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PTEN phosphorylates AKT. 10 / 183
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"Moreover, the specific decrease in PTEN activation and increase in Akt phosphorylation in livers of GDM offspring with CR improved insulin sensitivity and lipid metabolism."
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"Conversely, SF1670, a small molecule inhibitor for phosphatase and tensin homologue (PTEN) XREF_BIBR, markedly increased AKT and mTOR phosphorylation in CD4+ T cells with an inhibitory effect on their Foxp3 expression (XREF_FIG)."
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"Interestingly, we found a close association between the loss of PTEN, the overexpression of cyclin A2, and the phosphorylation of AKT in gastric MALT and DLBCL tumor cells."
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"In addition, PTEN deficiency leads to elevated phosphorylation of Akt, especially in the developing inner plexiform layer, where high levels of PTEN are normally expressed."
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"AKT signaling is important in endothelial-to-mesenchymal transition and myofibroblastic transformation in fibroblasts from the heart and lungs.32, 33 miR-486 may upregulate AKT activity through negative regulation of PTEN expression.43 The phosphoinositide phosphatase PTEN converts PIP3 to PIP2 and thereby negatively modulates AKT activity,31 thus downregulation of PTEN can upregulate AKT phosphorylation.43, 53 We evaluated the role of the AKT pathway in mediating alpha-SMA expression induced by miR-486 mimic."
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"miR inhibits the tumor suppressor gene PTEN which subsequently phosphorylates AKT via PI3K and Akt signaling, contributing to tumorigenesis."
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"These data support that E2 induced ROS signalling occurs upstream of AKT and E2 induced ROS inactivation of PTEN may allow the increased phosphorylation of the known downstream kinase AKT."
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"Mechanically, galangin increases the expression of phosphatase and tensin homolog (PTEN), a direct target of miR-21, resulting in decreased phosphorylation of AKT, a protein kinase which plays a critical role in controlling survival and apoptosis."
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"Dephosphorylation of PI (3,4,5) P3 by PTEN prevents the phosphorylation and activation of Akt kinase [XREF_BIBR]."
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"MOTS-c increases mTORC2 and inhibits PTEN activity, which modulates AKT phosphorylation."
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Modified PTEN leads to the phosphorylation of AKT. 10 / 20
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"Dominant negative Akt prevents IGF-I mediated survival in Schwann cells, and PTEN overexpression, which decreases Akt phosphorylation, enhances mannitol induced NBL cell apoptosis."
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"In these experiments, expression of PTEN C124S or PTEN G129E had no detectable effect on Akt phosphorylation, whereas expression of either wild-type PTEN or PTEN Y138L at approximately physiological levels greatly reduced the phosphorylation of Akt."
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"Expression of exogenous PTEN in mutant cells restores both their sensitivity to agonist induced apoptosis and normal pattern of PKB and Akt phosphorylation."
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"Di-Poi et al. suggested that PPARbeta and delta activation increases the expression of 3-phosphoinositide-dependent-protein kinae 1 (PDPK1) and integrin linked kinase (ILK), and decreases the expression of PTEN, causing increased phosphorylation of AKT, leading to antiapoptotic signaling and enhanced cell survival [XREF_BIBR]."
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"Thus, the signaling pathway by which TGFbeta and ALK5 regulates Clara cell differentiation may entail inhibition of Pten expression, which in turn activates ERK and AKT phosphorylation."
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"We previously demonstrated that Morgana binds to and inhibits ROCK I and II XREF_BIBR, XREF_BIBR and that through ROCK I inhibition Morgana downregulates PTEN expression levels thus enhancing AKT phosphorylation 14."
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"The downregulation of PTEN expression increased Akt phosphorylation, but did not increase that of ERK 1/2."
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"Transfection of miR-371b-5p mimic into hiPSC-ATIICs leads to significantly decreased expression of endogenous PTEN, which stimulates phosphorylation of Akt and its downstream substrates, GSK3beta and FOXOs, promoting cell proliferation."
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"PPARgamma and PTEN expression were increased and phosphorylated AKT was present at relatively low expression levels in rosiglitazone treated ovaries."
