP3 (A20) and TNIP1 (ABIN1), both repressors of NF-kappaB and of IKBKE (IKKepsilon), which is an NF-kappaB activator."
23944604
RNF11 binds TAX1BP1, TNFAIP3, and TNIP1. 1 / 1
| 1
sparser
"It is also unclear what regulates the interactions between A20, TAX1BP1, ABIN1 and RNF11 during virus infection to assemble the A20 antiviral complex."
23308279
TNFAIP3 binds TNIP1 and NFKB1. 1 / 1
| 1
reach
"Taken together, these results demonstrate that the inhibitory effect of ABIN-1 on p105 processing does not require complex formation between p105 and ABIN-1 and/or ABIN-1 and A20."
19695220
TNFAIP3 binds TNIP1 and IL-17 receptor. 1 / 1
| 1
reach
"Whether ABIN1 also directly interacts with the IL-17 receptor like A20, also remains an open question."
30543901
TNFAIP3 binds TNIP1, TNIP2, and IKBKG. 1 / 1
| 1
sparser
"A similar redundancy of the zinc fingers could be demonstrated for A20’s ability to bind to ABIN-1, ABIN-2, TXBP151, IKKγ, and A20 itself."
11389905
TNFAIP3 binds TNIP1 and KLK3. 1 / 1
| 1
sparser
"Independent polymorphisms in TNFAIP3 are associated with rheumatoid arthritis, and systemic lupus erythematosus. xref – xref , xref TNIP1 is upregulated in psoriasis lesions and uninvolved versus normal skin from controls xref and the association of TNFAIP3 and TNIP1 with PsA needs to be examined."
19182814
sparser
"Association of TNFAIP3 , ETS1 and TNIP1 with SLE."
22087647
TNFAIP3 binds TNIP1 and ETS1. 1 / 1
| 1
sparser
"Our replication study confirmed the association of TNFAIP3 , ETS1 and TNIP1 with SLE susceptibility in a southwestern Chinese population."
22087647
TAX1BP1 binds TNFAIP3 and TNIP1. 1 / 1
| 1
sparser
"For instance, A20, TAX1BP1 and ABIN1 form an inducible complex that restricts antiviral signaling and IFN-β production in response to virus infection ( xref , xref ) ( xref )."
22435550
TNFAIP3 binds NLRP1 and TNIP1. 1 / 1
| 1
sparser
"Besides psoriasis, the TNIP1 and TNFAIP3 gene have been associated with systemic lupus erythematosus (SLE) [ xref , xref ]."
26046540
TNFAIP3 binds TNIP1, CXXC1, and cooH. 1 / 1
| 1
sparser
"Therefore, the ability of A20 to block TNF-mediated NF-κB activation is likely to involve the binding of the NF-κB inhibitory protein ABIN to the COOH-terminal zinc finger domain of A20."
10385526
TNFAIP3 binds BLNK, TNIP1, TNIP1, and THSD1. 1 / 1
| 1
sparser
"The interaction between A20 and TNIP1, mediated by the ABIN-homology domain 1 (AHD1) domain of TNIP1 [ xref ], promotes negative regulation of MAPK activation as well as NF- κ B-mediated gene transcription downstream of TNFR and TLRs [ xref , xref ]."
30402506
TFRC binds TNFAIP3 and TNIP1. 1 / 1
| 1
sparser
"A20/ABIN1-mediated TfR1 reduction of macrophages is associated with extracellular HCVcc concentrations."
26382585
TNFAIP3 binds TNIP1, TNIP2, and CXXC1. 1 / 1
| 1
sparser
"Yeast two-hybrid studies revealed the binding of the zinc finger domain of A20 with two novel proteins, named ABIN-1 (previously called ABIN, for A20-binding inhibitor of NF-κB activation) and ABIN-2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12586352
TNIP1 inhibits TNFAIP3.
| 1 1
TNIP1 inhibits TNFAIP3. 2 / 2
| 1 1
reach
"ABIN1 attenuated inflammatory responses and colitis by regulating A20 and TNFAIP3 activities."
32843955
sparser
"ABIN-1 inhibits IL-17R signaling independently of A20."
30761389
TNIP1 activates TNFAIP3.
| 1 1
TNIP1 activates TNFAIP3. 2 / 2
| 1 1
reach
"Previous studies have demonstrated that ABIN1 mediated anti-inflammatory mechanisms are A20 and TNFAIP3 dependent."
32843955
eidos
"Similar to the loss of A20 , the loss of ABIN1 ( tnip1 - / - ) may lead to embryonic lethality ( 89 ) ."
