IndraLab

Statements


| 3 1

reach
"ABIN-1 binds to NEMO and IKKgamma and co-operates with A20 in inhibiting NF-kappaB."

sparser
"Conversely, the interaction of A20 with IKKγ and ABIN-1 seems to be mediated by different domains in A20 [19] , further demonstrating that the homologous AHD2 region is not an A20 interaction domain."

reach
"ABIN-1 binds to NEMO, facilitating A20 mediated removal of polyubiquitin chains from NEMO, and preventing NF-kappaB activation XREF_BIBR - XREF_BIBR."

reach
"6 ABIN1, A20, and NEMO were, later, demonstrated to interact as a complex; 14 supporting the hypothesis that ABIN1 may cooperatively bind with A20 and NEMO to alter the ubiquitination status of NEMO."