IndraLab

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ANG translocates to the nucleus. 10 / 291
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"To stimulate blood vessel growth, RNase 5 must be transported to the nucleus; thus, the receptor binding, nuclear translocation, and ribonucleolytic activity are all essential for its actions."
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"Moreover, neomycin, an aminoglycoside antibiotic and also an inhibitor that blocks nuclear translocation of human ANG [ xref ], caused reduced cellular internalization of human ANG in rickettsial-infected HUVECs (Figure  xref E-H)."
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"Indeed, one of the targets of nerve growth factor-triggered PKC phosphorylation is, once again, nucleolin ( xref ), and in a recent investigation evidence was reported that neomycin blocks nuclear translocation of angiogenin by virtue of this antibiotic's inhibitory action on phospholipase C ( xref )."
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"During the study of the mechanism by which ANG is translocated to the nucleus of endothelial cells, neomycin, a phospholipase C (PLC) inhibitor, was found to block nuclear translocation of ANG [XREF_BIBR]."
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"Tamoxifen reversed this increase as well as inhibited nuclear translocation of angiogenin."
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"Human angiogenin is translocated to the nucleus of human umbilical vein endothelial cells in a time dependent manner."
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"Neomycin, an aminoglycoside antibiotic, inhibits nuclear translocation of human angiogenin in human endothelial cells, an essential step for angiogenin-induced angiogenesis."
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"Current evidence suggests that nuclear translocation of ANG is via an unidentified receptor(s) system and independent of lysosomes and the microtubule system [ xref , xref ], but is strictly dependent on endothelial cell density [ xref ]."
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"During early infection, nuclear translocation of ANG was not associated with functional evidence of increased endothelial permeability."
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"In efforts to understand the mechanism by which ANG is translocated to the nucleus of endothelial cells, neomycin was discovered to block nuclear translocation of ANG and to inhibit ANG induced cell proliferation and angiogenesis [XREF_BIBR]."
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ANG translocates to the cytoplasm. 10 / 24
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"In addition, nuclear ANG translocates to the cytoplasm [ xref ]."
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"In addition, nuclear ANG translocates to the cytoplasm (Pizzo et al., 2013), which also promotes tiRNA production."
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"This detachment unwinds nuclear ANG, which is then translocated to the cytoplasm to finally generate more tsRNAs."
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"In addition, nuclear ANG translocates to the cytoplasm [4]."
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"In addition, nuclear ANG translocates to the cytoplasm ( xref ), which also promotes tiRNA production."
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"In primitive HSCs, which are under hypoxic conditions (an element of generalized cellular stress), angiogenin translocates to the cytoplasm and activates the synthesis of anti-apoptotic genes, suppresses global protein translation, and conserves anabolic energy."
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"Once exposed to stress stimuli, ANG dissociates from RNH1 and translocates to the cytoplasm for tRNA processing."
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"Under stress conditions such as oxidative stress, hypoxia, and starvation, ANG may translocate to cytoplasm and cleave tRNAs which will result in global translation inhibition (Fig. 3)."
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"Indeed it has been shown that angiogenin promotes rRNA transcription under permissive growth conditions: under stress conditions angiogenin translocates to the cytoplasm reducing protein translation a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In primitive HSCs, which are under hypoxic conditions (an element of generalized cellular stress), angiogenin translocates to the cytoplasm and activates the synthesis of anti-apoptotic genes, suppresses global protein translation, and conserves anabolic energy."
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ANG translocates from the nucleus. 7 / 7
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"Accordingly, our results suggest that exposure to environmental stressors such as LPS or PA weaken the binding and interaction between RNH1 and ANG, resulting in the release of ANG from the nucleus and increases in the levels of both ANG and tsRNAs in the cytoplasm of EEC."
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"In response to stress, ANG translocates into cytoplasm from the nucleus and dissociates from RNH1."
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"Oxidative stress reportedly alters the localization of RNases; Rny1 in yeast diffuses from the vacuole to the cytoplasm [7] and ANG in mammalian cells translocates from the nucleus to SGs [13] ."
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"At the same time, under stress conditions, ANG translocates from the nucleus and accumulates in the cytoplasm, slicing mature tRNAs to produce tiRNAs [ xref ]."
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"The release of nuclear angiogenin from the nucleus by DNase I indicates that it can directly bind to nuclear DNA."
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"Several stressors induce ANG translocation from the nucleus into the cytoplasm, where it cleaves transfer RNAs (tRNAs) in the anticodon loop to produce tRNA derived stress induced RNA (tiRNAs) [XREF_BIBR, XREF_BIBR]."
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"These findings suggest that age-dependent cleavage of tRNA Glu relies on the translocation of ANG from the nucleus to the cytoplasm.Phosphorylation status is a major determinant for the cellular distr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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ANG translocates to the cytosol. 4 / 4
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"While under stress, ANG translocates to the cytosol and cleaves tRNA into fragments which inhibit ribosome biogenesis and protein synthesis."
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"Under stress conditions, angiogenin also translocates to the cytosol where it cleaves non coding RNA into RNA fragments, in particular transfer RNAs (tRNAs)."
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"While under stress, ANG translocates to the cytosol and cleaves tRNA into fragments which inhibit ribosome biogenesis and protein synthesis."
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"Under stress conditions, angiogenin also translocates to the cytosol where it cleaves non-coding RNA into RNA fragments, in particular transfer RNAs (tRNAs)."
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ANG translocates to the nucleolus. 4 / 4
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"Angiogenin, produced by KSHV infection, translocates to the nucleolus and increases the production of rRNA to enhance the survival of the infected endothelial cell [70]."
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"Specifically, the infection of endothelial cells with KSHV induces the expression and secretion of the angiogenesis factor Angiogenin, which in turn translocates into the nucleus and to the nucleolus of subconfluent cells, stimulates proliferation and 45S rRNA gene transcription, and inhibits apoptosis [50]."
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"To promote cell growth and proliferation, angiogenin translocates to the nucleus and nucleolus where it stimulates rRNA transcription."
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"ANG binds to endothelial cells and translocates to nucleolus where it binds to DNA."
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ANG translocates from the nucleus to the cytoplasm. 4 / 4
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"In response to different stress stimuli such as sodium arsenite (SA) treatment, ANG translocates into the cytoplasm from the nucleus, and dissociates from RNH1 ( xref )."
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"In HeLa cells that are stressed with sodium arsenite, ANG translocates from the nucleus to the cytoplasm and accumulates in the SGs that are not associated with RNH1 [13] ."
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"Thus, we hypothesized that environmental stress weakened the interaction of RNH1 and ANG, which resulted in ANG release from the nucleus into the cytoplasm."
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"In response to stress, ANG translocates into cytoplasm from the nucleus and dissociates from RNH1."
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Modified ANG translocates to the cytoplasm. 1 / 1
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"Typically, exogenous ANG translocates into the nucleus at 24 hrs and to the cytoplasm at 72 hrs post-infection."
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Modified ANG translocates to the nucleus. 1 / 1
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"ANG translocates to the nucleus, where it binds ribosomal DNA and stimulates the transcription of rRNA XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR for diverse functions beyond angiogenesis."
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