31312197
TNFAIP3 affects TNIP1
8 2 | 20 74
TNFAIP3 binds TNIP1.
8 2 | 20 73
TNFAIP3 binds TNIP1. 10 / 87
8 2 | 13 58
sparser
"From the reported “NF-kB signaling” pathway, the genes coding for the interacting TNFAIP3 and TNIP1 molecules form Cluster 4, marked by their enrichment in interleukin and NF-kB GO terms."
31260503
sparser
"These findings are unexpected because A20 and ABIN-1 are binding partners considered to function together, in which case the predicted outcome would be that deleting one would be sufficient to ablate the activity of the other."
29934322
sparser
"45,46 ABIN1 and A20 directly interact, and A20-mediated deubiquitination and degradation of NEMO and subsequent NF-κB inhibition are ABIN1 dependent."
28935578
sparser
"Prior studies suggested that ABIN-1 binds A20, a potent restrictor of TNF-induced NFkB signaling, and that ABIN-1 inhibits NFkB signaling ( xref , xref )."
19060883
sparser
"Possibly, ABIN-1 binding to the A20 C-terminus may exert additional effects, such as shielding the MALT1 recognition motif of A20, which could protect A20 from MALT1-catalyzed inactivation."
35099607
sparser
"Although this may seem counterintuitive given the role of MCPIP1 in restricting inflammation, it is common for feedback inhibitors like TNFAIP3 and TNIP1 to be associated with inflammation ( xref )."
27920272
sparser
"Recently a genome-wide association study (GWAS) reported association of TNIP1 (5q32-q33.1) as well as TNFAIP3 SNPs with psoriasis in the Caucasian populations [ xref ]."
20849588
reach
"Notably, TNFAIP3, a binding partner of TNIP1, did not show significant evidence of association or interaction with TNIP1 (data not shown)."
23055271
sparser
"Collectively, these data demonstrate the importance of the ABIN1 UBD domain, which mediates the ABIN1-A20 axis, at limiting RIPK1 activation-dependent cell death during embryonic development."
35430614
reach
"Significant gene gene interaction between TNIP1 and TNFAIP3 was detected neither in SLE nor RA."
20849588
TNFAIP3 binds TNIP1 and IKBKG. 4 / 4
| 3 1
reach
"ABIN-1 binds to NEMO and IKKgamma and co-operates with A20 in inhibiting NF-kappaB."
16684768
sparser
"Conversely, the interaction of A20 with IKKγ and ABIN-1 seems to be mediated by different domains in A20 [19] , further demonstrating that the homologous AHD2 region is not an A20 interaction domain."
12586352
reach
"ABIN-1 binds to NEMO, facilitating A20 mediated removal of polyubiquitin chains from NEMO, and preventing NF-kappaB activation XREF_BIBR - XREF_BIBR."
20010814
reach
"6 ABIN1, A20, and NEMO were, later, demonstrated to interact as a complex; 14 supporting the hypothesis that ABIN1 may cooperatively bind with A20 and NEMO to alter the ubiquitination status of NEMO."
26097105
NFkappaB binds TNFAIP3 and TNIP1. 3 / 3
| 3
sparser
"A20 and TNIP1 (referred to as ABIN in that system) do not directly associate with NF-κB but they do decrease NF-κB-mediated transcription."
21967852
sparser
"TNIP1 interacts with A20 (TNFAIP3) to negatively regulate NF-kappaB."
21750679
sparser
"Acute T-lymphocyte leukaemia is a form of haematological malignancy with abnormal activation of NF-κB pathway, which results in high expression of A20 and ABIN1, which constitute a negative feedback mechanism for the regulation of NF-κB activation."
29776374
TNFAIP3 binds TNFAIP3 and TNIP1. 2 / 2
| 2
reach
"The TNFAIP3 interacting protein 1, (TNIP1), also known as ABIN1, interacts with TNFAIP3 and A20 and promotes inhibition of NF-kappaB activity [XREF_BIBR, XREF_BIBR]."
23227085
reach
"Genetic studies have shown an association between multiple autoimmune diseases and TNFAIP3 (A20) and TNIP1 (ABIN1), both repressors of NF-kappaB and of IKBKE (IKKepsilon), which is an NF-kappaB activator."
23944604
RNF11 binds TAX1BP1, TNFAIP3, and TNIP1. 1 / 1
| 1
sparser
"It is also unclear what regulates the interactions between A20, TAX1BP1, ABIN1 and RNF11 during virus infection to assemble the A20 antiviral complex."
23308279
TNFAIP3 binds TNIP1 and NFKB1. 1 / 1
| 1
reach
"Taken together, these results demonstrate that the inhibitory effect of ABIN-1 on p105 processing does not require complex formation between p105 and ABIN-1 and/or ABIN-1 and A20."
