IndraLab

Statements

TNIP1 activates TNFAIP3. 3 / 3
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"Previous studies have demonstrated that ABIN1 mediated anti-inflammatory mechanisms are A20 and TNFAIP3 dependent."
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"Similar to the loss of A20 , the loss of ABIN1 ( tnip1 - / - ) may lead to embryonic lethality ( 89 ) ."
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"The pro-necroptotic effect of CYLD on RIPK1 K63/M1 ubiquitination is opposed by the TNFAIP3 interacting protein 1 (TNIP1)/TNF alpha-induced protein 3 (TNFAIP3, also known as A20) complex, which interacts with M1 chains and prevents their removal [65]."
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