IndraLab

Statements

ANG translocates to the nucleus. 10 / 290
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"P112L ANG variant, which is found in amyotrophic lateral sclerosis (ALS) patients ( xref ) and which is incapable of nuclear localization, was unable to mediate tiRNA production, indicating that nuclear translocation of ANG, thus the cell surface receptor of ANG, is required for ANG to cleave tRNA in vivo ."
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"Constitutive nuclear translocation of ANG in cancer cells is a driving force for cancer progression ( xref ; xref ; xref )."
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"Under growth conditions, the receptor mediates internalization of ANG that is subsequently translocated to the nucleus."
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"Under favorable growth conditions, ANG translocates to the nucleus, triggering the synthesis of ribosomal RNA (rRNA) and actively participating in cell proliferation ( xref , xref )."
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"To stimulate blood-vessel growth, ANG must be transported to the nucleus and must retain its catalytic activity."
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"Angiogenin (ANG) translocates to the nucleus of target cells, which is essential for angiogenesis and cancer cell proliferation."
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"Next, we determined BDNF-induced nuclear translocation of angiogenin by immunofluorescent staining."
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"Classically, after entry into endothelial cells via receptor mediated endocytosis ( xref ), angiogenin translocate into the nucleus and subsequently into the nucleolus where it stimulates rRNA transcription, most important for ribosomal biogenesis and the control of transcription of other angiogenic factors and growth factors ( xref , xref )."
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"Under growth conditions, ANG translocates to the nucleus, where it stimulates rRNA transcription[ xref ]."
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"Indeed, neamine treatment blocked nuclear translocation of ANG and suppressed rRNA transcription in cancer cells ( xref )."
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ANG translocates to the cytoplasm. 10 / 24
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"In addition, nuclear ANG translocates to the cytoplasm [ xref ]."
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"In addition, nuclear ANG translocates to the cytoplasm (Pizzo et al., 2013), which also promotes tiRNA production."
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"This detachment unwinds nuclear ANG, which is then translocated to the cytoplasm to finally generate more tsRNAs."
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"In addition, nuclear ANG translocates to the cytoplasm [4]."
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"In addition, nuclear ANG translocates to the cytoplasm ( xref ), which also promotes tiRNA production."
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"In primitive HSCs, which are under hypoxic conditions (an element of generalized cellular stress), angiogenin translocates to the cytoplasm and activates the synthesis of anti-apoptotic genes, suppresses global protein translation, and conserves anabolic energy."
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"Once exposed to stress stimuli, ANG dissociates from RNH1 and translocates to the cytoplasm for tRNA processing."
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"Under stress conditions such as oxidative stress, hypoxia, and starvation, ANG may translocate to cytoplasm and cleave tRNAs which will result in global translation inhibition (Fig. 3)."
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"Indeed it has been shown that angiogenin promotes rRNA transcription under permissive growth conditions: under stress conditions angiogenin translocates to the cytoplasm reducing protein translation a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In primitive HSCs, which are under hypoxic conditions (an element of generalized cellular stress), angiogenin translocates to the cytoplasm and activates the synthesis of anti-apoptotic genes, suppresses global protein translation, and conserves anabolic energy."
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ANG translocates from the nucleus. 7 / 7
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"Accordingly, our results suggest that exposure to environmental stressors such as LPS or PA weaken the binding and interaction between RNH1 and ANG, resulting in the release of ANG from the nucleus and increases in the levels of both ANG and tsRNAs in the cytoplasm of EEC."
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"In response to stress, ANG translocates into cytoplasm from the nucleus and dissociates from RNH1."
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"Oxidative stress reportedly alters the localization of RNases; Rny1 in yeast diffuses from the vacuole to the cytoplasm [7] and ANG in mammalian cells translocates from the nucleus to SGs [13] ."
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"At the same time, under stress conditions, ANG translocates from the nucleus and accumulates in the cytoplasm, slicing mature tRNAs to produce tiRNAs [ xref ]."
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"The release of nuclear angiogenin from the nucleus by DNase I indicates that it can directly bind to nuclear DNA."
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"Several stressors induce ANG translocation from the nucleus into the cytoplasm, where it cleaves transfer RNAs (tRNAs) in the anticodon loop to produce tRNA derived stress induced RNA (tiRNAs) [XREF_BIBR, XREF_BIBR]."
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"These findings suggest that age-dependent cleavage of tRNA Glu relies on the translocation of ANG from the nucleus to the cytoplasm.Phosphorylation status is a major determinant for the cellular distr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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ANG translocates to the cytosol. 4 / 4
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"Under stress conditions, angiogenin also translocates to the cytosol where it cleaves non coding RNA into RNA fragments, in particular transfer RNAs (tRNAs)."
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"While under stress, ANG translocates to the cytosol and cleaves tRNA into fragments which inhibit ribosome biogenesis and protein synthesis."
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"Under stress conditions, angiogenin also translocates to the cytosol where it cleaves non-coding RNA into RNA fragments, in particular transfer RNAs (tRNAs)."
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"While under stress, ANG translocates to the cytosol and cleaves tRNA into fragments which inhibit ribosome biogenesis and protein synthesis."
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ANG translocates to the nucleolus. 4 / 4
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"Angiogenin, produced by KSHV infection, translocates to the nucleolus and increases the production of rRNA to enhance the survival of the infected endothelial cell [70]."
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"Specifically, the infection of endothelial cells with KSHV induces the expression and secretion of the angiogenesis factor Angiogenin, which in turn translocates into the nucleus and to the nucleolus of subconfluent cells, stimulates proliferation and 45S rRNA gene transcription, and inhibits apoptosis [50]."
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"To promote cell growth and proliferation, angiogenin translocates to the nucleus and nucleolus where it stimulates rRNA transcription."
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"ANG binds to endothelial cells and translocates to nucleolus where it binds to DNA."
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ANG translocates from the nucleus to the cytoplasm. 4 / 4
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"In response to different stress stimuli such as sodium arsenite (SA) treatment, ANG translocates into the cytoplasm from the nucleus, and dissociates from RNH1 ( xref )."
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"In HeLa cells that are stressed with sodium arsenite, ANG translocates from the nucleus to the cytoplasm and accumulates in the SGs that are not associated with RNH1 [13] ."
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"Thus, we hypothesized that environmental stress weakened the interaction of RNH1 and ANG, which resulted in ANG release from the nucleus into the cytoplasm."
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"In response to stress, ANG translocates into cytoplasm from the nucleus and dissociates from RNH1."
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Modified ANG translocates to the cytoplasm. 1 / 1
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"Typically, exogenous ANG translocates into the nucleus at 24 hrs and to the cytoplasm at 72 hrs post-infection."
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Modified ANG translocates to the nucleus. 1 / 1
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"ANG translocates to the nucleus, where it binds ribosomal DNA and stimulates the transcription of rRNA XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR for diverse functions beyond angiogenesis."
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