19695220
TNFAIP3 binds TNIP1 and IL-17 receptor. 1 / 1
| 1
reach
"Whether ABIN1 also directly interacts with the IL-17 receptor like A20, also remains an open question."
30543901
TNFAIP3 binds TNIP1, TNIP2, and IKBKG. 1 / 1
| 1
sparser
"A similar redundancy of the zinc fingers could be demonstrated for A20’s ability to bind to ABIN-1, ABIN-2, TXBP151, IKKγ, and A20 itself."
11389905
TNFAIP3 binds TNIP1 and KLK3. 1 / 1
| 1
sparser
"Independent polymorphisms in TNFAIP3 are associated with rheumatoid arthritis, and systemic lupus erythematosus. xref – xref , xref TNIP1 is upregulated in psoriasis lesions and uninvolved versus normal skin from controls xref and the association of TNFAIP3 and TNIP1 with PsA needs to be examined."
19182814
sparser
"Association of TNFAIP3 , ETS1 and TNIP1 with SLE."
22087647
TNFAIP3 binds TNIP1 and ETS1. 1 / 1
| 1
sparser
"Our replication study confirmed the association of TNFAIP3 , ETS1 and TNIP1 with SLE susceptibility in a southwestern Chinese population."
22087647
TAX1BP1 binds TNFAIP3 and TNIP1. 1 / 1
| 1
sparser
"For instance, A20, TAX1BP1 and ABIN1 form an inducible complex that restricts antiviral signaling and IFN-β production in response to virus infection ( xref , xref ) ( xref )."
22435550
TNFAIP3 binds NLRP1 and TNIP1. 1 / 1
| 1
sparser
"Besides psoriasis, the TNIP1 and TNFAIP3 gene have been associated with systemic lupus erythematosus (SLE) [ xref , xref ]."
26046540
TNFAIP3 binds TNIP1, CXXC1, and cooH. 1 / 1
| 1
sparser
"Therefore, the ability of A20 to block TNF-mediated NF-κB activation is likely to involve the binding of the NF-κB inhibitory protein ABIN to the COOH-terminal zinc finger domain of A20."
10385526
TNFAIP3 binds BLNK, TNIP1, TNIP1, and THSD1. 1 / 1
| 1
sparser
"The interaction between A20 and TNIP1, mediated by the ABIN-homology domain 1 (AHD1) domain of TNIP1 [ xref ], promotes negative regulation of MAPK activation as well as NF- κ B-mediated gene transcription downstream of TNFR and TLRs [ xref , xref ]."
30402506
TFRC binds TNFAIP3 and TNIP1. 1 / 1
| 1
sparser
"A20/ABIN1-mediated TfR1 reduction of macrophages is associated with extracellular HCVcc concentrations."
26382585
TNFAIP3 binds TNIP1, TNIP2, and CXXC1. 1 / 1
| 1
sparser
"Yeast two-hybrid studies revealed the binding of the zinc finger domain of A20 with two novel proteins, named ABIN-1 (previously called ABIN, for A20-binding inhibitor of NF-κB activation) and ABIN-2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12586352
TNFAIP3 ubiquitinates TNIP1.
| 1
TNFAIP3 ubiquitinates TNIP1. 1 / 1
| 1
sparser
"As proposed for RIPK1, other E3 ligases such as Itch or RNF11 may be involved in A20-dependent ABIN-1 or A20 ubiquitination and degradation [ xref , xref ]."
35099607
NFKBIA affects NFkappaB, REL, TNF, TNFAIP3, TNIP1, and TRAF3IP2
| 1
NFkappaB binds TNF, TNFAIP3, TRAF3IP2, TNIP1, NFKBIA, and REL. 1 / 1
| 1
sparser
"TNIP1 , TNFAIP3 , TRAF3IP2 , NFKBIA , and REL are associated with the TNF-α pathway and activation of NF-κB; while IL23R , IL12B , IL23A , and TYK2 are associated with activation of the Th17 pathway."
22577363
NFKB1 affects TNIP1
| 1
TNFAIP3 binds TNIP1 and NFKB1. 1 / 1
| 1
reach
"Taken together, these results demonstrate that the inhibitory effect of ABIN-1 on p105 processing does not require complex formation between p105 and ABIN-1 and/or ABIN-1 and A20."
19695220
sparser
"Association of TNFAIP3 , ETS1 and TNIP1 with SLE."