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"Expression of exogenous PTEN in mutant cells restores both their sensitivity to agonist induced apoptosis and normal pattern of PKB and Akt phosphorylation."
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PTEN phosphorylates AKT on S473. 10 / 11
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"Downregulation of PTEN increases phosphorylation of Akt at Ser473, activating a pathway that leads to increased cell migration."
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"Here, we report that Pten (-/-) mouse blood contains 25% more platelets than Pten (+/+) blood and that PTEN deficiency significantly shortened the bleeding time, increased the sensitivity of platelets to collagen induced activation and aggregation, and enhanced phosphorylation of Akt at Ser473 in response to collagen."
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"PTEN upregulation impaired Akt recruitment to the plasma membrane and suppressed Akt phosphorylation at Ser473, thereby inhibiting Akt/GSK3beta/beta-catenin signaling and the expression of COL1 and OCN in BMSCs in vitro and in vivo."
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"To verify the proposed signaling mechanisms for spiral ganglion defects in Pax2 Cre/+; Pten loxP and loxP mice, we examined whether Pten deficiency (XREF_SUPPLEMENTARY) upregulates Ser473 phosphorylation of Akt and triggers Ser9 phosphorylation of GSK3beta (pGSK3beta) in the PI3K signaling cascade."
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"In stimulated macrophages, PTEN oxidation led to the temporary inhibition of its phosphatase activity and in the phosphorylation of Akt on Serine 473."
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"Apart from acting as tumour suppressor, PTEN can negatively regulate the activity of AKT through its lipid phosphatase function by dephosphorylating AKT at Ser473 [XREF_BIBR]."
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"The data in XREF_FIG and XREF_SUPPLEMENTARY (repeat experiments) also show that the extent of Akt S473 phosphorylation induced in the cells upon rescue by P110 * or Pten ablation is moderate and closer to that seen in resting mature B cells than B cells activated by BCR engagement or even just exposed to serum containing culture medium."
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"As expected, Pten -/- mice had increased AKT S473 phosphorylation, a signature activity of mTORC2 activity in mature thymocytes (XREF_FIG)."
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"Immunohistochemical staining of dorsolateral prostate lobes indicated that deletion of Sox4 reduced the PTEN loss-induced phosphorylation of AKT at serine 473 ( xref )."
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"Pten deficiency induced increased phosphorylation of Akt at Ser473."
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Mutated PTEN leads to the phosphorylation of AKT. 7 / 7
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"In their study, Pten mutation alone led to enhanced Akt phosphorylation and lipid aggradation in hepatocytes."
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"While both PKB and Akt and GSK3 phosphorylation was inhibited by p110beta inhibitors in PTEN mutant cell lines, S6 phosphorylation remained unchanged (XREF_FIG)."
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"It has been reported that PTEN mutation could promote phosphorylation of Akt in the context of PIK3CA mutation, and in turn provide additive effect on the activation of PI3K pathway."
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"While both PKB and Akt and GSK3 phosphorylation was inhibited by p110beta inhibitors in PTEN mutant cell lines, S6 phosphorylation remained unchanged (XREF_FIG)."
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"However, the mutated PTEN-cell line EN-1078D express weak levels of phospho-Akt (data not shown) which suggests that the simple mutation of PTEN in this cell line is not sufficient to induce constitutive Akt phosphorylation."
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"These results suggest that PIK3CA and PTEN mutations more effectively activate AKT kinase activity and phosphorylation of select AKT downstream targets in cervical tumors when the patient is non obese."
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"In ovaries, PTEN mutation leaded to over-phosphorylation of AKT."
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PTEN leads to the phosphorylation of AKT on T308. 3 / 3
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"PTEN then acts to inhibits PI3K activity and thus block phosphorylation of Akt on its other activating site, at Thr308."
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"As expected, infection of Pten loxP and loxP MEFs with Adeno-Cre reduces PTEN expression, and elevates both Akt S473 and Akt T308 phosphorylation in serum deprived cells [XREF_FIG, lanes 1 & 3] and in insulin stimulated cells [XREF_FIG, lanes 2 & 4]."
