IndraLab

Statements


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"A20 and TNIP1 (referred to as ABIN in that system) do not directly associate with NF-κB but they do decrease NF-κB-mediated transcription."

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"TNIP1 interacts with A20 (TNFAIP3) to negatively regulate NF-kappaB."

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"Acute T-lymphocyte leukaemia is a form of haematological malignancy with abnormal activation of NF-κB pathway, which results in high expression of A20 and ABIN1, which constitute a negative feedback mechanism for the regulation of NF-κB activation."