22087647
KLK3 affects TNIP1
| 1
TNFAIP3 binds TNIP1 and KLK3. 1 / 1
| 1
sparser
"Independent polymorphisms in TNFAIP3 are associated with rheumatoid arthritis, and systemic lupus erythematosus. xref – xref , xref TNIP1 is upregulated in psoriasis lesions and uninvolved versus normal skin from controls xref and the association of TNFAIP3 and TNIP1 with PsA needs to be examined."
19182814
IL-17 receptor affects TNIP1
| 1
TNFAIP3 binds TNIP1 and IL-17 receptor. 1 / 1
| 1
reach
"Whether ABIN1 also directly interacts with the IL-17 receptor like A20, also remains an open question."
30543901
IKBKG affects TNIP2
| 1
TNFAIP3 binds TNIP1, TNIP2, and IKBKG. 1 / 1
| 1
sparser
"A similar redundancy of the zinc fingers could be demonstrated for A20’s ability to bind to ABIN-1, ABIN-2, TXBP151, IKKγ, and A20 itself."
11389905
IKBKG affects OPTN, TNFAIP3, TNIP1, TNIP2, and polyubiquitin
| 1
TNFAIP3 binds TNIP1, OPTN, TNIP2, IKBKG, and polyubiquitin. 1 / 1
| 1
sparser
"The majority of the identified interactors are known from previous work to bind polyubiquitin, including proteins known to modulate NF-κB signaling through their polyubiquitin binding such as NEMO, op[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19285159
ETS1 affects TNFAIP3, and TNIP1
| 1
TNFAIP3 binds TNIP1 and ETS1. 1 / 1
| 1
sparser
"Our replication study confirmed the association of TNFAIP3 , ETS1 and TNIP1 with SLE susceptibility in a southwestern Chinese population."
22087647
sparser
"Association of TNFAIP3 , ETS1 and TNIP1 with SLE."
22087647
CXXC1 affects cooH
| 1
TNFAIP3 binds TNIP1, CXXC1, and cooH. 1 / 1
| 1
sparser
"Therefore, the ability of A20 to block TNF-mediated NF-κB activation is likely to involve the binding of the NF-κB inhibitory protein ABIN to the COOH-terminal zinc finger domain of A20."
10385526
CXXC1 affects TNIP2
| 1
TNFAIP3 binds TNIP1, TNIP2, and CXXC1. 1 / 1
| 1
sparser
"Yeast two-hybrid studies revealed the binding of the zinc finger domain of A20 with two novel proteins, named ABIN-1 (previously called ABIN, for A20-binding inhibitor of NF-κB activation) and ABIN-2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12586352
CXXC1 affects TNFAIP3, TNIP1, and cooH
| 1
TNFAIP3 binds TNIP1, CXXC1, and cooH. 1 / 1
| 1
sparser
"Therefore, the ability of A20 to block TNF-mediated NF-κB activation is likely to involve the binding of the NF-κB inhibitory protein ABIN to the COOH-terminal zinc finger domain of A20."
10385526
CXXC1 affects TNFAIP3, TNIP1, and TNIP2
| 1
TNFAIP3 binds TNIP1, TNIP2, and CXXC1. 1 / 1
| 1
sparser
"Yeast two-hybrid studies revealed the binding of the zinc finger domain of A20 with two novel proteins, named ABIN-1 (previously called ABIN, for A20-binding inhibitor of NF-κB activation) and ABIN-2 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12586352
BLNK affects TNIP1
| 1
TNFAIP3 binds BLNK, TNIP1, TNIP1, and THSD1. 1 / 1
| 1
sparser
"The interaction between A20 and TNIP1, mediated by the ABIN-homology domain 1 (AHD1) domain of TNIP1 [ xref ], promotes negative regulation of MAPK activation as well as NF- κ B-mediated gene transcription downstream of TNFR and TLRs [ xref , xref ]."
30402506
BLK affects FCGR2B, HLA-DRB1, IRF5, STAT4, TNFAIP3, TNFSF13, and TNIP1
| 1
sparser
"Nonetheless, Koga and colleagues in 2011 evaluated 282 Japanese SLE patients and 222 healthy controls in order to assess the cumulative number of risk alleles associated with SNPs of HLA-DRB1, IRF5, STAT4, BLK, TNFAIP3, TNIP1, FCGR2B, and TNFSF13 genes."
26798662
BLK binds STAT4, TNFAIP3, TNIP1, ETS1, IRF5, Lupus Erythematosus, Systemic, and SPP1. 1 / 1
| 1
sparser
"The present study was conducted to determine whether the 7 candidate genes IRF5 , BLK , STAT4 , TNFAIP3 , SPP1 , TNIP1 and ETS1 were associated with childhood-onset SLE in the Japanese population."
24023622