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"However, a recent report by Rodrik-Outmezguine et al. showed that phosphorylation of AKT at the Thr308 site and of the AKT substrates including PRAS40, GSK-3beta and FOXO1/3 are only transiently repressed by mTORKIs in PIK3CA mutant (MCF7, BT474) and PTEN deficient (MDA-MB-468) breast cancer cell lines [XREF_BIBR]."
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PTEN-C124S leads to the phosphorylation of AKT. 2 / 2
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"Conclusion The wtPTEN inhibited insulin- or rhEGF stimulated phosphorylation of Akt, while PTEN C124S and G129E mutants failed to activate the phosphorylation of Akt consistently."
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"PTEN C124S mutant activated insulin stimulated phosphorylation of Akt, but not rhEGF stimulated phosphorylation of Akt."
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PTEN leads to the phosphorylation of phosphorylated AKT. 2 / 2
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"Under normal circumstances, PTEN negatively regulates PI3K-AKT mediated signaling by dephosphorylating phosphatidyl-inositol-triphosphate and p-AKT (Osaki et al., 2004), and thus plays critical roles [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Under normal circumstances, PTEN restrains the role of PI3K and negatively regulates PI3K-AKT mediated signaling by dephosphorylating phosphatidyl-inositol-triphosphate and p-AKT."
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Lysine-methylated PTEN leads to the phosphorylation of AKT. 1 / 1
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"Furthermore, the decrease of mono-ADP-ribosylation of histones in colorectal carcinoma cells resulted in an increase of histone H3 trimethylated at lysine 4 and phosphatase and tensin homolog, thus reducing the phosphorylation of the PI3K and Akt signaling pathway."
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PTEN leads to the phosphorylation of AKT on S9. 1 / 1
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"To verify the proposed signaling mechanisms for spiral ganglion defects in Pax2 Cre/+; Pten loxP and loxP mice, we examined whether Pten deficiency (XREF_SUPPLEMENTARY) upregulates Ser473 phosphorylation of Akt and triggers Ser9 phosphorylation of GSK3beta (pGSK3beta) in the PI3K signaling cascade."
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Phosphorylated PTEN leads to the phosphorylation of AKT. 1 / 1
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"Compared with the control group, silencing PlncRNA-1 expression with PCa DU145 and 22Rv1 cells increased PTEN protein and phosphorylated PTEN protein levels but decreased the expression levels of Akt protein and phosphorylated Akt protein in siPlncRNA-1 group (Figure 6D–6F)."
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Modified PTEN leads to the phosphorylation of AKT on serine. 1 / 1
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"Suppression of PTEN expression with siRNA significantly reduced the p53 and p21 levels and activated Akt phosphorylation at Ser (473) and Thr (308), resulting in decreased apoptosis and increased cell survival."
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Tyrosine-phosphorylated PTEN leads to the phosphorylation of AKT. 1 / 1
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"We demonstrated that tyrosine phosphorylation of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) underlies the increased Akt-Ser473 phosphorylation by orthovanadate."
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Phosphatase-active PTEN leads to the phosphorylation of AKT. 1 / 1
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"Ectopic expression of wild-type PTEN in MCF-7 epithelial breast cancer cells resulted in universal inhibition of Akt phosphorylation in response to stimulation by diverse growth factors and selective inhibition of MEK/extracellular signal-regulated kinase (ERK) phosphorylation stimulated by insulin or insulin-like growth factor 1 (IGF-1)"
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Modified PTEN leads to the phosphorylation of AKT on S473. 1 / 1
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"This IGF-2-overexpression-mediated Akt phosphorylation at Ser473 is modulated by PTEN protein expression levels, but the exact mechanism by which PTEN regulates Ser473 phosphorylation of Akt is unclear."
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Modified PTEN-C124S leads to the phosphorylation of AKT. 1 / 1
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"Deletion of Pten led to an increase in Akt phosphorylation which was not reduced by the expression of PTEN C124S."
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Modified PTEN leads to the phosphorylation of AKT on threonine. 1 / 1
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"Suppression of PTEN expression with siRNA significantly reduced the p53 and p21 levels and activated Akt phosphorylation at Ser (473) and Thr (308), resulting in decreased apoptosis and increased cell survival."
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